CN106109290B - Liquid prickly-heat lotion for infants and preparation method thereof - Google Patents

Liquid prickly-heat lotion for infants and preparation method thereof Download PDF

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CN106109290B
CN106109290B CN201610502570.XA CN201610502570A CN106109290B CN 106109290 B CN106109290 B CN 106109290B CN 201610502570 A CN201610502570 A CN 201610502570A CN 106109290 B CN106109290 B CN 106109290B
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chinese herbal
stirring
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CN106109290A (en
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徐力
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Yangzhou Zhonghui Biotechnology Co ltd
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Yangzhou Zhonghui Biotechnology Co ltd
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Abstract

A liquid prickly-heat lotion for infants comprises phase A, phase B and phase C, wherein phase A comprises emulsifying agent ceteareth-6 olive oleate 00801.00-6.00%, cetostearyl alcohol C16-180.03-2.00%, monoglyceride 0.50-3.00%, sunflower seed oil 3.00-8.00%, isomeric hexadecane IP 161.00-7.00%, nano ZnO with particle size less than 40nm 1.00-5.00%, polydimethylsiloxane DC200 silicone oil 0.08-4.00%, borneol 0.06-0.30%, and mint 0.10-0.80%; phase B comprises 55-70% of water, 0.10-0.60% of xanthan gum, 2.00-10.00% of 1, 3-butanediol, 0.02-0.07% of EDTA-2Na, 7.00-12.00% of Chinese herbal medicine, and 2.00-5.00% of flos Daturae Metelis and jasmine root extract; the phase C comprises phenoxyethanol PHG 0.15-0.80%, and herba Portulacae extract 0.30-1.00%. The invention also discloses a preparation method of the prickly heat lotion. Compared with powder products such as prickly heat powder and the like, the effective substance is applied by cream, has good skin sticking performance and does not generate dust.

