CN106074505A - The application in preparation treatment follicular keratosis disease drug of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof - Google Patents
The application in preparation treatment follicular keratosis disease drug of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof Download PDFInfo
- Publication number
- CN106074505A CN106074505A CN201610433555.4A CN201610433555A CN106074505A CN 106074505 A CN106074505 A CN 106074505A CN 201610433555 A CN201610433555 A CN 201610433555A CN 106074505 A CN106074505 A CN 106074505A
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- China
- Prior art keywords
- indole
- ointment
- parts
- auxiliary material
- carbinol
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The present invention relates to biomedicine technical field, specially indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof the application in preparation treatment follicular keratosis disease drug.The invention discloses the application in preparation treatment follicular keratosis disease drug of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof, this ointment includes following composition by weight: indoles 3 methyl alcohol 8 19 parts, di-indole methyl hydride 4 14 parts, 6 bromo indoles 3 methyl alcohol 5 13 parts, 49 parts of two indyl ethane, 39 parts of two indyl propane, auxiliary material 14 34 parts, grease matrix 7 15 parts.This ointment is prepared by following steps: S1: weigh proportioning；S2: auxiliary material stirs；S3: auxiliary material filters；S4: ointment makes.Inventive formulation is simpler, and more scientific and reasonable, and indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof have effect of inhibition cancer cell growth；The auxiliary of auxiliary material makes the ointment in this invention have the effect for the treatment of dyskeratosis follicularis.
Description
Technical field
The present invention relates to biomedicine technical field, specially indole-3-carbinol, di-indole methyl hydride and derivative thereof are in system
Application in standby treatment follicular keratosis disease drug.
Background technology
Dyskeratosis follicularis, without inflammatory reaction person also known as hair week seborrheic keratosis, be commonly called as borsten, be often mistaken for acne or
Skin health less cleaning position, is a kind of autosomal inheritance disease that cannot effect a radical cure actually.Occur most frequently in arm and leg
The front in portion or outside, be often mistaken for acne, whelk or there be not wash clean.It is found in buttocks, back and cheek once in a while.
This disease infancy case less or illness is inconspicuous, but puberty stage is situation occurred frequently, after with age and gradually
Mitigate until disappearing.Feature is that symptom is serious for winter.Dyskeratosis follicularis does not also have definite treatment method, dyskeratosis follicularis so far
Although there is no big harm, but very affect the skin beauty of dyskeratosis follicularis patient.
Content of the invention
It is an object of the invention to provide indole-3-carbinol, di-indole methyl hydride and derivative thereof at preparation treatment hair follicle angle
Change the application in disease drug, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme: indole-3-carbinol, di-indole methyl hydride and derivative
Application in preparation treatment follicular keratosis disease drug for the thing.
Preferably, this ointment includes following composition by weight: indole-3-carbinol 8-19 part, di-indole methyl hydride 4-14 part, 6-bromine
For indole-3-carbinol 5-13 part, two indyl ethane 4-9 parts, two indyl propane 3-9 parts, auxiliary material 14-34 part, grease matrix
7-15 part.
Preferably, described auxiliary material includes following components by weight percent: salicylic acid 1-3 part, vitamin A 2-5 part, Tretinoin 1-4 part,
Chamomile 0.5-0.8 part, glycerine 3-5 part, leaf beet extract 2-5 part, cod-liver oil extract 3-5 part, tomato extract solution 2-5
Part.
Preferably, this ointment is prepared by following steps:
Required raw material is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: auxiliary material stir, by salicylic acid, vitamin A, Tretinoin, chamomile, glycerine, leaf beet extract, cod-liver oil extract,
Tomato extract solution is all transferred to be stirred in same mixing plant, and during stirring, a length of 22-90 minute, raises during stirring simultaneously
Temperature in this mixing plant, wherein temperature is 50-85 degree Celsius；
S3: auxiliary material filters, and the auxiliary material after completing stirring is transferred to filter in the first filter plant, in the first filter plant
The solution having filtered, after completing once to filter, is transferred in the second filter plant carry out secondary by a diameter of 3-5 millimeter of filter opening
Filter, a diameter of 0.1-0.3 millimeter of filter opening in the second filter plant；
S4: ointment makes, the auxiliary material after filtering and indole-3-carbinol, di-indole methyl hydride, 6-bromo indole-3-carbinol, two Yin
Diindyl base ethane, two indyl propane, grease matrix all put in temperature control device, maintain the temperature at 68-75 degree Celsius, treat fat-based
When matter starts fusing, the raw material in temperature control device is stirred, a length of 30-77 minute during stirring, former after stirring is completed
Material all puts in emulsifying device and carries out emulsification treatment, and ointment completes.
