CN105694118A - Novel lightly crosslinked-starch succinate-based empty capsule and preparation method thereof - Google Patents
Novel lightly crosslinked-starch succinate-based empty capsule and preparation method thereof Download PDFInfo
- Publication number
- CN105694118A CN105694118A CN201610068363.8A CN201610068363A CN105694118A CN 105694118 A CN105694118 A CN 105694118A CN 201610068363 A CN201610068363 A CN 201610068363A CN 105694118 A CN105694118 A CN 105694118A
- Authority
- CN
- China
- Prior art keywords
- starch
- lightly crosslinked
- succinic acid
- acid esterification
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
- C08L3/04—Starch derivatives, e.g. crosslinked derivatives
- C08L3/06—Esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/02—Esters
- C08B31/04—Esters of organic acids, e.g. alkenyl-succinated starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a novel lightly crosslinked-starch succinate-based empty capsule and a preparation method thereof. The starch part in the capsule base material is 100% of lightly crosslinked-starch succinate derivatives, and accounts for 90-95% of the total weight of a capsule shell; a reinforcing agent accounts for 5-10% of the total weight of the capsule shell; and the lightly crosslinked-starch succinate derivatives comprise the following components in proportion: 10000 parts of starch derivative raw material and 10000-12000 parts which are subjected to pulp-mixing, a swelling inhibitor, a crosslinking agent, an esterifying agent and a PH acid-alkali conditioning agent. The starch-based empty capsule obtained through the coordination of the lightly crosslinked-starch succinate and the reinforcing agent has good moisturizing property and disintegrating property.
Description
[technical field]
The present invention relates to a kind of one group of raw material aggregation preparing starch base capsule and the preparation method utilizing this group aggregation production and processing starch base Capsules。
[background technology]
Utilizing animal skins, bone etc. to produce gelatin, recycling its processing Capsules is the medicine main wall material of solid preparation。But, owing to this wall material derives from animal body, there is certain risk by pathogen with people, simultaneously as gelatin Middle molecule chain contains a large amount of reactive group, it is easy to cooperating microorganisms etc. so that gelatine capsule is produced doubt by people。In addition, animal body is come from gelatin source, is also affected by the resistance of religion and vegetarian。
Making Capsules for replacing gelatin, scientist and the industry maker of every country direct attention to utilize plant, are carried out exploitation and the manufacture of Capsules by plant base raw material。The non-gelatin hollow capsule that it is raw material with hydroxypropyl methyl cellulose that Pfizer Inc. develops, and successfully introduce to the market。The non-gelatin plant-based capsule performance that the Capsugel company of France produces with pulullan for development of raw materials is suitable with gelatin, is deeply favored by market, but price comparison is expensive, restrict its sale commercially。
Domestic in recent years, also at the hollow starch capsule of Devoting Major Efforts To Developing plant base。Also there are many patent applications about plant base Capsules。But, major part does not put into actual production, puts on market also without Related product。Unique mass selling remain the hollow capsule being primary raw material with hydroxypropyl methyl cellulose。But it is relatively difficult to dewater with this raw material for the main production process preparing Capsules, meanwhile, production cost is not cheap yet。Therefore, market share at home is relatively low。
In prior art, the patent such as CN03070845A, CN13333006C, CN297601C, CN1483393A, CN895234A, CN947709A, CN03070845A, CN101182379B, CN101245157B, CN01273978A, CN101338045B, CN04324381A and CN104311887A also discloses the technical method utilizing the combination of starch, modified starch and plant gum to prepare Capsules。But above-mentioned all kinds of method Raw component is excessively numerous and diverse, due in the process preparing glue, the gelatinization point of each component is different, the component of first gelatinized starch will rupture at lasting heating process Middle molecule chain, and the strand of the high starch ingredients of gelatinization point is likely to but without abundant spread apart, the membrane material uniformity of formation is poor。
