CN105616380A - Novel high-moisture-retentivity starch-based hollow capsules and preparation method thereof - Google Patents
Novel high-moisture-retentivity starch-based hollow capsules and preparation method thereof Download PDFInfo
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- CN105616380A CN105616380A CN201610063727.3A CN201610063727A CN105616380A CN 105616380 A CN105616380 A CN 105616380A CN 201610063727 A CN201610063727 A CN 201610063727A CN 105616380 A CN105616380 A CN 105616380A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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Abstract
The invention relates to novel high-moisture-retentivity starch-based hollow capsules and a preparation method thereof. The capsules are composed of a lightly-cross-linked starch derivative and a reinforcing agent, a starch portion in a base material of the novel high-moisture-retentivity starch-based hollow capsules is 100% of the lightly-cross-linked starch derivative which accounts for 90-95% of total weigh of capsule shells, the reinforcing agent accounts for 5-10% of the total weight of the capsule shells, and the lightly-cross-linked starch derivative is composed of 10000 parts of starch derivative raw material and 10000-12000 parts of water. The preparation method includes: preparing size, and adding 200-300 parts of sodium sulfide, a PH acid-base regulator and cross-linking agent, wherein consumption of the PH acid-base regulator is calculated according to PH value after regulation, and consumption of the cross-linking agent is 0.1-0.4. The starch-based hollow capsules obtained by lightly cross-linking starch and then mixing with the reinforcing agent have high moisture retentivity and disintegrating performance.
Description
[technical field]
The present invention relates to a kind of one group of raw material aggregation preparing starch base capsule and the preparation method utilizing the novel high moisturizing starch base Capsules of this group aggregation production and processing.
[background technology]
Utilizing animal skins, bone etc. to produce gelatin, recycling its processing Capsules is the medicine main wall material of solid preparation. But, owing to this wall material derives from animal body, there is certain risk by pathogen with people, simultaneously as gelatin Middle molecule chain contains a large amount of reactive group, it is easy to cooperating microorganisms etc. so that gelatine capsule is produced doubt by people. In addition, animal body is come from gelatin source, is also affected by the resistance of religion and vegetarian.
Making Capsules for replacing gelatin, scientist and the industry maker of every country direct attention to utilize plant, are carried out exploitation and the manufacture of Capsules by plant base raw material. The non-gelatin hollow capsule that it is raw material with hydroxypropyl methyl cellulose that Pfizer Inc. develops, and successfully introduce to the market. The non-gelatin plant-based capsule performance that the Capsugel company of France produces with pulullan for development of raw materials is suitable with gelatin, is deeply favored by market, but price comparison is expensive, restrict its sale commercially.
Domestic in recent years, also at the hollow starch capsule of Devoting Major Efforts To Developing plant base. Also there are many patent applications about plant base Capsules. But, major part does not put into actual production, puts on market also without Related product. Unique mass selling remain the hollow capsule being primary raw material with hydroxypropyl methyl cellulose. But it is relatively difficult to dewater with this raw material for the main production process preparing Capsules, meanwhile, production cost is not cheap yet. Therefore, market share at home is relatively low.
In prior art, the patent such as CN03070845A, CN13333006C, CN297601C, CN1483393A, CN895234A, CN947709A, CN03070845A, CN101182379B, CN101245157B, CN01273978A, CN101338045B, CN04324381A and CN104311887A also discloses the technical method utilizing the combination of starch, modified starch and plant gum to prepare Capsules. But above-mentioned all kinds of method or the plant capsule performance of keeping humidity of preparation are not good, or raw material components is excessively numerous and diverse, and cost of manufacture is too high.
[summary of the invention]
Present invention is primarily targeted at: providing a kind of component simple, performance of keeping humidity is good, starch base Capsules raw material aggregation that cost is low and the Capsules that thus prepared by starch-based initial material aggregation.