Compared with prior art, the invention has the beneficial effects as follows: inventive formulation is simpler, and more science is closed
Reason, indole-3-carbinol, di-indole methyl hydride, and the derivative of indole-3-carbinol, di-indole methyl hydride: 6-bromo indoles-3-first
Alcohol, two indyl ethane and two indyl propane have effect of inhibition cancer cell growth；By salicylic acid, vitamin A, dimension A
Acid, chamomile, glycerine, leaf beet extract, cod-liver oil extract, tomato extract solution etc. are conducive to dyskeratosis follicularis rehabilitation
Auxiliary material made by raw material so that the ointment in this invention has the effect for the treatment of dyskeratosis follicularis.
Detailed description of the invention
Technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described enforcement
Example is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of not making creative work, broadly falls into the model of present invention protection
Enclose.
Embodiment one
The present invention provides indole-3-carbinol, di-indole methyl hydride and derivative thereof answering in preparation treatment follicular keratosis disease drug
By technical scheme: indole-3-carbinol, di-indole methyl hydride and derivative thereof treat the application in follicular keratosis disease drug in preparation.
This ointment includes following composition by weight: indole-3-carbinol 8 parts, di-indole methyl hydride 4 parts, 6-bromo indole-3-carbinol
5 parts, 4 parts of two indyl ethane, 3 parts of two indyl propane, auxiliary material 14.5 parts, grease matrix 7 parts.
Auxiliary material includes following components by weight percent: salicylic acid 1 part, vitamin A 2 parts, Tretinoin 1 part, chamomile 0.5 part, glycerine 3
Part, leaf beet extract 2 parts, cod-liver oil extract 3 parts, tomato extract solution 2 parts.
This ointment is prepared by following steps:
Required raw material is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: auxiliary material stir, by salicylic acid, vitamin A, Tretinoin, chamomile, glycerine, leaf beet extract, cod-liver oil extract,
Tomato extract solution is all transferred to be stirred in same mixing plant, during stirring a length of 22 minutes, raises this during stirring simultaneously
Temperature in mixing plant, wherein temperature is 50 degrees Celsius；
S3: auxiliary material filters, and the auxiliary material after completing stirring is transferred to filter in the first filter plant, in the first filter plant
The solution having filtered, after completing once to filter, is transferred in the second filter plant carry out secondary mistake by a diameter of 3 millimeters of filter opening
Filter, a diameter of 0.1 millimeter of filter opening in the second filter plant；
S4: ointment makes, the auxiliary material after filtering and indole-3-carbinol, di-indole methyl hydride, 6-bromo indole-3-carbinol, two Yin
Diindyl base ethane, two indyl propane, grease matrix all put in temperature control device, maintain the temperature at 68 degrees Celsius, treat grease matrix
When starting fusing, being stirred the raw material in temperature control device, during stirring a length of 30 minutes, the raw material after completing stirring is all thrown
Entering and carrying out emulsification treatment in emulsifying device, ointment completes.
Embodiment two
The application in preparation treatment follicular keratosis disease drug of indole-3-carbinol, di-indole methyl hydride and derivative thereof.
This ointment includes following composition by weight: indole-3-carbinol 19 parts, di-indole methyl hydride 14 parts, 6-bromo indoles-3-first
Alcohol 13 parts, 9 parts of two indyl ethane, 9 parts of two indyl propane, auxiliary material 34 parts, grease matrix 15 parts.
Auxiliary material includes following components by weight percent: salicylic acid 3 parts, vitamin A 5 parts, Tretinoin 4 parts, chamomile 0.8 part, glycerine 5
Part, leaf beet extract 5 parts, cod-liver oil extract 5 parts, tomato extract solution 5 parts.
