CN106109509A - The application in preparation treatment wound medicine of a kind of Cedrus deoclar (Roxb.) G. Don quintessence oil - Google Patents
The application in preparation treatment wound medicine of a kind of Cedrus deoclar (Roxb.) G. Don quintessence oil Download PDFInfo
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention discloses the application in preparation treatment wound medicine of a kind of Cedrus deoclar (Roxb.) G. Don quintessence oil.Cedrus deoclar (Roxb.) G. Don quintessence oil therein is containing the volatile oil that active component is cedrol and cedrene.And the contained content for cedrol and the active component of cedrene is not less than 50% in Cedrus deoclar (Roxb.) G. Don quintessence oil.The Cedrus deoclar (Roxb.) G. Don quintessence oil of the present invention be a kind of active component be the volatile oil of cedrol and cedrene, its fragrant matter is derived from natural, there is antibiotic property, blood circulation can be entered with skin permeation, improving microcirculation, promote wound healing, the pruritus simultaneously caused wound is inhibited, and the immunologic function of human body can be improved, from the purpose macroscopically reaching system call interception, treating both the principal and the secondary aspects of a disease at the same time.
Description
Technical field
The present invention relates to the application in preparation treatment wound medicine of a kind of Cedrus deoclar (Roxb.) G. Don quintessence oil.
Background technology
So-called wound is health or object owing to the erosion etc. of strike, collision or the chemical substance of external object causes
Outer damage.Wound includes bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury etc..
Wound normal healing processes is divided into inflammatory reaction phase, granulation phase and epithelium phase, general wound can heal for three weeks
Or close to healing, as wound healing sign did not the most occur more than three weeks, can be judged as that wound healing is slowly and wound
Disunion.The reason causing non-healing wounds has a lot, such as liquefaction of fat, wound infection, individual physique, cicatrix, diabetes, blood
Pipe choking and wound tears repeatedly etc., need to be analyzed just can drawing knot in detail for the disunion reason to concrete wound
Opinion.Non-healing wounds and daily wound care also have the biggest relation, and whether as the most correct in injured rear treatment of wounds, medication obtains
When, whether infection inflammation has much relations to wound.Non-healing wounds reason include following some: (1) liquefaction of fat: mainly occur
Reason is owing to surgery location fat deposit is thicker, causes the damage of fatty tissue during using electric knife, adds fat deposit originally
Body blood fortune is the most poor, and presented then flows out for white liquid, here it is liquefaction of fat.(2) wound infection: wound care is not
When causing infection, nonspecific infection passes through iodophor disinfection, as heavier in infected, then need to use hydrogen peroxide to carry out wound surface
Cleaning, notices that wound is not wrapped up the thickest.(3) diabetes and angiemphraxis: diabetes and angiemphraxis can be divided into a class,
Its common feature is that wound blood fortune is obstructed, so wound cannot heal, and the most serious patient's limb edema, then need to join
Conjunction transfusion dredging vascellum carries out treatment can.(4) scar diathesis: cicatrix is fibrous tissue, the most a small amount of blood capillary is deposited
, lack epithelial tissue, so the wound in cicatrix is particularly difficult to healing.Wound repeatedly tears and is upset, and can cause wound
Around form one layer of fibrous tissue it can be understood as cicatrix predecessor, hinder epithelial tissue to creep, cause non-healing wounds.In wound
During mouth healing, many patients are had to there will be the symptom that wound is itched.The agglutination of wound can divide three phases: (1)
Inflammatory phase or title ooze out the phase.(2) proliferation of fibrous tissue phase (abbreviation proliferative phase).(3) cicatrization repairs the phase (being called for short the reparation phase).
Clinical practice is called for short non-debridement phase, granulation phase and epithelium the most respectively and forms the phase.Wound pruritus occurred in second and third stage.
General wound gets final product rehabilitation for general two or three week, but the most serious wound then needs very long recovery such as burn grade
Journey.If not carrying out wound care during any wound care, wound inflammation is easily caused to infect, then when can delay wound healing
Between even result in non-healing wounds, therefore it is the most particularly important to carry out wound care, simultaneously by suitably intervening (medicine or Medical treatment device
Tool), wound healing can be promoted and pruritus adjoint in wound healing process is had certain inhibitory action.
