CN104548050A - Composition as well as preparation method and application thereof - Google Patents
Composition as well as preparation method and application thereof Download PDFInfo
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- CN104548050A CN104548050A CN201510050070.2A CN201510050070A CN104548050A CN 104548050 A CN104548050 A CN 104548050A CN 201510050070 A CN201510050070 A CN 201510050070A CN 104548050 A CN104548050 A CN 104548050A
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Abstract
The invention relates to a composition as well as a preparation method and application thereof. The composition comprises the following components in parts by weight: 30-50 parts of rose, 10-20 parts of hawthorn fruit, 5-10 parts of stigma croci, 15-30 parts of date, 1-5 parts of ginger, 25-30 parts of leonurus japonicas, 5-10 parts of brown sugar and 30-40 parts of donkey hide gelatin.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of composition and method of making the same and application.
Background technology
Menoxenia is common gynecological disease, shows as the exception of menstrual cycle or amount of bleeding.Although there is the medicine of a lot for the treatment of menoxenia in the market, cures the symptoms, not the disease more, easily recur after drug withdrawal.
Primary dysmenorrhea is gynecological's common disease that sickness rate is higher.Use different epidemiologic surveys to show, the sickness rate of primary dysmenorrhea, between 20% ~ 90%, normally works and the common cause of quality of life for affecting women.In recent years, both at home and abroad the research for the treatment of primary dysmenorrhea and mechanism of action aspect is deepened continuously.NSAID (non-steroidal anti-inflammatory drug) NSAIDs is the most frequently used first-line drug, after nearly 64 ~ 100% patients apply this type of medicine, subjective symptom alleviates, as oral indometacin (Metindo), ibuprofen (Ibuprofen) etc., but this type of medicine easily causes gastrointestinal tract and central nervous system to be main series of side effects.Oral contraceptive (OralContraceptives) treats the effective percentage of primary dysmenorrhea up to 90%.But this type of medicine has obvious impact to organism metabolism, thus there is more untoward reaction.Clinical observation shows, and most Western medicine bounces after there is drug withdrawal, the side effect such as hepatorenal damage.Contrast from people and female rats, mice physiological period: the physiological period of people is divided into the fourth phase and menstrual phase (1-4 days of menstrual cycle), the proliferative phase (5-14 days of menstrual cycle, be equivalent to the follicular development maturation period), the secretory phase (15-24 days of menstrual cycle, be equivalent to the corpus luteum maturation period), premenstrua (25-28 days of menstrual cycle, is equivalent to luteal regression stage).Oestrusing not by the impact of seasonal temperature of female Mus, has multiple, periodic Changing Pattern.Sexual cycle is 4-5 days.Within this cycle, there is a series of histological change in reproductive system, can make vaginal smear examination.According to the change of vaginal epithelial cell, typical sexual cycle is divided into proestrus (follicle acceleration of growth), rutting period (ooecium mature ovulation), metoestrus (corpus luteum generation) and diestrus (luteolysis).Clinical in the premenstrua (25-28 days of menstrual cycle from this prescription administration time, luteal regression stage) medication, be equivalent to the diestrus medication in female rats, mice physiological period, explore the mechanism of action of this prescription at therapeutic intervention primary dysmenorrhea luteal regression stage by zoopery.Therefore base oneself upon Chinese medicine, actively find and make great efforts to explore the specific medicament for the treatment of primary dysmenorrhea, illustrate the important topic that its mechanism of action becomes current.
Summary of the invention
The object of the invention is for deficiency of the prior art, provide one to treat the composition and method of making the same such as dysmenorrhea, menoxenia and application, concrete technical scheme is as follows:
A kind of compositions, the weight proportion of described composition material component is Flos Rosae Rugosae 30-50 part, Fructus Crataegi 10-20 part, Stigma Croci 5-10 part, Fructus Jujubae 15-30 part, Rhizoma Zingiberis Recens 1-5 part, Herba Leonuri 25-30 part, brown sugar 5-10 part, Colla Corii Asini 30-40 part.
The weight proportion of described composition material component is Flos Rosae Rugosae 35-45 part, Fructus Crataegi 15-20 part, Stigma Croci 6-8 part, Fructus Jujubae 20-25 part, Rhizoma Zingiberis Recens 1-5 part, Herba Leonuri 25-30 part, brown sugar 6-8 part, Colla Corii Asini 35-40 part.