Description

Liquid prickly-heat lotion for infants and preparation method thereof
Technical Field
The invention relates to prickly heat lotion, in particular to liquid prickly heat lotion for infants and a preparation method thereof.
Background
Miliaria (milieria) is a rash that develops as a result of the retention of perspiration due to the occlusion of the ducts of the eccrine glands. It usually occurs in hot, humid climates, such as tropical and temperate summer humid climates. It is presumed that an exopolysaccharide substance produced by staphylococcus epidermidis blocks sweat discharged from the skin surface, and finally forms a reverse pressure to cause rupture of sweat glands or ducts at different parts, and the excessive sweat flows into adjacent tissues to form miliaria.
The Chinese invention patent with publication number 103202876A and publication number 2013, 7 month and 17 days discloses prickly heat powder which comprises the following raw material components in parts by weight: 13-17 parts of kiwi fruit root, 18-22 parts of honeysuckle, 8-12 parts of pearl powder, 13-17 parts of calamine, 22-27 parts of talcum powder, 1-3 parts of borneol, 1-3 parts of menthol, 3-5 parts of moongrass, 3-7 parts of sargentgloryvine stem, 1-5 parts of groundsel, 2-6 parts of rabdosia rubescens, 4-8 parts of radix angelicae pubescentis, 2-6 parts of zinc oxide, 1-3 parts of acalypha australis and 4-8 parts of phoenix-tail fern.
Chinese patent publication No. 103202971A and Kokai No. 2013-07-17 disclose a powder for treating miliaria by using butterflybush flower, which comprises the following raw material components in parts by weight: 13-17 parts of butterflybush flower, 4-8 parts of cortex acanthopanacis, 3-7 parts of callicarpa bodinieri, 8-12 parts of kiwi fruit root, 1-5 parts of barbed skullcap herb, 13-17 parts of honeysuckle, 8-12 parts of coix seed, 1-3 parts of menthol, 3-5 parts of sophora flavescens root, 3-7 parts of sargentgloryvine stem, 4-6 parts of bunge corydalis herb, 13-17 parts of calamine, 6-10 parts of tinospora cordifolia, 20-24 parts of talcum powder and 1-2 parts of borneol; the formula is ground into powder of 80 meshes and mixed.
According to the technical scheme and the commercially available infant summer prickly heat powder, the use is inconvenient due to the fact that the powder is in a multi-position powder form, and the use is inconvenient due to the fact that the powder is in a multi-position powder form.
Disclosure of Invention
The invention aims to provide the liquid prickly heat lotion for the infants and the preparation method thereof, the liquid prickly heat lotion has low irritation, safe components and no side effect, has good relieving, preventing and repairing effects on the infants and the infants with the prickly heat in summer, and has good skin pasting property and no dust when the effective substances are smeared by cream compared with powder products such as prickly heat powder and the like.
The first purpose of the invention is realized by the following technical scheme that the liquid prickly heat lotion for infants comprises a phase A, a phase B and a phase C, wherein the phase A comprises an emulsifier of ceteareth-6-olive oleate 00801.00-6.00%, cetostearyl C16-180.03-2.00%, monoglyceride 0.50-3.00%, sunflower seed oil 3.00-8.00%, isomeric hexadecane IP 161.00-7.00%, nano ZnO 1.00-5.00% with the particle size smaller than 40nm, polydimethylsiloxane DC200 silicone oil 0.08-4.00%, borneol 0.06-0.30% and mint 0.10-0.80%; phase B comprises 55-70% of water, 0.10-0.60% of xanthan gum, 2.00-10.00% of 1, 3-butanediol, 0.02-0.07% of EDTA-2Na, 7.00-12.00% of Chinese herbal medicine, and 2.00-5.00% of flos Daturae Metelis and jasmine root extract; the phase C comprises phenoxyethanol PHG 0.15-0.80%, herba Portulacae extract 0.30-1.00%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae, 10% of cortex dictamni and 10 times of water.
Preferably, the liquid prickly heat lotion for infants comprises a phase A, a phase B and a phase C, wherein the phase A comprises an emulsifier of ceteareth-6 olive oleate 00802.00-4.00%, cetearyl alcohol C16-180.08-1.40%, monoglyceride 1.20-1.90%, sunflower seed oil 4.00-5.50%, isomeric hexadecane IP 162.20-3.60%, nano ZnO with the particle size less than 40nm 1.60-2.80%, polydimethylsiloxane DC200 silicone oil 1.40-3.10%, borneol 0.16-0.25% and mint 0.30-0.60%; phase B comprises 60-66% of water, 0.20-0.40% of xanthan gum, 4.00-8.00% of 1, 3-butanediol, 0.03-0.06% of EDTA-2Na, 8.00-11.00% of Chinese herbal medicine, and 2.60-4.00% of flos Daturae Metelis and jasmine root extract; the phase C comprises phenoxyethanol PHG 0.40-0.70%, herba Portulacae extract 0.60-0.90%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae, 10% of cortex dictamni and 10 times of water.
Preferably, the liquid prickly heat lotion for infants comprises an A phase, a B phase and a C phase, wherein the A phase comprises an emulsifier of ceteareth-6 olive oleate 00803.00%, cetearyl alcohol C16-181.00%, monoglyceride 1.50%, sunflower seed oil 5.00%, isomeric hexadecane IP 163.00%, nano ZnO 2.00 with the particle size of less than 40nm, polydimethylsiloxane DC200 silicone oil 2.00%, borneol 0.20% and mint 0.50%; phase B comprises 62.15% of water, 0.30% of xanthan gum, 5.00% of 1, 3-butanediol, 0.05% of EDTA-2 Na0.00%, 10.00% of Chinese herbal medicine, and 3.00% of an extract of flos Daturae and jasmine root; the phase C comprises phenoxyethanol PHG 0.60%, and herba Portulacae extract 0.70%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae, 10% of cortex dictamni and 10 times of water.
The second purpose of the invention is to provide a preparation method of the liquid prickly heat lotion for infants, which comprises the following steps:
(1) heating the weighed component A to 80-90 deg.C, dissolving completely, maintaining for 20min, and sterilizing; homogenizing the weighed component B for 20-30min, continuously stirring for 35-40r/min, heating to 80-85 deg.C after the component B is completely swelled, maintaining for 20min, and sterilizing;
