CN106075001A - Water-soluable gel containing Sanguis Draxonis polyphenol and the purposes on treatment cervical erosion medicine thereof - Google Patents
Water-soluable gel containing Sanguis Draxonis polyphenol and the purposes on treatment cervical erosion medicine thereof Download PDFInfo
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- CN106075001A CN106075001A CN201610664660.9A CN201610664660A CN106075001A CN 106075001 A CN106075001 A CN 106075001A CN 201610664660 A CN201610664660 A CN 201610664660A CN 106075001 A CN106075001 A CN 106075001A
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- sanguis draxonis
- polyphenol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The present invention relates to the purposes by being administered in topical vaginal, in the cervix diseases of prevention and treatment referred to as cervical erosion of the water-soluable gel containing Sanguis Draxonis polyphenol.
Description
Technical field
The present invention relates to a kind of medicine treating women cervicitis, specifically contain the water-soluable gel of Sanguis Draxonis polyphenol,
The collocation method of this medicine and application.
Background technology
Sanguis Draxonis is Liliaceae dracaena Dracaena cochinchinensis Dracaena cochinchinensis (Lour.)
The extracted resin obtained of S.C.Chen resiniferous wood, base plant is mainly distributed on Guangxi and the Yunnan Province of China.Sanguis Draxonis
There is the effects such as blood circulation promoting and blood stasis dispelling, hemostasis, pain relieving, promoting tissue regeneration and ulcer healing, be used for clinically treating traumatic hemorrhage, blood stasis amenorrhea, skin infection not
Hold back, angina pectoris, the disease such as myocardial infarction.Research for Sanguis Draxonis is the most deep in recent years, and pharmacological research shows that Sanguis Draxonis has
Having the effects such as anti-inflammatory and antalgic, protecting myocardial cell, antiplatelet aggregation, contained chemical composition mainly has phenols, steroid saponin
With terpenoid etc..
The knowledge of cervical erosion
Cervical erosion is the modal a kind of pathological changes of gynecological clinic, shows as cervical orifice circumferential surface and takes on a red color and thick
Rough, from normal cervix, the pale red of portio vaginalis and smooth different, rotten to the corn district is the most all true erosion, because its surface is neck
Pipe inner membrance columnar epithelium is coated to, and institute is it is seen that neck tube internal film tissue, owing to neck tube intimal epithelium only has simple columnar cell,
Therefore the redness of interstitial blood vessel just shows.
Cervical erosion can be divided into two big classes by its mechanism.
(1) physiological is rotten to the corn
These are so-called rotten to the corn in fact relevant with the change of estrogen.When neonate is owing to being affected by parent estrogen, make
Neck tube inner membrance columnar epithelium is displaced to beyond collar extension, and after birth, neonate inner estrogen gradually decreases, and neck tube mucosa swelling subtracts
Moving back, reduce, make displacement inner membrance return in neck tube, such squama column intersection enters in neck tube the most therewith.To adolescence ovary
Having secretion estrogen function, neck tube inner membrance lower bound starts again to move down, outside part adolescence women's neck tube inner membrance can be displaced to again
Outside Kou.Gestation the first tire neck tube inner membrance columnar epithelium hypertrophy, interstitial congestion and edema, in neck tube, membrane volume increases, and causes in neck tube
Film prolapses again and is displaced to outside cervical orifice, material is thus formed so-called physiological rotten to the corn.Produce female due to ovary after menopause
Hormone reduces so that disappearing, within neck tube endometrial atrophy is retracted into neck tube together with the squamous epithelial cancer of collar extension ectocervical.These
All belong to physiological variation.Therefore, there will be, at all ages and classes, the physiological erosion that the displacement of cervical canal inner membrance causes.So cervix uteri post
The transfer of columnar epithelium and squamous epithelial cancer intersection occurs position to move the most accordingly.
(2) true erosion
Women at fertile age is more common in [pathology] this erosion.Due to cervicovaginal close to the squamous epithelial cancer of collar extension because of inflammation or
Damage and strip off, belong to true erosion.But true erosion is quickly covered to the columnar epithelium of outgrowth by neck tube inner membrance, surface in
Red.This claims primary healing, and also referred to as gland is rotten to the corn.Later this columnar epithelium gradually squama is substituted by squamous epithelial cancer, is referred to as
Secondary healing.The squamous epithelial cancer repaired may be from rotten to the corn edge, the squamous epithelial cancer regeneration of the squamous epithelial cancer being originally present or residual,
But more is to be formed by squama by columnar epithelial cell.The surface of this cervical tissue is coated to by stratified squamous epithelium again
Time, the mucomembranous surface of ectocervical return to again original smooth and in pale red.In this new life's or metaplasia squamous
Skin participates in cervical mucosa squamous and columnar epithelium connects band and i.e. constitutes transitional zone or zone of transformation, due to squamous herein or column
Epithelial growth is active and is considered the predilection site of tumor.In addition to transitional zone, scattered Lin Hua island is also present in neck tube
In columnar epithelium.
