CN103976359A - Food nutrition enriched composition and application thereof as well as healthcare food and preparation method thereof - Google Patents
Food nutrition enriched composition and application thereof as well as healthcare food and preparation method thereof Download PDFInfo
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- CN103976359A CN103976359A CN201410222111.7A CN201410222111A CN103976359A CN 103976359 A CN103976359 A CN 103976359A CN 201410222111 A CN201410222111 A CN 201410222111A CN 103976359 A CN103976359 A CN 103976359A
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- food
- powder
- mixture
- health food
- lactoferrin
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to the field of healthcare food, and particularly relates to a food nutrition enriched composition and an application thereof as well as healthcare food and a preparation method thereof. The food nutrition enriched composition comprises galactooligosaccharide, milk minerals and lactoferrin. Compared with a single dosage, the food nutrition enriched composition provided by the invention has a remarkably synergistic effect in terms of immunity enhancement.
Description
Technical field
The present invention relates to field of health care food, particularly food nutrient fortifying composition and application thereof, health food and preparation method thereof.
Background technology
Immunity is the defense mechanism of human body self, that body is resisted external invasion and attack, safeguarded the ability of homoiostasis, be human body identification and any foreign matter (virus, bacterium etc.) of eliminating external intrusion, process the ability of self cell and identification and processing vivo mutations cell and the virus infected cell of old and feeble, damage, death, sex change.When immune function of human body imbalance, or immune system is when unsound, and health is easy to infected, as flu, tonsillitis, asthma, bronchitis, pneumonia, diarrhoea etc. show effects repeatedly, and Yi Haiyi brings out major disease, as cancer.Modern medicine scientific discovery, immunity is the factor that and aging have substantial connection.According to relevant, body's immunity just starts to subtract late about 30 years old, modern's rhythm of life accelerate, the live pressure of irregular, work and study environment and factor such as do not get enough athletic exercise in addition again, and hypoimmunity crowd's quantity is the trend increasing year by year.Therefore the immunity that, how to improve hypoimmunity crowd becomes the focus of modern medicine study.
The immunity of human body depends on gene mostly, but the impact of environment is also very large, as diet, sleep, motion, pressure etc.Wherein diet has conclusive influence power, because the composition of some food can be assisted stimulating immune system, strengthens immunocompetence.If lack these important nutritional labelings, can have a strong impact on the immune system function of health.The nutritional labeling that can strengthen immunity comprises vitamin, collagen, iron content zinc selenium food, newborn immune protein etc.Studies show that, the interferon of the external infringement of body resistance and the quantity of all kinds of immunocytes are all relevant with vitamin with vigor.Collagen is a kind of extracellular protein, is rich in the amino acid such as glycine that human body needs, proline, hydroxyproline, and immunocyte can be combined with collagen, and a succession of immune response occurs, and promotes immunity function, thereby resistance of human body is increased.Zinc can maintain thymus gland and periphery lymphocyte normal function, and scarce zinc can cause thymus gland and peripheral lymph nodes atrophy, and lymphocyte function is weakened, and immunocyte is grown and is subject to obstacle, thereby reduces immune function of human body and leucocyte bactericidal action; Zinc participates in metabolism and the oxidation-reduction process of nucleic acid, protein and energy, is conducive to the schizogamy of immunocyte, and balanced in holder, appropriate zinc can enhanced machine body immunity function.Yet simple food intake can not meet hypoimmunity crowd's demand completely.Therefore, provide a kind of health food that can strengthen body immunity to have important practical significance.
Summary of the invention
In view of this, the invention provides food nutrient fortifying composition and application thereof, health food and preparation method thereof.With respect to each single dose, the food nutrient fortifying composition making after galactooligosaccharide, newborn mineral salt and lactoferrin combination is having significant synergies aspect enhancing immunity.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of food nutrient fortifying composition, comprise galactooligosaccharide, newborn mineral salt and lactoferrin.
