CN106110129A - 化痰平喘片及制备方法 - Google Patents

化痰平喘片及制备方法 Download PDF

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CN106110129A
CN106110129A CN201610678853.XA CN201610678853A CN106110129A CN 106110129 A CN106110129 A CN 106110129A CN 201610678853 A CN201610678853 A CN 201610678853A CN 106110129 A CN106110129 A CN 106110129A
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radix
parts
relieving asthma
resolving phlegm
folium
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曲香仁
刘玉凤
张立伟
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TONGHUA WANTONG PHARMACEUTICAL CO Ltd
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TONGHUA WANTONG PHARMACEUTICAL CO Ltd
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Abstract

本发明涉及一种中药，即化痰平喘片及制备方法。对急慢性气管炎、肺气肿等病症的治疗有较好疗效。它由以下重量克数的原料药制成1000片：暴马子皮740g，南沙参250g，地龙250g，黄芩250g，百部150g，金银花125g，浮海石124g，甘草200g，苦杏仁170g，前胡130g，板蓝根100g，紫苏叶100g，地黄100g，陈皮100g，五味子75g，麻黄50g，川贝母50g，枇杷叶50g，款冬花50g，石膏50g，枳壳50g，白术30g，刺五加20g，麦冬20g，盐酸异丙嗪1.254g。临床经统计，本发明产品疗效明显提高。

Description

化痰平喘片及制备方法
技术领域
本发明涉及一种中药，即化痰平喘片及制备方法。对急慢性气管炎、肺气肿等病症的治疗有较好疗效。
背景技术
在现有技术中，现代社会工业化水平达到了一定的发达程度，但是带来了相应的环境破坏和大气严重污染，急慢性气管炎、肺气肿、咳痰不止的患者大大增加。国药标准（试行）YBZ28922005化痰平喘片。功效：清热化痰，止咳平喘，对急慢性气管炎、肺气肿等病症的治疗有疗效。处方：暴马子皮740g，南沙参250g，地龙250g，黄芩250g，百部150g，浮海石124g，盐酸异丙嗪1.254g。制法：以上七味，黄芩粉碎成细粉，暴马子皮，南沙参，地龙，百部，浮海石加水煎煮3次，第一、二次各3小时，第三次2小时，合并煎液，滤过，滤液浓缩成稠膏，与上述粉末混合，干燥、粉碎、过筛，加盐酸异丙嗪混匀，制粒，干燥，压制成1200片，即得。但是该药成方时间早，配方影响了疗效，工艺不尽合理，如何进一步提高产品疗效是面临的新问题。
发明内容
本发明的目的是针对上述不足而提供一种提高疗效的化痰平喘片及制备方法。
本发明的技术解决方案是：化痰平喘片，其药用有效成分由以下重量份数的原料药制成：暴马子皮600－800份，南沙参200－300份，地龙200－300份，黄芩200－300份，百部120－180份，金银花100－140份，浮海石100－140份，甘草180－220份，苦杏仁150－200份，前胡110－145份，板蓝根80－120份，紫苏叶80－120份，地黄80－120份，陈皮80－120份，五味子50－90份，麻黄40－60份，川贝母40－60份，枇杷叶40－60份，款冬花40－60份，石膏40－60份，枳壳40－60份，白术35－45份，刺五加18－22份，麦冬18－22份，盐酸异丙嗪1－1.5份。
化痰平喘片，其药用有效成分由以下重量份数的原料药制成：暴马子皮740份，南沙参250份，地龙250份，黄芩250份，百部150份，金银花125份，浮海石124份，甘草200份，苦杏仁170份，前胡130份，板蓝根100份，紫苏叶100份，地黄100份，陈皮100份，五味子75份，麻黄50份，川贝母50份，枇杷叶50份，款冬花50份，石膏50份，枳壳50份，白术30份，刺五加20份，麦冬20份，盐酸异丙嗪1.254份。
化痰平喘片，其药用有效成分由以下重量克数的原料药制成1000片：暴马子皮740g，南沙参250g，地龙250g，黄芩250g，百部150g，金银花125g，浮海石124g，甘草200g，苦杏仁170g，前胡130g，板蓝根100g，紫苏叶100g，地黄100g，陈皮100g，五味子75g，麻黄50g，川贝母50g，枇杷叶50g，款冬花50g，石膏50g，枳壳50g，白术30g，刺五加20g，麦冬20g，盐酸异丙嗪1.254g。
化痰平喘片制备方法，其步骤如下：以上二十四味中药材，甘草、前胡、川贝母、枇杷叶、陈皮、枳壳、五味子、紫苏叶8味药材，加60%乙醇提取二次，第一次3小时、第二次2小时，合并煎液，滤过，滤液回收乙醇至无醇味并浓缩，干燥，粉碎，备用；其余石膏、南沙参等15味药材，加水罐内煎煮0.5小时后，回流提取4.5小时，滤过，滤液浓缩，干燥，粉碎，备用；合并上述细粉，加入盐酸异丙嗪混合均匀，加入辅料，制成颗粒，压片即得。
功效：清热化痰，止咳平喘。用于急、慢性气管炎，肺气肿，咳嗽痰多。
服用方法：口服，一次4－6片，一日2次。
本发明的优点是：通过对老配方的改进、工艺改进，明显提高了疗效。临床经120名患者累计统计，A组（新处方60人）显效56人，显效率93.3％，有效4人，有效率6.7％，无效为0，总有效率100％；B组（老处方60人）显效40人，显效率66.7%，有效14人，有效率23.3%，无效6人，无效率为10%。可见，本发明产品疗效明显提高。
下面将结合实施例对本发明的实施方式作进一步详细描述。
具体实施方式
实施例1
化痰平喘片，其药用有效成分由以下重量克数的原料药制成1000片：暴马子皮740g，南沙参250g，地龙250g，黄芩250g，百部150g，金银花125g，浮海石124g，甘草200g，苦杏仁170g，前胡130g，板蓝根100g，紫苏叶100g，地黄100g，陈皮100g，五味子75g，麻黄50g，川贝母50g，枇杷叶50g，款冬花50g，石膏50g，枳壳50g，白术30g，刺五加20g，麦冬20g，盐酸异丙嗪1.254g。
实施例2
化痰平喘片制备方法，其步骤如下：以上二十四味中药材，甘草、前胡、川贝母、枇杷叶、陈皮、枳壳、五味子、紫苏叶8味药材，加60%乙醇提取二次，第一次3小时、第二次2小时，合并煎液，滤过，滤液回收乙醇至无醇味并浓缩至适量，干燥，粉碎，备用；其余石膏、南沙参等15味药材，加水罐内煎煮0.5小时后，回流提取4.5小时，滤过，滤液浓缩至适量，干燥，粉碎，备用；合并上述细粉，加入盐酸异丙嗪混合均匀，加入淀粉、糊精等适量辅料，制成颗粒，压制成1000片即得。
实验例
化痰平喘片临床报告
通过120例患者服用新老处方产品对比，结果如下：
1、试验方法：分为A、B两组，分别服用新配方产品（实施例1）、老配方产品（国药标准（试行）YBZ28922005化痰平喘片）。
2、服用方法：口服，一次4－6片，一日2次。10天为一个疗程。
3、疗效评定标准：
显效：全部症状消除或主要症状消除，理化检测指标基本正常。
有效：主要症状基本消除，主要理化检测指标有所改善。
无效：和治疗前相比较，各方面无变化或加重者。
4、治疗结果：
组别（人数） 显效 有效 无效 总有效率
A（60人） 56 4 0 100％
B（60人） 40 14 6 90%
临床经120名患者累计统计，A组（新处方）显效56人，显效率93.3％，有效4人，有效率6.7％，无效为0，总有效率100％；B组（老处方）显效40人，显效率66.7%，有效14人，有效率23.3%，无效6人，无效率为10%。
上面描述，只是本发明的具体实施方式，各种举例说明不对本发明的实质内容构成限制。

