CN106138199A - A kind of compound prescription that eyes nutrition protection vision is provided and preparation method thereof - Google Patents
A kind of compound prescription that eyes nutrition protection vision is provided and preparation method thereof Download PDFInfo
- Publication number
- CN106138199A CN106138199A CN201610624311.4A CN201610624311A CN106138199A CN 106138199 A CN106138199 A CN 106138199A CN 201610624311 A CN201610624311 A CN 201610624311A CN 106138199 A CN106138199 A CN 106138199A
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- powder
- microcapsule powder
- eyes
- compound prescription
- microcapsule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
Abstract
The invention discloses a kind of compound prescription that eyes nutrition protection vision is provided; by weight percentage; including: Lutein ester microcapsule powder 3 6%, blueberry extract 3 7%, Oleum Perillae microcapsule powder 15 25%; cryptoxanthin microcapsule powder 1 3%; maltodextrin 25 35%, vegetable oil 12 20%, milk powder 8 12%, silicon dioxide 0.5 1%; essence for food 3 5%, sucralose 0.1 0.2 ‰.This compound prescription not only solves the nutrition difficult problem supplemented required for eyes, and is greatly improved a difficult problem for sorption enhanced rate.
Description
Technical field
The invention belongs to prepare nutritional medicine field, particularly relate to a kind of compound prescription that eyes nutrition protection vision is provided
And preparation method thereof.
Background technology
At present, while electronic equipment occupies the vision life of our most people, it is worried that vision also becomes a lot of people
Thing, the either student of excess eye-using, or every day is in the face of the computer working clan more than 8 hours, then or has gone up age
Old people, occur that eyes are sour and astringent, tired the most more or less, pain, the malaise symptoms such as shed tears.
Occur that above symptom substantially can be divided into exogenous and endogenous two kinds damage.Exogenous include that various electronic equipment is released
Put royal purple light the directly injury of eyes, the long-time asthenopia that can not get having a rest in the face of computer and cause, dust storm haze etc. are drawn
The eye risen is dry and astringent etc.；Endogenous includes that people starts to degenerate to old organ, function, and function of human body goes down, such as age-related macular
Degenerate and cataract etc.；The coup injury to eyes it addition, the various ophthalmics that caused of diabetes, hypertension and smoking are drunk
Deng.
So many undesirable element affects our eyes, it appears that protection eyes, imperative.So, how could
Effectively prevention and alleviation？A lot of people have done eye exercises, also supplement vitamin, but effect inconspicuous.The most also
There is the product made for primary raw material with phylloxanthin, have the dosage form such as tablet and capsule, eye protection is had certain effect, but
It is to light, poor heat stability, and stomach juice-resistant is poor, is susceptible to degraded, and in human small intestine's absorption process, bioavailability is low,
Sorption enhanced rate is only about 60%.
Summary of the invention
It is an object of the invention to as overcoming above-mentioned the deficiencies in the prior art, it is provided that a kind of provide eyes nutrition protection vision
Compound prescription and preparation method thereof.
For achieving the above object, the present invention uses following technical proposals:
A kind of compound prescription that eyes nutrition protection vision is provided, by weight percentage, including: Lutein ester microcapsule powder 3-
6%, blueberry extract 3-7%, Oleum Perillae microcapsule powder 15-25%, cryptoxanthin microcapsule powder 1-3%, maltodextrin 25-
35%, vegetable oil 12-20%, milk powder 8-12%, silicon dioxide 0.5-1%, essence for food 3-5%, sucralose 0.1-
0.2‰。
The preparation method step of above-mentioned compound prescription has:
Step 1, by lightweight material Lutein ester microcapsule powder, blueberry extract, cryptoxanthin microcapsule powder, titanium dioxide
After silicon, essence for food, sucralose press formula proportion weighing, through three-dimensional mixer mix homogeneously；
Step 2, by the mixture after mix homogeneously in step 1 again with weigh respectively after Oleum Perillae microcapsule powder, Fructus Hordei Germinatus
Dextrin, vegetable oil, milk powder are mixed together uniformly；
Step 3, is placed in the mixture after mixing in step 2 in the environment of 60-70 DEG C and is dried 5 hours, and carry out sterilizing,
And carry out powder fill after cleaning shop cools down.
