CN104306351B - Alcohol soluble protein hard capsule and preparation method - Google Patents
Alcohol soluble protein hard capsule and preparation method Download PDFInfo
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- CN104306351B CN104306351B CN201410647743.8A CN201410647743A CN104306351B CN 104306351 B CN104306351 B CN 104306351B CN 201410647743 A CN201410647743 A CN 201410647743A CN 104306351 B CN104306351 B CN 104306351B
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- soluble protein
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Abstract
The invention discloses a kind of alcohol soluble protein hard capsules, and raw material includes following components in parts by weight: 30~60 parts of alcohol soluble protein, 20~40 parts of thickener, 20~50 parts of plasticizer, 200~450 parts of lytic agent.The preparation process of this product is simple, and product cost is low, and the comprehensive performance of product is more excellent.Alcohol soluble protein hard capsule of the invention, in gastric environment, dissolution rate is big, and disintegration time is short.
Description
Technical field
The invention belongs to formulation arts, and in particular to a kind of alcohol soluble protein hard capsule and preparation method thereof.
Background technique
Utilize gelatin production existing more than the 200 years history of capsule of animal origin.Currently, capsule product 90% in the market
Above using gelatin as capsule shell material.Gelatin derive from the byproduct after animal slaughtering (mainly from pig, ox, sheep bone and
A kind of protein degraded and extracted by multi-step in the connective tissue of pigskin and ox-hide), it is from a wealth of sources.It is same with this
When, gelatin is difficult to the shortcomings that overcoming there is some: 1, the degree of cross linking of gelatin has a great impact to disintegration；2, after gelatin crosslinking
The dissolution rate of capsule declines；3, the source of gelatin is extensive, and the psychology that businessman's fish mesh mixes is serious, leads to gelatin city
The safety problem of field occurs again and again；4, since gelatin is water solubility, adhesion strength is strong, easy to stick on larynx and oesophagus when taking, and drops
Low swallowing property of capsule, discharges pharmaceutical compositions too early, and forms ulcer.At the beginning of 2012, " toxic capsule " event of China's outburst will
Gelatine capsule is dragged in a serious trust crisis.Therefore, the capsule shell material for developing a kind of natural plant protein has very
Wide application prospect.
In recent years, have in the world using plant modified starch, hypromellose and plant polyose as the novel of raw material
Plant capsule product, current year sales volume reach 10,000,000,000 or so.
1, patent of invention, medical capsule factory, the city Chao Zhou, " hard capsule for containing, filling soft pharmaceutics new process "
(CN1440740A), in claim, it is characterised in that: " cap " and " body " of hard capsule can be by gelatin, natural plant gum, modified shallow lake
The raw materials such as powder, animal glue composition.
2, patent of invention, Shi Haifeng, " preparation method of a kind of composition for being used to prepare plant capsule and capsule "
(CN101167705A), in claim, it is characterised in that: Capsules group becomes 2~10 parts of coagulating agent (sodium alginate), filler
It is (hydroxypropyl methyl cellulose sodium, ethyl cellulose, carboxymethyl cellulose, methylcellulose, any in hydroxyethyl cellulose
Or two kinds of mixture) 40~60 parts, 1~20 part of plasticizer (glycerol or sorbierite), defoaming agent (ethyl alcohol).
3, patent of invention, Warmer-Lambert Co., " colored hard capsules " (CN1649573A), and in claim, feature
It is: comprising gardenia red pigment, Study of Marigold Pigments, purple corn pigment, tamarind pigment, sodium iron chlorophyllin and their mixture
Pigment.
4, patent of invention, Pfizer Products Inc, " hydroxypropyl methyl cellulose hard capsules and preparation method "
(CN101595133A), in claim, it is characterised in that: capsule shells contain hydroxypropyl methyl cellulose.
5, patent of invention, Changchun Inst. of Applied Chemistry, Chinese Academy of Sciences, " a kind of vegetative hard capsule and its preparation side
Method " (CN103638001A), in claim, it is characterised in that: capsule shells contain modified starch.
In conclusion although the advantage that new material prepares capsule is in the industry cycle reached common understanding, since its price is gelatin
3 times or so, high cost constrain its further genralrlization use.So from the popularity and the prices of raw materials of raw material sources
Consider in nature, alcohol soluble protein is all most potential to prepare capsule raw material.It is there is no based on alcohol soluble protein both at home and abroad at present
Raw material are wanted to prepare the research and patent of empty hard capsule.This sky can be filled up by preparing empty hard capsule using alcohol soluble protein
White, reduction prepares the production cost of capsule, and can be relieved the bad shadow that current " toxic capsule " event generates China's pharmaceuticals industry
It rings, extends corn deep processing industrial chain, reduce environmental pollution.
Alcohol soluble protein has water-insoluble, good film forming, inoxidizability, water resistance, heat resistance, is a kind of good
Edibility albumen glue capsule material, widely exists in various plants such as corn, wheat.Meanwhile the by-product of corn industry
Also contain a large amount of alcohol soluble protein in (maize yellow-powder and vinasse).But most of alcohol soluble proteins are all with low value feed
Form is sold, and significant wastage is caused.So improving alcohol soluble protein level of comprehensive utilization, have become China's corn deep processing industry
Therefore significant problem urgently to be resolved widens alcohol soluble protein using field, improving its industrialization level has great reality meaning
Justice.