[clinical symptoms] cervical erosion is the modal pathological changes that occurs together of cervix uteri chronic inflammation, and its symptom is chronic with cervix uteri
Inflammation, can have leucorrhoea grow in quantity, be sanguinous leukorrhea sometimes, can have waist and sacrum pain and pelvic cavity portion bearing down during serious symptom.
When [diagnosis] checks, visible cervix uteri has erosion in various degree.Big I according to rotten to the corn area is divided into three degree；Gently
Degree refers to that rotten to the corn face is less than the 1/3 of whole cervix uteri area；Moderate refers to that rotten to the corn face accounts for the 1/3-2/3 of whole cervix uteri area；Severe refers to gruel
Rotten face accounts for more than the 2/3 of whole cervix uteri area.Depth degree according to rotten to the corn face can be divided into simple type, granular pattern and emulsus type 3
Type.Rotten to the corn area and the depth should be represented during diagnosis cervical erosion simultaneously.Cervical erosion and Cervical intraepitheliaI neoplasia or early cervical
Cancer differentiates from being difficult in appearance, routine must make cervical scraping smear cytolgical examination, make biopsy if desired to clarify a diagnosis.
[preventing and treating] avoid childbirth time or apparatus damage cervix uteri, find that laceration of cervix should be sewed up in time puerperal；Periodically gynecological's inspection
Look into, find to give active treatment during Cervicitis.
Treatment cervical erosion, based on local treatment, can use naturopathy, Drug therapy and operative treatment, and with physics
Treat the most commonly used.
1, naturopathy, is to be destroyed by cervical erosion face epithelium with various physical methods, is allowed to downright bad, comes off, Yi Houyou
Newborn squamous epithelial cancer is covered, and typically needs 3-4 week, and the deeper person of pathological changes needs 6-8 week, and cervix uteri transfers to smooth.The most conventional thing
Physical therapy method is electricity rubbing hot medicated compress, is the most gradually frozen, the Therapeutic Method such as laser, infrared ray, microwave is substituted.Various physiotherapys
Similar, treatment time be selected in clean period after carry out in 3-7 day.Various edeitis person is had to avoid.The moon is had after treatment
Road secretions increase, very has a large amount of water sample discharge opeing.A little vaginal hemorrhage can be had during postoperative 1-2 week decrustation.The most complete at wound surface
(postoperative 4-8 week) taboo bath in a tub, sexual intercourse and vaginadouche etc. during healing.Postoperative periodic review of wanting, observes wound healing situation
And it is narrow with or without neck tube.
2, Drug therapy, can be divided into locally and systemically medication two kinds.Topical medications is less and scorching for rotten to the corn area
The case that disease infiltration is shallower.Conventional common local application of silver nitrate or chromic acid corrosion, use less.Antibiotic suppository has a constant current modulation
Effect.Whole body therapeutic is applicable to endocervicitis, its cervical canal smooth in appearance, the person that has purulent secretion in neck tube.Endocervicitis local is used
Medication heterodyne, palpus row whole body therapeutic, take cervical secretions and can cultivate and medicament sensitivity test, in order to select corresponding anti-sense
Dye medicine.
3, operative treatment when cervical erosion extensively and especially deeply particularly add up neck tube deeper time, it is contemplated that make cervix uteri taper and cut
Except art.See and edited by Shi Yifu, " cervix diseases " that People's Health Publisher publishes
Summary of the invention
Press relative to electricity, freezing, laser, the physiotherapy such as microwave and LEEP cutter, treatment cervical erosion is to destroy rotten to the corn group
Knit cervix uteri oral pillar columnar epithelium, the tissue squamous epithelial cancer then grown；And partial smearing Albothyl (policresulen) concentrated solution,
Silver nitrate or chromic acid are also chemical attack erosion tissue cervix uteri oral pillar columnar epitheliums, the tissue squamous epithelial cancer then grown.