The present invention provides a kind of compound prescription providing eyes nutrition protection vision and preparation method thereof, comprises phylloxanthin
Ester, studies through scientific research personnel, finds that the phylloxanthin being esterified, i.e. lutein ester are strong to light, heat stability, stomach juice-resistant and resistance to gold
Belong to ionic and should not consume degraded by force, higher than phylloxanthin 1.6 times in terms of bioavailability；Lutein ester can be natural at human body
Be hydrolyzed to free xanthophyll, free xanthophyll nourish optical fundus play usefulness；And except lutein ester in this compound prescription,
Further provided with the materials such as cryptoxanthin, blueberry extract, Oleum Perillae, wherein cryptoxanthin is also macular region in retina
Important component part, the anthocyanidin in blue berry can promote the regeneration of rhodopsin in retina cell, the а-Asia in Oleum Perillae
The absorption of fiber crops acid can be obviously improved the retinal function of old people, slows down function of nervous system's decline, and can improve vision.It addition,
This compound prescription product has used microencapsulation, microcapsule formulation naked eyes see it is powdery, under microscope viewing be many by spy
The tiny capsules of different capsule material parcel, the great advantage of this microcapsule formulation is that targeting location is decomposed, and effective percentage can improve 90%-
200%, this compound prescription not only solves the nutrition difficult problem supplemented required for eyes, and is greatly improved sorption enhanced rate
A difficult problem.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
A kind of compound prescription that eyes nutrition protection vision is provided, by weight percentage, including: Lutein ester microcapsule powder 3-
6%, blueberry extract 3-7%, Oleum Perillae microcapsule powder 15-25%, cryptoxanthin microcapsule powder 1-3%, maltodextrin 25-
35%, vegetable oil 12-20%, milk powder 8-12%, silicon dioxide 0.5-1%, essence for food 3-5%, sucralose 0.1-
0.2‰。
Lutein ester is the important basal nutrient of eyes, within 2008, is regarded as new resource food by Ministry of Public Health.Phylloxanthin
The ester phylloxanthin that automatic hydrolysis becomes in human body is the important component constituting human eye retina's macular area, and massive epidemiology is demonstrate,proved
Bright, phylloxanthin effect protected to vision.
Cryptoxanthin, as the important basal nutrient of eyes, is a kind of powerful antioxidant, and it can be with singlet-oxygen quenching
With the triplet of photosensitizer, remove damaging oxygen-derived free radicals, prevent Lipid peroxidation metabolism, reduce the formation of lipofuscin, and then prevent
Cataractous formation.
Perilla oil is the edible oil with Folium Perillae as raw material, reaches 56.14-64.82% containing alpha-linolenic acid, has human body more
Significantly health care and medical efficacy, and alpha-linolenic acid is the basal nutrient material of eyes equally.
Anthocyanidin in blue berry can promote the regeneration of rhodopsin in retina cell, can prevent laser high myopia and retina
Peel off, and vision can be promoted.The most more there is the ability accelerating rhodopsin regeneration, and rhodopsin good vision just is indispensable
Thing.
The preparation method step of above-mentioned a kind of compound prescription providing eyes nutrition protection vision has:
Embodiment one
Step 1, by lightweight material Lutein ester microcapsule powder 3%, blueberry extract 6%, cryptoxanthin microcapsule powder
1%, after silica 1 %, essence for food 4%, sucralose 0.1 ‰ press formula proportion weighing, mix through three-dimensional mixer
Uniformly；
Step 2, by the mixture after mix homogeneously in step 1 again with weigh respectively after Oleum Perillae microcapsule powder 25%,
Maltodextrin 30%, vegetable oil 20%, milk powder 10% are mixed together uniformly；
Step 3, is placed in the mixture after mixing in step 2 in the environment of 60-70 DEG C and is dried 5 hours, and carry out sterilizing,
And carry out powder fill after cleaning shop cools down.
Embodiment two
Step 1, by lightweight material Lutein ester microcapsule powder 6%, blueberry extract 7%, cryptoxanthin microcapsule powder
3%, after silica 1 %, essence for food 3%, sucralose 0.2 ‰ press formula proportion weighing, mix through three-dimensional mixer
Uniformly；
Step 2, by the mixture after mix homogeneously in step 1 again with weigh respectively after Oleum Perillae microcapsule powder 15%,
Maltodextrin 35%, vegetable oil 18%, milk powder 12% are mixed together uniformly；
Step 3, is placed in the mixture after mixing in step 2 in the environment of 60-70 DEG C and is dried 5 hours, and carry out sterilizing,
And carry out powder fill after cleaning shop cools down.
Embodiment three
Step 1, by lightweight material Lutein ester microcapsule powder 5%, blueberry extract 4%, cryptoxanthin microcapsule powder
2%, after silicon dioxide 0.5%, essence for food 5%, sucralose 0.1 ‰ press formula proportion weighing, mix through three-dimensional mixer
Close uniformly；
Step 2, by the mixture after mix homogeneously in step 1 again with weigh respectively after Oleum Perillae microcapsule powder 24%,
Maltodextrin 33%, vegetable oil 18.5%, milk powder 8% are mixed together uniformly；
Step 3, is placed in the mixture after mixing in step 2 in the environment of 60-70 DEG C and is dried 5 hours, and carry out sterilizing,
And carry out powder fill after cleaning shop cools down.
Although the above-mentioned detailed description of the invention to the present invention is described, but not limit to scope
System, one of ordinary skill in the art should be understood that on the basis of technical scheme, and those skilled in the art need not pay
Go out various amendments or deformation that creative work can make still within protection scope of the present invention.
