CN106110027A - A kind of external-applied ointment for treating cold injury and preparation method - Google Patents

A kind of external-applied ointment for treating cold injury and preparation method Download PDF

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CN106110027A
CN106110027A CN201610621538.3A CN201610621538A CN106110027A CN 106110027 A CN106110027 A CN 106110027A CN 201610621538 A CN201610621538 A CN 201610621538A CN 106110027 A CN106110027 A CN 106110027A
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parts
folium
ointment
herba
caulis
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李纪华
王鹏
孙百成
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of external-applied ointment for treating cold injury and preparation method, belong to the field of Chinese medicines；The raw material of ointment effective ingredient of the present invention consists of: Herba Chrysosplenii Macrophylli, Herba Solani Nigri, Folium Citri grandis, Herba polygoni senticosi, Radix et Caulis Opuntiae Dillenii, Folium Crataegi, Ramulus Et Folium Pithecellobii Lucidi, mountain, geaster, Fructus Capsici, Styrax, pyrolusitum, distiller grains, Flos Genkwa, Caulis et Folium Ammopiptanthi Mongolici and Camphora；Ointment of the present invention uses Chinese herbal medicine to be effective ingredient, all medicines are harmonious and have the effect such as heat-clearing and toxic substances removing, convergence granulation promoting, repellent antipruritic, warming spleen and stomach for dispelling cold, promoting blood circulation and stopping pain, for the pruritus caused for cold injury, herpes, macule, edema, skin frostbite, skin blister, the rear treatment forming the symptoms such as black dry crusts, the colour of skin be crimson, there is the advantage such as instant effect, cure rate is high, have no side effect, safe ready, and low price, easily preparation, can be widely used for the treatment of cold injury.

Description

A kind of external-applied ointment for treating cold injury and preparation method
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of external-applied ointment for treating cold injury and preparation method.
Background technology
Cold injury is the body local caused due to cold wet effect or whole body damage.Skin transient damage can be caused time light Wound, give treatment in time；Permanent disfunction can be caused during weight, specialty treatment need to be carried out.Time serious can threat to life, need to promptly rob Rescue.
The clinical manifestation of cold injury is divided into part frozen, hands cold injury, Pig's feets in aspic to hinder and numb with cold.
Part frozen is divided into reaction early stage, reaction phase and reaction later stage, before reaction early stage is melted to rewarming after meaning cold injury A stage, its main clinical manifestation endures cold that position is ice-cold, pale, hard, stolidity or forfeiture.Owing to local is in Frozen state, its damage range and degree are often difficult to judge.The reaction phase includes that rewarming melts the stage after melting with rewarming.Instead After the healing of one, two degree of cold injury should be meant the later stage and three, four degree of cold injury sloughs.
Hands cold injury once cold injury is the lightest, and the most common " chilblain " is impaired at epidermal area, and area skin redness of enduring cold is congested, Conscious heat, itch, causalgia, symptom disappears after a few days, the most afterwards in addition to having exfoliation, does not stay cicatrix.Two degree of cold injury injure corium Shallow-layer, after wound in addition to redness, with vesicle, can be courageous and upright liquid in bleb, and deep may occur in which that edema, severe pain, dermal sensation are blunt.Three Degree cold injury injures skin holostrome, black or puce, bitterly sensory deprivation occurs.It is difficult to healing after wound, in addition to something lost has cicatrix, can have Long-term hyperesthesia or pain.Four degree of cold injury injure skin, subcutaneous tissue, muscle even bone, may occur in which necrosis, sensation funeral Lose, more after can have cicatrization.
Pig's feets in aspic is hindered local skin and is felt cold, and feels to go down or sensitive.To cold sensitivity, cold season, skin occurred pale or blue or green Purple.Hyperalgesia, limbs can not be prudent etc..These performances are owing to after sympathetic nerve or peripheral nerve injury, dysfunction is drawn Rise.