The weight proportion of described composition material component is Flos Rosae Rugosae 35-45 part, Fructus Crataegi 15-20 part, Stigma Croci 6-8 part, Fructus Jujubae 20-25 part, Rhizoma Zingiberis Recens 1-5 part, Herba Leonuri 25-30 part, brown sugar 6-8 part, Colla Corii Asini 35-40 part.
The weight proportion of described composition material component is Flos Rosae Rugosae 35 parts, Fructus Crataegi 15 parts, Stigma Croci 6 parts, 20 parts, Fructus Jujubae, 1 part, Rhizoma Zingiberis Recens, Herba Leonuri 25 parts, 6 parts, brown sugar, 35 parts, Colla Corii Asini.
The weight proportion of described composition material component is Flos Rosae Rugosae 45 parts, Fructus Crataegi 20 parts, Stigma Croci 8 parts, 25 parts, Fructus Jujubae, 5 parts, Rhizoma Zingiberis Recens, Herba Leonuri 30 parts, 8 parts, brown sugar, 40 parts, Colla Corii Asini.
The weight proportion of described composition material component is Flos Rosae Rugosae 40 parts, Fructus Crataegi 16 parts, Stigma Croci 7 parts, 23 parts, Fructus Jujubae, 3 parts, Rhizoma Zingiberis Recens, Herba Leonuri 26 parts, 7 parts, brown sugar, 37 parts, Colla Corii Asini.
The weight proportion of described composition material component is Flos Rosae Rugosae 50 parts, Fructus Crataegi 20 parts, Stigma Croci 10 parts, 30 parts, Fructus Jujubae, 5 parts, Rhizoma Zingiberis Recens, Herba Leonuri 30 parts, 10 parts, brown sugar, 40 parts, Colla Corii Asini.
The weight proportion of described composition material component is Flos Rosae Rugosae 30 parts, Fructus Crataegi 10 parts, Stigma Croci 5 parts, 15 parts, Fructus Jujubae, 1 part, Rhizoma Zingiberis Recens, Herba Leonuri 25 parts, 5 parts, brown sugar, 30 parts, Colla Corii Asini.
A preparation method for described compositions, described method step is as follows:
Step one takes raw material according to the weight proportion of composition material component;
Step 2 is dried after being cleaned up by raw material, after extracting in water twice, Rhizoma Zingiberis Recens, Herba Leonuri and brown sugar is finely ground into clearly 200-300 order; By Fructus Crataegi and Fructus Jujubae section; Flos Rosae Rugosae, Stigma Croci, Herba Leonuri and Colla Corii Asini do not need to pulverize;
Step 3 is by after being uniformly mixed in step 2, and putting into weight portion is respectively 4 times, and the water of 3 times and 2 times respectively decocts once, and each 2 hours, often decoct once, filtrate poured out, the filtrate of pouring out for three times the most at last merges and get final product.
An application for described compositions, is used for the treatment of dysmenorrhea, menoxenia, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, breast augmentation and beauty treatment, defying age, prophylaxis of cancer.
Clinical research:
Take in primary dysmenorrhea patient 98 example in the attached Baokang hospital of Tianjin TCM Universities and the out-patient treatment of Tianjin hospital for obstetrics and gynaecology between in January, 2010 in December, 2014,14 ~ 28 years old age, through gynecologial examination discovery without exception, clinical diagnosis is primary dysmenorrhea, and voluntary participation is studied and coordinated the person of following up a case by regular visits to.Object of study is divided into two groups at random: Western medicine group: ibuprofen modified release capsule group, totally 48 examples, 15 ~ 27 years old age, average (21.17 ± 3.03) year; The course of disease 0.5 ~ 14 year, average (4.09 ± 2.89) year; Chinese drug-treated group: through first three agent pain relieving side group totally 50 examples, 14 ~ 27 years old age, average (19.57 ± 3.14) year; The course of disease 0.5 ~ 15 year, average (4.23 ± 3.15) year.Two groups of data comparing differences, without significance (P>0.05), have comparability.Chinese drug-treated group starts to take the application's compositions in the moon premenstrual 3d, every day 2 times, each 20 grams, serve on 3d.Continuous treatment 3 menstrual cycle.Follow up a case by regular visits to 3 menstrual cycle.Western medicine group 3d or start oral ibuprofen slow releasing capsule 300mg when starting there is symptom, every 12h 1 time before menstrual onset, serve on 3 d or to remission, treatment 3 menstrual cycle continuously.Follow up a case by regular visits to 3 menstrual cycle.