Galactooligosaccharide is that modern glycobiology and modern micro-ecological medical science merge and the functional oligose that grows up mutually, is to have representational high-tech leading-edge products.Galactooligosaccharide is bred Bifidobacterium by highly selective to be made human body maximum microecosystem---intestinal microecology system is able to balance, thereby the prevention of host's nutrition, immunity and disease and treatment are being brought into play to positive effect, be called as " outstanding representative of functional oligose of new generation ".Galactooligosaccharide is after by Bifidobacterium, optionally glycolysis utilizes, and the beneficial bacteriums such as Bifidobacterium with in 40 times of speed propagation human body intestinal canals that increase progressively, suppress the generation of harmful bacteria, and regulating intestinal canal microecological balance, produces the health-care efficacy that is conducive to host.Its health-care efficacy comprises: the absorption rate, the promotion mineral absorption that 1. promote synthetic B family vitamin, raising protein; 2. strengthen field planting drag and the immunity of human body intestinal canal: galactooligosaccharide is by propagation Bifidobacterium, suppress harmful bacteria, strengthen field planting drag and the immunity of human body intestinal canal, also make the harmful substances such as ammonia in body, hydrogen sulfide, amine, phenol, indole, bacteriotoxin, carcinogenic substance (nitroso compound, epoxides, secondary bile acid) reduce simultaneously; 3. promote human body intestinal canal to wriggle: galactooligosaccharide can promote human body intestinal canal to wriggle, the ahead running ability of enteron aisle is strengthened, thereby harmful substance is discharged from human body in time.4. caries prevention: galactooligosaccharide has not digested, low sugariness, feature low in calories, is not utilized by the streptococcus in oral cavity, is not also decomposed by oral cavity enzyme, so have the function of caries prevention; 5. suppress endotoxin: bifidobacterium fermentation compound sugar, produces SCFA (be mainly acetic acid and lactic acid, mol ratio is 3:2) and some antibiotic substance, thereby otherwise can suppress the growth of external source pathogenic bacteria and the interior intrinsic putrefactivebacteria of intestines.Acetic acid and newborn bacterium all can suppress the growth of intestines putrefactivebacteria in enteron aisle, reduce carcinogenic substance and the infringements of other toxicants to body such as these bacteriogenic toxic amines, indole, indoles, ammonia, hydrogen sulfide, delay body aging process.
Breast mineral salt is a kind of new resource food, have another name called milk calcium, whey mineral concentrate, whey calcium, derive from cow's milk, it is the off-white powder that cow's milk is permeated, obtained after the PROCESS FOR TREATMENT such as separated, concentrated and spraying is dry by film, its main component is calcium phosphate, in addition also comprises the abundant nutritional labelings such as protein, lactose and zinc, phosphorus, sodium, potassium, magnesium, and calcium content is about 23%～28%, its calcium-phosphorus ratio is 2:1, is beneficial to absorbing of human body.Breast mineral salt not only can supplement the absorption of calcium, reduces blood pressure in addition, prevents the health-care effects such as arteries is narrow.
Lactoferrin is a kind of multifunctional protein, has broad-spectrum antiseptic, viral infection resisting function, has iron balance in the human body of adjusting, promotes to regulate body's immunity, strengthens the functions such as body resistance against diseases.In recent years, along with development and the maturation of biotechnology, many countries start to notice the practical value of lactoferrin.Scientific research personnel utilizes molecular biology principle, through research experiment, and has carried out clinical testing, has determined that it has the seven large functions such as broad-spectrum antiseptic to human body: 1. lactoferrin has broad-spectrum antibacterial action; 2. lactoferrin has antivirus action: lactoferrin, by suppressing cell entry cell, alleviates the infringement to human hepatocyte; 3. lactoferrin has antitumaous effect: alimentary tract cancer is had to chemoprophylaxis effect the metastases that can suppress to cause thus as colon cancer, cancer of the stomach, liver cancer etc.; 4. lactoferrin has antioxidation: can suppress easyproization barbiturates that the lipid peroxidation process of iron induction produces and the generation of MDA; 5. lactoferrin regulates organism immune response: antagonist generates, T Hemapoiesis, and in lymphocyte, NK ratio all has regulating action; 6. lactoferrin is with the synergy of medicine: can reduce drug dose with Multiple Classes of Antibiotics and antiviral drugs synergy, reduce antibiotic or antifungal preparation to the infringement of human liver function etc.; 7. lactoferrin regulates the absorption of intestines and stomach iron.Along with the exploitation of the functional mechanism of lactoferrin, its range of application will constantly expand, and lactoferrin will be widely used in the aspects such as disease treatment, nutritional supplementation, food.