(2) starting an emulsifying pot, adding the component B, adding the component A into the component B, starting stirring and homogenizing, setting the homogenizing time to be 12-18min, scraping the wall and regulating the speed to be 35-40r/min, starting condensed water when the homogenization reaches 8min, cooling to 60-65 ℃, and starting homogenizing again for 8 min; after homogenizing, starting a vacuum pump, setting the vacuum degree to be 0.05-0.07MPa, adjusting the stirring speed to 20-40r/min, stopping condensed water when the temperature in the emulsifying pot is reduced to 48-53 ℃, continuously cooling and stirring, and maintaining the vacuum for not less than 30 min;
(3) cooling the materials in the emulsifying pot to 40-45 deg.C, adding component C, vacuumizing to 0.05-0.07MPa, stirring for 20-40r/min for 1-3h, and stirring.
Compared with the prior art, the invention has the following beneficial effects:
firstly, the product is prepared by applying the characteristics of various Chinese herbal medicines per se and adding a proper proportion and utilizing a mature emulsification technology, the product is low in irritation, the components are safe and free of side effects, the effect of well relieving, preventing and repairing the infant miliaria in summer is achieved, compared with powder products such as miliaria powder, the effective substances are smeared by cream, the skin sticking effect is good, and dust cannot appear.
Drawings
Fig. 1 is a process flow chart of a preparation method of the liquid prickly heat lotion for infants.
Detailed Description
Example 1
A liquid prickly-heat lotion for infants comprises phase A, phase B and phase C, wherein phase A comprises emulsifying agent ceteareth-6 olive oleate 00801.00-6.00%, cetostearyl alcohol C16-180.03-2.00%, monoglyceride 0.50-3.00%, sunflower seed oil 3.00-8.00%, isomeric hexadecane IP 161.00-7.00%, nano ZnO with particle size less than 40nm 1.00-5.00%, polydimethylsiloxane DC200 silicone oil 0.08-4.00%, borneol 0.06-0.30%, and mint 0.10-0.80%; phase B comprises 55-70% of water, 0.10-0.60% of xanthan gum, 2.00-10.00% of 1, 3-butanediol, 0.02-0.07% of EDTA-2Na, 7.00-12.00% of Chinese herbal medicine, and 2.00-5.00% of flos Daturae Metelis and jasmine root extract; the phase C comprises phenoxyethanol PHG 0.15-0.80%, herba Portulacae extract 0.30-1.00%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae, 10% of cortex dictamni and 10 times of water.
Preparation work before preparation:
1. and (3) weighing control: and one person weighs and one person rechecks each time of weighing.
2. Temperature and speed control: when the material is melted, the correct temperature control is set, and the temperature control is corrected.
3. When homogenizing, 2500-; the wall scraping speed is 35-40r/min, and the wall scraping stirring time is 2-5 h; the wall scraping speed of the added phase C is 20-40r/min, and 1-3h, which depends on the viscosity of the frost body.
4. The xanthan gum or carbomer in the phase B needs to be weighed in advance, and the xanthan gum or carbomer is heated after being homogenized and swelled completely.
5. The pH and the viscosity of the paste can be adjusted by changing the addition amount of triethanolamine.
The production process comprises the following steps:
firstly, cleaning and disinfecting machine equipment.
Secondly, heating the weighed component A to 80-90 ℃, keeping for 20min after complete dissolution, and sterilizing; homogenizing the weighed component B for 20-30min, continuously stirring for 35-40r/min, heating to 80-85 deg.C after it is completely swelled, maintaining for 20min, and sterilizing.
And thirdly, starting the emulsifying pot, adding the component B, adding the component A into the component B, starting stirring and homogenizing. Setting homogenizing time at 12-18min, scraping wall at 35-40r/min, starting condensate water when homogenizing for 8min, cooling to 60-65 deg.C, and starting homogenizing for 8min again. After homogenizing, starting a vacuum pump, setting the vacuum degree to be 0.05-0.07MPa, adjusting the stirring speed to 20-40r/min, stopping the condensate water when the temperature in the pot is reduced to about 50 ℃, continuously cooling and stirring, and maintaining the vacuum for not less than 30 min.
Fifthly, when the temperature is reduced to about 40-45 ℃, adding the component C, vacuumizing to 0.05-0.07MPa, stirring for 20-40r/min for 1-3h, and stirring uniformly.
Example 2
A liquid prickly-heat lotion for infants comprises phase A, phase B and phase C, wherein phase A comprises emulsifying agent ceteareth-6 olive oleate 00802.00-4.00%, cetostearyl alcohol C16-180.08-1.40%, monoglyceride 1.20-1.90%, sunflower seed oil 4.00-5.50%, isomeric hexadecane IP 162.20-3.60%, nano ZnO with particle size less than 40nm 1.60-2.80%, polydimethylsiloxane DC200 silicone oil 1.40-3.10%, borneol 0.16-0.25%, and mint 0.30-0.60%; phase B comprises 60-66% of water, 0.20-0.40% of xanthan gum, 4.00-8.00% of 1, 3-butanediol, 0.03-0.06% of EDTA-2Na, 8.00-11.00% of Chinese herbal medicine, and 2.60-4.00% of flos Daturae Metelis and jasmine root extract; the phase C comprises phenoxyethanol PHG 0.40-0.70%, herba Portulacae extract 0.60-0.90%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae, 10% of cortex dictamni and 10 times of water.
The preparation method is the same as example 1.
Example 3
A liquid prickly-heat lotion for infants comprises phase A, phase B and phase C, wherein the phase A comprises emulsifying agent ceteareth-6 olive oleate 00803.00%, cetostearyl C16-181.00%, monoglyceride 1.50%, sunflower seed oil 5.00%, isomeric hexadecane IP 163.00%, nano ZnO 2.00% with particle size less than 40nm, polydimethylsiloxane DC200 silicone oil 2.00%, borneol 0.20% and mint 0.50%; phase B comprises 62.15% of water, 0.30% of xanthan gum, 5.00% of 1, 3-butanediol, 0.05% of EDTA-2Na, 10.00% of Chinese herbal medicine and 3.00% of an extract of flos Daturae Metelis and jasmine root; the phase C comprises phenoxyethanol PHG 0.60%, and herba Portulacae extract 0.70%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae, 10% of cortex dictamni and 10 times of water.
The preparation method is the same as example 1.