Wounded's palor numb with cold, ice-cold, face and surrounding tissue have edema sometimes, and in a certain state of delirium or stupor, muscle is strong Directly, pupillary light reflex is blunt or disappears, bradycardia, arrhythmia, and blood pressure does not detects in reducing, may occur in which atrium and ventricle Fibrillation, time serious, heart beating stops.Breathe slow and shallow, severe patient visible first and second feeble respiration once in a while.
The method for the treatment of cold injury is mainly Drug therapy at present, and based on Western medicine in Drug therapy, but Western medicine has pair Effect, and easily recur, to this end, we are badly in need of developing a kind of medicine to help patient to break away from the misery that cold injury is brought.
Summary of the invention
The invention provides a kind of external-applied ointment for treating cold injury and preparation method；Ointment of the present invention uses Chinese herbal medicine For effective ingredient, all medicines be harmonious have heat-clearing and toxic substances removing, convergence granulation promoting, promoting blood circulation and detumescence and wet antipruritic, cooling blood for hemostasis, warming spleen and stomach for dispelling cold, The effects such as promoting blood circulation and stopping pain, for the pruritus caused for cold injury, herpes, macule, edema, skin frostbite, skin blister, are formed afterwards The treatment of the symptoms such as black dry crusts, the colour of skin are crimson has the advantage such as instant effect, cure rate is high, have no side effect, safe ready, and Low price, easily prepares, and can be widely used for the treatment of cold injury.
For achieving the above object, technical scheme is implemented as follows:
A kind of external-applied ointment for treating chilblain, makes raw material composition and the parts by weight of described ointment effective ingredient For:
Make described ointment effective ingredient raw material composition and parts by weight be:
Make described ointment effective ingredient raw material composition and parts by weight be:
Make described ointment effective ingredient raw material composition and parts by weight be:
The preparation method of a kind of external-applied ointment for treating chilblain, comprises the following steps that:
(1) Herba Chrysosplenii Macrophylli, Herba polygoni senticosi, Radix et Caulis Opuntiae Dillenii and Ramulus Et Folium Pithecellobii Lucidi are twisted juice, filter impurity, stay juice, standby；
(2) water of 8 times amount is added after Herba Solani Nigri, Folium Citri grandis, Folium Crataegi, mountain, Fructus Capsici, distiller grains, Flos Genkwa and Caulis et Folium Ammopiptanthi Mongolici being mixed, Extract 2-3 hour, filter, taking liquid；In remaining residue, add the water of 6 times amount, extract 1-2 hour, filter, get it filled Liquid；Merge twice medicinal liquid, be condensed into the thick paste of relative density 1.10-1.15 at 60 DEG C, drying under reduced pressure, standby；
(3) geaster and pyrolusitum being dried, section is ground into powder, obtains 120 mesh fine powders, standby；
(4) alcoholic solution of Styrax and Camphora 5ml90% is melted, stay solution, standby；
(5) juice, thick paste, fine powder and solution mixing step (1)-step (4) prepared, after adding vaseline, preparation For externally-applied soft ointment, it is the described external-applied ointment for treating cold injury.
The property of medicine of Chinese medicine used by the present invention is as follows:
Herba Chrysosplenii Macrophylli: bitter in the mouth, puckery, cold in nature.Heat-clearing and toxic substances removing, cough-relieving, leukorrhagia stopping, restrain granulation promoting.Main ecthyma, scalds." Shaanxi medium-height grass Medicine " carry: " heat-clearing and toxic substances removing, granulation promoting, convergence.Control ecthyma, burn and scald.”
Herba Solani Nigri: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Main furuncle, carbuncle, erysipelas, osteopatia sprain, Chronic Airway Inflammation, oedema due to nephritis." Treatise on Dietetic Therapy " carries: " main fourth swells, and suffers from erysipelas skin ulcer.With soil pestle, apply it.”
Folium Citri grandis: acrid in the mouth, hardship, warm in nature；Return spleen, Liver Channel.Promoting the circulation of QI to relieve pain, removing toxic substances and promoting subsidence of swelling.Main wind syndrome of head pain, arthralgia due to cold-dampnes, dyspepsia Stomachache, acute mastitis, tonsillitis, otitis media." Chongqing medical herbs " carries: " control children's's cold food tripe distending pain, cold-damp foot gonalgia, chilblain.”