It is an object of the invention to provide a kind of physical damage therapy and chemical attack therapy for treating cervical erosion of being different from
New product, is ready to accept, do not have new wound, do not have misery in treatment cervicitis especially patients of cervical ruin, and uses more square
Just, expense is less.
It is another object of the present invention to can as the auxiliary of naturopathy, use electricity press, freezing, laser, microwave and
After the treatment of LEEP cutter, in order to promote to repair, product of the present invention local can be used to use, wound healing can be made faster, make thing
After reason treatment, averagely 4-8 week ground healing stage is reduced to 2-4 week.And make the sense of discomfort after naturopathy substantially alleviate.
Sight is turned to Sanguis Draxonis by inventor, is based on documents below and personal experiment.China's mother and child care 2013 years the
Volume 28 " pharmacological action of Sanguis Draxonis treatment cervical erosion and clinical curative effect analysis ", mentions Sanguis Draxonis and has promoting blood circulation to remove blood stasis, analgesic therapy
Hemostasis, expelling pus and promoting granulation effect.Theory of Chinese medical science is thought, mostly cervicitis is by caused by damp invasion of lower energizer, blood-stasis internal-depression.Blood stasis releases, micro-
Circulation improves, unblocked blood flowing, disappearance of swelling and ache, and blood supply is sufficient, and local antibody increases, and slough is sloughed；Slough goes, and new meat is raw,
Reach putrefaction-removing granulation-promoting, the purpose for the treatment of cervical erosion.Traditional Chinese Medicine University Of Guangzhou's journal in May, 2009 volume 26 the 3rd phase " Sanguis Draxonis
Effect to organization engineering skin reparing skin defect ", mention Sanguis Draxonis and act on the animal mould after organization engineering skin is transplanted
Type, can promote that the extracellular matrix components such as Ln, NTx increases in early days in inflammation, and prompting Sanguis Draxonis can promote Skin Cell
Proliferation and differentiation and secretion, and promote that blood capillary regenerates, blood supply increases, and then promotes that organization engineering skin is to skin wound
Reparation.The granulation promoting effect utilizing Chinese medicine is expected to improve or solve vascularization process present in the research of current organization engineering skin
The problem such as slowly, transplanting succeed rate is low.Pharmacology and Clinics of Chinese Materia Medica 02 phase in 2013, " Sanguis Draxonis ointment promoted rat skin wound healing
Effect study ", mention Sanguis Draxonis ointment formulation and there is the effect promoting rat acute skin wound healing, and wound healing time
Relevant with Sanguis Draxonis polyphenolics content.For cervical erosion, medically it is generally acknowledged that physiological erosion is not required to treatment, and have
Symptom true erosion should treat and with examining check.Inventor thinks that the true erosion of cervical erosion has symptom to be because
Being associated with Cervicitis in various degree, in the case of or transfusion unsatisfactory curative effect oral at antibiotic, local application is more satisfactory
Mode.Sanguis Draxonis polyphenol is executed and is spread at the erosion of cervix uteri local, can provide energy for human body cell, maintain the normal of human body cell
Function, can suppress again the breeding of common microbiological, antibacterial hungry to death.Described topical intravaginal medicament contains 0.1～5 weight %
Sanguis Draxonis polyphenol.
The present inventor through consulting literatures and tests repeatedly, determines that the best carrier using Sanguis Draxonis polyphenol is that water solublity coagulates
Glue.This is because Sanguis Draxonis polyphenol is water miscible, water-soluable gel is conducive to Sanguis Draxonis polyphenol to discharge, and enters tissue；Water-soluble
Property gel be prone to coating, without greasy feeling, can absorptive tissue transudate, make erosion slough be fallen by vaginal discharge, do not hinder
Mucocutaneous normal function.Here water-soluable gel substrate refers to bio-adhesiveness or mucoadhesive carriers, specifically
Carbomer, sodium polyacrylate, sodium alginate, hydroxypropyl cellulose etc..According to the present invention, except bio-adhesiveness or mucosa are adhered
Outside property carrier, this medicament also can contain optional composition, such as preservative and antibacterial, absorption enhancer, thickening agent, antioxidation
Agent, acidity regulator etc..Preservative and antibacterial can be selected for ethylparaben, methyl ester, propyl ester and butyl ester, benzoic acid,
Benzylalcohol, chloroethene are fixed, triclosan, Benzalkonii Chloridum etc..Absorption enhancer can be selected for propylene glycol.Bio-adhesiveness or mucoadhesive carry
When body carrier is carbomer, acidity regulator can be selected for triethanolamine, sodium bicarbonate, diluted sodium hydroxide solution, bio-adhesiveness or
When mucoadhesive carriers is sodium polyacrylate or hydroxypropyl cellulose, acidity regulator can be selected for lactic acid, and regulation pH value is 3.5
～between 5.5, close with normal vagina sour environment.
