CN106110009A - 一种治疗白内障的中药制剂及制备方法 - Google Patents
一种治疗白内障的中药制剂及制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗白内障的中药制剂及制备方法,属中药领域;本发明中药制剂有效成分的原料组成为:车前子、枸杞、芙蓉根、花椒、蔓荆子、岩扫把、吐铁、千里光、黑芝麻、洋甘菊、槐花、金沙草、甘蓝、甜石榴、马唐和苦瓜;本发明中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,并具有杀菌消毒、凉血止血、清肝明目之功效,对治疗白内障具有独特疗效,且疗效显著,安全可靠,无毒副作用,治愈后不复发,标本兼治,值得临床上广泛推广应用。
Description
所属技术领域
本发明涉及中药领域,尤其涉及一种治疗白内障的中药制剂及制备方法。
背景技术
白内障是种眼睛晶状体发生混浊的疾病,是首位致盲性眼病,白内障的流行情况各地区有很大的差异,中医中又称“青盲”。典型的白内障的临床表现是渐进性视力下降,由于晶状体的密度变化,还可能伴有近视度数加深,单眼复视单眼看东西时出现多个物像等症状,一般不伴有眼红眼痛。目前虽然有许多药物,但尚无药物可以使白内障的进程逆转,所以真正可以使患者视力恢复的治疗仍是手术治疗,根据调查,白内障是最常见的致盲和视力残疾的原因,人类约25%患有白内障。
凡是各种原因如老化、遗传、局部营养障碍、免疫与代谢异常、外伤、中毒、辐射等,都能引起晶状体代谢紊乱,导致晶状体蛋白质变性而发生混浊,称为白内障。此时光线被混浊晶状体阻扰无法投射在视网膜上,就不能看清物体。世界卫生组织从群体防盲、治盲角度出发,对晶状体发生变性和混浊,变为不透明,以至影响视力,而矫正视力在0.7或以下者,才归入白内障诊断范围。
目前,治疗白内障的最有效方法是手术摘除治疗,手术治疗只能治标而不能治本,且患有高血压、心脏病或其它疾病的患者不宜进行手术,由于患有白内障的患者大多都是老年人,手术会给他们带来很大的心理负担和经济负担;而有些药物只能延缓病情的发生、发展,效果仍不理想。因此,研制疗效确切、安全高效的治疗白内障药物十分必要。
发明内容
本发明提供了一种治疗白内障的中药制剂及制备方法;本发明中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,并具有杀菌消毒、凉血止血、清肝明目之功效,对治疗白内障具有独特疗效,且疗效显著,安全可靠,无毒副作用,治愈后不复发,标本兼治,值得临床上广泛推广应用。
为实现上述目的,本发明的技术方案实施如下:
一种治疗白内障的中药制剂,制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
一种治疗白内障的中药制剂的制备方法,包括以下工艺步骤:
(1)将车前子、枸杞、金沙草、甘蓝和甜石榴、洗净,切碎,放入容器内,绞汁,滤杂质,留汁液备用;
(2)将芙蓉根、花椒和黑芝麻放入容器内,进行粉碎处理,研末,得到过180目的细粉,备用;
(3)将蔓荆子洗净,浸入5倍量的80%的乙醇溶液浸泡1~2小时,加热提取3小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.12~1.16的稠膏,备用;
(4)将岩扫把、吐铁、千里光、洋甘菊、马唐、苦瓜洗净,放入容器内,加入8~10倍量的蒸馏水,浸泡5~6小时后,煮沸3~4小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6倍量蒸馏水,加热煮沸1~2小时,提取;合并三次提取液,过滤,得滤液,浓缩成60℃下相对密度为1.10~1.13的稠膏,备用;
(5)将槐花、放入锅内武火炒,炒制至微黄,取出放凉,研末,得到过200目的细粉,备用;
(6)将上述步骤(1)~(5)所制得的汁液、细粉以及稠膏制成胶囊,即得所述的治疗白内障的中药制剂。
本发明所用中药的药性如下:
车前子:味甘、淡,性微寒;归肺、肝、肾、膀胱经。《药性沦》载:“能去风毒,肝中风热,毒风冲眼目,赤痛障翳,脑痛泪出,去心胸烦热。”现代医学研究证实,车前草清热利尿,凉血,解毒。
