CN106074362A - 角鲨胺的眼用制剂 - Google Patents
角鲨胺的眼用制剂 Download PDFInfo
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- CN106074362A CN106074362A CN201610553185.8A CN201610553185A CN106074362A CN 106074362 A CN106074362 A CN 106074362A CN 201610553185 A CN201610553185 A CN 201610553185A CN 106074362 A CN106074362 A CN 106074362A
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- squalamine
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 230000004614 tumor growth Effects 0.000 description 1
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- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-M undecanoate Chemical compound CCCCCCCCCCC([O-])=O ZDPHROOEEOARMN-UHFFFAOYSA-M 0.000 description 1
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- 229960001661 ursodiol Drugs 0.000 description 1
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US37452410P | 2010-08-17 | 2010-08-17 | |
| US61/374,524 | 2010-08-17 | ||
| CN201180047840.8A CN103209683B (zh) | 2010-08-17 | 2011-08-16 | 角鲨胺的眼用制剂 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180047840.8A Division CN103209683B (zh) | 2010-08-17 | 2011-08-16 | 角鲨胺的眼用制剂 |
Publications (1)
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| CN106074362A true CN106074362A (zh) | 2016-11-09 |
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| CN201610553185.8A Pending CN106074362A (zh) | 2010-08-17 | 2011-08-16 | 角鲨胺的眼用制剂 |
| CN201180047840.8A Expired - Fee Related CN103209683B (zh) | 2010-08-17 | 2011-08-16 | 角鲨胺的眼用制剂 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201180047840.8A Expired - Fee Related CN103209683B (zh) | 2010-08-17 | 2011-08-16 | 角鲨胺的眼用制剂 |
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| Country | Link |
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| US (2) | US20130281420A1 (enExample) |
| EP (1) | EP2605752A1 (enExample) |
| JP (2) | JP5956992B2 (enExample) |
| KR (1) | KR101845107B1 (enExample) |
| CN (2) | CN106074362A (enExample) |
| AU (1) | AU2011292160B2 (enExample) |
| CA (1) | CA2808628A1 (enExample) |
| MX (1) | MX2013001870A (enExample) |
| WO (1) | WO2012024298A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
| US9814702B2 (en) * | 2014-09-17 | 2017-11-14 | Panoptica, Inc. | Ocular formulations for drug-delivery and protection of the anterior segment of the eye |
| WO2017083800A1 (en) * | 2015-11-13 | 2017-05-18 | Ohr Pharmaceutical, Inc. | Occult cnv size as a predictor for treatment with squalamine |
| TW201720445A (zh) * | 2015-11-13 | 2017-06-16 | Ｏｈｒ製藥公司 | 角鯊胺之眼用調配物 |
| KR20180036580A (ko) | 2016-09-30 | 2018-04-09 | 주식회사 유스바이오팜 | 수가용화(水加溶化)된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물 |
| US11241443B2 (en) * | 2017-04-07 | 2022-02-08 | Sun Pharma Advanced Research Company Ltd. | Ophthalmic solution of bimatoprost |
| IT202300017430A1 (it) * | 2023-08-22 | 2025-02-22 | Service Biotech srl | Soluzione oftalmica in forma di collirio contenente una isoforma umana ricombinante di manganese superossido dismutasi (rmnsod) per la cura di patologie dell’occhio |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070010504A1 (en) * | 2005-04-25 | 2007-01-11 | Eric Chellquist | Polymorphic and amorphous salt forms of squalamine dilactate |
| WO2007011874A2 (en) * | 2005-07-15 | 2007-01-25 | Chakshu Research Inc. | Formulation and method for administration of ophthalmologically active agents |
| US20070116730A1 (en) * | 2005-11-21 | 2007-05-24 | Schering-Plough Animal Health Corp. | Pharmaceutical compositions |