Detailed description of the invention
Embodiment 1
Formula forms
Preparation process:
Precision weighs carbomer 4g and is scattered in swelling 24 hours in about 600g pure water, adds triethanolamine and adjusts pH value extremely
4.0～5.0.Separately with appropriate warm dissolved in purified water ethylparaben 0.3g, propylene glycol 2g, Sanguis Draxonis polyphenol 53g, and
Being slowly added in liquid, interpolation deionized water, to 1000g, stirs evenly and i.e. obtains transparent Sanguis Draxonis polyphenol carbomer gel I.
Embodiment 2
Formula forms:
Preparation process:
Precision weighs hydroxypropyl cellulose 3g and is scattered in swelling 24 hours in about 600g pure water, adds sodium bicarbonate and adjusts
PH value is to 4.0～5.0.Separately with appropriate warm dissolved in purified water ethylparaben 0.3g, propylene glycol 2g, Sanguis Draxonis polyphenol
1.5g, and be slowly added in liquid, interpolation deionized water, to 1000g, stirs evenly and i.e. obtains transparent Sanguis Draxonis polyphenol gel II.
Embodiment 3
Formula forms:
Preparation process:
Take 60 DEG C of deionized water 600g, cross-linked sodium polyacrylate 400 is spread on liquid level, place 24h, allow its swelling formation coagulate
Glue.Separately with appropriate warm dissolved in purified water ethylparaben 0.3g, propylene glycol 1g, Sanguis Draxonis polyphenol 11g, and slowly add
Entering in upper liquid, interpolation deionized water, to 1000g, stirs evenly and i.e. obtains transparent Sanguis Draxonis polyphenol gel III.
Embodiment 4
Formula forms:
Preparation process:
Take 60 DEG C of deionized water 600g, sodium alginate is spread on liquid level, place 24h, allow its swelling formation gel.Separately with suitable
Amount warm dissolved in purified water ethylparaben 0.3g, propylene glycol 1g, Sanguis Draxonis polyphenol 32g, and be slowly added in liquid,
Interpolation deionized water, to 1000g, stirs evenly and i.e. obtains transparent Sanguis Draxonis polyphenol gel IV.
Embodiment 5
Formula forms:
Preparation process:
Precision weighs hydroxypropyl cellulose 3g and is scattered in swelling 24 hours in about 600g pure water, adds sodium bicarbonate and adjusts
PH value is to 4.0～5.0.Separately with appropriate warm dissolved in purified water ethylparaben 0.3g, propylene glycol 2g, Sanguis Draxonis polyphenol
20g, and be slowly added in liquid, interpolation deionized water, to 1000g, stirs evenly and i.e. obtains transparent Sanguis Draxonis polyphenol gel V.
Clinical effectiveness
For simple patients of cervical ruin, use the water-soluable gel partial smearing containing Sanguis Draxonis polyphenol, before every day sleeps
Once, general 6 to 8 times, clinical symptom disappearance, cervical epithelium restores completely and recovers.The leading laser of patients of cervical ruin or
After micro-wave therapeutic, at the wound surface coating water-soluable gel containing Sanguis Draxonis polyphenol, the wound healing phase substantially shortens, general about two weeks
Wound healing, compares the normal healing phase after laser or micro-wave therapeutic (four weeks to eight weeks).The application present invention is presented herein below containing sanguis draconis
Exhaust some clinical effectiveness examples of polyphenol water-soluable gel:
Example one,
Dong so-and-so, women, date of birth in December, 1975.On March 4th, 2008, leucorrhoea grow in quantity, in menstruation because of lower abdomen dull pain
Phase increases the weight of, medical.Physics (laser) treatment cervical erosion was once done in patient's private prosecution in the year before.