枸杞:味甘、性平。补肝益肾。《本草纲目》载:“久服坚筋骨,轻身不老,耐寒暑。”中医常用它来治疗肝肾阴亏、腰膝酸软、头晕、健忘、目眩、目昏多泪、消渴、遗精等病症。现代药理学研究证实,枸杞子可调节机体免疫功能、能有效抑制肿瘤细胞生长和细胞突变、具有延缓衰老、抗脂肪肝、调节血脂和血糖、促进造血功能等方面的作用,并应用于临床。
芙蓉根:味辛、微苦,性凉;归心、肺、肝经。清热解毒,凉血消肿。主治痈疽肿毒初起,臁疮,目赤肿痛,肺痈,咳喘,赤白痢疾,妇人白带,肾盂肾炎。
花椒:味辛、性热;归脾、胃经。芳香健胃,温中散寒,除湿止痛,杀虫解毒,止痒解腥。用于脾胃虚寒,食欲减退,或脘腹冷痛,呕吐,腹泻;蛔虫引起的腹痛。《神农本草经》载:“主风邪气,温中,除寒痹,坚齿发,明目。主邪气咳逆,温中,逐骨节皮肤死肌,寒湿痹痛,下气。”
蔓荆子:味辛、苦,性微寒;归肺、膀胱、肝经。疏散风热,清利头目,除湿处关节。主治外感头痛,偏正头风,昏晕目暗,赤眼多泪,目睛内痛,齿龈肿痛,湿痹拘挛。
岩扫把:味苦,性寒;归肝、胃、大肠经。清热解毒,燥湿。主治湿热黄疸,湿热痢疾,小儿惊风,目赤肿痛,丹毒游风,鹅口疮,跌打损伤。《中国药植志》载:“全草:散寒除风,去目雾,消浮肿。治耳聋,身发黄。亦作健胃驱蛔药。”
吐铁:味甘、咸,性寒;归肺、肝经。养肝明目,生津润燥。主治眼目视物不清,咽喉炎,肺结核。《医林纂要》载:“除烦醒酒。”
千里光:味苦,性寒;归肺、肝、大肠经。清热解毒,明目,止痒。用于风热感冒、目赤肿痛、泄泻痢疾、皮肤湿疹、疮疖。《生草药性备要》载:“治疳疔,消热毒。”《百草镜》载,“治目不清,去红丝白障,迎风流泪”。
黑芝麻:味甘,性平;归肝、肾、大肠经。补肝肾,益精血,润肠燥。用于头晕眼花,耳鸣耳聋,须发早白,病后脱发,肠燥便秘。药理实验表面,黑芝麻可降低血糖,增加肝脏及肌肉中糖元的含量,并具有炎症恢复的作用,能够增加肾上腺中抗坏血酸及胆固醇含量。
洋甘菊:味微苦、甘香。明目、退肝火,治疗失眠,降低血压。可治减轻烫伤,水疱、发炎的伤口,溃疡和愈。帮助改善湿疹、面疱、疱疹、干癣、超敏感皮肤,及一般的过敏现象。平复破裂的微血管,增进弹性,对干燥易痒的皮肤极佳。消除浮肿,强化组织,是非常优良的皮肤净化保养品。
槐花:味苦,性微寒;入肝、肺、心、大肠经。凉血止血,清肝明目。主治肠风便血,痔疮下血,血痢,尿血,血淋,崩漏,吐血,衄血,肝热头痛,目赤肿痛,痈肿疮疡。《本草正》载:“凉大肠,杀疳虫。治痈疽疮毒,阴疮湿痒,痔漏,解杨梅恶疮,下疳伏毒。”现代医学研究证实,槐花所含的芸香甙可增强毛细血管抵抗力,改善血管壁脆性,降低血压、抗水肿,对高血压有防止脑血管破裂的功效,此外还有抗炎作用。
金沙草:味甘、微苦,性寒。清热,利湿,舒筋活络,止血。主治尿路感染,尿路结石,肾炎水肿,肝炎,痢疾,目赤肿痛,风湿痹痛,筋骨麻木,跌打骨折,外伤出血。
甘蓝:味甘;性平;归胃、肾经。清利湿热,散结止痛,益肾补虚。主湿热黄疸,消化道溃疡疼痛,关节不利,虚损。《本草拾遗》载:“补骨髓,利五藏六腑,利苯节,通经络中结气,明耳目,健人,少睡,益心力,壮筋骨。治黄毒,煮作菹,经宿渍色黄,和盐食之,去心下结伏气。”
甜石榴:味甘、酸、涩,性温。生津止渴,杀虫。主咽燥口渴,虫积,久痢。《滇南本草》载:“治筋骨疼痛,四肢无力,化虫,止痢,或咽喉疼痛肿胀,齿床出血,退胆热,明目。”
马唐:味甘,性寒,明目润肺。主治目暗不明,肺热咳嗽。《别录》载,“主调中,明耳目。”
苦瓜:味苦,性寒;入心、脾、胃三经。清暑涤热,明目,解毒。治热病烦渴引饮,中暑,痢疾,赤眼疼痛,痈肿丹毒,恶疮。《泉州本草》载:“主治烦热消渴引饮,风热赤眼,中暑下痢。”
本发明与现有技术相比,具有以下有益效果:
本发明中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,并具有杀菌消毒、凉血止血、清肝明目之功效,对治疗白内障具有独特疗效,且疗效显著,安全可靠,无毒副作用,治愈后不复发,标本兼治,值得临床上广泛推广应用。
具体实施方式
下面结合具体实施例对本发明做进一步阐述。
