CN106132405B - N,n-二-2-巯基乙基异邻苯二甲酰胺的用途 - Google Patents

N,n-二-2-巯基乙基异邻苯二甲酰胺的用途 Download PDF

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Publication number
CN106132405B
CN106132405B CN201580017210.4A CN201580017210A CN106132405B CN 106132405 B CN106132405 B CN 106132405B CN 201580017210 A CN201580017210 A CN 201580017210A CN 106132405 B CN106132405 B CN 106132405B
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CN106132405A (zh
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博伊德·尤金·哈利
雷格纳·阿克塞尔·西奥多·克林伯格
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Ermes Medical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/10Expectorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201580017210.4A 2014-04-04 2015-03-31 N,n-二-2-巯基乙基异邻苯二甲酰胺的用途 Active CN106132405B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1406115.4 2014-04-04
GB1406115.4A GB2524831A (en) 2014-04-04 2014-04-04 New pharmaceutical use
PCT/GB2015/050999 WO2015150793A1 (en) 2014-04-04 2015-03-31 New use of n,n-bis-2-mercaptoethyl isophthalamide

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CN106132405A CN106132405A (zh) 2016-11-16
CN106132405B true CN106132405B (zh) 2019-06-18

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US (1) US9782368B2 (enExample)
EP (1) EP3125876B8 (enExample)
JP (1) JP6474423B2 (enExample)
KR (1) KR102482699B1 (enExample)
CN (1) CN106132405B (enExample)
AU (1) AU2015242374B2 (enExample)
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Families Citing this family (2)

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GB202005057D0 (en) * 2020-04-06 2020-05-20 Emeramed Ltd New Use
CN114778234B (zh) * 2022-03-18 2025-08-15 武汉新烽光电股份有限公司 一种用于微流控总磷测试的抗坏血酸溶液的保存方法及保存结构

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586600B2 (en) * 2000-12-06 2003-07-01 University Of Kentucky Research Foundation Multidentate sulfur-containing ligands
JP2011026204A (ja) * 2007-11-26 2011-02-10 Rei Furukawa タバコの煙を吸入することにより引き起こされる疾患の予防及び/又は治療用組成物
RU2528396C2 (ru) * 2009-09-28 2014-09-20 Юнивёрсити Оф Кентукки Рисёч Фаундейшн Тиолсодержащие соединения для удаления элементов из загрязненной окружающей среды и способы их применения
US8575218B2 (en) 2009-09-28 2013-11-05 The University Of Kentucky Research Foundation Thiol-containing compounds for the removal of elements from tissues and formulations therefor
US20110237776A1 (en) 2010-03-25 2011-09-29 Haley Boyd E Aromatic compounds with sulfur containing ligands
US8426368B2 (en) * 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Antioxidant therapeutic advances in COPD;Irfan Rahman;《Therapeutic Advances in Respiratory Disease》;20081231;第2卷(第6期);第351-374页 *
Rishi B. Patel等.Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N’-bis-2-mercap.《TOXICOLOGY MECHANISMS AND METHODS》.2012,第22卷(第5期),第383-396页. *
Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N’-bis-2-mercap;Rishi B. Patel等;《TOXICOLOGY MECHANISMS AND METHODS》;20120630;第22卷(第5期);第383-396页 *

Also Published As

Publication number Publication date
MA39833B1 (fr) 2018-04-30
CN106132405A (zh) 2016-11-16
EA201692013A1 (ru) 2017-03-31
SG11201607478RA (en) 2016-10-28
GB201406115D0 (en) 2014-05-21
KR20160140929A (ko) 2016-12-07
ZA201606406B (en) 2018-04-25
CL2016002499A1 (es) 2017-01-27
MA39833A (fr) 2017-02-08
WO2015150793A1 (en) 2015-10-08
ME03012B (me) 2018-10-20
JP2017511307A (ja) 2017-04-20
CA2944113C (en) 2022-06-21
EP3125876B8 (en) 2018-01-24
NZ724678A (en) 2022-12-23
DK3125876T3 (en) 2018-01-15
AU2015242374A1 (en) 2016-10-13
SA516371966B1 (ar) 2019-04-14
HRP20180325T1 (hr) 2018-04-06
PT3125876T (pt) 2018-02-22
BR112016022880A2 (enExample) 2017-08-15
JP6474423B2 (ja) 2019-02-27
GB2524831A (en) 2015-10-07
UA119558C2 (uk) 2019-07-10
US20170157072A1 (en) 2017-06-08
PH12016501975A1 (en) 2017-01-09
PE20170586A1 (es) 2017-05-20
RS56905B1 (sr) 2018-05-31
PL3125876T3 (pl) 2018-05-30
US9782368B2 (en) 2017-10-10
MX2016012591A (es) 2017-04-06
EA032116B1 (ru) 2019-04-30
SI3125876T1 (en) 2018-04-30
BR112016022880B1 (pt) 2022-09-13
EP3125876B1 (en) 2017-11-29
KR102482699B1 (ko) 2022-12-28
CY1121235T1 (el) 2020-05-29
ECSP16078100A (es) 2018-03-31
ES2659174T3 (es) 2018-03-14
CA2944113A1 (en) 2015-10-08
LT3125876T (lt) 2018-02-12
SMT201800116T1 (it) 2018-03-08
NO3125876T3 (enExample) 2018-04-28
AU2015242374B2 (en) 2019-10-10
HUE036206T2 (hu) 2018-06-28
IL248027B (en) 2019-03-31
EP3125876A1 (en) 2017-02-08

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