CN106074439A - A kind of oxidation hydroxypropyl starch capsule and preparation method thereof - Google Patents
A kind of oxidation hydroxypropyl starch capsule and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/077—Manufacturing capsule shells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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Abstract
The invention belongs to biomedicine field, particularly relate to a kind of oxidation hydroxypropyl starch capsule and preparation method thereof, it is prepared from by the raw material of following parts by weight: oxidation hydroxypropyl starch 30 40 parts, acetate starch 20 30 parts, 15 parts of mannitol, hypromellose 0.5 2 parts, sorbitol 0.5 5 parts, polyvidone 14 parts, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.The starch acetate of low degree of substitution contains acetyl, by any special measures, this composition and other components is processed into capsule, and its capsule has the advantage that housing clarity is high, storage stability is good.Sodium lauryl sulphate and American Avocado Tree oil improve film property and the plasticity of capsule.
Description
Technical field
The invention belongs to biomedicine field, particularly relate to a kind of oxidation hydroxypropyl starch capsule and preparation method thereof.
Background technology
There is a lot of shortcoming in gelatine capsule itself, such as: is prone to cooperating microorganisms, the easy moisture absorption, the low then pliability of ambient humidity
Poor, frangible, ambient humidity is the most then prone to stick together, thus can not load easy moisture absorption or the medicine to water sensitive；Gelatin divides
Subchain contains a large amount of reactive groups, it is easy to fill drug reaction；Additionally, due to religious reasons, gelatine capsule by Moslem and
Jewry and the conflict of vegetarian.
Being improved in industry, such as Chinese patent discloses a kind of oxidation hydroxypropyl starch capsule and preparation side thereof
Method, application number 201510405995.4, a kind of oxidation hydroxypropyl starch capsule and preparation method thereof, this premixing auxiliary material is by following one-tenth
It is grouped into: oxidation hydroxypropyl starch 30-40 part, starch 20-30 part, mannitol 1-5 part, hypromellose 0.5-2 part, Pyrusussuriensis
Alcohol 0.5-5 part, polyvidone 1-4 part.
The deficiency that technique scheme exists is: directly use starch to have clear as major ingredient, the capsule made
Lightness relatively low (capsule is the brightest), the shortcomings such as stability is the highest.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of oxidation hydroxypropyl starch capsule, and this starch capsule has clear and bright
Degree height and storage stability advantages of higher.Additionally, the present invention also provides for a kind of preparation method aoxidizing hydroxypropyl starch capsule.
A kind of hydroxypropyl starch capsule that aoxidizes of the present invention is prepared from by the raw material of following parts by weight:
Oxidation hydroxypropyl starch 30-40 part, acetate starch 20-30 part, mannitol 1-5 part, hypromellose 0.5-2
Part, sorbitol 0.5-5 part, polyvidone 1-4 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
The component preferably going out 3 starch capsules is:
1, oxidation hydroxypropyl starch 35-40 part, acetate starch 25-30 part, mannitol 1-3 part, hypromellose
0.5-1 part, sorbitol 0.5-2 part, polyvidone 1-2 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
2, oxidation hydroxypropyl starch 30-35 part, acetate starch 20-25 part, mannitol 3-5 part, hypromellose 1-2
Part, sorbitol 2-5 part, polyvidone 2-4 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
3, oxidation hydroxypropyl starch 35 parts, acetate starch 25 parts, 3 parts of mannitol, hypromellose 1 part, sorbitol 1
Part, polyvidone 1 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
Preferably, described acetate starch is tapioca, sweet potato starch, corn starch, barley starch, waxy corn
One or more in the starch that acetic acid esterified obtains of starch, amylomaize, pea starch, wheaten starch；Described
Oxidation hydroxypropyl starch be tapioca, sweet potato starch, corn starch, barley starch, waxy corn starch, high straight-chain maize
One or more in the starch that hydroxypropylation obtains of starch, pea starch, wheaten starch.