Herba polygoni senticosi: bitter in the mouth, acid, micro-pungent, property is put down.Heat-clearing and toxic substances removing, and wet antipruritic, dissipating blood stasis for subsidence of swelling.Main ulcerative carbuncle furuncle furuncle, poisonous snake stings Wound, eczema, impetigo, herpes zoster, traumatic injury, pleased, internal hemorrhoid external hemorrhoid.Jiangxi " medical herbs handbook " carries: " promoting the circulation of blood dissipating blood stasis, detumescence Removing toxic substances.Controlling carbuncle of the nape, altauna furuncle, baby's fetal toxicosis, venom, get injured by a fall, eczema is itched bitterly, external hemorrhoid, internal hemorrhoid.”
Radix et Caulis Opuntiae Dillenii: bitter in the mouth, cold in nature；GUIXIN, lung, stomach warp.Promoting flow of QI and blood, heat-clearing and toxic substances removing, cooling blood for hemostasis, clearing away lung-heat to relieve cough.Main Stomachache, mass in the abdomen, dysentery, laryngalgia, cough due to lung-heat, pulmonary tuberculosis is spat blood, and spits blood, hemorrhoidal bleeding, skin infection furuncle furuncle, acute mastitis, the cheek of itching, tinea, snakeworm Bite, scald, cold injury." Luchuan book on Chinese herbal medicine " carries: " eliminating inflammation and expelling toxin, evacuation of pus granulation promoting.Cure mainly carbuncle sore furuncle and phyma, cough.”
Folium Crataegi: sour in the mouth, property is put down；Return lung meridian.Antipruritic, sore, blood pressure lowering.Main dermatitis rhus, ulcer being unable to heal, hypertension." elbow Rear " carry: " stem and leaf liquor, washes dermatitis rhus.”
Ramulus Et Folium Pithecellobii Lucidi: mildly bitter flavor, pungent, cool in nature, mild toxicity；GUIXIN, liver, spleen, stomach warp.Dispeling the wind detumescence, removing pathogenic heat from blood and toxic substance from the body, convergence is raw Flesh.Main rheumatic ostalgia, traumatic injury, burn and scald, ulcer." register planted by Guangxi medicine " carries: " detumescence.Dispelling the wind and dampness pathogens pain, traumatic injury is burning hot Wound.”
Mountain: acrid in the mouth, warm in nature；Return lung, spleen channel.Expelling wind and removing dampness, promoting blood circulation and detumescence, promoting the circulation of QI to relieve pain, preventing phlegm from forming and stopping coughing.Main air arthralgia chiefly caused by damp pathogen Bitterly, stomachache, dysmenorrhea, traumatic injury, wind and cold cough with asthma, colicky." Guangxi practicality Chinese herbal medicine newly selects " carries: " reducing swelling and alleviating pain, wind dispelling Cold, stimulate the menstrual flow.Control traumatic injury, venom.”
Geaster: acrid in the mouth, property is put down.Lung heat clearing, sore-throat relieving, removing toxic substances, detumescence, hemostasis.Main cough, laryngopharynx swelling and pain, carbuncle sore tumefacting virus, chilblain Flowing water, spits blood, epistaxis, traumatic hemorrhage.
Fructus Capsici: acrid in the mouth, property heat；Return spleen, stomach warp.Warming spleen and stomach for dispelling cold, the therapeutic method to keep the adverse QI flowing downwards helps digestion.The main cold syndrome of the stomach stagnation of QI, abdominal distention, vomiting, Dysentery, rheumatalgia, chilblain." BAICAO mirror " carries: " washes chilblain, bathes cold scabies, rush down large intestine channel cold-mass." modern medicine study confirmation, outward It is used as inuncts skin is had to send out effect red, makes local skin blood vessel play reflex dilatation, promote the prosperous of local blood circulation Contain.Tincture can be used for chilblain.