| CN101262886A (zh) * | 2005-07-15 | 2008-09-10 | 视可舒研究公司 | 用于给药眼科活性剂的制剂和方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL97075A0 (en) * | 1990-02-14 | 1992-03-29 | Alcon Lab Inc | Topical pharmaceutical composition containing an alkyl saccharide |
| US5631004A (en) * | 1993-09-30 | 1997-05-20 | Alcon Laboratories, Inc. | Use of sustained release antibiotic compositions in ophthalmic surgical procedures |
| AU4772696A (en) | 1996-01-26 | 1997-08-20 | Alcon Laboratories, Inc. | Use of squalamine and its analogues in ophthalmic compositions |
| US6262283B1 (en) | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
| US20050234018A1 (en) * | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| WO2006082588A2 (en) * | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| WO2006119211A2 (en) * | 2005-05-02 | 2006-11-09 | Genaera Corporation | Methods and compositions for treating ocular disorders |
| US7893040B2 (en) * | 2005-07-22 | 2011-02-22 | Oculis Ehf | Cyclodextrin nanotechnology for ophthalmic drug delivery |
| US8216575B2 (en) | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
| WO2008031113A2 (en) * | 2006-09-08 | 2008-03-13 | Genaera Corporation | Improved method for inhibition of neovascularization |
| GB0625844D0 (en) * | 2006-12-22 | 2007-02-07 | Daniolabs Ltd | The treatment of macular degeneration |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
-
2011
- 2011-08-16 CA CA2808628A patent/CA2808628A1/en not_active Abandoned
- 2011-08-16 EP EP11749654.7A patent/EP2605752A1/en not_active Withdrawn
- 2011-08-16 MX MX2013001870A patent/MX2013001870A/es unknown
- 2011-08-16 CN CN201610553185.8A patent/CN106074362A/zh active Pending
- 2011-08-16 JP JP2013524928A patent/JP5956992B2/ja not_active Expired - Fee Related
- 2011-08-16 WO PCT/US2011/047920 patent/WO2012024298A1/en not_active Ceased
- 2011-08-16 US US13/817,306 patent/US20130281420A1/en not_active Abandoned
- 2011-08-16 KR KR1020137006746A patent/KR101845107B1/ko not_active Expired - Fee Related
- 2011-08-16 AU AU2011292160A patent/AU2011292160B2/en not_active Ceased
- 2011-08-16 CN CN201180047840.8A patent/CN103209683B/zh not_active Expired - Fee Related
-
2015
- 2015-08-13 US US14/825,492 patent/US20150342874A1/en not_active Abandoned
-
2016
- 2016-06-17 JP JP2016120681A patent/JP6214726B2/ja not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070010504A1 (en) * | 2005-04-25 | 2007-01-11 | Eric Chellquist | Polymorphic and amorphous salt forms of squalamine dilactate |
| WO2007011874A2 (en) * | 2005-07-15 | 2007-01-25 | Chakshu Research Inc. | Formulation and method for administration of ophthalmologically active agents |
| CN101262886A (zh) * | 2005-07-15 | 2008-09-10 | 视可舒研究公司 | 用于给药眼科活性剂的制剂和方法 |
| US20070116730A1 (en) * | 2005-11-21 | 2007-05-24 | Schering-Plough Animal Health Corp. | Pharmaceutical compositions |
Non-Patent Citations (2)
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| 刘志东: "渗透促进剂在眼用制剂中的应用", 《中国新药杂志》 * |
| 张欣华: "羟丙基-β-环糊精对黄芩苷角膜透过性研究", 《天津中医药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011292160B2 (en) | 2015-09-03 |
| CN103209683A (zh) | 2013-07-17 |
| US20150342874A1 (en) | 2015-12-03 |
| CN103209683B (zh) | 2016-08-31 |
| MX2013001870A (es) | 2013-07-03 |
| JP6214726B2 (ja) | 2017-10-18 |
| KR20140021505A (ko) | 2014-02-20 |
| JP2013537551A (ja) | 2013-10-03 |
| AU2011292160A1 (en) | 2013-03-14 |
| WO2012024298A1 (en) | 2012-02-23 |
| US20130281420A1 (en) | 2013-10-24 |
| JP2016166250A (ja) | 2016-09-15 |
| CA2808628A1 (en) | 2012-02-23 |
| JP5956992B2 (ja) | 2016-07-27 |
| EP2605752A1 (en) | 2013-06-26 |
| KR101845107B1 (ko) | 2018-04-03 |
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