The preparation method of starch capsule of the present invention comprises following step:
A, take oxidation hydroxypropyl starch 30-40 part, acetate starch 20-30 part, cross after 80 mesh sieves, add room temperature magnetized
The solution that mass concentration is 30-50% it is configured to after purified water.Add mass concentration after 80 DEG C-100 DEG C magnetized purified water
For the solution of 15-20%, using centrifugal spraying spray dryer to be spray-dried, controlling inlet temperature is 160 DEG C-210
DEG C, leaving air temp is 90 DEG C-120 DEG C, obtains mixed-powder A, preferably oxidation hydroxypropyl starch 35-40 part, acetate starch 25-
30 parts；
B, take mannitol 1-5 part, hypromellose 0.5-2 part, sorbitol 0.5-5 part, polyvidone 1-4 part, dodecane
0.1 part of base sodium sulfate, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, being configured to mass concentration after adding magnetized purified water is 35-
The solution of 50%.After adding 80 DEG C-100 DEG C magnetized purified water, mass concentration is the solution of 5-10%, 50 DEG C of-60 DEG C of vacuum
It is dried, obtains mixed powder B, preferred mannitol 1-3 part, hypromellose 0.5-1 part, sorbitol 0.5-2 part, polyvidone 1-
2 parts；
C, by mixed-powder A, mixed powder B 2-5:1 mix homogeneously in proportion；
D, toward in step c gained material, add the water of its 2-3 mass multiple, stirring obtains glue, can be added as needed on
Pigment or plasticizer；
E, employing are dipped in glue legal system and are obtained Capsules, or use pelleting legal system to obtain soft capsule.
Further, described step a is configured to mass concentration after adding the magnetized purified water of room temperature is the molten of 30-50%
Liquid.After adding 80 DEG C-100 DEG C magnetized purified water, mass concentration is the solution of 15-20%.
Further, in described step b, centrifugal spraying spray dryer controls inlet temperature is 160 DEG C-210 DEG C, goes out
Air temperature is 90 DEG C-120 DEG C.
Further, the solution that mass concentration is 35-50% it is configured to after described step c adding magnetized purified water.
After adding 80 DEG C-100 DEG C magnetized purified water, mass concentration is the solution of 5-10%.
Further, being vacuum dried temperature in described step c is 50 DEG C-60 DEG C.
American Avocado Tree oil mentioned in this article refers to squeeze the grease being filtrated to get by being smashed by American Avocado Tree.American Avocado Tree oil has antioxygen
Changing effect, be beneficial to the holding of capsule color and luster after addition, additionally American Avocado Tree oil also has the similar performance of keeping humidity with glycerol and coagulability
Can, the beneficially molding of capsule.
Compared with prior art, the present invention has a following technical advantage:
The starch acetate of low degree of substitution contains acetyl 0.5%～2.5%.By any special measures by this composition and other components
Being processed into capsule, its capsule has the advantage that housing clarity is high, storage stability is good.Add as capsule additionally by magnetic water
Work water, to reducing the generation of the materials such as incrustation scale.Sodium lauryl sulphate and American Avocado Tree oil improve the film property of capsule and plastic
Property.
Detailed description of the invention
It will be understood by those skilled in the art that in following example disclosed technology represent the inventors discovered that at this
Bright practice plays the technology of good action.But, disclosed specific embodiments can be made many changes, and
Still same or analogous result is obtained, without departing from the spirit and scope of the present invention.
Embodiment 1
Take waxy corn oxidation hydroxypropyl starch 30 parts, through the tapioca 20 parts of acetic acid esterified, add after crossing 80 mesh sieves
The solution that mass concentration is 30% it is configured to after entering the magnetized purified water of room temperature.After adding 80 DEG C-100 DEG C magnetized purified water
Mass concentration is the solution of 15%, and controlling inlet temperature is 160 DEG C, and leaving air temp is 90 DEG C, uses centrifugal spraying spray dried
Dry device is spray-dried, and obtains mixed-powder A；1 part of mannitol, hypromellose 0.5 part, sorbitol 0.5 part, polyvidone 1
Part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, after magnetized purified water, be configured to mass concentration
It is the solution of 35%.After adding 80 DEG C-100 DEG C magnetized purified water, mass concentration is the solution of 5%, 50 DEG C of vacuum drying,
Obtain mixed powder B；By mixed-powder A, mixed powder B in 2:1 ratio mix homogeneously, vacuum defoaming after being sufficiently mixed uniformly,
To glue dip in glue legal system and obtain modified starch compositions plant hollow capsule, encystation temperature 30 DEG C, be dried 48 hours, prepare capsule
Finished product.