Styrax: acrid in the mouth, sweet, warm in nature；Return lung, liver, spleen, stomach warp.Sensible ward off dirty, dissipating depression of QI eliminating phlegm, promoting the circulation of QI to relieve pain.In master Wind, syncope due to accumulation of phlegm, the constipation due to cold pathogen disease lost consciousness, pyrexial malaria, infantile convulsion, turbid damp vomiting and diarrhea, sudden attack of pain in the chest and abdomen and chilblain, scabies." beautiful Chinese catalpa medicine solution " carries: " inducing diuresis to remove edema, controls swollen, rash miliaria, QI-mass mass formed by blood stasis, mediation internal organs." modern medicine study confirmation, Styrax has the stimulation of gentleness to make With, inflammation can be alleviated for local, such as eczema and pruritus, and the healing of ulcer and wound can be promoted.
Pyrolusitum: sweet in the mouth, flat, salty, cold in nature；Return kidney, Liver Channel.Blood stasis removing stops blooding, reducing swelling and alleviating pain, promoting tissue regeneration and ulcer healing.Main traumatic injury damages Wound, incised wound is hemorrhage, carbuncle skin infection, burn due to hot liquid or fire." Bencao Jingshu " carries: " pyrolusitum, salty can enter blood, sweet can enrich blood, and cold can remove Heat, therefore undermine pain relieving granulation promoting meat in main incised wound injured also.Su Song vinegar rubs edema of the dorsum of the foot poison carbuncle person, also takes the merit ear of its promoting blood circulation and cooling blood.”
Distiller grains: sweet in the mouth, pungent, warm in nature；Return stomach, liver, kidney channel.Promoting blood circulation and stopping pain, warming spleen and stomach for dispelling cold.Lead and traumatic fracture the stagnant pain of the stasis of blood, chilblain, Anemofrigid-damp arthralgia, snakebite, honeybee stings.Supplement to the Herbal carries: " main warming middle-JIAO cold air, helps digestion and kill raw meat, burring dish poison, moistens skin, adjusts internal organs.”
Flos Genkwa: acrid in the mouth, hardship, warm in nature, poisonous；Return lung, spleen, kidney, bladder warp.Removing fluid-retention by purgation, expelling phlegm for arresting cough, detoxify parasite killing. Main edema, expands, phlegm retention hydrothorax, breathes with cough, carbuncle furuncle tinea." property of medicine opinion " carries: " control trusted subordinate's distension, go aqueous vapor, profit the five internal organs cold-phlegm, Tears saliva such as glue person.Main promoting blood circulation, controls malignant boil migratory arthralgia wet, all poison wind, and extremity contraction is anxious, it is impossible to row step, and energy removing water retention by purgation swelling is full.”
Caulis et Folium Ammopiptanthi Mongolici: acrid in the mouth, hardship, warm in nature, poisonous；GUIXIN warp.Expelling wind and removing dampness, relaxing muscles and tendons dissipating blood stasis.Main chilblain, chronic rheumatic closes Arthralgia.
Camphora: acrid in the mouth, property heat, slightly poisonous；GUIXIN, spleen channel.Orifice opening, qi stagnation removing, to ward off foul, killing parasites for relieving itching, detumescence is only Bitterly.Main calentura coma, attacked by pestiferous factors dampings off, and acute filthy disease is vomited and diarrhoea stomachache, and the disturbance of lower legs due to pathogenic cold and dampness, scabies stubborn dermatitis, tinea alba, chilblain, ecthyma, extreme misery scalds Wound, traumatic pain, toothache, wind-fire acute conjunctivitis." Prescriptions for Universal Relief " carries: " control all malignant boil as cream and beat and flutter damage, the disease such as rheumatism tinea pedis.”