Dysmenorrhea symptom score standard: according to dysmenorrhea symptom score standard in " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea " that Ministry of Health of the People's Republic of China issues.1. slight: dysmenorrhea symptom integral >8 divides; 2. moderate: dysmenorrhea symptom integral is at 8 ~ 13.5 points; 3. severe: dysmenorrhea symptom integral >=14 point.Criterion of therapeutical effect after treatment: effective: dysmenorrhea transference cure or significantly alleviate after taking medicine, all the other symptoms are obviously improved, and dysmenorrhea symptom score reduces more than 50% before comparatively treating; Effective: after taking medicine, dysmenorrhea symptom alleviates, all the other symptoms take a turn for the better, and dysmenorrhea symptom score reduces 55% ~ 80% before comparatively treating; Invalid: to improve not obvious before dysmenorrhea symptom and other symptom and treatment, dysmenorrhea symptom score reduces less than 5% before comparatively treating.Follow up a case by regular visits to criterion of therapeutical effect: cure: continuous 3 menstrual cycle of drug withdrawal have no recurrence, stomachache and other transference cures, dysmenorrhea symptom integral value reduces >=98%; Effective: for stomachache alleviates, all the other symptoms take a turn for the better, dysmenorrhea symptom score reduces more than 40% before comparatively treating; Invalid: stomachache and other symptoms are improved not obvious, dysmenorrhea symptom score reduces less than 5% before comparatively treating.
Two groups of patient clinical comparitive study: Western medicine group and Chinese drug-treated group mild pain through patient's total effective rate without significant difference (P>0.05), two groups of dysmenorrhea patient total effective rates there was no significant difference (P>0.05) in therapeutic process.Before and after two groups of treatments, pain degree integration situation compares, and before and after treatment, integration differential Chinese drug-treated group is apparently higher than Western medicine group, and there were significant differences (P<0.01), illustrates that we are remarkable to severe dysmenorrhea patient outcomes.Drug withdrawal is followed the trail of three months dysmenorrhea patients, two groups of therapeutic effect and is compared, and Chinese drug-treated group total effective rate is obviously better than Western medicine group (P<0.01).Two treatment groups all occur without adverse effect.
Typical case:
Model case 1
Liu, female, 22 years old, unmarried, student, first visit on April 11 in 2000.
Dysmenorrhea 5 years, readme 14 the beginning of the year tide, menstrual period 5-7 days, often carrying out a few days ago abdominal part in menstruation is paroxysmal colic, lumbosacral region falling inflation, even nausea and vomiting, cold sweat limb is cool, companion's hypomenorrhea, and menses have purple dim, clot, breast is felt sick distending pain, and this time pain is done again, looks into its pale complexion, in painful shape, tongue light red limit purple secretly has petechia.Deep-thready pulse string, card belongs to cold blood stasis, companion's stagnation of QI due to depression of the liver.
Diagnosis: menorrhalgia of cold-stagnation and blood-stasis type, companion's Liver depression and Qi stagnation
Treatment: top is premenstrual takes 5 doses, serve on three menstrual cycle, period in a medicine pain disappears, and a 4th month drug withdrawal is followed up a case by regular visits to, and does not recur.
Model case 2
Wang, female, 28 years old, married, service man, first visit on August 13 in 2012.
Patient is from menarche, and disease sees lower abdomen and pudendum sky pendant in menstrual period, happiness rub by, the light amount of menstruation color is few, and matter is rare without block, spiritlessness and weakness, lustreless complexion, anorexia loose stool, and light red tongue tongue is few, and pulse condition is empty carefully.
Diagnosis: weak type of qi and blood dysmenorrhea
Treatment: top is premenstrual takes 3 doses, serve on three menstrual cycle, period in a medicine pain disappears, and a 4th month drug withdrawal is followed up a case by regular visits to, and does not recur.