Embodiment 2
Take Maninot esculenta crantz. oxidation hydroxypropyl starch 35 parts, through the tapioca 25 parts of acetic acid esterified, cross 80 mesh after crossing 80 mesh sieves
It is configured to, after adding the magnetized purified water of room temperature after sieve, the solution that mass concentration is 30%.Add 100 DEG C of magnetized purified water
Rear mass concentration is the solution of 15%, controlling inlet temperature is 160 DEG C, and leaving air temp is 90 DEG C, uses centrifugal spraying spraying
Exsiccator is spray-dried, and obtains mixed-powder A；1 part of mannitol, hypromellose 0.5 part, sorbitol 0.5 part, polyvidone
1 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, after magnetized purified water, be configured to mass concentration
It is the solution of 35%.After adding 100 DEG C of magnetized purified water, mass concentration is the solution of 5%, 50 DEG C of vacuum drying, obtains mixing
Powder B；By mixed-powder A, mixed powder B in 3:1 ratio mix homogeneously, vacuum defoaming after being sufficiently mixed uniformly, the glue obtained
Liquid dips in glue legal system and obtains modified starch compositions plant hollow capsule, encystation temperature 30-35 DEG C, is dried 36-48 hour, prepares capsule
Finished product.
Embodiment 3
Take Rhizoma Dioscoreae esculentae oxidation hydroxypropyl starch 40 parts, through the wheaten starch 30 parts of acetic acid esterified, mix after crossing 80 mesh sieves, add
Entering 100 DEG C of magnetized purified water, be configured to the solution that mass concentration is 20%, controlling inlet temperature is 210 DEG C, and leaving air temp is
120 DEG C, use centrifugal spraying spray dryer to be spray-dried, obtain mixed-powder A；3 parts of mannitol, hypromellose
1.0 parts, sorbitol 2 parts, polyvidone 2 parts, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, add
100 DEG C of magnetized purified water, are configured to the solution that mass concentration is 10%, 60 DEG C of vacuum drying, obtain mixed powder B；Will mixing
Powders A, mixed powder B are in 4:1 ratio mix homogeneously, and vacuum defoaming after being sufficiently mixed uniformly, the glue obtained dips in glue method and prepares
Modified starch compositions plant hollow capsule, encystation temperature 30 DEG C, it is dried 48 hours, prepares capsule finished product.
Embodiment 4
Take Fructus Hordei Vulgaris oxidation hydroxypropyl starch 35 parts, through the corn starch 30 parts of acetic acid esterified, mix after crossing 80 mesh sieves, add
Entering 100 DEG C of magnetized purified water, be configured to the solution that mass concentration is 18%, controlling inlet temperature is 180 DEG C, and leaving air temp is
90 DEG C, use centrifugal spraying spray dryer to be spray-dried, obtain mixed-powder A；2 parts of mannitol, hypromellose
1.5 parts, sorbitol 1.5 parts, polyvidone 2 parts, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, add
100 DEG C of magnetized purified water, are configured to the solution that mass concentration is 10%, 55 DEG C of vacuum drying, obtain mixed powder B；Will mixing
Powders A, mixed powder B are in 5:1 ratio mix homogeneously, and vacuum defoaming after being sufficiently mixed uniformly, the glue obtained dips in glue method and prepares
Modified starch compositions plant hollow capsule, encystation temperature 30 DEG C, it is dried 48 hours, prepares capsule finished product.
Embodiment 5
Take Semen Maydis oxidation hydroxypropyl starch 40 parts, through the tapioca 25 parts of acetic acid esterified, mix after crossing 80 mesh sieves, add
Entering 100 DEG C of magnetized purified water, be configured to the solution that mass concentration is 20%, controlling inlet temperature is 200 DEG C, and leaving air temp is
120 DEG C, use centrifugal spraying spray dryer to be spray-dried, obtain mixed-powder A；1 part of mannitol, hypromellose
1 part, sorbitol 1 part, polyvidone 1 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, add 100
DEG C magnetized purified water, is configured to the solution that mass concentration is 10%, 60 DEG C of vacuum drying, obtains mixed powder B；By mixed-powder
A, mixed powder B are in 3:1 ratio mix homogeneously, and vacuum defoaming after being sufficiently mixed uniformly, the glue obtained dips in glue legal system and obtains degeneration
Starch composites plant hollow capsule, encystation temperature 30 DEG C, it is dried 48 hours, prepares capsule finished product.
