CN106104271B - 具有锥形珠陷获腔的微流体芯片及其制造 - Google Patents

具有锥形珠陷获腔的微流体芯片及其制造 Download PDF

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Publication number
CN106104271B
CN106104271B CN201580012689.2A CN201580012689A CN106104271B CN 106104271 B CN106104271 B CN 106104271B CN 201580012689 A CN201580012689 A CN 201580012689A CN 106104271 B CN106104271 B CN 106104271B
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chamber
pearl
micro
array
fluid chip
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Chinese (zh)
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CN106104271A (zh
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E·德拉马尔什
Y·特米兹
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International Business Machines Corp
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International Business Machines Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Fluid Mechanics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
CN201580012689.2A 2014-03-26 2015-03-04 具有锥形珠陷获腔的微流体芯片及其制造 Expired - Fee Related CN106104271B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1405402.7 2014-03-26
GB1405402.7A GB2524541A (en) 2014-03-26 2014-03-26 Microfluidic chip with conic bead trapping cavities and fabrication thereof
PCT/IB2015/051579 WO2015145280A1 (fr) 2014-03-26 2015-03-04 Puce microfluidique à cavités de piégeage de billes coniques et son procédé de fabrication

Publications (2)

Publication Number Publication Date
CN106104271A CN106104271A (zh) 2016-11-09
CN106104271B true CN106104271B (zh) 2018-04-20

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CN201580012689.2A Expired - Fee Related CN106104271B (zh) 2014-03-26 2015-03-04 具有锥形珠陷获腔的微流体芯片及其制造

Country Status (5)

Country Link
JP (1) JP2017512987A (fr)
CN (1) CN106104271B (fr)
DE (1) DE112015000920B4 (fr)
GB (2) GB2524541A (fr)
WO (1) WO2015145280A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201610426D0 (en) 2016-06-15 2016-07-27 Q-Linea Ab Sample holder for image based analysis of samples
WO2018175500A1 (fr) * 2017-03-21 2018-09-27 Hexanomics, Inc. Dosage de micropuits scellés
CN107583692B (zh) * 2017-05-23 2022-11-11 深圳市博瑞生物科技有限公司 液滴微流控芯片及其制备方法
WO2019088904A1 (fr) 2017-10-31 2019-05-09 Astrego Diagnostics Ab Dispositif microfluidique de caractérisation cellulaire
DE102018203047A1 (de) * 2018-03-01 2019-09-05 Robert Bosch Gmbh Mikrofluidische Vorrichtung
WO2020062149A1 (fr) * 2018-09-29 2020-04-02 天津大学 Structure d'encapsulation flexible et son procédé de fabrication
CN109701671A (zh) * 2018-12-27 2019-05-03 复旦大学 一种微液滴阵列芯片及其制造和使用方法
US11173486B2 (en) 2019-02-13 2021-11-16 International Business Machines Corporation Fluidic cavities for on-chip layering and sealing of separation arrays
CN112723303B (zh) * 2020-12-14 2021-09-24 苏州拉索生物芯片科技有限公司 微珠芯片及其旋涂制备方法
US20230132688A1 (en) * 2021-10-28 2023-05-04 Worcester Polytechnic Institute Gravity independent liquid cooling for electronics
CN114308163B (zh) * 2021-12-31 2024-01-09 北京京东方技术开发有限公司 微流控芯片检测卡盒

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10332593A (ja) * 1997-05-27 1998-12-18 Hitachi Ltd 電気化学発光検出セル
CN1267089A (zh) * 1999-03-15 2000-09-20 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
US6589779B1 (en) * 1999-07-16 2003-07-08 Board Of Regents, The University Of Texas System General signaling protocol for chemical receptors in immobilized matrices
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
CN1656380A (zh) * 2001-12-28 2005-08-17 生物芯片溶液有限公司 微粒阵列及其制备方法

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EP0347579B1 (fr) 1988-06-01 1994-03-30 Daimler-Benz Aerospace Aktiengesellschaft Dispositif comportant un support de structure particulière pour la réception, l'analyse et le traitement d'échantillons
JPH0332593A (ja) * 1989-06-27 1991-02-13 Toshiba Tungaloy Co Ltd テープの切断装置
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US7316899B2 (en) * 2000-01-31 2008-01-08 The Board Of Regents Of The University Of Texas System Portable sensor array system
US20020160363A1 (en) * 2001-01-31 2002-10-31 Mcdevitt John T. Magnetic-based placement and retention of sensor elements in a sensor array
US20030091475A1 (en) * 2001-09-26 2003-05-15 Micralyne Inc. Bead trapping device
WO2004111260A2 (fr) * 2003-06-12 2004-12-23 Bioarray Solutions, Ltd. Immobilisation de ligands presentes sur des billes sur des surfaces de substrat
JP4431724B2 (ja) * 2005-07-05 2010-03-17 独立行政法人産業技術総合研究所 マイクロ流路ビーズアレイデバイス及びその作製方法
JP5009125B2 (ja) * 2007-10-26 2012-08-22 日立マクセル株式会社 機能性粒子を利用したマイクロデバイスおよびそれを用いた処理方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10332593A (ja) * 1997-05-27 1998-12-18 Hitachi Ltd 電気化学発光検出セル
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
CN1267089A (zh) * 1999-03-15 2000-09-20 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
US6589779B1 (en) * 1999-07-16 2003-07-08 Board Of Regents, The University Of Texas System General signaling protocol for chemical receptors in immobilized matrices
CN1656380A (zh) * 2001-12-28 2005-08-17 生物芯片溶液有限公司 微粒阵列及其制备方法

Also Published As

Publication number Publication date
GB2548941B (en) 2020-08-19
DE112015000920B4 (de) 2021-09-30
DE112015000920T5 (de) 2016-11-24
GB201617833D0 (en) 2016-12-07
GB2548941A (en) 2017-10-04
JP2017512987A (ja) 2017-05-25
GB2524541A (en) 2015-09-30
GB201405402D0 (en) 2014-05-07
WO2015145280A1 (fr) 2015-10-01
CN106104271A (zh) 2016-11-09

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