Summary of the invention
The technical problem to be solved in the present invention is to provide the application in preparation treatment wound medicine of a kind of Cedrus deoclar (Roxb.) G. Don quintessence oil.
The another one technical problem that the invention solves the problems that is to provide one and has promotion wound healing, convergence itching-relieving efficacies
And for treating the composition of medicine of wound.
The technical problem that the present invention is to be solved is to provide a kind of protects traumatic material for treat wound.
The another one technical problem that the present invention is to be solved is to provide a kind of based composite dressing for medical use.
For the application in preparation treatment wound medicine of the Cedrus deoclar (Roxb.) G. Don quintessence oil, Cedrus deoclar (Roxb.) G. Don quintessence oil is to be cedrol containing active component
Volatile oil with cedrene.
As preferably, the content for cedrol and the active component of cedrene contained in Cedrus deoclar (Roxb.) G. Don quintessence oil is not less than
50%.
As preferably:
Cedrus deoclar (Roxb.) G. Don quintessence oil is to be prepared by distillation from Cedrus libani or western Himalaya Cedrus deoclar (Roxb.) G. Don.
Further preferably, Cedrus deoclar (Roxb.) G. Don quintessence oil is prepared by following steps:
(1) carry out being ground into granular by Cedrus libani or western Himalaya plant；
(2) by distillation, the crude extract containing cedrol Yu the volatile oil of cedrene can tentatively be extracted；
(3) crude extract is i.e. obtained after rectification Cedrus deoclar (Roxb.) G. Don quintessence oil.
Total effectively using dosage of Cedrus deoclar (Roxb.) G. Don quintessence oil is 2%～4%.
For there is promotion wound healing, restraining itching-relieving efficacies and for treating the Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine of wound, by
Cedrus deoclar (Roxb.) G. Don quintessence oil, eye-catching Herba Lysimachiae foenum-graeci quintessence oil, Matricaria recutita quintessence oil, the Mentha piperita quintessence oil group of 1:1～2:1:1 in mass ratio respectively
Become, and be diluted to the concentration of not higher than 10% by oil based on Oleum Vitis viniferae or olive oil.
For protecting traumatic material, by release paper, chitosan dressing block, water-absorption fiber cloth, Breathable adhesive tape for treating wound
Overlapping combinations forms the most successively；Chitosan dressing block is adsorbed with Cedrus deoclar (Roxb.) G. Don quintessence oil or Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine.
As preferably, chitosan dressing block is also adsorbed with one or more in following penetration enhancer: the surface of synthesis
Activating agent, chlolic acid derivatives, alkyl substituted beta-schardinger dextrin-class, annular peptides.Wherein, the surfactant of synthesis is selected from polyoxy
Ethylene-9-Laurel ether, sulfur are for Laurel sodium alkoxide；Chlolic acid derivatives be selected from Bile Salts, glucose sodium cholate, NaTDC and
Deoxidation Bile Salts；Annular peptides is selected from bacitracin.
For based composite dressing for medical use, including internal layer and outer layer；Internal layer is made up of water wetted material, and water wetted material contains Cedrus deoclar (Roxb.) G. Don
Quintessence oil or Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine；Outer layer is made up of hydrophobic material.
As preferably, water wetted material is propenyl resin, and it is saturated to it to add Cedrus deoclar (Roxb.) G. Don quintessence oil, then through Stereolithography；
Hydrophobic material is cellulosic material.
The experiment proved that, containing the volatile oil that active component is cedrol and cedrene, there are promotion wound healing, receipts
Hold back antipruritic effect.
The invention has the beneficial effects as follows:
Cedrus deoclar (Roxb.) G. Don quintessence oil is a kind of containing the volatile oil that active component is cedrol and cedrene, and its fragrant matter is derived from sky
So, there is antibiotic property, blood circulation can be entered with skin permeation, improve microcirculation, promote wound healing, wound is caused simultaneously
Pruritus inhibited, it is possible to improve human body immunologic function, from the mesh macroscopically reaching system call interception, treating both the principal and the secondary aspects of a disease at the same time
's.
