CN106074851B - A kind of Chinese medicine composition is preparing the application in the drug for treating kidney - Google Patents
A kind of Chinese medicine composition is preparing the application in the drug for treating kidney Download PDFInfo
- Publication number
- CN106074851B CN106074851B CN201610629864.9A CN201610629864A CN106074851B CN 106074851 B CN106074851 B CN 106074851B CN 201610629864 A CN201610629864 A CN 201610629864A CN 106074851 B CN106074851 B CN 106074851B
- Authority
- CN
- China
- Prior art keywords
- added
- chinese medicine
- filtering
- extract
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 39
- 210000003734 kidney Anatomy 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 229940079593 drug Drugs 0.000 title claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 56
- 239000000284 extract Substances 0.000 claims abstract description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000009636 Huang Qi Substances 0.000 claims abstract description 17
- 244000143590 Salvia chinensis Species 0.000 claims abstract description 17
- 235000007154 Salvia chinensis Nutrition 0.000 claims abstract description 17
- 235000002594 Solanum nigrum Nutrition 0.000 claims abstract description 16
- 240000002307 Solanum ptychanthum Species 0.000 claims abstract description 16
- 235000019441 ethanol Nutrition 0.000 claims description 34
- 238000001914 filtration Methods 0.000 claims description 22
- 239000000706 filtrate Substances 0.000 claims description 18
- 238000010992 reflux Methods 0.000 claims description 18
- 238000000605 extraction Methods 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 10
- 239000002244 precipitate Substances 0.000 claims description 6
- 239000013049 sediment Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 2
- 206010067484 Adverse reaction Diseases 0.000 abstract description 12
- 230000006838 adverse reaction Effects 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- 208000006265 Renal cell carcinoma Diseases 0.000 abstract description 3
- 238000012546 transfer Methods 0.000 abstract description 3
- 238000009096 combination chemotherapy Methods 0.000 abstract description 2
- 230000000857 drug effect Effects 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 description 13
- 238000000034 method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 239000002398 materia medica Substances 0.000 description 2
- 238000003359 percent control normalization Methods 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 208000009060 clear cell adenocarcinoma Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000011242 molecular targeted therapy Methods 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000011248 postoperative chemotherapy Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of Chinese medicine compositions to prepare the application in the drug for treating kidney, belongs to application in TCM field.The Chinese medicine composition is made of alcohol extract/water extract of Radix Astragali, black nightshade and salvia chinensis.The Chinese medicine composition improves the content of the wherein effective component, and then improve drug effect, in combination chemotherapy kidney, the recurrence and transfer of kidney can be effectively prevented from, achieve the effect that attenuation, synergy, it reduces patients with renal cell carcinoma and the adverse reaction occurred when chemotherapeutics is used for a long time, improve the quality of life of patient.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions to prepare the application in the drug for treating kidney, belongs to application in TCM
Field.
Background technique
Kidney is also known as clear-cell carcinoma, this disease originates from renal cells, can occur at any position of kidney essence, but
With the superior and the subordinate be it is common, in China, kidney accounts for about the 3% of all adult malignancies, is the most common malignant tumour of urinary system
One of, disease incidence is only second to bladder cancer and occupies second, and age bigger illness rate is higher.The cause of disease of kidney is not yet clear, and one
Aspect and living habit factor, such as smoke, drink, food, obesity and drug it is related, on the other hand and environmental factor, such as duty
Industry is exposed to the correlations such as chemical substance, ray, Rend dialysis, also with the factors phase such as family history, hypertension, diabetes and drug
It closes.Kidney is clinically mainly shown as blood urine, lump, pain in the loins, it is usually become to " three signs " of kidney, kidney early stage nothing
Manifest symptom, Most patients have had 1-2 symptom when medical, and small number of patients lesion is confined to kidney when there is manifest symptom
It is dirty, and about 60% patient has occurred that and is difficult to expect transfer, occur recurring or shift there is also about 40% patient is postoperative,
Non- 3 annual survival rate of curer is lower than 5%, and prognosis is poor.
In Chinese medicine medicine, " kidney " name of disease is had no.It, can according to having block or the swollen or clinical symptoms such as pain or hematuria in abdomen
Belonged to the scopes such as Chinese medicine " accumulation ", " kidney product ", " hematuria ", " pain in the loins ".The generation of kidney is mostly by healthy energy is insufficient, multiple because of seven feelings
Pent-up, diet internal injury, cult poison invasion make body imbalance of yin and yang, and qi and blood is inverse disorderly, and with gas, phlegm, wet, the stasis of blood, heat etc. fight knot accumulation and
At.Belong to the card of asthenia in origin and asthenia in superficiality, interpretation of the cause, onset and process of an illness key is the positive deficiency of vital energy.