The present invention compared with prior art, has the advantages that
Ointment of the present invention use Chinese herbal medicine be effective ingredient, all medicines be harmonious have heat-clearing and toxic substances removing, convergence granulation promoting, invigorating blood circulation disappears The effects such as swollen and wet antipruritic, cooling blood for hemostasis, warming spleen and stomach for dispelling cold, promoting blood circulation and stopping pain, for the pruritus caused for cold injury, herpes, speckle The treatment of the symptoms such as rash, edema, skin frostbite, skin blister, rear formation black dry crusts, the colour of skin are crimson has instant effect, healing The advantages such as rate is high, have no side effect, safe ready, and low price, easily prepare, can be widely used for the treatment of cold injury.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of ointment effective ingredient of the present invention forms and weight is:
The processing step of ointment preparation method of the present invention is:
(1) Herba Chrysosplenii Macrophylli, Herba polygoni senticosi, Radix et Caulis Opuntiae Dillenii and Ramulus Et Folium Pithecellobii Lucidi are twisted juice, filter impurity, stay juice, standby；
(2) water of 8 times amount is added after Herba Solani Nigri, Folium Citri grandis, Folium Crataegi, mountain, Fructus Capsici, distiller grains, Flos Genkwa and Caulis et Folium Ammopiptanthi Mongolici being mixed, Extract 2-3 hour, filter, taking liquid；In remaining residue, add the water of 6 times amount, extract 1-2 hour, filter, get it filled Liquid；Merge twice medicinal liquid, be condensed into the thick paste of relative density 1.10-1.15 at 60 DEG C, drying under reduced pressure, standby；
(3) geaster and pyrolusitum being dried, section is ground into powder, obtains 120 mesh fine powders, standby；
(4) alcoholic solution of Styrax and Camphora 5ml90% is melted, stay solution, standby；
(5) juice, thick paste, fine powder and solution mixing step (1)-step (4) prepared, after adding vaseline, preparation For externally-applied soft ointment, it is the described external-applied ointment for treating cold injury.
Usage and dosage: three times a day, each 4-6g, uniform application is in affected part.Within 5 days, it is a course for the treatment of, usual 1-2 the course for the treatment of Onset.
Embodiment 2
The raw material of ointment effective ingredient of the present invention forms and weight is:
The ointment preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of ointment effective ingredient of the present invention forms and weight is:
The ointment preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of ointment effective ingredient of the present invention forms and weight is:
The ointment preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Clinical data:
1, case selection:
Selecting the cold injury patient 260 example clinical observation that my institute or outer court make a definite diagnosis, patient is randomly divided into two groups, treatment group 130 Example, wherein male 65 example, women 65 example, age 10-68 year, 38.1 years old mean age, the course of disease 1 month-15 years；Matched group 130 Example, wherein male 65 example, women 65 example, age 10-68 year, 38 years old mean age, the course of disease 1 month-15 years.The disease of two groups of cases Journey, degrees of symptoms are basically identical, without significant difference, have comparability.
2, Therapeutic Method:
Treatment group patient smears ointment of the present invention, three times a day, each 4-6g, within 7 days, is a course for the treatment of, usual 1-2 the course for the treatment of Effectively, pertinacious disease needs 3-4 the course for the treatment of.
Matched group uses chilblain spirit, by specification use, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, efficacy determination:
(1) cure: arterial oxygen saturation reduction, " numb with cold " phenomenon, chilblain, pruritus, herpes, macule, edema, skin freeze The transference cures such as wound, skin blister, rear formation black dry crusts, the colour of skin are crimson, physical recovery is normal.
(2) effective: above-mentioned symptom has been alleviated.
(3) invalid: disease is unchanged.
4, result:
Smearing in the treatment group of ointment of the present invention, cure 107 examples, effective 20 examples, invalid 3 examples, cure rate is 82.3%, always Effective percentage 97.7%.
Curing 30 examples, effective 40 examples, invalid 60 examples in matched group, cure rate is 23.1%, total effective rate 53.8%.
Result above shows, treatment group cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, week certain, female, 59 years old, self-employed entrepreneurs, people from Cangzhou, Hebei.Patient suffers from cold injury more than 12 years, and patient enters at local hospital After row medication, the most all having recurrence, pruritus is more than.For further diagnosis and treatment, introduce to our hospital through friend.Smear this 1 course for the treatment of of invention ointment, cold injury symptom alleviates；Continue to smear 3 courses for the treatment of of ointment of the present invention, cold injury transference cure, follow up a case by regular visits to multiple Send out, thoroughly cure.