Accompanying drawing explanation
The present invention is further detailed explanation with detailed description of the invention below in conjunction with the accompanying drawings.
Fig. 1 is that the present invention is for treating the structural representation protecting traumatic material embodiment of wound.
Labelling in Fig. 1,1-release paper, 2-non-woven chitosan dressing block, 3-non-woven water-absorption fiber cloth, 4-breathes freely glue
Cloth.
Fig. 2 is the structural representation of based composite dressing for medical use embodiment of the present invention.
Labelling in Fig. 2,5-internal layer, 6-outer layer.
Detailed description of the invention
Cedrus deoclar (Roxb.) G. Don quintessence oil is a kind of to the experiment proved that containing the volatile oil that active component is cedrol and cedrene, this virtue
Essential oil has promotion wound healing, restrains antipruritic effect, may be used for the medicine of preparation treatment wound.
The Cedrus deoclar (Roxb.) G. Don quintessence oil of the present embodiment be a kind of be cedrol and cedrene and this active component content containing active component
It is not less than the volatile oil of 50%, is prepared by distillation from Cedrus libani or western Himalaya Cedrus deoclar (Roxb.) G. Don, specifically make
Preparation Method is as follows:
(1) carry out being ground into granular by Cedrus libani or western Himalaya plant；
(2) can tentatively extract the crude extract containing cedrol Yu cedrene carry out essence again by Rotary Evaporators or distillation
For testing after evaporating, analyze through GC/MS and carry out composition qualification.
It is Cedrus deoclar (Roxb.) G. Don that following traumatic animal model experiment and animal model of burn experiment contain active component for checking
The volatile oil of alcohol is for the Healing of wound.
In following wound and burn type zoopery, Cedrus deoclar (Roxb.) G. Don used compound quintessence oil be by Cedrus deoclar (Roxb.) G. Don quintessence oil 2%～
4%, Semen Ricini oil 47%～49%, the mass percent of olive oil 47%～49% are mixed, and wherein Cedrus deoclar (Roxb.) G. Don quintessence oil is total
Effectively using dosage controls in the range of 2%～4%.
The most traumatic animal model experiment
1.1 whole bark breaks damage animal model and make: selective body quality 2.5～3.0kg rabbit 8, and half-and-half, back takes off male and female
Hair preserved skin anesthesia, back routine is shedded sterilization, in 2 positions at every rabbit back, the most surgically deducts 3 pieces of diameters about
The circular full thickness skin of 1.5cm, as deep as sarolemma, makes whole bark break and damages animal model.
1.2 experiment packets: after being successfully established 8 rabbit models of Traumatic wound, use normal saline flushing wound, iodine tincture,
Ethanol disinfection, the 1st wound of every rabbit is set to blank, only smears normal saline；2nd wound is smeared Cedrus deoclar (Roxb.) G. Don and is compounded
Quintessence oil, consumption is 0.3ml～0.4ml.Each 1 time of morning and afternoon.Use Petroleum gauze mulching after the wound drug of topical application, then use dry gauze bag
Prick.Respectively process by former method after wound normal saline washing every day, ethanol disinfection and change dressings.Every rabbit sub-cage rearing.
1.3 observation index:
1.3.1 wound healing rate is observed: 4d, 7d, 12d after the wound same day and wound, with fixed range, fixing Jiao
Respectively each wound surface is carried out digital photographing away from, fixing amplification, process photo with image analysis software, draw each wound surface
Area in agglutination, and calculate wound healing rate: wound healing rate=[(original wound surface area-do not heal wound surface area)/
Original wound surface area] × 100%, as statistics counting index.
1.3.2 pruritus is observed: as main evaluation index, observe two groups of families according to the number of times of scratching of animal in 30min
Rabbit wound surface 1d, 7d days and the situation of 12 days cicatrix prurituss after healing.