[summary of the invention]
Present invention is primarily targeted at: providing a kind of component simple, performance of keeping humidity is good, starch base Capsules raw material aggregation that cost is low and the Capsules that thus prepared by starch-based initial material aggregation。
For achieving the above object, design a kind of novel lightly crosslinked-succinic acid esterification starch base Capsules, it is characterized in that, it is made up of lightly crosslinked-succinic acid esterification starch derivatives and reinforcing agent, in capsule base material Starch Fraction be 100% above-mentioned lightly crosslinked-succinic acid esterification starch derivatives, it accounts for the 90-95% of capsule shells gross weight, and reinforcing agent accounts for the 5-10% of capsule shells gross weight；Described lightly crosslinked-succinic acid esterification starch derivatives, its component proportion is as follows: the starch material of 10000 parts and 10000-12000 part water are sized mixing, repression of swelling agent make consumption 100-500 part, cross-linking agent make consumption between 0.1-0.6 part, esterifying agent makes consumption between the 0.5-19% of starch on dry basis weight, and PH acid-base modifier consumption is in pH value after adjusting。
Described lightly crosslinked-succinic acid esterification starch derivatives raw material is tapioca, also includes the combination of corn starch, wheaten starch, rice starch, sweet potato starch and above-mentioned starch simultaneously。
Described repression of swelling agent is sodium sulfate or sodium chloride, cross-linking agent is phosphorus oxychloride, and esterifying agent is succinic anhydrides。
One or more combinations in Konjac glucomannan, sodium alginate, sodium polyacrylate micropowder, carboxymethyl cellulose glycerol, carrageenan of described reinforcing agent。
Described reinforcing agent is calculated by weight percentage, Konjac glucomannan 50%, glycerol 50% or sodium polyacrylate micropowder 55-65%, glycerol 44-35% constitute solvent。
The preparation method of a kind of novel succinic acid esterification starch base Capsules as claimed in claim 1, it is characterised in that comprise the following steps:
(1) in the starch derivatives of lightly crosslinked-succinic acid esterification, add the water mixing of above-mentioned starch base 4 times of weight of Capsules compositions, heat 0.5-3h in 70-85 DEG C；
(2) adopt three layers Fibrous membrane filtration starch fluid, remove the impurity in starch fluid；
(3) reinforcing agent accounting for raw material weight 5-10% is dissolved in deionized water, is added in above-mentioned starch solution, further mixing and stirring；
(4) dip in glue, and dry at 35-50 DEG C, further degumming, obtain above-mentioned starch hollow capsule。
Described lightly crosslinked-preparation of the starch derivatives of succinic acid esterification, after in 10000-12000 part water, 10000 parts of starch materials of addition stir, add 100-500 part repression of swelling agent, pH value is adjusted within the scope of 10-11 by the liquid caustic soda with 5%, add 0.1-0.6 part cross-linking agent, after reacting 1-2 hour under room temperature condition, it is neutralized within the scope of 8-9, add 50-1900 part succinic anhydrides, keep carrying out esterification under the constant room temperature condition of pH value until reaction terminates, then, pH value=6 are neutralized with acid, 0, send into post processing to wash, dehydration, obtain moisture 45% lightly crosslinked-starch derivatives of succinic acid esterification。
The present invention provides a kind of and has the starch base Capsules that good moisture retention energy, component are simple and with low cost, unlike the prior art, does not have simple amylose and simple amylopectin raw material in the starch base capsule of the present invention。Be by tapioca appropriately crosslinked-succinic acid esterification degeneration, the tensile strength strengthening starch film keeps the integrity of starch expanded granular, make amylopectin optionally be retained in expansion starch granule, keep dense amylose to stick with paste the feature of liquid in the forming process of film。Phosphorus oxychloride chemical reagent is utilized to regulate the degree of cross linking, it is possible to control the amylose quantity that tapioca separates out in masking digestion process from expansion starch granule middle reaches, thus regulating brittleness and the suppleness of film。Simultaneously as introduced succinic acid esterification functional group, enhance the water retention property of starch ingredients。Originally complicated capsule material combination is become simple and easy to get, and cost of manufacture declines to a great extent。
