CN106083844A - 一种制备抗乳腺癌药物帕博西尼中间体的方法 - Google Patents
一种制备抗乳腺癌药物帕博西尼中间体的方法 Download PDFInfo
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- CN106083844A CN106083844A CN201610399201.2A CN201610399201A CN106083844A CN 106083844 A CN106083844 A CN 106083844A CN 201610399201 A CN201610399201 A CN 201610399201A CN 106083844 A CN106083844 A CN 106083844A
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- methyl
- cyclopenta
- pyrimidine
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- NKIUGVOYIYKPDF-UHFFFAOYSA-N CC(C(C=NC(N1)Cl)=C1N1C2CCCC2)=CC1=O Chemical compound CC(C(C=NC(N1)Cl)=C1N1C2CCCC2)=CC1=O NKIUGVOYIYKPDF-UHFFFAOYSA-N 0.000 description 1
- QLLFVTYJKVEHGS-UHFFFAOYSA-N CC(c(cn1)c(N(C2CCCC2)C2=O)nc1Cl)=C2C#C Chemical compound CC(c(cn1)c(N(C2CCCC2)C2=O)nc1Cl)=C2C#C QLLFVTYJKVEHGS-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
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CN201610399201.2A CN106083844B (zh) | 2016-06-05 | 2016-06-05 | 一种制备抗乳腺癌药物帕博西尼中间体的方法 |
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CN201610399201.2A CN106083844B (zh) | 2016-06-05 | 2016-06-05 | 一种制备抗乳腺癌药物帕博西尼中间体的方法 |
Publications (2)
Publication Number | Publication Date |
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CN106083844A true CN106083844A (zh) | 2016-11-09 |
CN106083844B CN106083844B (zh) | 2017-11-10 |
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CN201610399201.2A Expired - Fee Related CN106083844B (zh) | 2016-06-05 | 2016-06-05 | 一种制备抗乳腺癌药物帕博西尼中间体的方法 |
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CN (1) | CN106083844B (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020025968A1 (en) * | 1998-04-15 | 2002-02-28 | Rifat Pamukcu | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives |
CN101511829A (zh) * | 2006-09-08 | 2009-08-19 | 辉瑞产品公司 | 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮的合成 |
CN104892604A (zh) * | 2015-06-19 | 2015-09-09 | 北京康立生医药技术开发有限公司 | 一种新型的cdk4抑制剂的合成方法 |
CN105130986A (zh) * | 2015-09-30 | 2015-12-09 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
CN105294681A (zh) * | 2014-07-26 | 2016-02-03 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
-
2016
- 2016-06-05 CN CN201610399201.2A patent/CN106083844B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020025968A1 (en) * | 1998-04-15 | 2002-02-28 | Rifat Pamukcu | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives |
CN101511829A (zh) * | 2006-09-08 | 2009-08-19 | 辉瑞产品公司 | 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮的合成 |
CN105294681A (zh) * | 2014-07-26 | 2016-02-03 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
CN104892604A (zh) * | 2015-06-19 | 2015-09-09 | 北京康立生医药技术开发有限公司 | 一种新型的cdk4抑制剂的合成方法 |
CN105130986A (zh) * | 2015-09-30 | 2015-12-09 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
Non-Patent Citations (2)
Title |
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ANNA-MARIE LORD ET AL.: "Design, Synthesis, and Evaluation in Vitro of Quinoline-8-carboxamides, a New Class of Poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) Inhibitor", 《J. MED. CHEM.》 * |
SHENGQUAN DUAN ET AL.: "Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated SNAr Coupling", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 * |
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CN106083844B (zh) | 2017-11-10 |
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CB03 | Change of inventor or designer information |
Inventor after: Chen Zhiming Inventor after: Shao Qi Inventor before: Tong Mingqiong Inventor before: Liu Enhui Inventor before: Wang Xinxing |
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CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20171010 Address after: 226001 Jiangsu Province, Nantong City West Temple Road No. 20 Hospital Affiliated to Nantong University Applicant after: Chen Zhiming Applicant after: Shao Qi Address before: 276000 No. 30, Mount broom Road, Lanshan District, Linyi, Shandong Applicant before: Tong Mingqiong |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171110 Termination date: 20180605 |
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