1.4 experimental results:
1.4.1 the comparison of two groups of wound healing rates
Compared with matched group, experimental group in the wound healing rate of post-traumatic 4d, 7d and 12d obviously higher than comparison
Group, difference is respectively provided with statistical significance (P is respectively less than 0.05), is shown in Table 1.
1 liang of table group wound healing rate comparison (%)
| Group | n | 4d | 7d | 12d |
| Experimental group | 8 | 22.7±2.4* | 55.4±2.9* | 92.3±2.8* |
| Matched group | 8 | 15.5±2.1 | 21.0±3.2 | 34.7±3.2 |
Note: * compared with matched group, (P < 0.05)
1.4.2 the comparison of two groups of number of times of scratching
Compared with matched group, the number of times of scratching of experimental group 1d, 7d and 12d after wound healing is all significantly lower than comparison
Group, difference is respectively provided with statistical significance (P is respectively less than 0.05), is shown in Table 2.
2 liang of groups of table scratch number of times comparison (Secondary)
| Group | n | 1d | 7d | 12d |
| Experimental group | 8 | 15±3* | 16±3* | 13±4* |
| Matched group | 8 | 27±5 | 29±4 | 30±4 |
Note: * compared with matched group, (P < 0.05)
2. animal model of burn experiment
2.1 animal model of burn: selective body quality 2.5～3.0kg rabbit 8, male and female double, after losing hair or feathers and anaesthetizing,
Experimental rabbit back, with vertebra as axis of symmetry, with the artificial burning apparatus (quality 500g) of 100 DEG C of boiled water of splendid attire, is close to rabbit skin
Skin 3s, makes Superficial bums wound surface 24, and 5s makes deep II degree of wound surface 24, each wound surface average area 16cm2, left side is created
Face is experimental group, and right side is matched group.
2.2 experiment packets: after skin burn wound surface is set up, compound quintessence oil to left side experimental group wound surface coating Cedrus deoclar (Roxb.) G. Don immediately,
Consumption is 0.3ml～0.4ml, right side wound surface coating vaseline, 2 times/d, each 1 time of morning and afternoon.
2.3 observation index
2.3.1 the difference of two groups is compared with burn wound's area of 7d and scab forming time and decrustation healing time.
2.3.2 pruritus is observed: as main evaluation index, observe two groups of families according to the number of times of scratching of animal in 30min
Rabbit wound surface 1d, 7d days and the situation of 12 days cicatrix prurituss after healing.
1.4 experimental results:
1.4.1 the Cedrus deoclar (Roxb.) G. Don quintessence oil curative effect (relatively matched group) to burn wound
Compared with matched group, the wound surface of experimental group averagely reduces percentage rate, scab forming time and averagely shortens percentage rate and decrustation
Healing time averagely shortens percentage rate and is shown in Table 1.
The table 1 Cedrus deoclar (Roxb.) G. Don quintessence oil curative effect to burn wound
1.4.2 the comparison of two groups of number of times of scratching
Compared with matched group, the number of times of scratching of experimental group 1d, 7d and 12d after wound healing is all significantly lower than comparison
Group, difference is respectively provided with statistical significance (P is respectively less than 0.05), is shown in Table 2.
2 liang of groups of table scratch number of times comparison (Secondary)
| Group | n | 1d | 7d | 12d |
| Experimental group | 8 | 18±4* | 14±2* | 13±6* |
| Matched group | 8 | 35±7 | 38±8 | 39±6 |
Note: * compared with matched group, (P < 0.05)
Above description of test, Cedrus deoclar (Roxb.) G. Don quintessence oil is significantly better than matched group for the healing itching-relieving action of wound.
Being below primary raw material for using above-mentioned Cedrus deoclar (Roxb.) G. Don quintessence oil, prepared 3 kinds are for treating the medicine of wound.