The present Research that zeins is extracted from zein is as follows:
1,2007, Duan Chunming, Dong Haizhou " characteristic of zeins and were answered in " food science and technology " (first phase) paper
With research " in research shows that: in ethanol solution rapidly extracting come out alcohol soluble protein particle can be combined together, to be formed
Fibrous structure has film forming；It is stable in acid condition after zeins film forming, under neutral and alkaline condition not
Stablize, there is enteric solubility；There are three types of the extracting method of zeins is current, i.e. isopropanol extraction method, ethanol extraction method, super
Critical CO2 extraction etc..
2,2007, Liu Zhiguo etc. was in " Wuhan University of Technology's journal " phase paper " painting of zeins of volume 26 the 3rd
Show in film preservation research ": optimal membrance casting condition is: 80% ethanol solution, 1: 10 solid-to-liquid ratio, adds glycerol and lemon
Lemon acid can obviously improve the performance and appearance of film, and the film of formation has at holding apple slice moisture, color and anti-oxidant aspect
Good effect.
Summary of the invention
Aiming at the above shortcomings existing in the prior art, it is good that technical problem to be solved by the invention is to provide a kind of properties
Alcohol soluble protein hard capsule.
Object of the present invention is to what is be achieved through the following technical solutions:
A kind of alcohol soluble protein hard capsule, raw material includes following components in parts by weight: 30~60 parts of alcohol soluble protein, thickener
20~40 parts, 20~50 parts of plasticizer, 200~450 parts of lytic agent.
Preferably,
The alcohol soluble protein is selected from zeins, the mixture of wheat gliadin or both；
The thickener is selected from one of sodium carboxymethylcellulose, glycerol and oleic acid or a variety of；
The plasticizer is selected from one of polyvinylpyrrolidone, hydroxypropyl cellulose, sodium alginate and ghatti gum
Or it is a variety of；
The lytic agent is the ethanol water that mass fraction is 40~85%.
It is further preferred that the plasticizer is grouped as by the group of following weight point: 20-40 parts of polyvinylpyrrolidone,
5-15 parts of hydroxypropyl cellulose, sodium alginate 10-30 and 20-40 parts of ghatti gum.
It is further preferred that the alcohol soluble protein hard capsule, which is characterized in that its raw material includes the group of following weight parts
Point: 30~60 parts of zeins, 10~20 parts of sodium carboxymethylcellulose, 10-20 parts of oleic acid, polyvinylpyrrolidone 8-16
Part, 2-6 parts of hydroxypropyl cellulose, sodium alginate 4-12,8-16 parts of ghatti gum, mass fraction is 40~85% ethanol waters
200~450 parts.
In the present invention,
Sodium carboxymethylcellulose, is abbreviated as CMC, and No. CAS: 9004-32-4.
Glycerol, i.e. glycerine, No. CAS: 56-81-5.
Oleic acid, No. CAS: 112-80-1.
Polyvinylpyrrolidone, is abbreviated as PVP, and No. CAS: 9003-39-8.
Hydroxypropyl cellulose, No. CAS: 9004-64-2.
Sodium alginate, No. CAS: 9005-38-3.
Ghatti gum, No. CAS: 9000-28-6.
The present invention also provides the preparation methods of the alcohol soluble protein hard capsule comprising following steps:
(1) alcohol soluble protein, thickener, plasticizer are uniformly mixed according to the ratio, lytic agent is then added according to the ratio, divided
Dispersion liquid；
(2) it after dissolving by heating dispersion liquid, pours into mold and obtains alcohol soluble protein hard capsule after biofilm drying.
Wherein, step (2) heating temperature is 35-55 DEG C；Heating time is 20-40min；Biofilm temperature is 20-50
℃；Drying temperature is 40-70 DEG C, drying time 30-60min.
The preparation process of this product is simple, and product cost is low, and the comprehensive performance of product is more excellent.Alcohol soluble protein of the invention
Hard capsule, in gastric environment, dissolution rate is big, and disintegration time is short.
Specific embodiment
The present invention will be further described below with reference to examples.Corn used in the embodiment of the present invention and comparative example
Alcohol soluble protein purchase is from Shanghai Yu Tao Industrial Co., Ltd., and No. CAS: 9010-66-6.
Embodiment 1
Each component is weighed according to 1 data of embodiment corresponding in table 1, is made dispersion liquid, after 40 DEG C of heating for dissolving 30min,
Pour into mold, then 50 DEG C of biofilms dry 30min at 70 DEG C, obtain the zeins hard capsule of embodiment 1.