In the present invention, with respect to each single dose, the food nutrient fortifying composition making after galactooligosaccharide, newborn mineral salt and lactoferrin combination is having significant synergies aspect enhancing immunity.
As preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and lactoferrin is (1600～1800): (830～930): (70～170).
Preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and lactoferrin is 1700:880:120.
As preferably, the degree of polymerization of galactooligosaccharide is 4～10.
In embodiment more provided by the invention, the average degree of polymerization of galactooligosaccharide is 3.2.
In embodiment more provided by the invention, galactooligosaccharide, newborn mineral salt, lactoferrin are all commercially available.
The present invention also provides this food nutrient fortifying composition to strengthen the application in immunity health food in preparation; This food nutrient fortifying composition comprises galactooligosaccharide, newborn mineral salt and lactoferrin; As preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and lactoferrin is (1600～1800): (830～930): (70～170).
The present invention also provides a kind of health food, comprises acceptable auxiliary material and food nutrient fortifying composition provided by the invention in bromatology; This food nutrient fortifying composition comprises galactooligosaccharide, newborn mineral salt and lactoferrin; As preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and lactoferrin is (1600～1800): (830～930): (70～170); Preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and lactoferrin is 1700:880:120.
In embodiment more provided by the invention, pharmaceutically acceptable auxiliary material is a kind of or both the above mixtures in Fruit powder, flavoring essence, sweetener, acid, filler, lubricant, anticorrisive agent, food coloring, disintegrant.
As preferably, Fruit powder is a kind of or both the above mixtures in orange powder, orange powder, lemon powder, cherry powder, apple powder or coconut palm powder.But those skilled in the art think that feasible Fruit powder is all within protection scope of the present invention, and Fruit powder kind is not limited to this, and the present invention does not limit at this.
As preferably, flavoring essence is a kind of or both the above mixtures in flavoring orange essence, orange essence, lemon extract, cherry essence, menthol, flavoring apple essence or coconut palm essence.But those skilled in the art think that feasible flavoring essence is all within protection scope of the present invention, and flavoring essence kind is not limited to this, and the present invention does not limit at this.
In order to increase the mouthfeel of health products, also can add sweetener to increase the sugariness of health products.As preferably, sweetener is a kind of or both the above mixtures in Sucralose, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, Aspartame or mogroside.But those skilled in the art think that feasible sweetener is all within protection scope of the present invention, and sweetener kind is not limited to this, and the present invention does not limit at this.
As preferably, acid is a kind of or both the above mixtures in citric acid, malic acid, lactic acid or citric acid.But those skilled in the art think that feasible acid is all within protection scope of the present invention, and acid kind is not limited to this, and the present invention does not limit at this.
Filler refers to increase the weight and volume of tablet, is beneficial to the auxiliary material of compressing tablet.Filler requirement mobility, compressibility as tablet are good, and adhesion is strong, and medicine is had to larger saturation.As preferably, filler is a kind of or both the above mixtures in fructose, glycitols, sucrose, starch, pregelatinized starch, microcrystalline cellulose or dextrin.But those skilled in the art think that feasible disintegrant is all within protection scope of the present invention, and filler kind is not limited to this, and the present invention does not limit at this.