Embodiment 6
Take Fructus Hordei Vulgaris oxidation hydroxypropyl starch 35 parts, through the corn starch 25 parts of acetic acid esterified, mix after crossing 80 mesh sieves, add
Entering 80 DEG C of magnetized purified water, be configured to the solution that mass concentration is 15%, controlling inlet temperature is 190 DEG C, and leaving air temp is
100 DEG C, use centrifugal spraying spray dryer to be spray-dried, obtain mixed-powder A；2 parts of mannitol, hypromellose
1 part, sorbitol 2 parts, polyvidone 2 parts, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, add 80 DEG C
Magnetized purified water, is configured to the solution that mass concentration is 5%, 50 DEG C of vacuum drying, obtains mixed powder B；By mixed-powder A,
Glue, in 4:1 ratio mix homogeneously, is put into and is incubated in advance in the glue-storing barrel of 60 DEG C by mixed powder B, and glue is 60 DEG C of insulations
Froth breaking carries out pelleting compacting with Soft Capsule Machinery after standing 4 hours.
Embodiment 7
Take Maninot esculenta crantz. oxidation hydroxypropyl starch 40 parts, through the barley starch 25 parts of acetic acid esterified, mix after crossing 80 mesh sieves, add
Entering 100 DEG C of magnetized purified water, be configured to the solution that mass concentration is 17%, controlling inlet temperature is 210 DEG C, and leaving air temp is
120 DEG C, use centrifugal spraying spray dryer to be spray-dried, obtain mixed-powder A；2 parts of mannitol, hypromellose
1 part, sorbitol 2 parts, polyvidone 1 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, add 90 DEG C
Magnetized purified water, is configured to the solution that mass concentration is 7%, 55 DEG C of vacuum drying, obtains mixed powder B；By mixed-powder A,
Glue, in 2:1 ratio mix homogeneously, is put into and is incubated in advance in the glue-storing barrel of 60 DEG C by mixed powder B, and glue is 60 DEG C of insulations
Froth breaking carries out pelleting compacting with Soft Capsule Machinery after standing 4 hours.
Owing to describing the present invention by above preferred embodiment, the present invention spirit and or scope in, any
The present invention is implemented in replacement or combination for the present invention, will be apparent from for a person skilled in the art, and
It is included among the present invention.
Claims (10)
1. an oxidation hydroxypropyl starch capsule, it is characterised in that: it is prepared from by the raw material of following parts by weight:
Oxidation hydroxypropyl starch 30-40 part, acetate starch 20-30 part, mannitol 1-5 part, hypromellose 0.5-2 part,
Sorbitol 0.5-5 part, polyvidone 1-4 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
Starch capsule the most according to claim 1, it is characterised in that it is prepared from by the raw material of following parts by weight:
Oxidation hydroxypropyl starch 35-40 part, acetate starch 25-30 part, mannitol 1-3 part, hypromellose 0.5-1 part, Pyrusussuriensis
Alcohol 0.5-2 part, polyvidone 1-2 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
Starch capsule the most according to claim 1, it is characterised in that it is prepared from by the raw material of following parts by weight:
Oxidation hydroxypropyl starch 30-35 part, acetate starch 20-25 part, mannitol 3-5 part, hypromellose 1-2 part, sorbitol
2-5 part, polyvidone 2-4 part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
Starch capsule the most according to claim 1, it is characterised in that it is prepared from by the raw material of following parts by weight:
Oxidation hydroxypropyl starch 35 parts, acetate starch 25 parts, 3 parts of mannitol, hypromellose 1 part, sorbitol 1 part, polyvidone 1
Part, sodium lauryl sulphate 0.1 part, American Avocado Tree oil 1 part.
Starch capsule the most according to claim 1, it is characterised in that it is prepared from by the raw material of following parts by weight:
Described acetate starch is tapioca, sweet potato starch, corn starch, barley starch, waxy corn starch, high straight-chain maize
One or more in the starch that acetic acid esterified obtains of starch, pea starch, wheaten starch；Described oxidation hydroxypropyl starch
For tapioca, sweet potato starch, corn starch, barley starch, waxy corn starch, amylomaize, pea starch, little
One or more in the starch that hydroxypropylation obtains of wheat starch.