Claims (4)

1.化痰平喘片，其特征在于其药用有效成分由以下重量份数的原料药制成：暴马子皮600－800份，南沙参200－300份，地龙200－300份，黄芩200－300份，百部120－180份，金银花100－140份，浮海石100－140份，甘草180－220份，苦杏仁150－200份，前胡110－145份，板蓝根80－120份，紫苏叶80－120份，地黄80－120份，陈皮80－120份，五味子50－90份，麻黄40－60份，川贝母40－60份，枇杷叶40－60份，款冬花40－60份，石膏40－60份，枳壳40－60份，白术35－45份，刺五加18－22份，麦冬18－22份，盐酸异丙嗪1－1.5份。
2.按照权利要求1所述的化痰平喘片，其特征在于其药用有效成分由以下重量份数的原料药制成：暴马子皮740份，南沙参250份，地龙250份，黄芩250份，百部150份，金银花125份，浮海石124份，甘草200份，苦杏仁170份，前胡130份，板蓝根100份，紫苏叶100份，地黄100份，陈皮100份，五味子75份，麻黄50份，川贝母50份，枇杷叶50份，款冬花50份，石膏50份，枳壳50份，白术30份，刺五加20份，麦冬20份，盐酸异丙嗪1.254份。
3.按照权利要求1或2所述的化痰平喘片，其特征在于其药用有效成分由以下重量克数的原料药制成1000片：暴马子皮740g，南沙参250g，地龙250g，黄芩250g，百部150g，金银花125g，浮海石124g，甘草200g，苦杏仁170g，前胡130g，板蓝根100g，紫苏叶100g，地黄100g，陈皮100g，五味子75g，麻黄50g，川贝母50g，枇杷叶50g，款冬花50g，石膏50g，枳壳50g，白术30g，刺五加20g，麦冬20g，盐酸异丙嗪1.254g。
4.一种如权利要求3所述的化痰平喘片制备方法，其特征在于步骤如下：以上二十四味中药材，甘草、前胡、川贝母、枇杷叶、陈皮、枳壳、五味子、紫苏叶8味药材，加60%乙醇提取二次，第一次3小时、第二次2小时，合并煎液，滤过，滤液回收乙醇至无醇味并浓缩，干燥，粉碎，备用；其余石膏、南沙参等15味药材，加水罐内煎煮0.5小时后，回流提取4.5小时，滤过，滤液浓缩，干燥，粉碎，备用；合并上述细粉，加入盐酸异丙嗪混合均匀，加入辅料，制成颗粒，压片即得。
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CN106728090A (zh) * 2016-12-07 2017-05-31 郑州仁宏医药科技有限公司 一种止咳药物及其制备方法
CN116850248A (zh) * 2023-08-22 2023-10-10 通化万通药业股份有限公司 咳克平胶囊及其制备方法

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CN104971277A (zh) * 2015-06-15 2015-10-14 通化万通药业股份有限公司 化痰平喘片及其制备方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728090A (zh) * 2016-12-07 2017-05-31 郑州仁宏医药科技有限公司 一种止咳药物及其制备方法
CN116850248A (zh) * 2023-08-22 2023-10-10 通化万通药业股份有限公司 咳克平胶囊及其制备方法
CN116850248B (zh) * 2023-08-22 2024-03-19 通化万通药业股份有限公司 咳克平胶囊及其制备方法

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