Table 1: the zeins hard capsule formula table unit of embodiment and comparative example: kilogram
| Embodiment | Embodiment | Embodiment | Embodiment | Embodiment | Embodiment | Embodiment | Comparison Example |
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 1 | |
| Zeins | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 |
| CMC | 10 | 20 | 10 | 10 | 10 | 10 | 10 | / |
| Oleic acid | 10 | / | 10 | 10 | 10 | 10 | 10 | / |
| PVP | 10 | 10 | / | 10 | 10 | 10 | 34 | / |
| Hydroxypropyl cellulose | 4 | 4 | 14 | / | 12 | 16 | / | / |
| Sodium alginate | 8 | 8 | 8 | 12 | / | 8 | / | / |
| Ghatti gum | 12 | 12 | 12 | 12 | 12 | / | / | / |
| Triethyl citrate | / | / | / | / | / | / | / | 54 |
| 75% ethanol solution | 400 | 400 | 400 | 400 | 400 | 400 | 400 | 400 |
Embodiment 2
Each component is weighed according to 2 data of embodiment corresponding in table 1, according to 1 the method for embodiment, obtains embodiment 2
Zeins hard capsule.
Embodiment 3
Each component is weighed according to 3 data of embodiment corresponding in table 1, according to 1 the method for embodiment, obtains embodiment 3
Zeins hard capsule.
Embodiment 4
Each component is weighed according to 4 data of embodiment corresponding in table 1, according to 1 the method for embodiment, obtains embodiment 4
Zeins hard capsule.
Embodiment 5
Each component is weighed according to 5 data of embodiment corresponding in table 1, according to 1 the method for embodiment, obtains embodiment 5
Zeins hard capsule.
Embodiment 6
Each component is weighed according to 6 data of embodiment corresponding in table 1, according to 1 the method for embodiment, obtains embodiment 6
Zeins hard capsule.
Embodiment 7
Each component is weighed according to 7 data of embodiment corresponding in table 1, according to 1 the method for embodiment, obtains embodiment 7
Zeins hard capsule.
Comparative example 1
Each component is weighed according to 1 data of comparative example corresponding in table 1, according to 1 the method for embodiment, obtains and implements comparison
The zeins hard capsule of example 1.
Test case 1
The zeins hard capsule of embodiment 1-7 and comparative example 1 is tested for the property, test result is as follows table 2
It is shown.
Table 2: the zeins hard capsule performance test table of embodiment 1-7
As seen from the data in Table 2, zeins hard capsule produced by the present invention, friability, transparency, disintegration time etc.
Aspect is had excellent performance, especially with polyvinylpyrrolidone, hydroxypropyl cellulose, sodium alginate and ghatti gum compounding
Plasticizer, performance are more significantly improved, and illustrate there is synergistic function in the performance of hard capsule.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those skilled in the art within the technical scope disclosed by the invention, can without the variation that creative work is expected or
Replacement, should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be limited with claims
Subject to fixed protection scope.
Claims (2)
1. a kind of gastric solubility alcohol soluble protein hard capsule, which is characterized in that its raw material includes following components in parts by weight: corn alcohol is molten
50 parts of albumen, 10 parts of sodium carboxymethylcellulose, 10 parts of oleic acid, 10 parts of polyvinylpyrrolidone, 4 parts of hydroxypropyl cellulose, seaweed
8 parts of sour sodium, 12 parts of ghatti gum, mass fraction is 400 parts of 75% ethanol water.
2. the preparation method of gastric solubility alcohol soluble protein hard capsule as described in claim 1, which is characterized in that including following step
It is rapid:
(1) alcohol soluble protein, thickener, plasticizer are uniformly mixed according to the ratio, lytic agent is then added according to the ratio, dispersed
Liquid；
(2) it after dissolving by heating dispersion liquid, pours into mold and obtains gastric solubility alcohol soluble protein hard capsule after biofilm drying.
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| CN201410647743.8A CN104306351B (en) | 2014-11-14 | 2014-11-14 | Alcohol soluble protein hard capsule and preparation method |
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| CN201410647743.8A CN104306351B (en) | 2014-11-14 | 2014-11-14 | Alcohol soluble protein hard capsule and preparation method |
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| CN104306351B true CN104306351B (en) | 2019-07-23 |
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| CN104784148B (en) * | 2015-04-17 | 2017-12-22 | 湖南尔康制药股份有限公司 | A kind of film-forming composition for preparing plant capsule and preparation method thereof |
| CN110301798A (en) * | 2019-06-26 | 2019-10-08 | 众智汇（厦门）生物科技有限公司 | A kind of environmental friendly edible tubulose articles and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662148A (en) * | 2002-06-20 | 2005-08-31 | Wm.雷格利Jr.公司 | Plasticized prolamine compositions |
| CN102526750A (en) * | 2012-01-06 | 2012-07-04 | 安徽黄山胶囊股份有限公司 | Plant colonic-coated hollow capsule |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662148A (en) * | 2002-06-20 | 2005-08-31 | Wm.雷格利Jr.公司 | Plasticized prolamine compositions |
| CN102526750A (en) * | 2012-01-06 | 2012-07-04 | 安徽黄山胶囊股份有限公司 | Plant colonic-coated hollow capsule |
Non-Patent Citations (1)
| Title |
|---|
| 可食性玉米醇溶蛋白膜研究进展;李运罡等;《粮食与油脂》;20081231(第12期);10-13页 |
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