6. the preparation method aoxidizing hydroxypropyl starch capsule, it is characterised in that: it comprises following step:
A, take oxidation hydroxypropyl starch 30-40 part, acetate starch 20-30 part, cross after 80 mesh sieves, add the magnetized purification of room temperature
The solution that mass concentration is 30-50% it is configured to after water.After adding 80 DEG C-100 DEG C magnetized purified water, mass concentration is 15-
The solution of 20%, uses centrifugal spraying spray dryer to be spray-dried, and controlling inlet temperature is 160 DEG C-210 DEG C, goes out
Air temperature is 90 DEG C-120 DEG C, obtains mixed-powder A, preferably oxidation hydroxypropyl starch 35-40 part, acetate starch 25-30 part；
B, take mannitol 1-5 part, hypromellose 0.5-2 part, sorbitol 0.5-5 part, polyvidone 1-4 part, dodecyl sulfur
0.1 part of sodium of acid, American Avocado Tree oil 1 part, mix after crossing 80 mesh sieves, being configured to mass concentration after adding magnetized purified water is 35-50%
Solution.After adding 80 DEG C-100 DEG C magnetized purified water, mass concentration is the solution of 5-10%, and 50 DEG C of-60 DEG C of vacuum are done
Dry, obtain mixed powder B, preferred mannitol 1-3 part, hypromellose 0.5-1 part, sorbitol 0.5-2 part, polyvidone 1-2
Part；
C, by mixed-powder A, mixed powder B 2-5:1 mix homogeneously in proportion；
D, toward in step c gained material, add the water of its 2-3 mass multiple, stirring obtains glue, can be added as needed on pigment
Or plasticizer；
E, employing are dipped in glue legal system and are obtained Capsules, or use pelleting legal system to obtain soft capsule.
The preparation method of starch capsule the most according to claim 6, it is characterised in that: described step a adds room temperature magnetization
Purified water after be configured to the solution that mass concentration is 30-50%.After adding 80 DEG C-100 DEG C magnetized purified water, quality is dense
Degree is the solution of 15-20%.
The preparation method of starch capsule the most according to claim 6, it is characterised in that: centrifugal spraying in described step b
It is 160 DEG C-210 DEG C that spray dryer controls inlet temperature, and leaving air temp is 90 DEG C-120 DEG C.
The preparation method of starch capsule the most according to claim 6, it is characterised in that: described step c add magnetized
It is configured to the solution that mass concentration is 35-50% after purified water, adds mass concentration after 80 DEG C-100 DEG C magnetized purified water
Solution for 5-10%.
The preparation method of starch capsule the most according to claim 6, it is characterised in that: vacuum drying temperature in described step c
Degree is 50 DEG C-60 DEG C.
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| CN108201531A (en) * | 2016-12-19 | 2018-06-26 | 湖南尔康湘药制药有限公司 | Segmented intestine targeted starch capsule of highly dissoluble sulbenicillin sodium and preparation method thereof |
| CN109044987A (en) * | 2018-09-17 | 2018-12-21 | 青海清华博众生物技术有限公司 | A kind of hydroxypropul starch Capsules and preparation method thereof |
| CN109400726A (en) * | 2018-10-23 | 2019-03-01 | 东莞东美食品有限公司 | A kind of preparation method of the oxidation hydroxypropul starch for capsule for medicine |
| CN109966501A (en) * | 2019-05-09 | 2019-07-05 | 徐燕滨 | Sodium carboxymethyl starch is preparing application and hard capsule in plant polyose hard capsule |
| CN112294775A (en) * | 2020-12-10 | 2021-02-02 | 浙江艾兰得生物科技有限公司 | Plant-based soft capsule rubber with anti-adhesion function |
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| CN104873977A (en) * | 2015-05-08 | 2015-09-02 | 浙江万里学院 | Special glue for composite starch and preparation method of empty capsule of special glue |
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| CN108201531A (en) * | 2016-12-19 | 2018-06-26 | 湖南尔康湘药制药有限公司 | Segmented intestine targeted starch capsule of highly dissoluble sulbenicillin sodium and preparation method thereof |
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| CN109400726A (en) * | 2018-10-23 | 2019-03-01 | 东莞东美食品有限公司 | A kind of preparation method of the oxidation hydroxypropul starch for capsule for medicine |
| CN109966501A (en) * | 2019-05-09 | 2019-07-05 | 徐燕滨 | Sodium carboxymethyl starch is preparing application and hard capsule in plant polyose hard capsule |
| CN112294775A (en) * | 2020-12-10 | 2021-02-02 | 浙江艾兰得生物科技有限公司 | Plant-based soft capsule rubber with anti-adhesion function |
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