Model case 3
Mrs Wen, 35 years old, to beat after thinning face pin 20 days in the period late, belly pain, drinks this side warp over latter second day, without pain, and blood volume showed increased, and blood stasis block in body is discharged, small pox is also obviously eliminated on the face.
Beneficial effect
The herb liquid for the treatment of menoxenia disclosed in this invention, taste-aromatic, has no side effect, and manufacture method is simple, and cost of manufacture is low, after patient drinks, obviously can improve the symptom of menoxenia, after eumenorrhea drug withdrawal, also not easily recur.
Improve dysmenorrhea, the various gynecological such as menoxenia is ailing, and blood circulation promoting and blood stasis dispelling, dredge the meridian passage, breast augmentation and beauty treatment, defying age, prophylaxis of cancer, can make beverage, medicine.
Detailed description of the invention
Embodiment 1
The weight proportion of described composition material component is Flos Rosae Rugosae 35 parts, Fructus Crataegi 15 parts, Stigma Croci 6 parts, 20 parts, Fructus Jujubae, 1 part, Rhizoma Zingiberis Recens, Herba Leonuri 25 parts, 6 parts, brown sugar, 35 parts, Colla Corii Asini.
Embodiment 2
The weight proportion of described composition material component is Flos Rosae Rugosae 45 parts, Fructus Crataegi 20 parts, Stigma Croci 8 parts, 25 parts, Fructus Jujubae, 5 parts, Rhizoma Zingiberis Recens, Herba Leonuri 30 parts, 8 parts, brown sugar, 40 parts, Colla Corii Asini.
Embodiment 3
The weight proportion of described composition material component is Flos Rosae Rugosae 40 parts, Fructus Crataegi 16 parts, Stigma Croci 7 parts, 23 parts, Fructus Jujubae, 3 parts, Rhizoma Zingiberis Recens, Herba Leonuri 26 parts, 7 parts, brown sugar, 37 parts, Colla Corii Asini.
Embodiment 4
The weight proportion of described composition material component is Flos Rosae Rugosae 50 parts, Fructus Crataegi 20 parts, Stigma Croci 10 parts, 30 parts, Fructus Jujubae, 5 parts, Rhizoma Zingiberis Recens, Herba Leonuri 30 parts, 10 parts, brown sugar, 40 parts, Colla Corii Asini.
Embodiment 5
The weight proportion of described composition material component is Flos Rosae Rugosae 30 parts, Fructus Crataegi 10 parts, Stigma Croci 5 parts, 15 parts, Fructus Jujubae, 1 part, Rhizoma Zingiberis Recens, Herba Leonuri 25 parts, 5 parts, brown sugar, 30 parts, Colla Corii Asini.
The preparation method of above-described embodiment
A preparation method for described compositions, described method step is as follows:
Step one takes raw material according to the weight proportion of composition material component;
Step 2 is dried after being cleaned up by raw material, after extracting in water twice, Rhizoma Zingiberis Recens, Herba Leonuri and brown sugar is finely ground into clearly 200-300 order; By Fructus Crataegi and Fructus Jujubae section; Flos Rosae Rugosae, Stigma Croci, Herba Leonuri and Colla Corii Asini do not need to pulverize;
Step 3 is by after being uniformly mixed in step 2, and putting into weight portion is respectively 4 times, and the water of 3 times and 2 times respectively decocts once, and each 2 hours, often decoct once, filtrate poured out, the filtrate of pouring out for three times the most at last merges and get final product.
An application for described compositions, is used for the treatment of dysmenorrhea, menoxenia, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, breast augmentation and beauty treatment, defying age, prophylaxis of cancer.
Last it is noted that obviously, above-described embodiment is only for example of the present invention is clearly described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of amplifying out or variation be still among protection scope of the present invention.
Claims (10)
1. a compositions, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 30-50 part, Fructus Crataegi 10-20 part, Stigma Croci 5-10 part, Fructus Jujubae 15-30 part, Rhizoma Zingiberis Recens 1-5 part, Herba Leonuri 25-30 part, brown sugar 5-10 part, Colla Corii Asini 30-40 part.
2. compositions according to claim 1, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 35-45 part, Fructus Crataegi 15-20 part, Stigma Croci 6-8 part, Fructus Jujubae 20-25 part, Rhizoma Zingiberis Recens 1-5 part, Herba Leonuri 25-30 part, brown sugar 6-8 part, Colla Corii Asini 35-40 part.