Lubricant refers to the auxiliary material that can reduce frictional force between tablet and die wall, and to prevent that frictional force from making greatly compressing tablet difficulty, in the time of can making compressing tablet, pressure distribution is even, and makes the even density of tablet, can also improve the outward appearance of tablet, makes tablet surface light, smooth.As preferably, lubricant is a kind of or both the above mixtures in talcum powder, dolomol, silica or stearic acid.But those skilled in the art think that feasible lubricant is all within protection scope of the present invention, and lubricant kind is not limited to this, and the present invention does not limit at this.
As preferably, anticorrisive agent is a kind of or both the above mixtures in Sodium Benzoate, Potassium Benzoate, sorbic acid methyl esters, ethyl-para-hydroxybenzoate or P-hydroxybenzoic acid phenyl ester.But those skilled in the art think that feasible anticorrisive agent is all within protection scope of the present invention, and anticorrisive agent kind is not limited to this, and the present invention does not limit at this.
As preferably, food coloring is a kind of or both the above mixtures in burnt sugar coloring, Gardenia Yellow, curcumin or chlorophyll.But those skilled in the art think that feasible food coloring is all within protection scope of the present invention, and food coloring kind is not limited to this, and the present invention does not limit at this.
The Main Function of disintegrant is to eliminate because adhesive or the adhesion that forms tablet by pressurizeing make the rapid disintegration of tablet, makes tablet can bring into play rapidly drug effect.As preferably, disintegrant is a kind of or both the above mixtures in dried starch, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, PVPP or sodium carboxymethylcellulose.But those skilled in the art think that feasible disintegrant is all within protection scope of the present invention, and filler kind is not limited to this, and the present invention does not limit at this.
In embodiment more provided by the invention, the formulation of health food is pulvis, tablet, capsule or granule.
As preferably, the formulation of health food is pulvis or tablet.
In embodiment more provided by the invention, health caring food tablet is chewable tablets or buccal tablet.
In embodiment more provided by the invention, acceptable Optimization of Adjuvant whole-fat milk powder and/or fructose in bromatology in pulvis.
As preferably, fructose is crystal diabetin.
As preferably, in pulvis, the mass ratio of galactooligosaccharide, newborn mineral salt, lactoferrin, whole-fat milk powder and fructose is (1600～1800): (830～930): (70～170): (1600～1750): (50～200).
The present invention also provides the preparation method of this health food, takes food acceptable auxiliary material in conduct and learning and mixes with food nutrient fortifying composition provided by the invention, obtains; This food nutrient fortifying composition comprises galactooligosaccharide, newborn mineral salt and lactoferrin; As preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and lactoferrin is (1600～1800): (830～930): (70～170); Preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and lactoferrin is 1700:880:120.
In embodiment more provided by the invention, the composition of health products chewable tablets comprises galactooligosaccharide, newborn mineral salt, lactoferrin, filler, sweetener, flavoring essence.
As preferably, the mass ratio of galactooligosaccharide, newborn mineral salt, lactoferrin, filler, sweetener and flavoring essence is (1600～1800): (830～930): (70～170): (1000～2000): (50～100): (50～100).
As preferably, filler is the mixture of microcrystalline cellulose and sweet mellow wine.
As preferably, sweetener is Aspartame.
As preferably, aromatic is flavoring orange essence.
In the preparation method of chewable tablets, during softwood processed, need add ethanol, the addition of ethanol is held i.e. loose being advisable of agglomerating, light pressure with softwood.
Buccal refers to that medicine oral transmucosal directly and fast absorbs and brings into play the tablet of general action, and it can avoid the first-pass effect of liver to medicine.In embodiment more provided by the invention, buccal is buccal tablet or oral disnitegration tablet.
In embodiment more provided by the invention, the composition of health product oral disintegrated tablet comprises galactooligosaccharide, newborn mineral salt, lactoferrin, filler, lubricant, disintegrant, sweetener, flavoring essence, adhesive.
As preferably, the mass ratio of galactooligosaccharide, newborn mineral salt, lactoferrin, filler, disintegrant, sweetener and flavoring essence is (1600～1800): (830～930): (70～170): (1000～2000): (100～150): (50～100): (50～100).