Treatment for kidney, complex treatment is using operation, immunization therapy, chemotherapy, radiotherapy, molecular targeted therapy and Chinese medicine
Medicine treatment etc..And traditional Chinese medicine, as adjuvant treatment, effect is unquestionable.Operative treatment is the most frequently used, most effective side
Method, and possibility generally acknowledged at present cure the unique method of kidney, but most of patient has just lost most when making a definite diagnosis
Good operative chance；And the biological characteristics and multi-drug resistant of kidney cancer cell keep kidney unwise to chemicotherapy and hormone therapy
Sense；Alpha-interferon (INF- α) and interleukin 2 (IL-2) are to study more biological immune treatment preparation at present, to kidney
The postoperative chemotherapy of cancer has certain curative effect, but only some patientss achieve good therapeutic effect, and how many curative effect cannot be lasting, Er Qiezhi
Treatment brings many adverse reactions, such as Nausea and vomiting, bone marrow suppression, brings difficulty to long-term treatment.
Traditional Chinese medicine has suitable advantage to the Synergy and attenuation aspect of Radiotherapy chemotherapy and immunization therapy, and certain ingredients in Chinese medicine were both
Energy cancer inhibitting and killing cell, and immune function can be protected, it can also stimulate hematopoiesis function.Traditional Chinese medicine treatment mends postoperative tune, promotes machine
Body health, mitigation immunization therapy, radiotherapy, the toxicity of chemotherapy, improvement clinical symptoms, raising life treatment can not be ignored
Effect.
Summary of the invention
It is an object of the present invention to provide a kind of Chinese medicine compositions to prepare the application in the drug for treating kidney,
The Chinese medicine composition is made of alcohol extract/water extract of Radix Astragali, black nightshade and salvia chinensis.
In one embodiment, the Chinese medicine composition is by Radix Astragali water extract, black nightshade alcohol extract and salvia chinensis water extract
Composition.
In one embodiment, the weight ratio of the Radix Astragali water extract, black nightshade alcohol extract and salvia chinensis water extract is 8-
10:2-5:1-4；Preferably 9: 4: 3.
In another embodiment, the preparation method of the Radix Astragali water extract is that Radix Astragali is ground into coarse powder, adds 5-7 times
Water impregnates 0.5-1h, refluxing extraction 1.5-2h, and filtering, filtrate is spare, and the dregs of a decoction are added 5-7 times of water, refluxing extraction 1.5-2h,
Filtering merges filtrate twice, is concentrated into the one third of original volume, ethyl alcohol to the determining alcohol for being added 95% reaches 70-75%, quiet
It sets, precipitates, filtering is dry by gained sediment, pulverizes to 200-300 mesh, obtains the Radix Astragali water extract.
In another embodiment, the preparation method of the black nightshade alcohol extract is that black nightshade is ground into coarse powder, and 5-8 is added
The ethanol solution heating and refluxing extraction of the 70-75% of amount again extracts 1.5-2h, and filtering, filtrate is spare, and the dregs of a decoction are added 4-7
The ethanol solution heating and refluxing extraction of the 70%-75% of amount again, extracts 1-1.5h, and filtering merges filtrate, reduced pressure twice and removes
Ethyl alcohol is removed, gained thick paste is dry, it pulverizes to 200-300 mesh, obtains the black nightshade alcohol extract.
In another embodiment, the preparation method of the salvia chinensis water extract is that salvia chinensis is ground into coarse powder, is added
5-7 times of water impregnates 0.5-1h, refluxing extraction 2-2.5h, and filtering, filtrate is spare, and the dregs of a decoction are added 5-7 times of water, refluxing extraction
1.5-2h, filtering merge filtrate twice, are concentrated into the one third of original volume, ethyl alcohol to the determining alcohol for being added 95% reaches 70-
75%, it stands, precipitates, filtering is dry by gained sediment, pulverizes to 200-300 mesh, obtains the salvia chinensis water extract.
In another embodiment, the preparation method of the Chinese medicine composition is by the Radix Astragali water extract, black nightshade alcohol
Extract and salvia chinensis water extract are uniformly mixed, and obtain the Chinese medicine composition.
In one embodiment, the preparation method of the drug is that Chinese medicine composition addition is pharmaceutically acceptable
Auxiliary material be made conventional Chinese materia medica preparation, i.e., it is described for treating the drug of kidney.