Claims (5)

1. The liquid prickly heat lotion for infants is characterized by comprising a phase A, a phase B and a phase C, wherein the phase A comprises an emulsifier of ceteareth-6 olive oleate 1.00-6.00%, cetostearyl alcohol 0.03-2.00%, monoglyceride 0.50-3.00%, sunflower seed oil 3.00-8.00%, isomeric hexadecane 1.00-7.00%, nano ZnO with the particle size of less than 40nm 1.00-5.00%, polydimethylsiloxane 0.08-4.00%, borneol 0.06-0.30% and mint 0.10-0.80%; phase B comprises 55-70% of water, 0.10-0.60% of xanthan gum, 2.00-10.00% of 1, 3-butanediol, 0.02-0.07% of EDTA-2Na, 7.00-12.00% of Chinese herbal medicine, and 2.00-5.00% of a combination of flos Daturae extract and jasmine root extract; the phase C comprises phenoxyethanol 0.15-0.80%, herba Portulacae extract 0.30-1.00%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae and 10% of cortex dictamni.
2. The liquid prickly heat lotion for infants is characterized by comprising a phase A, a phase B and a phase C, wherein the phase A comprises an emulsifier of 2.00-4.00% of ceteareth-6-olive oleate, 0.08-1.40% of cetostearyl alcohol, 1.20-1.90% of monoglyceride, 4.00-5.50% of sunflower seed oil, 2.20-3.60% of isomeric hexadecane, 1.60-2.80% of nano ZnO with the particle size of less than 40nm, 1.40-3.10% of polydimethylsiloxane, 0.16-0.25% of borneol and 0.30-0.60% of mint; phase B comprises 60-66% of water, 0.20-0.40% of xanthan gum, 4.00-8.00% of 1, 3-butanediol, 0.03-0.06% of EDTA-2Na, 8.00-11.00% of Chinese herbal medicine, and 2.60-4.00% of a combination of flos Daturae extract and flos Jasmini sambac root extract; the phase C comprises phenoxyethanol 0.40-0.70%, herba Portulacae extract 0.60-0.90%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae and 10% of cortex dictamni.
3. The liquid prickly heat lotion for infants is characterized by comprising an A phase, a B phase and a C phase, wherein the A phase comprises 3.00% of ceteareth-6 olive oleate serving as an emulsifier, 1.00% of cetostearyl alcohol, 1.50% of monoglyceride, 5.00% of sunflower seed oil, 3.00% of isomeric hexadecane, 2.00% of nano ZnO with the particle size of less than 40nm, 2.00% of polydimethylsiloxane, 0.20% of borneol and 0.50% of mint; phase B comprises 62.15% of water, 0.30% of xanthan gum, 5.00% of 1, 3-butanediol, 0.05% of EDTA-2Na, 10.00% of Chinese herbal medicine, and 3.00% of a combination of flos Daturae extract and jasmine root extract; the phase C comprises phenoxyethanol 0.60%, and herba Portulacae extract 0.70%;
the Chinese herbal medicine in the phase B comprises the following components in percentage by weight: 10% of radix sophorae flavescentis, 60% of fructus cnidii, 10% of cortex phellodendri, 10% of radix scutellariae and 10% of cortex dictamni.
4. The preparation method of the liquid prickly heat lotion for infants according to claims 1 to 3, which is characterized by comprising the following steps:
(1) heating the weighed component A to 80-90 ℃, keeping for 20min after complete dissolution, and sterilizing; homogenizing the weighed component B for 20-30min, continuously stirring for 35-40r/min, heating to 80-85 ℃ after the component B is completely swelled, maintaining for 20min, and sterilizing;
(2) starting an emulsifying pot, adding the component B, adding the component A into the component B, starting stirring and homogenizing, setting the homogenizing time to be 12-18min, scraping the wall and regulating the speed to be 35-40r/min, starting condensed water when the homogenization reaches 8min, cooling to 60-65 ℃, and starting homogenizing again for 8 min; after homogenizing, starting a vacuum pump, setting the vacuum degree to be 0.05-0.07MPa, adjusting the stirring speed to 20-40r/min, stopping condensed water when the temperature in the emulsifying pot is reduced to 48-53 ℃, continuously cooling and stirring, and maintaining the vacuum for not less than 30 min;
(3) when the temperature of the materials in the emulsifying pot is reduced to 40-45 ℃, adding the component C, vacuumizing to 0.05-0.07MPa, stirring for 20-40r/min, controlling the stirring time for 1-3h, and stirring uniformly.
5. The preparation method of the liquid prickly heat lotion for infants according to claim 4, wherein the homogenizing rotation speed in the step (2) is 2500-3500 r/min.
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