As preferably, filler is the mixture of microcrystalline cellulose, sweet mellow wine.
As preferably, disintegrant is the mixture of sodium carboxymethylcellulose (CMS-Na) and low-substituted hydroxypropyl cellulose (L-HPC).
As preferably, lubricant is talcum powder.
As preferably, sweetener is Aspartame.
As preferably, flavoring essence is flavoring orange essence.
As preferably, adhesive is starch slurry.
In embodiment more provided by the invention, the concentration of starch slurry is 4%.
In embodiment more provided by the invention, agglomerating to hold, the light pressure of the addition of the addition starch slurry of starch slurry i.e. loose being advisable.
In embodiment more provided by the invention, the composition of health products buccal tablet comprises galactooligosaccharide, newborn mineral salt, lactoferrin, filler, sweetener, flavoring essence.
As preferably, the mass ratio of galactooligosaccharide, newborn mineral salt, lactoferrin, filler, sweetener and flavoring essence is (1600～1800): (830～930): (70～170): (1000～2000): (50～100): (50～100).
As preferably, filler is the mixture of sucrose and xylitol.
As preferably, sweetener is Aspartame.
As preferably, flavoring essence is flavoring orange essence and/or menthol.
In embodiment more provided by the invention, in this preparation method, the formulation of health food is pulvis or tablet.
In embodiment more provided by the invention, in this preparation method, in tablet, in bromatology, acceptable auxiliary material is whole-fat milk powder and/or fructose.
As preferably, in this preparation method, fructose is crystal diabetin.
As preferably, the mass ratio of the galactooligosaccharide in this preparation method's tablet, newborn mineral salt, lactoferrin, whole-fat milk powder and fructose is (1600～1800): (830～930): (70～170): (1600～1750): (50～200).
Preferably, the mass ratio of galactooligosaccharide, newborn mineral salt and the lactoferrin in this preparation method's tablet is 1700:880:120.
The invention provides food nutrient fortifying composition and application thereof, health food and preparation method thereof.This food nutrient fortifying composition comprises galactooligosaccharide, newborn mineral salt and lactoferrin.Antibody-producting cell detects result of the test and shows the significantly number (P<0.05) of enhancing antibody formation cell of food nutrient fortifying composition provided by the invention, with respect to single dose, this food nutrient fortifying composition is having significant synergies aspect enhancing immunity; Human feeding trial result shows that health food pulvis provided by the invention can significantly improve the content of macrophage in blood medium size lymphocyte and body, has the effect of remarkable enhancing immunity of organisms.
The specific embodiment
The invention discloses food nutrient fortifying composition and application thereof, health food and preparation method thereof, those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can change methods and applications as herein described or suitably change and combination within not departing from content of the present invention, spirit and scope, realizes and apply the technology of the present invention.
In food nutrient fortifying composition provided by the invention and application thereof, health food and preparation method thereof, raw materials used or auxiliary material all can be buied by market.Wherein, galactooligosaccharide is purchased from Jiangmen Quantum High-tech Biology Co., Ltd; Breast mineral salt is purchased from the permanent natural group of New Zealand; Lactoferrin is purchased from New Zealand TATUA.
The healthy Male Kunming strain mice of SPF level is bred by Guangxi Medical University's medical experiment animal center, production licence number: SCXK (osmanthus) 2009-0002, the Quality of Experimental Animals quality certification number: 00021243.
Key instrument and reagent: animal platform balance, electronic analytical balance, centrifuge, clean bench, CO2gas incubator, constant water bath box, microscope, aseptic operation apparatus, micro syringe, cell counter, the flat Tissue Culture Plate in 24 holes and 96 holes, the 96 U-shaped Tissue Culture Plates in hole, glass dish, gauze, slide, test tube, 200 eye mesh screens, timer hemoglobin pipet etc.; Sheep red blood cell (SRBC) (SRBC), physiological saline, Hank's liquid (pH7.2～7.4), RPMI1640 nutrient solution, complement (GPS), SA buffer solution, agarose etc.