In another embodiment, the Chinese materia medica preparation is tablet or capsule.
Beneficial effects of the present invention: the present invention is different from the big herbal mixture of common treating cancer, is only mentioned with Radix Astragali water
Object, black nightshade alcohol extract and salvia chinensis water extract are effective component, improve the content of effective component in the composition, and then improve
Drug effect can be effectively prevented from the recurrence and transfer of kidney, achieve the effect that attenuation, synergy, subtract in combination chemotherapy kidney
The adverse reaction occurred when chemotherapeutics is used for a long time in few patients with renal cell carcinoma, improves the quality of life of patient.
Specific embodiment
Also the present invention further can be understood by embodiment, wherein the embodiment illustrates some preparations or user
Method.It is to be appreciated, however, that these embodiments do not limit the present invention.The change of the invention of currently known or further exploitation
Change is considered within the scope of the invention described herein and claimed below.
The preparation of 1 capsule of embodiment
The preparation of Radix Astragali water extract: being ground into coarse powder for Radix Astragali, and 7 times of water is added to impregnate 1h, refluxing extraction 2h, filtering, filtrate
It is spare, the dregs of a decoction are added into 5 times of water, refluxing extraction 1.5h, filtering merges filtrate twice, is concentrated into the one third of original volume,
Ethyl alcohol to the determining alcohol for being added 95% reaches 70%, stands, and precipitates, and filtering is dry by gained sediment, pulverizes to 300
Mesh obtains the Radix Astragali water extract.
The preparation of black nightshade alcohol extract: being ground into coarse powder for black nightshade, and 75% ethanol solution that 8 times of amounts are added, which is heated to reflux, to be mentioned
It takes, extracts 1.5h, filtering, filtrate is spare, and the dregs of a decoction are added to 75% ethanol solution heating and refluxing extraction of 6 times of amounts, extracts
1h, filtering merge filtrate twice, are concentrated under reduced pressure and remove ethyl alcohol, and gained thick paste is dry, pulverize to 300 mesh, obtain the dragon
Certain herbaceous plants with big flowers alcohol extract.
The preparation of salvia chinensis water extract: being ground into coarse powder for salvia chinensis, and 7 times of water is added to impregnate 1h, refluxing extraction 2.5h, mistake
Filter, filtrate is spare, the dregs of a decoction is added 5 times of water, refluxing extraction 2h, filtering merges filtrate twice, is concentrated into three points of original volume
One of, ethyl alcohol to the determining alcohol for being added 95% reaches 75%, stands, and precipitates, and filtering is dry by gained sediment, pulverizes
To 300 mesh, the salvia chinensis water extract is obtained.
The Radix Astragali water extract, black nightshade alcohol extract and salvia chinensis water extract are uniformly mixed by 9: 4: 3 weight ratio, obtain institute
State Chinese medicine composition.
Appropriate microcrystalline cellulose will be added in the Chinese medicine composition, be uniformly mixed, be fitted into hard capsule case, capsule is made
Agent.
The clinical trial of 2 traditional Chinese medicine composition for treating kidney of embodiment
General information
Randomly select patients with renal cell carcinoma 38 for receiving chemotherapeutic treatment, male 26, women 12, age 41.6-70.3
Year, average age are 55.7 years old.This 38 patients are randomly divided into two groups, respectively test group and control group, two groups of patients exist
Age, gender and kidney by stages etc. equal no difference of science of statistics.
Treatment method: control group keeps original chemotherapy medication, and test group adds capsule made from embodiment 1,
3 times a day, 3-5 each, continue 3 months.
Evaluation method: after taking medicine 3 months to patient, routine inspection is done to the hepatic and renal function of all patients, blood urine, evaluation is controlled
The toxic side effect for the treatment of.The imageological examinations such as B ultrasound, CT, rabat are given during to follow-up of patients, analyze the recurrence of tumour and are turned
Shift one's love condition, compares the treatment condition of 2 groups of patients.
Statistical analysis: by the data obtained processing for statistical analysis, comparison among groups are carried out.Two groups when comparing p < 0.05,
There is significant difference, there is statistical significance.
