GB201405402D0 - Microfluidic chip with conic bead trapping cavities and fabrication therefor - Google Patents

Microfluidic chip with conic bead trapping cavities and fabrication therefor

Info

Publication number
GB201405402D0
GB201405402D0 GBGB1405402.7A GB201405402A GB201405402D0 GB 201405402 D0 GB201405402 D0 GB 201405402D0 GB 201405402 A GB201405402 A GB 201405402A GB 201405402 D0 GB201405402 D0 GB 201405402D0
Authority
GB
United Kingdom
Prior art keywords
conic
microfluidic chip
fabrication therefor
bead trapping
trapping cavities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GBGB1405402.7A
Other versions
GB2524541A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Business Machines Corp
Original Assignee
International Business Machines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Business Machines Corp filed Critical International Business Machines Corp
Priority to GB1405402.7A priority Critical patent/GB2524541A/en
Publication of GB201405402D0 publication Critical patent/GB201405402D0/en
Priority to DE112015000920.5T priority patent/DE112015000920B4/en
Priority to PCT/IB2015/051579 priority patent/WO2015145280A1/en
Priority to GB1617833.7A priority patent/GB2548941B/en
Priority to JP2016556828A priority patent/JP2017512987A/en
Priority to CN201580012689.2A priority patent/CN106104271B/en
Publication of GB2524541A publication Critical patent/GB2524541A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Fluid Mechanics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
GB1405402.7A 2014-03-26 2014-03-26 Microfluidic chip with conic bead trapping cavities and fabrication thereof Withdrawn GB2524541A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB1405402.7A GB2524541A (en) 2014-03-26 2014-03-26 Microfluidic chip with conic bead trapping cavities and fabrication thereof
DE112015000920.5T DE112015000920B4 (en) 2014-03-26 2015-03-04 Microfluidic chip with pyramidal, bead-trapping cavities and manufacturing process of the same
PCT/IB2015/051579 WO2015145280A1 (en) 2014-03-26 2015-03-04 Microfluidic chip with conic bead trapping cavities and fabrication thereof
GB1617833.7A GB2548941B (en) 2014-03-26 2015-03-04 Microfluidic chip with conic bead trapping cavities and fabrication thereof
JP2016556828A JP2017512987A (en) 2014-03-26 2015-03-04 Microfluidic chip with conical bead capture cavity and its fabrication
CN201580012689.2A CN106104271B (en) 2014-03-26 2015-03-04 Micro-fluid chip and its manufacture with conical bead trapping chamber

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1405402.7A GB2524541A (en) 2014-03-26 2014-03-26 Microfluidic chip with conic bead trapping cavities and fabrication thereof

Publications (2)

Publication Number Publication Date
GB201405402D0 true GB201405402D0 (en) 2014-05-07
GB2524541A GB2524541A (en) 2015-09-30

Family

ID=50686941

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1405402.7A Withdrawn GB2524541A (en) 2014-03-26 2014-03-26 Microfluidic chip with conic bead trapping cavities and fabrication thereof
GB1617833.7A Active GB2548941B (en) 2014-03-26 2015-03-04 Microfluidic chip with conic bead trapping cavities and fabrication thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1617833.7A Active GB2548941B (en) 2014-03-26 2015-03-04 Microfluidic chip with conic bead trapping cavities and fabrication thereof

Country Status (5)

Country Link
JP (1) JP2017512987A (en)
CN (1) CN106104271B (en)
DE (1) DE112015000920B4 (en)
GB (2) GB2524541A (en)
WO (1) WO2015145280A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201610426D0 (en) 2016-06-15 2016-07-27 Q-Linea Ab Sample holder for image based analysis of samples
WO2018175500A1 (en) * 2017-03-21 2018-09-27 Hexanomics, Inc. Sealed microwell assay
CN107583692B (en) * 2017-05-23 2022-11-11 深圳市博瑞生物科技有限公司 Liquid drop micro-fluidic chip and preparation method thereof
WO2019088904A1 (en) 2017-10-31 2019-05-09 Astrego Diagnostics Ab Microfluidic device for cell characterization
DE102018203047A1 (en) * 2018-03-01 2019-09-05 Robert Bosch Gmbh Microfluidic device
WO2020062149A1 (en) * 2018-09-29 2020-04-02 天津大学 Flexible encapsulation structure and manufacturing method therefor
CN109701671A (en) * 2018-12-27 2019-05-03 复旦大学 A kind of microlayer model array chip and production and preparation method thereof
US11173486B2 (en) 2019-02-13 2021-11-16 International Business Machines Corporation Fluidic cavities for on-chip layering and sealing of separation arrays
CN112723303B (en) * 2020-12-14 2021-09-24 苏州拉索生物芯片科技有限公司 Microbead chip and spin coating preparation method thereof
US20230132688A1 (en) * 2021-10-28 2023-05-04 Worcester Polytechnic Institute Gravity independent liquid cooling for electronics
CN114308163B (en) * 2021-12-31 2024-01-09 北京京东方技术开发有限公司 Microfluidic chip detection cartridge

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347579B1 (en) 1988-06-01 1994-03-30 Daimler-Benz Aerospace Aktiengesellschaft Device having a specific support structure for receiving, analysing and treating samples
JPH0332593A (en) * 1989-06-27 1991-02-13 Toshiba Tungaloy Co Ltd Tape cutting device
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
JP3641100B2 (en) * 1997-05-27 2005-04-20 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング Electrochemiluminescence detection cell
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
CN1185492C (en) * 1999-03-15 2005-01-19 清华大学 Single-point gating type micro-electromagnetic unit array chip, electromagnetic biochip and application
WO2001006244A2 (en) * 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System General signaling protocols for chemical receptors in immobilized matrices
US7316899B2 (en) * 2000-01-31 2008-01-08 The Board Of Regents Of The University Of Texas System Portable sensor array system
US20020160363A1 (en) * 2001-01-31 2002-10-31 Mcdevitt John T. Magnetic-based placement and retention of sensor elements in a sensor array
US20030091475A1 (en) * 2001-09-26 2003-05-15 Micralyne Inc. Bead trapping device
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
WO2004111260A2 (en) * 2003-06-12 2004-12-23 Bioarray Solutions, Ltd. Immobilization of bead-displayed ligands on substrate surfaces
JP4431724B2 (en) * 2005-07-05 2010-03-17 独立行政法人産業技術総合研究所 Microchannel bead array device and manufacturing method thereof
JP5009125B2 (en) * 2007-10-26 2012-08-22 日立マクセル株式会社 Microdevice using functional particles and processing method using the same

Also Published As

Publication number Publication date
GB2548941B (en) 2020-08-19
DE112015000920B4 (en) 2021-09-30
DE112015000920T5 (en) 2016-11-24
GB201617833D0 (en) 2016-12-07
GB2548941A (en) 2017-10-04
CN106104271B (en) 2018-04-20
JP2017512987A (en) 2017-05-25
GB2524541A (en) 2015-09-30
WO2015145280A1 (en) 2015-10-01
CN106104271A (en) 2016-11-09

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)