Below in conjunction with embodiment, further set forth the present invention:
The preparation of embodiment 1 food nutrient fortifying composition
Get galactooligosaccharide 1600g, newborn mineral salt 930g, lactoferrin 170g mixing, obtain.
The preparation of embodiment 2 food nutrient fortifying compositions
Get galactooligosaccharide 1700g, newborn mineral salt 880g, lactoferrin 120g mixing, obtain.
The preparation of embodiment 3 food nutrient fortifying compositions
Get galactooligosaccharide 1800g, newborn mineral salt 830g, lactoferrin 70g mixing, obtain.
Embodiment 4 animal experiments
Select 70 of the healthy Male Kunming strain mice of SPF level, body weight is 18～22 grams, experimental situation condition: 22～25 ℃ of animal used as test room temperatures, relative humidity 55～70%.
Every batch of animal is divided into 7 groups at random by body weight, every 10 mouse are 1 group, comprise control group and test group, control group is the first control group (giving deionized water), the second control group (giving galactooligosaccharide single dose), the 3rd control group (giving newborn mineral salt single dose), the 4th control group (giving lactoferrin single dose), test group is the first test group (the food nutrient fortifying composition that embodiment 1 provides), the second test group (the food nutrient fortifying composition that embodiment 2 provides), the 3rd test group (the food nutrient fortifying composition that embodiment 3 provides), each group is all by 0.075g/kg.bw per os gavage, every day gavage once, gavage is 30 days continuously.
Adopt Jerne improvement slide method to carry out antibody-producting cell detection.Concrete test method is: get the sheep blood of defiber, with physiological saline washing 3 times, each centrifugal 10min (2000r/min), is made into hematocrit SRBC with physiological saline the cell suspension of 2% (v/v), every mouse lumbar injection 0.2mL.The immunity mouse of latter 5 days is put to death, get spleen, grind gently, with Hank's liquid, make cell suspension, 200 eye mesh screens filter, and wash, centrifugal 2 times, finally cell are suspended in 5mL RPMI1640 nutrient solution.By after top layer culture medium (1g agarose adds distilled water to 100mL) heating for dissolving, put 45～50 ℃ of water bath heat preservations, with equivalent pH7.2～7.4, the Hank's liquid of 2 times of concentration mixes, packing small test tube, every pipe 0.5mL, in pipe, add the 10%SRBC50 μ L (v/v) with the preparation of SA liquid again, 25 μ L splenocyte suspensions, after mixing rapidly, be poured on the slide of oneself brush agarose thin layer, after solidifying, the flat button of slide is placed on fragmentation frame, put into CO2gas incubator and hatch 1.5h, with the complement (1:8) of SA buffer solution dilution, add in slide frame groove, continue to hatch 1.5h, counting hemolysis plaque number.With plaque number/10
6splenocyte represents antibody-producting cell number.
Result of the test is as shown in table 1.
Table 1 antibody-producting cell detects result of the test
Data result from table 1, the average hemolysis plaque number of test group is between 252 ± 67～275 ± 72, the food nutrient fortifying composition that demonstration embodiment 1 to 3 provides is the number (P<0.05) of enhancing antibody formation cell significantly, with respect to single dose, the food nutrient fortifying composition that embodiment 1 to 3 provides has significant synergies, and the synergistic effect of the food nutrient fortifying composition that especially embodiment 2 provides is the most remarkable.Result of the test shows the significantly generation of enhancing antibody of food nutrient fortifying composition that embodiment 1 to 3 provides, and strengthens immunity.
The preparation of embodiment 5 health food pulvis
The prescription of health food pulvis is as shown in table 2.
The prescription of table 2 health food pulvis (making 1000 bags)
Crystal diabetin is used pelletizing machine to cross 40 mesh sieves, takes recipe quantity, standby.
The food nutrient fortifying composition that embodiment 1 is provided, whole-fat milk powder, crystal diabetin mix 30 minutes even to color.