One, for treating the Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine of wound
A kind of have promotion wound healing, convergence itching-relieving efficacies and for treating the Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine of wound, by
Cedrus deoclar (Roxb.) G. Don quintessence oil, eye-catching Herba Lysimachiae foenum-graeci quintessence oil, Matricaria recutita quintessence oil, Mentha piperita quintessence oil are respectively by weight 1:1:1:1 or 1:2:
1:1 forms, then is diluted to the concentration of not higher than 10% with the base oil such as Oleum Vitis viniferae or olive oil.The most eye-catching Herba Lysimachiae foenum-graeci quintessence oil
Having calm antiinflammation, Matricaria recutita has anti-allergic effects, and Mentha piperita quintessence oil has anti-inflammation and promotees infiltration work
With, composition of medicine by Mutiple Targets multipath effect and can with reinforced effects, reduce consumption and reduce cost.
Using method: combinations thereof medicine is made spray wound wound is sprayed, or directly will combine medicine
Thing spreads upon wound.
This composition of medicine is with Cedrus deoclar (Roxb.) G. Don quintessence oil as main component, auxiliary in other spice quintessence oils, through directly contacting with wound surface,
Entering human body after being absorbed by Cedrus deoclar (Roxb.) G. Don quintessence oil liposoluble active composition easily transdermal percutaneous skin, local can be improved microcirculation, be reached
Blood circulation promoting, it is possible to promote the healing of wound, operative incision, the pruritus produced when simultaneously also can effectively stop wound healing,
And have rapid-action, concentration is low, have no side effect, easy to use, preserve easily.
Two, traumatic material is protected for treat wound
Fig. 1 is a kind of to protect traumatic material for treat wound, by release paper 1, non-woven chitosan dressing block 2, non-woven
Water-absorption fiber cloth 3, Breathable adhesive tape 4 combine.The most non-woven chitosan dressing block is adsorbed with contained Cedrus deoclar (Roxb.) G. Don essential oil concentration
The Cedrus deoclar (Roxb.) G. Don of 2%～4% compounds quintessence oil or above-mentioned Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine, and consumption is 0.3ml～0.4ml.
This chitosan dressing block is also adsorbed with one or more in following penetration enhancer: the 1) surface activity synthesized
Agent: selected from polyoxyethylene-9-Laurel ether, sulfur for Laurel sodium alkoxide；2) chlolic acid derivatives: selected from Bile Salts, glucose cholic acid
Sodium, NaTDC and deoxidation Bile Salts；3) alkyl substituted beta-schardinger dextrin-class；4) annular peptides: selected from bacitracin；
It addition, chitosan dressing block also include the one in ethylene diamine tetra acetic acid disodium, citric acid and polyacrylic acid or
Two or more.
Using method: directly apply the wound in wound.
This protects traumatic material and in use directly contacts with wound surface, the Cedrus deoclar (Roxb.) G. Don essence of absorption in non-woven chitosan dressing block
Oil pole, easily by skin Transdermal absorption, enters blood circulation of human body after being absorbed by the skin, by improving microcirculation, antipruritic disappearing
Effects such as inflammation, reducing swelling and alleviating pain, it is possible to reach to promote wound and operative incision healing, produce when also can effectively stop wound healing simultaneously
Raw pruritus anti-inflammatory effect, and have rapid-action, concentration is low, have no side effect, easy to use, preserve easily.
Three, Medical composite dressing
Such as a kind of Medical composite dressing of Fig. 2, it is made up of inside and outside two-layer.Wherein internal layer 5 is hydrophilic material with propenyl resin
Expect, and interpolation compounds quintessence oil or Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine to propenyl tree containing the Cedrus deoclar (Roxb.) G. Don that Cedrus deoclar (Roxb.) G. Don essential oil concentration is 2%～4%
Fat is saturated, then carries out optical soliton interaction, and outer layer 6 uses cellulose material to make.
Using method: directly apply the wound in wound.
The present embodiment uses inside and outside double-layer structure to make Medical composite dressing, and wherein internal layer uses third containing Cedrus deoclar (Roxb.) G. Don quintessence oil
Enol resin, this propenyl resin is through directly contacting with wound surface, and Cedrus deoclar (Roxb.) G. Don quintessence oil therein enters human body after being absorbed by the skin
Blood circulation, it is possible to promote wound healing, the pruritus produced when also can effectively stop wound healing simultaneously, and have rapid-action,
Concentration is low, have no side effect.