As a result
The curative effect of two groups of patients compares
After table 1 shows treatment in 3 months, the state of an illness of test group patient improves situation and is substantially better than control group, between two groups
Difference has statistical significance (p < 0.05)
The curative effect of 1 two groups of patients of table compares
| Group | Case load | The state of an illness improves | Stable disease | Sb.'s illness took a turn for the worse | Total effective rate |
| Test group | 19 | 15 | 3 | 1 | 94.7% |
| Control group | 19 | 4 | 8 | 7 | 63.2% |
Note: total effective rate=1- sb.'s illness took a turn for the worse number/total case loads
A situation arises for the adverse reaction of two groups of patients
During table 2 shows follow-up, test group patient occur adverse reaction rate be significantly lower than control group patient, two groups
Between difference have statistical significance (p < 0.05).Wherein adverse reaction includes Nausea and vomiting, fever, headache, abdominal pain, mind
Through systemic disease etc..When calculating adverse reaction rate, as long as it is 1 that adverse reaction, which occurs, the same patient occurs 1 or more
Adverse reaction is not repeated to count.
The adverse reaction situation that 2 two groups of patients of table occur compares
| Group | Case load | The case load of adverse reaction occurs | Adverse reaction rate |
| Test group | 19 | 3 | 15.7% |
| Control group | 19 | 10 | 52.6% |
The content of present invention merely illustrates claimed some specific embodiments, one of them or more skill
Documented technical characteristic can be combined with arbitrary one or more technical solutions in art scheme, these are combined and obtain
Technical solution also in the application protection scope, the technical solution just as obtained from these are combined is disclosed in the present invention
It is specifically recorded in content the same.
Claims (1)
1. a kind of Chinese medicine composition is preparing the application in the drug for treating kidney, it is characterised in that the Chinese medicine composition
It is made of Radix Astragali water extract, black nightshade alcohol extract and salvia chinensis water extract by 9: 4: 3 weight ratio；
The preparation method of the Radix Astragali water extract is: Radix Astragali being ground into coarse powder, 7 times of water is added to impregnate 1h, refluxing extraction 2h, mistake
Filter, filtrate is spare, the dregs of a decoction is added 5 times of water, refluxing extraction 1.5h, filtering merges filtrate twice, is concentrated into the three of original volume
/ mono-, ethyl alcohol to the determining alcohol for being added 95% reaches 70%, stands, and precipitates, and filtering is dry by gained sediment, Ultramicro-powder
300 mesh are broken to, the Radix Astragali water extract is obtained；
The preparation method of the black nightshade alcohol extract is: black nightshade being ground into coarse powder, the 75% ethanol solution heating of 8 times of amounts is added
Refluxing extraction extracts 1.5h, and filtering, filtrate is spare, and 75% ethanol solution that the dregs of a decoction add 6 times of amounts is heated to reflux and is mentioned
It taking, extracts 1h, filtering merges filtrate twice, is concentrated under reduced pressure and removes ethyl alcohol, and gained thick paste is dry, it pulverizes to 300 mesh,
Obtain the black nightshade alcohol extract；
The preparation method of the salvia chinensis water extract is: salvia chinensis being ground into coarse powder, 7 times of water is added to impregnate 1h, refluxing extraction
2.5h, filtering, filtrate is spare, the dregs of a decoction is added 5 times of water, refluxing extraction 2h, filtering merges filtrate twice, is concentrated into substance
Long-pending one third, ethyl alcohol to the determining alcohol for being added 95% reach 75%, stand, precipitate, and filtering is dry by gained sediment,
It pulverizes to 300 mesh, obtains the salvia chinensis water extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610629864.9A CN106074851B (en) | 2016-08-03 | 2016-08-03 | A kind of Chinese medicine composition is preparing the application in the drug for treating kidney |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610629864.9A CN106074851B (en) | 2016-08-03 | 2016-08-03 | A kind of Chinese medicine composition is preparing the application in the drug for treating kidney |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106074851A CN106074851A (en) | 2016-11-09 |
| CN106074851B true CN106074851B (en) | 2019-08-09 |
Family
ID=57454448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610629864.9A Expired - Fee Related CN106074851B (en) | 2016-08-03 | 2016-08-03 | A kind of Chinese medicine composition is preparing the application in the drug for treating kidney |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106074851B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116327857B (en) * | 2021-12-23 | 2024-06-11 | 山西省中医药研究院（山西省中医院） | Traditional Chinese medicine composition for treating malignant peritoneal effusion as well as preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007052A (en) * | 2006-01-24 | 2007-08-01 | 江苏康缘药业股份有限公司 | An antitumor medicine and its preparation method |