Finally pack, controlled humidity is below 50%, and the back of the body seals, the blank aluminium foil of 80mm, 4.5g/ bag, every bag of content uniformity ± 4.5%.
The preparation of embodiment 6 health food pulvis
The prescription of health food pulvis is as shown in table 3.
The prescription of table 3 health food pulvis (making 1000 bags)
Crystal diabetin is used pelletizing machine to cross 40 mesh sieves, takes recipe quantity, standby.
The food nutrient fortifying composition that embodiment 2 is provided, whole-fat milk powder, crystal diabetin mix 30 minutes even to color.
Finally pack, controlled humidity is below 50%, and the back of the body seals, the blank aluminium foil of 80mm, 4.5g/ bag, every bag of content uniformity ± 4.5%.
The preparation of embodiment 7 health food pulvis
The prescription of health food pulvis is as shown in table 4.
The prescription of table 4 health food pulvis (making 1000 bags)
Crystal diabetin is used pelletizing machine to cross 40 mesh sieves, takes recipe quantity, standby.
The food nutrient fortifying composition that embodiment 3 is provided, whole-fat milk powder, crystal diabetin mix 30 minutes even to color.
Finally pack, controlled humidity is below 50%, and the back of the body seals, the blank aluminium foil of 80mm, 4.5g/ bag, every bag of content uniformity ± 4.5%.
The preparation of embodiment 8 health food chewable tablets
The prescription of health food chewable tablets is as shown in table 5.
The prescription of table 5 health food chewable tablets (making 1000)
Food nutrient fortifying composition, sweet mellow wine that getting embodiment 1 provides are crossed respectively 80 mesh sieves, mix, with ethanolic solution softwood processed (addition of ethanol is held i.e. loose being advisable of agglomerating, light pressure with softwood), 16 mesh sieves are granulated, dry, the whole grain of 12 mesh sieves, add that microcrystalline cellulose, A Siba are sweet, flavoring orange essence, mix, compressing tablet, obtains.
The preparation of embodiment 9 health food buccal tablets
The prescription of health food buccal tablet is as shown in table 6.
The prescription of table 6 health food buccal tablet (making 1000)
Food nutrient fortifying composition, sucrose, xylitol that getting embodiment 2 provides are crossed respectively 80 mesh sieves, mix, with 40% ethanolic solution softwood processed (addition of ethanolic solution is held i.e. loose being advisable of agglomerating, light pressure with softwood), 16 mesh sieves are granulated, dry, the whole grain of 12 mesh sieves, add Aspartame, flavoring orange essence, menthol, mix, compressing tablet, obtains.
Embodiment 10 human feeding trials
Study subject choice criteria: the crowd of simple hypoimmunity, the age is between 45～65 years old.
Experimental design and grouping: adopt two kinds of control design between self and group.By the routine experimenter of above-mentioned Standard Selection 120, according to the requirement of randomized double-blind, divide into groups, be divided into test-meal group and control group, every group of experimenter's 60 examples, consider that as far as possible the principal element that affects result is as age, sex, diet etc., carry out harmony check, to guarantee the comparativity between group, grouping situation is in Table 5.The front two groups of blood of test-meal, urine, just routine and hepatic and renal function, Chest X-rays, electrocardiogram, B ultrasonic etc. check all in normal range (NR), in two groups of subject age, sex, blood medium size lymphocyte and bodies, the equal no significant difference of content (P > 0.05) of macrophage, has comparativity.
Physical data comparison before table 5 test-meal
| Project | Control group | Test-meal group |
| Number of cases | 60 | 60 |
| Male/female | 32/28 | 34/26 |
| Age (year) | 49.72±5.21 | 50.32±5.83 |
| Lymphocyte (on average) % | 15.36±0.43 | 15.58±0.48 |
| Macrophage (on average) % | 1.57±0.49 | 1.66±0.33 |
Test-meal group is taken the health food pulvis 1 time that embodiment 5 provides for each person every day, and each 1 bag, control group is taken placebo (placebo is whole-fat milk powder, and consumption is 4.5g, is consistent with test group pulvis consumption), takes continuously 60 days.After test-meal situation in Table 6, table 7.