2, remaining certain, man, 50 years old, builder, Tianshui city people.Patient suffers from cold injury history more than 5 years, carries out at local hospital After treatment, the most all have recurrence.For further diagnosis and treatment, to our hospital.Smear 2 courses for the treatment of of ointment of the present invention, cold injury Symptom starts to take a turn for the better；Continue to smear 2 courses for the treatment of of ointment of the present invention, cold injury transference cure, follow up a case by regular visits to not recur, thoroughly cure.
3, Di, man, 48 years old, office manager, Heilungkiang grand celebration people.Patient before 2 years out of doors after activity hand water occurs Swollen, the symptom of pruritus, takes a turn for the better after unction, sends out after drug withdrawal again.To our hospital, make a definite diagnosis on inspection and suffer from cold injury.It is coated with Smearing 2 courses for the treatment of of ointment of the present invention, above-mentioned symptom takes a turn for the better；Continuing to smear 2 courses for the treatment of of ointment of the present invention, above-mentioned symptom disappears, follows up a case by regular visits to Do not recur.
4, certain is practised, female, 34 years old, salesman, Chao County of Anhui Province Lakers.Patient suffers from hand cold injury for many years, carries out at local hospital After diagnosis and treatment, do not take a favorable turn, introduce to our hospital through local doctor.Smearing 1 course for the treatment of of ointment of the present invention, cold injury symptom subtracts Gently；Continuing to smear 2 courses for the treatment of of ointment of the present invention, cold injury symptom all disappears, and follows up a case by regular visits to not recur, thoroughly cures.
5, Bai, female, 26 years old, self-employed entrepreneurs, Tonghua, Jilin Province people.There is red and swollen, the symptom of pruritus in patient thigh portion, the most not Pay attention to, after gradually increase the weight of, area increases.Control for rooting, to our hospital, it is diagnosed as cold injury by inspection.Smear this 2 courses for the treatment of of bright ointment, redness alleviates；After continuing to smear 1 course for the treatment of of ointment of the present invention, above-mentioned symptom disappears, and health is fully recovered, and follows up a case by regular visits to Do not recur.
6, what certain, man, 16 years old, student, people from Pu'er, Yunnan.There is red and swollen, skin after exposing the most for a long time in patient hand The symptom of skin vesicle, rear formation black dry crusts, the colour of skin is crimson, to our hospital, is diagnosed as cold injury on inspection.Smear this After 1 course for the treatment of of bright ointment, above-mentioned symptom takes a turn for the better；Continuing to smear 2 courses for the treatment of of ointment of the present invention, above-mentioned symptom disappears, and health is fully recovered, Follow up a case by regular visits to not recur, thoroughly cure.

Claims (5)

1. one kind for treating the external-applied ointment of chilblain, it is characterised in that: make described ointment effective ingredient raw material composition and Parts by weight are:
Herba Chrysosplenii Macrophylli 23-55 part Herba Solani Nigri 21-53 part Folium Citri grandis 21-53 part Herba polygoni senticosi 19-51 part
Radix et Caulis Opuntiae Dillenii 19-43 part Folium Crataegi 18-42 part Ramulus Et Folium Pithecellobii Lucidi 17-41 part mountain 13-37 part
Geaster 11-35 part Fructus Capsici 11-35 part Styrax 8-28 part pyrolusitum 8-28 part
Distiller grains 7-27 part Flos Genkwa 5-25 part Caulis et Folium Ammopiptanthi Mongolici 3-23 part Camphora 2-21 part.
A kind of external-applied ointment for treating chilblain the most according to claim 1, it is characterised in that: making described ointment has The raw material of effect composition forms and parts by weight are:
47 portions of Herba Solani Nigris of Herba Chrysosplenii Macrophylli, 45 parts of Herba polygoni senticosi of 45 parts of Folium Citri grandis 43 parts
31 parts of 35 parts of mountains of 36 parts of Ramulus Et Folium Pithecellobii Lucidis of 37 parts of Folium Crataegi of Radix et Caulis Opuntiae Dillenii
29 portions of Fructus Capsicis of geaster, 23 parts of pyrolusitums of 29 parts of Styrax 23 parts
22 parts of Flos Genkwas of distiller grains, 18 parts of Camphoras of 20 parts of Caulis et Folium Ammopiptanthi Mongolici 16 parts.
