CN106073751A - A kind of portable brain magnetic detection device - Google Patents
A kind of portable brain magnetic detection device Download PDFInfo
- Publication number
- CN106073751A CN106073751A CN201610367559.7A CN201610367559A CN106073751A CN 106073751 A CN106073751 A CN 106073751A CN 201610367559 A CN201610367559 A CN 201610367559A CN 106073751 A CN106073751 A CN 106073751A
- Authority
- CN
- China
- Prior art keywords
- array
- current source
- temperature
- heater
- signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0223—Magnetic field sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2576/00—Medical imaging apparatus involving image processing or analysis
- A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
- A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
A kind of portable brain magnetic detection device, including the brain magnetic measurement helmet (100), optics atom magnetometer (101a～101h), drive system (103), signal detection system (104) and storage system (105).The input of optics atom magnetometer (101a～101h) is connected with the outfan of drive system (103), outfan is connected with the input of signal detection system (104), first outfan of signal detection system (104) is connected with storage system (105), and the second outfan of signal detection system (104) is connected with the input of drive system (103).Optics atom magnetometer (101a～101h) is embedded on the brain magnetic measurement helmet (100), gathers brain magnetic signal.Drive system (103) maintains optics atom magnetometer normal operating conditions.Signal detection system (104) is for identifying the output signal of optics atom magnetometer, the storage of storage system (105) complete pair signals.
Description
Technical field
The present invention relates to a kind of brain magnetic detection device, particularly to the portable brain magnetic of a kind of optically-based atom magnetometer
Detection device.
Background technology
Electrical activity of neurons in human brain can produce magnetic field, magneticencephalogram (Magnetoencephalography, MEG)
Be a kind of can be in the technology in this magnetic field of scalp surface Non-invasive detection.When brain magnetic signal is through the anatomical structure such as scalp, skull
Will not be distorted, therefore image is the most easily distinguished, brain diseases diagnosis is had higher accuracy.Owing to brain neuron produces
Magnetic field the faintest, the most hundreds of fT (10-15T), maximum neural magnetic signal such as epileptic spike only has a few pT (10-12T), because of
This must have reliable magnetic field shielding system and sensitive brain magnetic field measuring device.Existing magneticencephalogram is with superconductive quantum interference
Instrument (super-conducting quantum interference device, SQUID) is core devices, superconductive quantum interference
Instrument is operated in low-temperature superconducting state, need use liquid helium cool down, in theory the sensitivity of superconducting quantum interference device (SQUID) up to
1fT/Hz1/2, the sensitivity of commercial magneticencephalogram instrument is up to 2～3fT/Hz1/2.Meanwhile, when measuring brain magnetic, also need to magnetic shield room, use
Filtering the interference of earth's magnetic field, power frequency magnetic field etc., screened room is typically built by permalloy and is formed.But low-temperature superconducting system and
High performance magnetic shield room causes existing brain magnetic signal detection device structure based on SQUID complexity, manufactures and maintenance cost
High, seriously limit the clinical practice of magneticencephalogram.
Optics atom magnetometer is the Magnetic Sensor that a kind of sensitivity is high equally, recently as semiconductor laser and
The development of Atomic Physics, the sensitivity of optics atom magnetometer alreadys more than superconducting quantum interference device (SQUID).With superconducting quantum interference device (SQUID)
Comparing, optics atom magnetometer need not low-temperature maintaining device, thus causes the extensive concern of each side.But the most not yet
See the brain magnetic signal detection device of optically-based atom magnetometer.
Summary of the invention
It is an object of the invention to overcome the shortcoming of prior art, propose the portable brain of a kind of optically-based atom magnetometer
Magnetic signal detection device.
Brain magnetic signal is measured by portable brain magnetic detection device of the present invention by optics atom magnetometer, it is not necessary to screen
Cover room.Optics atom magnetometer is a kind of highly sensitive magnetic field measurement device based on optical pumping effect.Atom is in optical pumping
Effect is lower to be aligned, and the change of externally-applied magnetic field affects the ordered state of atom, can counter be released by detection transmission light
Externally-applied magnetic field.