Table 6 blood testing-lymphocyte
Table 7 body fluid chemical examination-macrophage
From table 6, table 7, take latter 60 days, content with respect to the lymphocyte before test-meal and macrophage after the test-meal of test-meal group is significantly increased (P < 0.01), and two group differences very significantly (P < 0.01).Result shows that examination took health food pulvis that the embodiment of the present invention 5 provides after 60 days, after test-meal group test-meal front and back self comparison and test-meal, between test-meal group and control group group, compare, in blood medium size lymphocyte and body, the content of macrophage significantly increases (P < 0.01), and the health food pulvis that the visible embodiment of the present invention 5 provides has the effect of remarkable enhancing immunity of organisms.
The health food that getting embodiment 6 to 11 provides carries out human feeding trial, and similarly, the health food that the visible embodiment of the present invention 6 to 11 provides has the effect of remarkable enhancing immunity of organisms to result equally.
As can be seen here, health food provided by the invention has the effect of remarkable enhancing immunity of organisms.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a food nutrient fortifying composition, is characterized in that, comprises galactooligosaccharide, newborn mineral salt and lactoferrin.
2. food nutrient fortifying composition according to claim 1, is characterized in that, the mass ratio of described galactooligosaccharide, described newborn mineral salt and described lactoferrin is (1600～1800): (830～930): (70～170).
3. food nutrient fortifying composition according to claim 1, is characterized in that, the mass ratio of described galactooligosaccharide, described newborn mineral salt and described lactoferrin is 1700:880:120.
4. according to the food nutrient fortifying composition described in any one in claims 1 to 3, in preparation, strengthen the application in immunity health food.
5. a health food, is characterized in that, comprises in bromatology acceptable auxiliary material and food nutrient fortifying composition as claimed any one in claims 1 to 3.
6. health food according to claim 5, is characterized in that, the formulation of described health food is pulvis, tablet, capsule or granule.
7. health food according to claim 5, it is characterized in that, in described bromatology, acceptable auxiliary material is selected from one or more the mixture in Fruit powder, flavoring essence, sweetener, acid, filler, lubricant, anticorrisive agent, food coloring or disintegrant.
8. health food according to claim 5, is characterized in that:
Described Fruit powder is one or more the mixture in orange powder, orange powder, lemon powder, cherry powder, apple powder or coconut palm powder;
Described flavoring essence is one or more the mixture in flavoring orange essence, orange essence, lemon extract, cherry essence, menthol, flavoring apple essence or coconut palm essence;
Described sweetener is one or more the mixture in Sucralose, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, Aspartame or mogroside;
Described acid is one or more the mixture in citric acid, malic acid, lactic acid or citric acid;
Described filler is one or more the mixture in fructose, glycitols, sucrose, starch, pregelatinized starch, microcrystalline cellulose or dextrin;
Described lubricant is one or more the mixture in talcum powder, dolomol, silica or stearic acid;
Described anticorrisive agent is one or more the mixture in Sodium Benzoate, Potassium Benzoate, sorbic acid methyl esters, ethyl-para-hydroxybenzoate or P-hydroxybenzoic acid phenyl ester;
Described food coloring is one or more the mixture in burnt sugar coloring, Gardenia Yellow, curcumin or chlorophyll;
Described disintegrant is one or more the mixture in dried starch, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, PVPP or sodium carboxymethylcellulose.
9. health food according to claim 6, is characterized in that, in described pulvis, in bromatology, acceptable auxiliary material is whole-fat milk powder and/or fructose.
10. the preparation method of health food as described in any one in claim 5 to 9, is characterized in that, takes food in conduct and learning acceptable auxiliary material and mixes with food nutrient fortifying composition as claimed any one in claims 1 to 3, obtains.
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