Additionally, due to lightly crosslinked-succinic acid esterification starch is as the base stock of capsule membrane material, there is certain moisture retention。But moisturizing remains a need for adding the reinforcing agents such as Konjac glucomannan, improves the overall moisture-retaining capacity of capsule。
Due to the raw material components with lightly crosslinked-succinic acid esterification starch for main capsule membrane material, heat and mechanical shear stress are had extraordinary stability by the liquid glue formed。In manufacturing process, the facility of processing is provided for the raw material components of various capsules。Capsule raw material components is mixed in digesting technoloy process more abundant, be maintained with its various physicochemical properties and do not change。
[detailed description of the invention]
In conjunction with embodiment, technical scheme is further elaborated, it is believed that be evident from for a person skilled in the art。
Embodiment 1
After 10000 portions of tapiocas of addition stir in 10000 parts of water, add 250 parts of repression of swelling agent, with the liquid caustic soda of 5%, pH value is adjusted to about 10.5。Add 0.22 part of cross-linking agent, after reacting 2 hours, be neutralized to about 8。Add 200 parts of succinic anhydrides, keep pH value constant until reaction terminates。Then, neutralize pH value=6 with acid, about 0。Send into post processing carry out washing, dehydration, obtain the raw material aggregation of the starch base Capsules of moisture 45%。
Embodiment (1)
The above-mentioned raw material aggregation being used for preparing starch base Capsules prepared is mixed with described reinforcing agent Konjac glucomannan, glycerol, wherein, Konjac glucomannan 45 parts, glycerol 58 parts。Add the water of above-mentioned starch base 4 times of weight of Capsules aggregation, after temperature is 60 minutes gelatinizing plastics of 82 degree of heating, adopt the process equipment that routine prepares capsule to prepare the starch base Capsules with better disintegrating property and flexibility。
Method of testing with reference to Chinese Pharmacopoeia two regulations of version in 2010, send out, with huge sky, the starch base Capsules that said method obtains by ZB-IE Intelligent disintegration tester to detect, test 30 samples all can whole disintegrates within 7 minutes, its disintegration reaches Chinese Pharmacopoeia requirement。
Embodiment (2)
The glycerol of raw material aggregation 14kg and the 500g of the above-mentioned Capsules prepared and the sodium alginate mixing of 560g, add and will enter the water of 56kg, after temperature is 60 minutes gelatinizing plastics of 82 degree of heating, the process equipment that routine prepares capsule is adopted to prepare the starch base Capsules with better disintegrating property and flexibility。
Described routine prepares the technique of capsule specifically, adopts three layers Fibrous membrane filtration starch fluid, removes the impurity in starch fluid；Dip in glue, and dry at 35-50 DEG C, further degumming, obtain above-mentioned starch hollow capsule。
Method of testing with reference to Chinese Pharmacopoeia two regulations of version in 2010, send out, with huge sky, the starch base Capsules that said method obtains by ZB-IE Intelligent disintegration tester to detect, test 30 samples all can whole disintegrates within 7 minutes, its disintegration reaches Chinese Pharmacopoeia requirement。
Embodiment (3)
The glycerol of raw material aggregation 30kg and 1.8kg of the above-mentioned Capsules prepared and the sodium polyacrylate micropowder mixing of the sodium alginate of 1.0kg and 0.5kg, add and will enter the water of 120kg, after temperature is 60 minutes gelatinizing plastics of 82 degree of heating, the process equipment that routine prepares capsule is adopted to prepare the starch base Capsules with better disintegrating property and flexibility。
Method of testing with reference to Chinese Pharmacopoeia two regulations of version in 2010, send out, with huge sky, the starch base Capsules that said method obtains by ZB-IE Intelligent disintegration tester to detect, test 30 samples all can whole disintegrates within 7 minutes, its disintegration reaches Chinese Pharmacopoeia requirement。
Claims (7)