实施例1
本发明中药制剂有效成分的原料组成及重量为:
一种治疗白内障的中药制剂的制备方法,包括以下工艺步骤:
(1)将车前子、枸杞、金沙草、甘蓝和甜石榴、洗净,切碎,放入容器内,绞汁,滤杂质,留汁液备用;
(2)将芙蓉根、花椒和黑芝麻放入容器内,进行粉碎处理,研末,得到过180目的细粉,备用;
(3)将蔓荆子洗净,浸入5倍量的80%的乙醇溶液浸泡1~2小时,加热提取3小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.12~1.16的稠膏,备用;
(4)将岩扫把、吐铁、千里光、洋甘菊、马唐、苦瓜洗净,放入容器内,加入8~10倍量的蒸馏水,浸泡5~6小时后,煮沸3~4小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6倍量蒸馏水,加热煮沸1~2小时,提取;合并三次提取液,过滤,得滤液,浓缩成60℃下相对密度为1.10~1.13的稠膏,备用;
(5)将槐花、放入锅内武火炒,炒制至微黄,取出放凉,研末,得到过200目的细粉,备用;
(6)将上述步骤(1)~(5)所制得的汁液、细粉以及稠膏制成胶囊,即得所述的治疗白内障的中药制剂。
用法用量:口服即可,每日2次,早晚各1次,每次2粒(每粒0.5g),饭后温开水送服;10天为1个疗程,2~3个疗程即可痊愈,病情严重者遵医嘱酌增用量。
实施例2
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。实施例3
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。实施例4
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。实施例5
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。临床资料:
1、病例选择:
作为治疗白内障的中药制剂,选择确诊的白内障患者153例临床观察,病人随机分成治疗组和对照组两组,治疗组76例,其中男性38例,女性38例,年龄49~74岁,平均年龄61.5岁,平均病程3年;对照组77例,其中男性38例,女性39例,年龄48~75岁,平均年龄61.5岁,平均病程3年。
治疗组和对照组两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。
2、药物选择:
治疗组服用本发明中药制剂,口服即可,每日2次,早晚各1次,每次2粒(每粒0.5g),饭后温开水送服;10天为1个疗程,2~3个疗程即可痊愈,病情严重者遵医嘱酌增用量。
对照组外用苄达赖氨酸滴眼液,滴眼即可,每日3次,每次2滴,或遵医嘱酌增用量。
3、疗效判定:
(1)治愈:头痛、视力下降、模糊症状全部消失,眼部功能恢复正常。
(2)显效:上述症状明显减轻,眼部功能有所好转。
(3)有效:上述症状有所减轻,眼部功能明显好转。
(4)无效:通过治疗后上述症状无减轻或加重。
4、结果:
以上结果显示,治疗组的治愈率和总有效率明显高于对照组。
典型病例举例:
1、沈某,男,49岁,四川雅安人。患者患有白内障,去医院就诊,使用过几种药物治疗,未见任何好转,经人介绍来我院就诊,服用本发明中药制剂治疗,服用1个疗程后,症状有所好转,继续服用2个疗程后,症状消失,痊愈,半年后随访无复发。
2、曾某,女,50岁,湖南邵阳人。患者双眼患白内障3年余,视力不好,由于心脏也不好,不易手术治疗,只能用药治疗,使用过多种药物治疗,未见好转,来我院治疗,给予服用本发明中药制剂治疗,服用1个疗程后,不适症状有所减轻,服用2个疗程后,症状消失,视力恢复到正常水平。
3、彭某,女,57岁,山西阳泉人。浙江湖州人。患者患重度白内障,右眼的眼球被白内障盖住一半,用过几种药物治疗,治疗效果一般,经朋友介绍,来我院就诊,服用本发明中药制剂治疗,服用1个疗程后,症状有所好转,服用3个疗程后,症状消失,痊愈,1年后随访无复发。