For achieving the above object, a kind of novel high moisturizing starch base Capsules of design, it is characterized in that, it is made up of lightly crosslinked starch derivatives and reinforcing agent, in the base material of novel high moisturizing starch base Capsules, Starch Fraction is the above-mentioned lightly crosslinked starch derivatives of 100%, it accounts for the 90-95% of capsule shells gross weight, and reinforcing agent accounts for the 5-10% of capsule shells gross weight; Described lightly crosslinked starch derivatives, its component proportion is as follows: the starch derivatives raw material of 10000 parts and 10000-12000 part water are sized mixing, add the sodium sulfate of 200-300 part, PH acid-base modifier consumption is in pH value after adjusting, cross-linking agent, cross-linking agent make consumption between 0.1-0.4 part.
Described starch derivatives raw material is tapioca, also includes the combination of corn starch, wheaten starch, rice starch, sweet potato starch and above-mentioned starch simultaneously.
Described cross-linking agent is phosphorus oxychloride.
One or more combinations in Konjac glucomannan, sodium alginate, sodium polyacrylate micropowder, carboxymethyl cellulose glycerol, carrageenan of described reinforcing agent.
Described reinforcing agent is calculated by weight percentage, Konjac glucomannan 50%, glycerol 50% or sodium polyacrylate micropowder 55-65%, glycerol 44-35% constitute solvent.
The preparation method of a kind of described novel high moisturizing starch base Capsules, it is characterised in that comprise the following steps:
(1) in lightly crosslinked starch derivatives, add the water mixing of above-mentioned starch base 4 times of weight of Capsules compositions, heat 0.5-3h in 70-85 DEG C;
(2) adopt three layers Fibrous membrane filtration starch fluid, remove the impurity in starch fluid;
(3) reinforcing agent accounting for raw material weight 5-10% is dissolved in deionized water, is added in above-mentioned starch solution, further mixing and stirring;
(4) dip in glue, and dry at 35-50 DEG C, further degumming, obtain above-mentioned starch hollow capsule.
The preparation of described lightly crosslinked obtained starch derivatives, sizes mixing the starch derivatives raw materials of 10000 parts and 10000-12000 part water, adds the sodium sulfate of 200-300 part, the pH value of mixing starch solution is adjusted 10-11; Add the phosphorus oxychloride of 0.1-0.4 part, under mechanical stirring after reaction 1 hour, terminate reaction, be washed out, dehydration, obtain the lightly crosslinked starch derivatives of moisture 45%.
Unlike the prior art, the starch base capsule of the present invention does not have simple amylose and simple amylopectin raw material, it is by the appropriately crosslinked degeneration to tapioca, the tensile strength strengthening starch film keeps the integrity of starch expanded granular, make amylopectin optionally be retained in expansion starch granule, keep dense amylose to stick with paste the feature of liquid in the forming process of film. Phosphorus oxychloride chemical reagent is utilized to regulate the degree of cross linking, it is possible to control the amylose quantity that tapioca separates out in masking digestion process from expansion starch granule middle reaches, thus regulating brittleness and the suppleness of film. Originally complicated capsule material combination is become simple and easy to get by this performance, and cost of manufacture declines to a great extent.
Additionally, due to lightly crosslinked cassava modified starch is as the base stock of capsule membrane material, there is certain moisture retention. But moisturizing remains a need for adding the reinforcing agents such as Konjac glucomannan, improves the overall moisture-retaining capacity of capsule.
Due to the raw material components with lightly crosslinked cassava modified starch for main capsule membrane material, heat, acid and mechanical shear stress are had extraordinary stability by the liquid glue formed. In manufacturing process, the facility of processing is provided for the raw material components of various capsules. Capsule raw material components is mixed in digesting technoloy process more abundant, be maintained with its various physicochemical properties and do not change.
[detailed description of the invention]
In conjunction with embodiment, technical scheme is further elaborated, it is believed that be evident from for a person skilled in the art.
Embodiment 1
The tapioca of 140kg and 160L water are sized mixing, at the sodium sulfate adding 0.35kg. The pH value of mixing starch solution is adjusted within the scope of 10-11; Adding the phosphorus oxychloride of 0.4ml, under room temperature condition, mechanic whirl-nett reaction is after 1 hour, terminates reaction. Be washed out, dehydration, obtain the raw material aggregation of the starch base Capsules of moisture 45%, lightly crosslinked starch derivatives. Chemical reaction reagent phosphorus oxychloride consumption be strictly limited at 10-40ml/T.