A kind of external-applied ointment for treating chilblain the most according to claim 1, it is characterised in that: making described ointment has The raw material of effect composition forms and parts by weight are:
39 portions of Herba Solani Nigris of Herba Chrysosplenii Macrophylli, 37 parts of Herba polygoni senticosi of 37 parts of Folium Citri grandis 35 parts
25 parts of 29 parts of mountains of 30 parts of Ramulus Et Folium Pithecellobii Lucidis of 31 parts of Folium Crataegi of Radix et Caulis Opuntiae Dillenii
23 portions of Fructus Capsicis of geaster, 18 parts of pyrolusitums of 23 parts of Styrax 18 parts
17 parts of Flos Genkwas of distiller grains, 13 parts of Camphoras of 15 parts of Caulis et Folium Ammopiptanthi Mongolici 11 parts.
A kind of external-applied ointment for treating chilblain the most according to claim 1, it is characterised in that: making described ointment has The raw material of effect composition forms and parts by weight are:
31 portions of Herba Solani Nigris of Herba Chrysosplenii Macrophylli, 29 parts of Herba polygoni senticosi of 29 parts of Folium Citri grandis 27 parts
19 parts of 23 parts of mountains of 24 parts of Ramulus Et Folium Pithecellobii Lucidis of 25 parts of Folium Crataegi of Radix et Caulis Opuntiae Dillenii
17 portions of Fructus Capsicis of geaster, 13 parts of pyrolusitums of 17 parts of Styrax 13 parts
12 parts of Flos Genkwas of distiller grains, 8 parts of Camphoras of 10 parts of Caulis et Folium Ammopiptanthi Mongolici 6 parts.
5. a preparation method for the external-applied ointment for treating chilblain as described in any one of claim 1-4, its feature exists In: comprise the following steps that:
(1) Herba Chrysosplenii Macrophylli, Herba polygoni senticosi, Radix et Caulis Opuntiae Dillenii and Ramulus Et Folium Pithecellobii Lucidi are twisted juice, filter impurity, stay juice, standby；
(2) add the water of 8 times amount after Herba Solani Nigri, Folium Citri grandis, Folium Crataegi, mountain, Fructus Capsici, distiller grains, Flos Genkwa and Caulis et Folium Ammopiptanthi Mongolici being mixed, extract 2-3 hour, filter, taking liquid；In remaining residue, add the water of 6 times amount, extract 1-2 hour, filter, taking liquid；Close And twice medicinal liquid, it is condensed into the thick paste of relative density 1.10-1.15 at 60 DEG C, drying under reduced pressure, standby；
(3) geaster and pyrolusitum being dried, section is ground into powder, obtains 120 mesh fine powders, standby；
(4) alcoholic solution of Styrax and Camphora 5ml90% is melted, stay solution, standby；
(5) juice, thick paste, fine powder and solution mixing step (1)-step (4) prepared, after adding vaseline, outside being prepared as With ointment, it is the described external-applied ointment for treating cold injury.
CN201610621538.3A 2016-07-29 2016-07-29 A kind of external-applied ointment for treating cold injury and preparation method Pending CN106110027A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102028850A (en) * 2009-09-28 2011-04-27 李冬专 Specific ointment for treating chilblain
CN102755459A (en) * 2012-06-28 2012-10-31 固镇县中医院 External ointment for treating chilblain and preparation method of external ointment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102028850A (en) * 2009-09-28 2011-04-27 李冬专 Specific ointment for treating chilblain
CN102755459A (en) * 2012-06-28 2012-10-31 固镇县中医院 External ointment for treating chilblain and preparation method of external ointment

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Application publication date: 20161116