4、吕某,男,69岁,陕西商洛人。患者患白内障4年余,因心脏不好不敢做手术,只能用药物治疗,使用多种治疗白内障的药物,治疗效果不佳,经人介绍服用本发明中药制剂治疗,服用1个疗程后,视力模糊等症状有所好转,继续服用2个疗程后,白内障症状全部消失,痊愈。
5、谭某,女,49岁,浙江湖州人。患者因工作压力大,经常头痛,两眼视力下降,看东西模糊,去医院检查诊断为急性白内障;服用本发明中药制剂治疗,服用1个疗程后,症状明显缓解,继续服用2个疗程后,症状全部消失,视力恢复正常,1年后随访无复发。
6、廖某,男,53岁,山东威海人。患者自诉右眼视力逐渐下降,看视物模糊,去医院检查,右眼视力仅为0.2,被确诊为白内障,由于体质虚弱,医生建议服用本发明中药制剂治疗,服用1个疗程后,视力明显改善,服用3个疗程后,症状全部消失,经查右眼视力恢复为0.6,半年后随访无复发。
Claims (5)
1.一种治疗白内障的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
车前子57~80份 枸杞54~78份 芙蓉根53~77份 花椒51~75份
蔓荆子49~73份 岩扫把47~71份 吐铁46~70份 千里光45~69份
黑芝麻42~66份 洋甘菊41~65份 槐花38~62份 金沙草34~58份
甘蓝34~58份 甜石榴32~55份 马唐28~52份 苦瓜25~48份。
2.根据权利要求1所述的一种治疗白内障的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
车前子60~76份 枸杞58~74份 芙蓉根57~73份 花椒55~71份
蔓荆子53~69份 岩扫把51~67份 吐铁50~66份 千里光49~65份
黑芝麻46~62份 洋甘菊45~61份 槐花42~58份 金沙草38~54份
甘蓝38~54份 甜石榴36~51份 马唐32~48份 苦瓜29~44份。
3.根据权利要求1所述的一种治疗白内障的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
车前子64~72份 枸杞62~70份 芙蓉根61~69份 花椒59~67份
蔓荆子57~65份 岩扫把55~63份 吐铁54~62份 千里光53~61份
黑芝麻50~58份 洋甘菊49~57份 槐花46~54份 金沙草42~50份
甘蓝42~50份 甜石榴39~47份 马唐36~44份 苦瓜33~41份。
4.根据权利要求1所述的一种治疗白内障的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
车前子68份 枸杞66份 芙蓉根65份 花椒63份
蔓荆子61份 岩扫把59份 吐铁58份 千里光57份
黑芝麻54份 洋甘菊53份 槐花50份 金沙草46份
甘蓝46份 甜石榴43份 马唐40份 苦瓜37份。
5.一种如权利要求1~4任一项所述治疗白内障的中药制剂的制备方法,其特征在于:包括以下工艺步骤:
(1)将车前子、枸杞、金沙草、甘蓝和甜石榴、洗净,切碎,放入容器内,绞汁,滤杂质,留汁液备用;
(2)将芙蓉根、花椒和黑芝麻放入容器内,进行粉碎处理,研末,得到过180目的细粉,备用;
(3)将蔓荆子洗净,浸入5倍量的80%的乙醇溶液浸泡1~2小时,加热提取3小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.12~1.16的稠膏,备用;
(4)将岩扫把、吐铁、千里光、洋甘菊、马唐、苦瓜洗净,放入容器内,加入8~10倍量的蒸馏水,浸泡5~6小时后,煮沸3~4小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6倍量蒸馏水,加热煮沸1~2小时,提取;合并三次提取液,过滤,得滤液,浓缩成60℃下相对密度为1.10~1.13的稠膏,备用;
(5)将槐花、放入锅内武火炒,炒制至微黄,取出放凉,研末,得到过200目的细粉,备用;
(6)将上述步骤(1)~(5)所制得的汁液、细粉以及稠膏制成胶囊,即得所述的治疗白内障的中药制剂。
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