3. compositions according to claim 2, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 35-45 part, Fructus Crataegi 15-20 part, Stigma Croci 6-8 part, Fructus Jujubae 20-25 part, Rhizoma Zingiberis Recens 1-5 part, Herba Leonuri 25-30 part, brown sugar 6-8 part, Colla Corii Asini 35-40 part.
4. compositions according to claim 3, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 35 parts, Fructus Crataegi 15 parts, Stigma Croci 6 parts, 20 parts, Fructus Jujubae, 1 part, Rhizoma Zingiberis Recens, Herba Leonuri 25 parts, 6 parts, brown sugar, 35 parts, Colla Corii Asini.
5. compositions according to claim 3, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 45 parts, Fructus Crataegi 20 parts, Stigma Croci 8 parts, 25 parts, Fructus Jujubae, 5 parts, Rhizoma Zingiberis Recens, Herba Leonuri 30 parts, 8 parts, brown sugar, 40 parts, Colla Corii Asini.
6. compositions according to claim 3, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 40 parts, Fructus Crataegi 16 parts, Stigma Croci 7 parts, 23 parts, Fructus Jujubae, 3 parts, Rhizoma Zingiberis Recens, Herba Leonuri 26 parts, 7 parts, brown sugar, 37 parts, Colla Corii Asini.
7. compositions according to claim 1, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 50 parts, Fructus Crataegi 20 parts, Stigma Croci 10 parts, 30 parts, Fructus Jujubae, 5 parts, Rhizoma Zingiberis Recens, Herba Leonuri 30 parts, 10 parts, brown sugar, 40 parts, Colla Corii Asini.
8. compositions according to claim 1, is characterized in that: the weight proportion of described composition material component is Flos Rosae Rugosae 30 parts, Fructus Crataegi 10 parts, Stigma Croci 5 parts, 15 parts, Fructus Jujubae, 1 part, Rhizoma Zingiberis Recens, Herba Leonuri 25 parts, 5 parts, brown sugar, 30 parts, Colla Corii Asini.
9. a preparation method for compositions described in claim 1-8 any one, is characterized in that, described method step is as follows:
Step one takes raw material according to the weight proportion of composition material component;
Step 2 is dried after being cleaned up by raw material, after extracting in water twice, Rhizoma Zingiberis Recens, Herba Leonuri and brown sugar is finely ground into clearly 200-300 order; By Fructus Crataegi and Fructus Jujubae section; Flos Rosae Rugosae, Stigma Croci, Herba Leonuri and Colla Corii Asini do not need to pulverize;
Step 3 is by after being uniformly mixed in step 2, and putting into weight portion is respectively 4 times, and the water of 3 times and 2 times respectively decocts once, and each 2 hours, often decoct once, filtrate poured out, the filtrate of pouring out for three times the most at last merges and get final product.
10. an application for compositions described in claim 1-8 any one, is characterized in that: be used for the treatment of dysmenorrhea, menoxenia, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, breast augmentation and beauty treatment, defying age, prophylaxis of cancer.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106563034A (en) * | 2016-01-15 | 2017-04-19 | 中卫清华园生物科技有限公司 | Health-care medicine for treating uterus blood-stasis type dysmenorrhoea |
| CN111388631A (en) * | 2020-04-29 | 2020-07-10 | 重庆三峡医药高等专科学校 | Traditional Chinese medicine composition for preventing and treating primary dysmenorrhea as well as extract and application thereof |
| CN111657381A (en) * | 2020-06-12 | 2020-09-15 | 史发良 | Blood circulation promoting and stasis removing safflower tea and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106563034A (en) * | 2016-01-15 | 2017-04-19 | 中卫清华园生物科技有限公司 | Health-care medicine for treating uterus blood-stasis type dysmenorrhoea |
| CN111388631A (en) * | 2020-04-29 | 2020-07-10 | 重庆三峡医药高等专科学校 | Traditional Chinese medicine composition for preventing and treating primary dysmenorrhea as well as extract and application thereof |
| CN111657381A (en) * | 2020-06-12 | 2020-09-15 | 史发良 | Blood circulation promoting and stasis removing safflower tea and preparation method thereof |
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Application publication date: 20150429 |