This ointment is prepared by following steps:
Required raw material is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: auxiliary material stir, by salicylic acid, vitamin A, Tretinoin, chamomile, glycerine, leaf beet extract, cod-liver oil extract,
Tomato extract solution is all transferred to be stirred in same mixing plant, during stirring a length of 90 minutes, raises this during stirring simultaneously
Temperature in mixing plant, wherein temperature is 85 degrees Celsius；
S3: auxiliary material filters, and the auxiliary material after completing stirring is transferred to filter in the first filter plant, in the first filter plant
The solution having filtered, after completing once to filter, is transferred in the second filter plant carry out secondary mistake by a diameter of 5 millimeters of filter opening
Filter, a diameter of 0.3 millimeter of filter opening in the second filter plant；
S4: ointment makes, the auxiliary material after filtering and indole-3-carbinol, di-indole methyl hydride, 6-bromo indole-3-carbinol, two Yin
Diindyl base ethane, two indyl propane, grease matrix all put in temperature control device, maintain the temperature at 75 degrees Celsius, treat grease matrix
When starting fusing, being stirred the raw material in temperature control device, during stirring a length of 77 minutes, the raw material after completing stirring is all thrown
Entering and carrying out emulsification treatment in emulsifying device, ointment completes.
Embodiment three
The application in preparation treatment follicular keratosis disease drug of indole-3-carbinol, di-indole methyl hydride and derivative thereof.
This ointment includes following composition by weight: indole-3-carbinol 10 parts, di-indole methyl hydride 9 parts, 6-bromo indoles-3-first
Alcohol 7 parts, 5 parts of two indyl ethane, 7 parts of two indyl propane, auxiliary material 23.3 parts, grease matrix 11 parts.
Auxiliary material includes following components by weight percent: salicylic acid 2 parts, vitamin A 3 parts, Tretinoin 3 parts, chamomile 0.3 part, glycerine 4
Part, leaf beet extract 4 parts, cod-liver oil extract 4 parts, tomato extract solution 3 parts.
This ointment is prepared by following steps:
Required raw material is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: auxiliary material stir, by salicylic acid, vitamin A, Tretinoin, chamomile, glycerine, leaf beet extract, cod-liver oil extract,
Tomato extract solution is all transferred to be stirred in same mixing plant, during stirring a length of 45 minutes, raises this during stirring simultaneously
Temperature in mixing plant, wherein temperature is 67 degrees Celsius；
S3: auxiliary material filters, and the auxiliary material after completing stirring is transferred to filter in the first filter plant, in the first filter plant
The solution having filtered, after completing once to filter, is transferred in the second filter plant carry out secondary mistake by a diameter of 4 millimeters of filter opening
Filter, a diameter of 0.2 millimeter of filter opening in the second filter plant；
S4: ointment makes, the auxiliary material after filtering and indole-3-carbinol, di-indole methyl hydride, 6-bromo indole-3-carbinol, two Yin
Diindyl base ethane, two indyl propane, grease matrix all put in temperature control device, maintain the temperature at 70 degrees Celsius, treat grease matrix
When starting fusing, being stirred the raw material in temperature control device, during stirring a length of 44 minutes, the raw material after completing stirring is all thrown
Entering and carrying out emulsification treatment in emulsifying device, ointment completes.
By contrast experiment is carried out to above-mentioned three groups of embodiments, it can be found that, three groups of embodiments all can be to the hair of patient
Capsule seborrheic keratosis plays certain result for the treatment of, and inventive formulation is simpler, and more scientific and reasonable, indole-3-carbinol,
Di-indole methyl hydride, and the derivative of indole-3-carbinol, di-indole methyl hydride: 6-bromo indole-3-carbinol, two indyl ethane
There is effect of inhibition cancer cell growth with two indyl propane；By salicylic acid, vitamin A, Tretinoin, chamomile, glycerine,
Leaf beet extract, cod-liver oil extract, tomato extract solution etc. are conducive to the raw material of dyskeratosis follicularis rehabilitation to make auxiliary material, make
Obtain the ointment in this invention and there is the effect for the treatment of dyskeratosis follicularis.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, permissible
Understand and multiple change, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention
And modification, the scope of the present invention be defined by the appended.
Claims (4)
1. indole-3-carbinol, di-indole methyl hydride and derivative thereof the application in preparation treatment follicular keratosis disease drug.