Embodiment (1)
The above-mentioned lightly crosslinked starch derivatives prepared is mixed with described reinforcing agent Konjac glucomannan, glycerol, wherein, Konjac glucomannan 3.5kg, glycerol 4kg. Add the water of above-mentioned starch base 4 times of weight of Capsules aggregation, after temperature is 60 minutes gelatinizing plastics of 82 degree of heating, adopt the process equipment that routine prepares capsule to prepare the starch base Capsules with better disintegrating property and flexibility.
Described routine prepares the technique of capsule specifically, adopts three layers Fibrous membrane filtration starch fluid, removes the impurity in starch fluid; Dip in glue, and dry at 35-50 DEG C, further degumming, obtain above-mentioned starch hollow capsule.
Method of testing with reference to Chinese Pharmacopoeia two regulations of version in 2010, send out, with huge sky, the starch base Capsules that said method obtains by ZB-IE Intelligent disintegration tester to detect, test 30 samples all can whole disintegrates within 7 minutes, its disintegration reaches Chinese Pharmacopoeia requirement.
Embodiment (2)
The glycerol of above-mentioned lightly crosslinked cassava modified starch 1.4kg and the 50g prepared and the sodium alginate mixing of 50g, add and will enter the water of 3.55kg, after temperature is 60 minutes gelatinizing plastics of 82 degree of heating, the process equipment that routine prepares capsule is adopted to prepare the starch base Capsules with better disintegrating property and flexibility.
Method of testing with reference to Chinese Pharmacopoeia two regulations of version in 2010, send out, with huge sky, the starch base Capsules that said method obtains by ZB-IE Intelligent disintegration tester to detect, test 30 samples all can whole disintegrates within 7 minutes, its disintegration reaches Chinese Pharmacopoeia requirement.
Embodiment (3)
The sodium polyacrylate micropowder mixing of the above-mentioned lightly crosslinked glycerol of cassava modified starch 1.4kg and 50g prepared and the sodium alginate of 20g and 35g, add and will enter the water of 3.55kg, after temperature is 60 minutes gelatinizing plastics of 82 degree of heating, the process equipment that routine prepares capsule is adopted to prepare the starch base Capsules with better disintegrating property and flexibility.
Method of testing with reference to Chinese Pharmacopoeia two regulations of version in 2010, send out, with huge sky, the starch base Capsules that said method obtains by ZB-IE Intelligent disintegration tester to detect, test 30 samples all can whole disintegrates within 7 minutes, its disintegration reaches Chinese Pharmacopoeia requirement.
Claims (7)
1. a novel high moisturizing starch base Capsules, it is characterized in that, it is made up of lightly crosslinked starch derivatives and reinforcing agent, in the base material of novel high moisturizing starch base Capsules, Starch Fraction is the above-mentioned lightly crosslinked starch derivatives of 100%, it accounts for the 90-95% of capsule shells gross weight, and reinforcing agent accounts for the 5-10% of capsule shells gross weight; Described lightly crosslinked starch derivatives, its component proportion is as follows: the starch derivatives raw material of 10000 parts and 10000-12000 part water are sized mixing, add the sodium sulfate of 200-300 part, PH acid-base modifier consumption is in pH value after adjusting, cross-linking agent, cross-linking agent make consumption between 0.1-0.4 part.
2. the novel high moisturizing starch base Capsules of one according to claim 1, it is characterized in that, described starch derivatives raw material is tapioca, also includes the combination of corn starch, wheaten starch, rice starch, sweet potato starch and above-mentioned starch simultaneously.
3. the novel high moisturizing starch base Capsules of one according to claim 1, it is characterised in that described cross-linking agent is phosphorus oxychloride.
4. the novel high moisturizing starch base Capsules of one according to claim 1, it is characterised in that described reinforcing agent one or more combinations in Konjac glucomannan, sodium alginate, sodium polyacrylate micropowder, carboxymethyl cellulose glycerol, carrageenan.