1. one kind novel lightly crosslinked-succinic acid esterification starch base Capsules, it is characterized in that, it is made up of lightly crosslinked-succinic acid esterification starch derivatives and reinforcing agent, in capsule base material Starch Fraction be 100% above-mentioned lightly crosslinked-succinic acid esterification starch derivatives, it accounts for the 90-95% of capsule shells gross weight, and reinforcing agent accounts for the 5-10% of capsule shells gross weight；Described lightly crosslinked-succinic acid esterification starch derivatives, its component proportion is as follows: the starch material of 10000 parts and 10000-12000 part water are sized mixing, it is suppressed that extender makes consumption 100-500 part；Cross-linking agent make consumption between 0.1-0.6 part, esterifying agent makes consumption between the 0.5-19% of starch on dry basis weight, PH acid-base modifier consumption in adjust after pH value。
2. one according to claim 1 novel lightly crosslinked-succinic acid esterification starch base Capsules, it is characterized in that, described lightly crosslinked-succinic acid esterification starch derivatives raw material is tapioca, also includes the combination of corn starch, wheaten starch, rice starch, sweet potato starch and above-mentioned starch simultaneously。
3. one according to claim 1 novel lightly crosslinked-succinic acid esterification starch base Capsules, it is characterised in that described repression of swelling agent is sodium sulfate or sodium chloride, and cross-linking agent is phosphorus oxychloride, and esterifying agent is succinic anhydrides。
4. one according to claim 1 novel lightly crosslinked-succinic acid esterification starch base Capsules, it is characterized in that, one or more combinations in Konjac glucomannan, sodium alginate, sodium polyacrylate micropowder, carboxymethyl cellulose glycerol, carrageenan of described reinforcing agent。
5. one according to claim 4 novel lightly crosslinked-succinic acid esterification starch base Capsules, it is characterized in that, described reinforcing agent is calculated by weight percentage, by Konjac glucomannan 50%, glycerol 50% or sodium polyacrylate micropowder 55-65%, glycerol 44-35% constitute solvent。
6. one kind as claimed in claim 1 novel lightly crosslinked-preparation method of succinic acid esterification starch base Capsules, it is characterised in that comprise the following steps:
(1) in the starch derivatives of lightly crosslinked-succinic acid esterification, add the water mixing of above-mentioned starch base 4 times of weight of Capsules compositions, heat 0.5-3h in 70-85 DEG C；
(2) adopt three layers Fibrous membrane filtration starch fluid, remove the impurity in starch fluid；
(3) reinforcing agent accounting for raw material weight 5-10% is dissolved in deionized water, is added in above-mentioned starch solution, further mixing and stirring；
(4) dip in glue, and dry at 35-50 DEG C, further degumming, obtain above-mentioned starch hollow capsule。
7. according to claim 6 novel lightly crosslinked-preparation method of succinic acid esterification starch base Capsules, it is characterized in that, described lightly crosslinked-preparation of the starch derivatives of succinic acid esterification, after in 10000-12000 part water, 10000 parts of starch materials of addition stir, add 100-500 part repression of swelling agent, pH value is adjusted within the scope of 10-11 by the liquid caustic soda with 5%, add 0.1-0.6 part cross-linking agent, after reacting 1-2 hour under room temperature condition, it is neutralized within the scope of 8-9, add 50-1900 part succinic anhydrides, keep carrying out esterification under the constant room temperature condition of pH value until reaction terminates, then, pH value=6 are neutralized with acid, 0, send into post processing to wash, dehydration, obtain moisture 45% lightly crosslinked-starch derivatives of succinic acid esterification。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610068363.8A CN105694118A (en) | 2016-01-29 | 2016-01-29 | Novel lightly crosslinked-starch succinate-based empty capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610068363.8A CN105694118A (en) | 2016-01-29 | 2016-01-29 | Novel lightly crosslinked-starch succinate-based empty capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105694118A true CN105694118A (en) | 2016-06-22 |
Family