Ultrasound diagnosis is without exception.BV(-).Colposcopy: vulvovaginal (-), cervix uteri moderate is rotten to the corn, and (rotten to the corn face accounts for Quan Gong
The 1/3 of neck area～2/3), then allow patient once a day night directly use 3 cron Sanguis Draxonis polyphenol carbomer gel I in
Cervix uteri, continuous six days.January checked later, and display cervix uteri is restored completely, and patient also feels good, without uncomfortable.
Example two,
Liu so-and-so, women, in January, 1970 date of birth.On March 18th, 2008 is many because of pudendum Pruritus, flank pain, leucorrhea
Medical.Patient last menstrual period March 3, ultrasound diagnosis is without exception, and vaginal secretions smear is shown in typical case's spore and pseudohypha, and ammonia is tested
(+), prompting vulvovaginal candida infects, and separately sees cervix uteri moderate rotten to the corn (rotten to the corn face accounts for 1/3～the 2/3 of full cervix uteri area) first
Treatment vulvovaginal candida, intravaginal uses Kai Niting (clotrimazole sheet), one week relief patient straight in night once a day
Connect and use 3 cron Sanguis Draxonis polyphenol gel II in cervix uteri, continuous eight days.Menstrual period disable.January checked later, showed vulvovaginal
Candidiasis is cured, and cervix uteri is restored completely, and patient also feels good.
Claims (7)
1. the local that Sanguis Draxonis polyphenol restores for making the cervical mucous membrane abrasion epithelial tissue occurred at cervical erosion in preparation
Purposes on intravaginal medicament.
2. purposes as claimed in claim 1, it is characterised in that described topical intravaginal medicament contains 0.1～5 weight %
Sanguis Draxonis polyphenol.
3. purposes as claimed in claim 1, it is characterised in that described topical intravaginal medicament is raw possibly together with one or more
Thing cohesiveness or mucoadhesive carriers.
4. purposes as claimed in claim 3, it is characterised in that described bio-adhesiveness or mucoadhesive carriers are selected from card
Ripple nurse, sodium polyacrylate, sodium alginate, hydroxypropyl cellulose.
5. purposes as claimed in claim 1, it is characterised in that the form of described topical intravaginal medicament is containing 1～3 weights
Amount % Sanguis Draxonis polyphenol and the carbomer gel as bio-adhesiveness/mucoadhesive ingredient.
6. purposes as claimed in claim 1, it is characterised in that the pH value of described topical intravaginal medicament 3.5～5.5 it
Between.
7. purposes as claimed in claim 1, it is characterised in that described topical intravaginal medicament is suitable to properly execute by being furnished with
Apply with the intravaginal of means and deliver medicine to infection site.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610664660.9A CN106075001A (en) | 2016-08-13 | 2016-08-13 | Water-soluable gel containing Sanguis Draxonis polyphenol and the purposes on treatment cervical erosion medicine thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610664660.9A CN106075001A (en) | 2016-08-13 | 2016-08-13 | Water-soluable gel containing Sanguis Draxonis polyphenol and the purposes on treatment cervical erosion medicine thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582806A (en) * | 2017-10-25 | 2018-01-16 | 桂林浩新科技服务有限公司 | A kind of pharmaceutical composition and purposes for treating cervical erosion |
| CN107596075A (en) * | 2017-10-25 | 2018-01-19 | 桂林浩新科技服务有限公司 | A kind of drug regimen composition formula for treating cervicitis and purposes |
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| CN101164583A (en) * | 2006-10-16 | 2008-04-23 | 海南森瑞谱生命科学药业股份有限公司 | Composite preparation for treating epithelial erosion and preparation method thereof |
| CN101721395A (en) * | 2008-10-27 | 2010-06-09 | 郭进军 | Water soluble gel containing xylitol and application thereof in medicine for treating cervical erosion |
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2016
- 2016-08-13 CN CN201610664660.9A patent/CN106075001A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101164583A (en) * | 2006-10-16 | 2008-04-23 | 海南森瑞谱生命科学药业股份有限公司 | Composite preparation for treating epithelial erosion and preparation method thereof |
| CN101721395A (en) * | 2008-10-27 | 2010-06-09 | 郭进军 | Water soluble gel containing xylitol and application thereof in medicine for treating cervical erosion |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582806A (en) * | 2017-10-25 | 2018-01-16 | 桂林浩新科技服务有限公司 | A kind of pharmaceutical composition and purposes for treating cervical erosion |
| CN107596075A (en) * | 2017-10-25 | 2018-01-19 | 桂林浩新科技服务有限公司 | A kind of drug regimen composition formula for treating cervicitis and purposes |
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