| CN101884665A (en) * | 2010-07-06 | 2010-11-17 | 南京中医药大学 | Traditional Chinese medicine extract with alpha-glucuroide and xanthine oxidase inhibiting effect and preparation method and usage thereof |
| CN105535256A (en) * | 2014-11-03 | 2016-05-04 | 青岛信立德中药技术研究开发有限公司 | Kidney cancer treating traditional Chinese medicine decoction |
| CN105617063A (en) * | 2014-11-03 | 2016-06-01 | 青岛信立德中药技术研究开发有限公司 | Traditional Chinese medicine composition used for treating kidney cancer |
| CN105663446A (en) * | 2016-02-27 | 2016-06-15 | 李仁珍 | Drug for treating kidney cancer and preparation method |
-
2016
- 2016-08-03 CN CN201610629864.9A patent/CN106074851B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007052A (en) * | 2006-01-24 | 2007-08-01 | 江苏康缘药业股份有限公司 | An antitumor medicine and its preparation method |
| CN101884665A (en) * | 2010-07-06 | 2010-11-17 | 南京中医药大学 | Traditional Chinese medicine extract with alpha-glucuroide and xanthine oxidase inhibiting effect and preparation method and usage thereof |
| CN105535256A (en) * | 2014-11-03 | 2016-05-04 | 青岛信立德中药技术研究开发有限公司 | Kidney cancer treating traditional Chinese medicine decoction |
| CN105617063A (en) * | 2014-11-03 | 2016-06-01 | 青岛信立德中药技术研究开发有限公司 | Traditional Chinese medicine composition used for treating kidney cancer |
| CN105663446A (en) * | 2016-02-27 | 2016-06-15 | 李仁珍 | Drug for treating kidney cancer and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106074851A (en) | 2016-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101181529B (en) | Chinese medicine composition for curing tumor and preparation method thereof | |
| CN101700393B (en) | Traditional Chinese medicine composition for treating breast cancer | |
| CN102008650B (en) | Compound traditional Chinese medicine preparation for treating tumors and preparation method thereof | |
| CN102284049A (en) | Traditional Chinese medicine compound preparation for resisting ulcer and relieving chemoradiotherapeutic toxic and side effects, and preparation method and application thereof | |
| CN102861193B (en) | Traditional Chinese medicine composition for treating gastric cancer | |
| CN101091769B (en) | Medicine for treating and preventing esophagus cancer and gastric cancer, and preparation method | |
| CN106074851B (en) | A kind of Chinese medicine composition is preparing the application in the drug for treating kidney | |
| CN106038818B (en) | It is a kind of for treating the Chinese medicine composition of kidney | |
| CN101693084B (en) | Medical composition for treating epigastric pain yin deficiency syndrome and preparation method thereof | |
| CN101007159A (en) | Traditional Chinese medicine for preventing and controlling tumor | |
| CN103223149A (en) | Chinese herb medicine composition for treating lung cancer | |
| CN103599236B (en) | Traditional Chinese medicine for treating liver-stomach disharmony stomach cancer and preparation method thereof | |
| CN100382818C (en) | Prepn process of Chinese medicine and its coated tablet for treating cystic mastoproliferation and mastitis | |
| CN104324091A (en) | Traditional Chinese medicine formula for treating rectal cancer | |
| CN104547819A (en) | Traditional Chinese medicine for treating spleen-stomach deficiency type stomach cancer and preparation method thereof | |
| CN100518764C (en) | Analgesic and anticancer traditional Chinese medicine preparation and preparation method thereof | |
| CN103285359B (en) | Medicament for treating functional dyspepsia and preparation method thereof | |
| CN101530589B (en) | Chinese medicinal preparation for treating cancers | |
| CN101391074B (en) | Medicine composition for treating digestive system carcinoma and preparation method thereof | |
| CN106729502A (en) | A kind of Chinese medicine composition for treating yang deficiency of spleen and stomache intestinal irritable syndrome and preparation method thereof | |
| CN104491416A (en) | Traditional Chinese medicine composition used for treating diabetes | |
| CN105125903A (en) | Traditional Chinese medicinal composition for treating diabetes | |
| CN104689246B (en) | A kind of medicine for the treatment of gastric cancer | |
| CN103550633A (en) | Traditional Chinese medicine for treating stomach cancer of disharmony between liver and stomach type and preparation method thereof | |
| CN103432367B (en) | Traditional Chinese medicine effective part composition for treating diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181203 Address after: 150000 No. 24 Heping Road, Xiangfang District, Harbin City, Heilongjiang Province Applicant after: Heilongjiang University of Chinese Medicine Applicant after: Mudanjiang Medical College Address before: 150040 Heilongjiang University of Traditional Chinese Medicine, No. 24 Heping Road, Harbin, Heilongjiang Province Applicant before: Jie Ying |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190809 Termination date: 20200803 |