ID=56230034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610068363.8A Pending CN105694118A (en) | 2016-01-29 | 2016-01-29 | Novel lightly crosslinked-starch succinate-based empty capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105694118A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106243408A (en) * | 2016-08-26 | 2016-12-21 | 湖南尔康制药股份有限公司 | A kind of starch capsule improving mechanical performance |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001091721A2 (en) * | 2000-06-01 | 2001-12-06 | A.E. Staley Manufacturing Co. | Modified starch as a replacement for gelatin in soft gel films and capsules |
| CN101974092A (en) * | 2010-09-29 | 2011-02-16 | 广西明阳生化科技股份有限公司 | Production method of succinate starch for food industry |
| CN102716489A (en) * | 2012-05-31 | 2012-10-10 | 浙江中同科技有限公司 | Modified starch composition plant capsule and preparation method thereof |
-
2016
- 2016-01-29 CN CN201610068363.8A patent/CN105694118A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001091721A2 (en) * | 2000-06-01 | 2001-12-06 | A.E. Staley Manufacturing Co. | Modified starch as a replacement for gelatin in soft gel films and capsules |
| CN101974092A (en) * | 2010-09-29 | 2011-02-16 | 广西明阳生化科技股份有限公司 | Production method of succinate starch for food industry |
| CN102716489A (en) * | 2012-05-31 | 2012-10-10 | 浙江中同科技有限公司 | Modified starch composition plant capsule and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘树兴等: "《食品添加剂》", 31 May 2001, 中国石油出版社 * |
| 李新华等: "《粮油加工工艺学》", 30 September 2011, 郑州大学出版社 * |
| 童丹等: "《马铃薯变性淀粉加工技术》", 31 October 2015, 武汉大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106243408A (en) * | 2016-08-26 | 2016-12-21 | 湖南尔康制药股份有限公司 | A kind of starch capsule improving mechanical performance |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ren et al. | A current review of structure, functional properties, and industrial applications of pulse starches for value‐added utilization | |
| CN103937038B (en) | For preparing composition and the starch matrix Capsules thereof of Capsules | |
| Wu | Acetylated and hydroxypropylated distarch phosphates from waxy barley: paste properties and freeze-thaw stability | |
| US3467647A (en) | Cationic and anionic substituted polysaccharides and process for preparing same | |
| US3865603A (en) | Modified starch-extended gelatin compositions | |
| Chen et al. | Preparation and properties of granular cold-water-soluble porous starch | |
| CN104324381B (en) | Starch capsule having moisturizing capability and preparation method thereof | |
| CN103937037B (en) | For preparing modified starch glue and the starch matrix Capsules thereof of Capsules | |
| CN104351473B (en) | A kind of preparation method of Aquavite micropill for livestock and poultry | |
| CN104800186B (en) | A kind of starch hollow capsule and its preparation technology | |
| EP1756167A1 (en) | Oxidized reversibly swelling granular starch products | |
| Gonzalez-Soto et al. | Preparation of spherical aggregates of taro starch granules | |
| CN111040256A (en) | Raw material composition for preparing starch matrix hollow capsule and starch matrix hollow capsule | |
| Maulani et al. | Characterization of chemical and physical properties of hydroxypropylated and cross-linked arrowroot (Marantha arundinacea) starch | |
| CN104784148B (en) | A kind of film-forming composition for preparing plant capsule and preparation method thereof | |
| Krithika et al. | Modifiction of starch: A review of various techniques | |
| Yu et al. | Changes in physicochemical properties and structural characteristics of rice starch during extrusion processing: The role of glutelin and different extrusion zones | |
| CN105616380A (en) | Novel high-moisture-retentivity starch-based hollow capsules and preparation method thereof | |
| CN105694118A (en) | Novel lightly crosslinked-starch succinate-based empty capsule and preparation method thereof | |
| CN103282423A (en) | Improved starch composition for use in paper manufacture | |
| CN105482169A (en) | Novel starch-based empty capsules and preparation method thereof | |
| CN106729729A (en) | A kind of Capsules plant amylum composition | |
| CN106279789B (en) | It is used to prepare the composite modified starch and preparation method of Capsules | |
| Huang et al. | Physical, thermal and structural properties of rice starch as affected by the addition of bamboo shoot shell fibres | |
| Bodjrenou et al. | Effects of crosslinking with sodium trimetaphosphate on structural, physicochemical, rheological and in vitro digestibility properties of purple sweet potato starch |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160622 |
|
| RJ01 | Rejection of invention patent application after publication |