5. the novel high moisturizing starch base Capsules of one according to claim 4, it is characterised in that described reinforcing agent is calculated by weight percentage, Konjac glucomannan 50%, glycerol 50% or sodium polyacrylate micropowder 55-65%, glycerol 44-35% constitute solvent.
6. the preparation method of a novel high moisturizing starch base Capsules as claimed in claim 1, it is characterised in that comprise the following steps:
(1) in lightly crosslinked starch derivatives, add the water mixing of above-mentioned starch base 4 times of weight of Capsules compositions, heat 0.5-3h in 70-85 DEG C;
(2) adopt three layers Fibrous membrane filtration starch fluid, remove the impurity in starch fluid;
(3) reinforcing agent accounting for raw material weight 5-10% is dissolved in deionized water, is added in above-mentioned starch solution, further mixing and stirring;
(4) dip in glue, and dry at 35-50 DEG C, further degumming, obtain above-mentioned starch hollow capsule.
7. the preparation method of novel high moisturizing starch base Capsules according to claim 6, it is characterized in that, the preparation of described lightly crosslinked obtained starch derivatives, the starch derivatives raw materials of 10000 parts and 10000-12000 part water are sized mixing, add the sodium sulfate of 200-300 part, the pH value of mixing starch solution is adjusted 10-11; Add the phosphorus oxychloride of 0.1-0.4 part, under mechanical stirring after reaction 1 hour, terminate reaction, be washed out, dehydration, obtain the lightly crosslinked starch derivatives of moisture 45%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610063727.3A CN105616380A (en) | 2016-01-29 | 2016-01-29 | Novel high-moisture-retentivity starch-based hollow capsules and preparation method thereof |
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| CN201610063727.3A CN105616380A (en) | 2016-01-29 | 2016-01-29 | Novel high-moisture-retentivity starch-based hollow capsules and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106279789A (en) * | 2016-08-29 | 2017-01-04 | 湖北欣恺生物科技有限公司 | For preparing composite modified starch and the preparation method of Capsules |
| CN115778915A (en) * | 2022-12-20 | 2023-03-14 | 广东粤港澳大湾区黄埔材料研究院 | Starch-based plant capsule and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101864094A (en) * | 2010-02-03 | 2010-10-20 | 内蒙古奈伦农业科技股份有限公司 | Potato modified starch and preparation method and application thereof |
| CN101974092A (en) * | 2010-09-29 | 2011-02-16 | 广西明阳生化科技股份有限公司 | Production method of succinate starch for food industry |
| CN104800186A (en) * | 2015-04-17 | 2015-07-29 | 湖南尔康制药股份有限公司 | Starch-based vacant capsule and preparation process thereof |
-
2016
- 2016-01-29 CN CN201610063727.3A patent/CN105616380A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101864094A (en) * | 2010-02-03 | 2010-10-20 | 内蒙古奈伦农业科技股份有限公司 | Potato modified starch and preparation method and application thereof |
| CN101974092A (en) * | 2010-09-29 | 2011-02-16 | 广西明阳生化科技股份有限公司 | Production method of succinate starch for food industry |
| CN104800186A (en) * | 2015-04-17 | 2015-07-29 | 湖南尔康制药股份有限公司 | Starch-based vacant capsule and preparation process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵春涛等: "食品用交联淀粉的研究（上）", 《中国粮油学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106279789A (en) * | 2016-08-29 | 2017-01-04 | 湖北欣恺生物科技有限公司 | For preparing composite modified starch and the preparation method of Capsules |
| CN106279789B (en) * | 2016-08-29 | 2019-06-07 | 湖北欣恺生物科技有限公司 | It is used to prepare the composite modified starch and preparation method of Capsules |
| CN115778915A (en) * | 2022-12-20 | 2023-03-14 | 广东粤港澳大湾区黄埔材料研究院 | Starch-based plant capsule and preparation method thereof |
| CN115778915B (en) * | 2022-12-20 | 2023-10-10 | 广东粤港澳大湾区黄埔材料研究院 | Starch-based plant capsule and preparation method thereof |
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