Claims (2)
1. the compound prescription that eyes nutrition protection vision is provided, it is characterised in that by weight percentage, including: phylloxanthin
Ester micro capsule powder 3-6%, blueberry extract 3-7%, Oleum Perillae microcapsule powder 15-25%, cryptoxanthin microcapsule powder 1-3%, Fructus Hordei Germinatus
Dextrin 25-35%, vegetable oil 12-20%, milk powder 8-12%, silicon dioxide 0.5-1%, essence for food 3-5%, sucralose
0.1-0.2‰。
The preparation method of the compound prescription of offer eyes nutrition the most according to claim 1 protection vision, it is characterised in that
Comprise the following steps:
Step 1, by lightweight material Lutein ester microcapsule powder, blueberry extract, cryptoxanthin microcapsule powder, silicon dioxide, food
After product essence, sucralose press formula proportion weighing, through three-dimensional mixer mix homogeneously；
Step 2, by the mixture after mix homogeneously in step 1 again with weigh respectively after Oleum Perillae microcapsule powder, maltodextrin,
Vegetable oil, milk powder are mixed together uniformly；
Step 3, is placed in the mixture after mixing in step 2 in the environment of 60-70 DEG C and is dried 5 hours, and carry out sterilizing, and
Powder fill is carried out after the cooling of cleaning shop.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610624311.4A CN106138199A (en) | 2016-07-29 | 2016-07-29 | A kind of compound prescription that eyes nutrition protection vision is provided and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610624311.4A CN106138199A (en) | 2016-07-29 | 2016-07-29 | A kind of compound prescription that eyes nutrition protection vision is provided and preparation method thereof |
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| CN106138199A true CN106138199A (en) | 2016-11-23 |
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| CN201610624311.4A Pending CN106138199A (en) | 2016-07-29 | 2016-07-29 | A kind of compound prescription that eyes nutrition protection vision is provided and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375505A (en) * | 2017-08-15 | 2017-11-24 | 庞会心 | A kind of composition for preventing and treating eye disease and preparation method and application |
| CN107616399A (en) * | 2017-09-30 | 2018-01-23 | 山东瑞芝生物科技有限公司 | A kind of Lutein ester microcapsule drink and preparation method thereof |
| CN107897910A (en) * | 2017-11-20 | 2018-04-13 | 江苏艾兰得营养品有限公司 | A kind of preparation for protecting eyesight to alleviate eye strain and preparation method thereof |
| CN108077438A (en) * | 2017-12-29 | 2018-05-29 | 澳优乳业（中国）有限公司 | A kind of eyeshield modulation milk powder and preparation method thereof |
| CN108208815A (en) * | 2018-02-06 | 2018-06-29 | 山东圣海保健品有限公司 | Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof |
| CN108294297A (en) * | 2017-02-24 | 2018-07-20 | 南通励成生物工程有限公司 | A kind of preparation method of lutein nutrition fortifier |
| CN108713760A (en) * | 2018-05-14 | 2018-10-30 | 青岛欧潽凯药业有限公司 | A kind of antifatigue eye protecting nutritious liquid and preparation method thereof |
| CN109123646A (en) * | 2018-09-30 | 2019-01-04 | 广东亿超生物科技有限公司 | A kind of product and method for production containing zeaxanthin, lutein ester |
| CN113331420A (en) * | 2021-06-21 | 2021-09-03 | 北京兰厚化妆品有限责任公司 | Composition for protecting eyes, health food and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108294297A (en) * | 2017-02-24 | 2018-07-20 | 南通励成生物工程有限公司 | A kind of preparation method of lutein nutrition fortifier |
| CN107375505A (en) * | 2017-08-15 | 2017-11-24 | 庞会心 | A kind of composition for preventing and treating eye disease and preparation method and application |
| CN107616399A (en) * | 2017-09-30 | 2018-01-23 | 山东瑞芝生物科技有限公司 | A kind of Lutein ester microcapsule drink and preparation method thereof |
| CN107897910A (en) * | 2017-11-20 | 2018-04-13 | 江苏艾兰得营养品有限公司 | A kind of preparation for protecting eyesight to alleviate eye strain and preparation method thereof |
| CN108077438A (en) * | 2017-12-29 | 2018-05-29 | 澳优乳业（中国）有限公司 | A kind of eyeshield modulation milk powder and preparation method thereof |
| CN108208815A (en) * | 2018-02-06 | 2018-06-29 | 山东圣海保健品有限公司 | Blueberry and the double-colored composite sheet of lutein ester and preparation method thereof |
| CN108713760A (en) * | 2018-05-14 | 2018-10-30 | 青岛欧潽凯药业有限公司 | A kind of antifatigue eye protecting nutritious liquid and preparation method thereof |
| CN109123646A (en) * | 2018-09-30 | 2019-01-04 | 广东亿超生物科技有限公司 | A kind of product and method for production containing zeaxanthin, lutein ester |
| CN113331420A (en) * | 2021-06-21 | 2021-09-03 | 北京兰厚化妆品有限责任公司 | Composition for protecting eyes, health food and preparation method thereof |
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Application publication date: 20161123 |