2. the ointment of indole-3-carbinol according to claim 1, di-indole methyl hydride and derivative thereof, it is characterised in that: should
Ointment includes following composition by weight: indole-3-carbinol 8-19 part, di-indole methyl hydride 4-14 part, 6-bromo indole-3-carbinol 5-13
Part, two indyl ethane 4-9 parts, two indyl propane 3-9 parts, auxiliary material 14-34 part, grease matrix 7-15 part.
3. the ointment of indole-3-carbinol according to claim 2, di-indole methyl hydride and derivative thereof, it is characterised in that: institute
State auxiliary material and include following components by weight percent: salicylic acid 1-3 part, vitamin A 2-5 part, Tretinoin 1-4 part, chamomile 0.5-0.8 part,
Glycerine 3-5 part, leaf beet extract 2-5 part, cod-liver oil extract 3-5 part, tomato extract solution 2-5 part.
4. the ointment of the indole-3-carbinol according to Claims 2 or 3, di-indole methyl hydride and derivative thereof, its feature exists
In: this ointment is prepared by following steps:
Required raw material is weighed according to certain component ratio and takes by S1: weigh proportioning；
S2: auxiliary material stir, by salicylic acid, vitamin A, Tretinoin, chamomile, glycerine, leaf beet extract, cod-liver oil extract,
Tomato extract solution is all transferred to be stirred in same mixing plant, and during stirring, a length of 22-90 minute, raises during stirring simultaneously
Temperature in this mixing plant, wherein temperature is 50-85 degree Celsius；
S3: auxiliary material filters, and the auxiliary material after completing stirring is transferred to filter in the first filter plant, in the first filter plant
The solution having filtered, after completing once to filter, is transferred in the second filter plant carry out secondary by a diameter of 3-5 millimeter of filter opening
Filter, a diameter of 0.1-0.3 millimeter of filter opening in the second filter plant；
S4: ointment makes, the auxiliary material after filtering and indole-3-carbinol, di-indole methyl hydride, 6-bromo indole-3-carbinol, two Yin
Diindyl base ethane, two indyl propane, grease matrix all put in temperature control device, maintain the temperature at 68-75 degree Celsius, treat fat-based
When matter starts fusing, the raw material in temperature control device is stirred, a length of 30-77 minute during stirring, former after stirring is completed
Material all puts in emulsifying device and carries out emulsification treatment, and ointment completes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610433555.4A CN106074505A (en) | 2016-06-18 | 2016-06-18 | The application in preparation treatment follicular keratosis disease drug of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610433555.4A CN106074505A (en) | 2016-06-18 | 2016-06-18 | The application in preparation treatment follicular keratosis disease drug of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106074505A true CN106074505A (en) | 2016-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610433555.4A Pending CN106074505A (en) | 2016-06-18 | 2016-06-18 | The application in preparation treatment follicular keratosis disease drug of indoles 3 methyl alcohol, di-indole methyl hydride and derivative thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940568A (en) * | 2010-08-17 | 2011-01-12 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-methanol, diindolylmethane and derivatives thereof in preparing medicament for treating cardiac failure caused by anthracycline |
| CN102335168A (en) * | 2011-10-25 | 2012-02-01 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-carbinol, diindolyl methane and derivatives thereof in preparation of medicaments for treating osteoporosis |
| CN105343450A (en) * | 2015-10-28 | 2016-02-24 | 皖南医学院 | Emulsion for treating keratosis pilaris and preparation method of emulsion |
-
2016
- 2016-06-18 CN CN201610433555.4A patent/CN106074505A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940568A (en) * | 2010-08-17 | 2011-01-12 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-methanol, diindolylmethane and derivatives thereof in preparing medicament for treating cardiac failure caused by anthracycline |
| CN102335168A (en) * | 2011-10-25 | 2012-02-01 | 合肥博太医药生物技术发展有限公司 | Application of indole-3-carbinol, diindolyl methane and derivatives thereof in preparation of medicaments for treating osteoporosis |
| CN105343450A (en) * | 2015-10-28 | 2016-02-24 | 皖南医学院 | Emulsion for treating keratosis pilaris and preparation method of emulsion |
Non-Patent Citations (1)
| Title |
|---|
| 张乐华: "中西医结合治疗鳞状毛囊角化症1例", 《天津中医》 * |
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Application publication date: 20161109 |