Invention described above embodiment, is not intended that limiting the scope of the present invention.Any in the present invention
Spirit and principle within amendment, equivalent and the improvement etc. made, should be included in the claim protection model of the present invention
Within enclosing.
Claims (10)
1. a Cedrus deoclar (Roxb.) G. Don quintessence oil is preparing the application treated in wound medicine, it is characterised in that described Cedrus deoclar (Roxb.) G. Don quintessence oil is containing living
Property composition is the volatile oil of cedrol and cedrene.
Application the most according to claim 1, it is characterised in that: contained for cedrol and Cedrus deoclar (Roxb.) G. Don in described Cedrus deoclar (Roxb.) G. Don quintessence oil
The content of the active component of alkene is not less than 50%.
Application the most according to claim 2, it is characterised in that: described Cedrus deoclar (Roxb.) G. Don quintessence oil is from Cedrus libani or west happiness horse traction
Refined Cedrus deoclar (Roxb.) G. Don is prepared by distillation.
Application the most according to claim 3, it is characterised in that: described Cedrus deoclar (Roxb.) G. Don quintessence oil is prepared by following steps:
(1) carry out being ground into granular by Cedrus libani or western Himalaya plant；
(2) by distillation, the crude extract containing cedrol Yu the volatile oil of cedrene can tentatively be extracted；
(3) crude extract is i.e. obtained after rectification Cedrus deoclar (Roxb.) G. Don quintessence oil.
5. according to the application described in Claims 1 to 4 any one, it is characterised in that: the total of described Cedrus deoclar (Roxb.) G. Don quintessence oil effectively uses
Dosage is 2%～4%.
6. having promotion wound healing, restrain itching-relieving efficacies and for treating a Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine for wound, it is special
Levy and be, by Cedrus deoclar (Roxb.) G. Don quintessence oil, eye-catching Herba Lysimachiae foenum-graeci quintessence oil, Matricaria recutita quintessence oil, Mentha piperita quintessence oil respectively 1:1 in mass ratio～
2:1:1 forms, and is diluted to the concentration of not higher than 10% by oil based on Oleum Vitis viniferae or olive oil.
7. protect a traumatic material for treat wound, by release paper, chitosan dressing block, water-absorption fiber cloth, Breathable adhesive tape from
Under supreme overlapping combinations successively form；It is characterized in that: described chitosan dressing block is adsorbed with Cedrus deoclar (Roxb.) G. Don quintessence oil or Cedrus deoclar (Roxb.) G. Don quintessence oil group
Composite medicine.
The most according to claim 7 protect traumatic material, it is characterised in that: described chitosan dressing block is also adsorbed with following infiltration
One or more in accelerator: the surfactant of synthesis, chlolic acid derivatives, alkyl substituted beta-schardinger dextrin-class, cyclic peptide
Class.
9. a based composite dressing for medical use, including internal layer and outer layer；It is characterized in that: described internal layer is made up of water wetted material, institute
State water wetted material and contain Cedrus deoclar (Roxb.) G. Don quintessence oil or Cedrus deoclar (Roxb.) G. Don quintessence oil composition of medicine；Described outer layer is made up of hydrophobic material.
Based composite dressing for medical use the most according to claim 9, it is characterised in that described water wetted material is propenyl resin, and
Add Cedrus deoclar (Roxb.) G. Don quintessence oil saturated to it, then through Stereolithography；Described hydrophobic material is cellulosic material.
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| CN201610557374.2A CN106109509A (en) | 2016-07-14 | 2016-07-14 | The application in preparation treatment wound medicine of a kind of Cedrus deoclar (Roxb.) G. Don quintessence oil |
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| CN201610557374.2A CN106109509A (en) | 2016-07-14 | 2016-07-14 | The application in preparation treatment wound medicine of a kind of Cedrus deoclar (Roxb.) G. Don quintessence oil |
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Cited By (1)
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Application publication date: 20161116 |