Portable brain magnetic detection device of the present invention include the brain magnetic measurement helmet, optics atom magnetometer array, drive system,
Signal detection system and storage system.Optics atom magnetometer array is embedded on the brain magnetic measurement helmet, optics nonmagnetic atom
The input of strong meter array is connected with the outfan of drive system, the outfan of optics atom magnetometer array and signal detection system
The input of system connects, and the first outfan of signal detection system is connected with storage system, the second of signal detection system
Outfan is connected with the input of drive system.The brain magnetic measurement helmet is for the connection of this detection device with subjects.Optics is former
Brain magnetic signal is acquired by sub-gaussmeter as sensor.The effect of drive system is to maintain optics atom magnetometer normal
Duty.Signal detection system is for identifying the output signal of optics atom magnetometer, the complete pair signals of storage system
Storage.
Described drive system includes laser source array, heater constant current source array and modulated Field constant current source array.Swash
Radiant array is connected with the first input end of optics atom magnetometer array, the outfan of heater constant current source array and optics
Second input of atom magnetometer array connects, and modulated Field constant current source array inputs with the 3rd of optics atom magnetometer array
End connects.Laser source array provides incident laser for optics atom magnetometer array, and heater constant current source array is that optics is former
Sub-magnetometer array provides and adds thermocurrent, and modulated Field constant current source array provides for optics atom magnetometer array and produces modulation magnetic field
Electric current.
Described signal detection system includes photodetector array, temperature-control circuit array and phase-sensitive detection circuit battle array
Row.The input of photodetector array is connected with the first outfan of optics atom magnetometer array, temperature-control circuit battle array
The input of row is connected with the second outfan of optics atom magnetometer array, and the outfan of photodetector array is examined with phase sensitivity
The input of wave circuit array connects, the outfan of temperature-control circuit array and heater constant current source array in drive system
Input connects.Photodetector array is used for detecting the emergent light of optics atom magnetometer array output, carries in emergent light
There is brain magnetic signal to be measured.Temperature-control circuit array can detect the temperature of optics atom magnetometer array, and according to setting
Temperature adjusts the duty of heater constant current source array in drive system, if the temperature of optics atom magnetometer array is less than
Design temperature then heater constant current source array is started working, and output adds thermocurrent, and otherwise heater constant current source array does not works.Phase
Quick detecting circuit array is used for filtering, the noise filtering that can will mix in photodetector array output signal.
Described storage system includes difference engine array and signal storage.The input of difference engine array and signal
In detecting system, the outfan of phase-sensitive detection circuit array connects, and the outfan of difference engine array is connected with signal storage.Difference
The function dividing device array is to calculate the difference between the signal that different optics atom magnetometer measurement is arrived.Signal storage is used for believing
Number storage.
Optics atom magnetometer array is made up of multiple identical chip-scale optics atom magnetometers, multiple chip-scale optics
Atom magnetometer is distributed on the brain magnetic measurement helmet.Laser source array is made up of the LASER Light Source that multiple structures are identical.Heating
Device constant current source array is made up of the heater constant-current source that multiple structures are identical.Modulated Field constant current source array is identical by multiple structures
Modulated Field constant-current source forms.Photodetector array is made up of the photodetector that multiple structures are identical.Temperature-control circuit battle array
Row are made up of the temperature-control circuit that multiple structures are identical.Phase-sensitive detection circuit array is made up of multiple phase-sensitive detection circuits.Swash
Radiant, heater constant-current source, modulated Field constant-current source, photodetector, temperature-control circuit and the quantity of phase-sensitive detection circuit
Equal with the quantity of optics atom magnetometer, and with optics atom magnetometer one_to_one corresponding.In modulated Field constant current source array each
Modulated Field constant-current source uses different power frequencies, and different from the frequency of heater constant current source array, in order to during Filtering Processing
The electromagnetic interference caused between adjacent signals acquisition channel can be filtered by modulation magnetic field or heater.
1 LASER Light Source in 1 chip-scale optics atom magnetometer, laser source array, heater constant current source array
In 1 heater constant-current source, in 1 modulated Field constant-current source, photodetector array in modulated Field constant current source array 1
1 temperature-control circuit in photodetector, temperature-control circuit array, 1 phase sensitivity inspection in phase-sensitive detection circuit array
Wave circuit constitutes the peripheral components of optics atom magnetometer.1 chip-scale optics atom magnetometer and peripheral components thereof constitute 1
Brain magnetic signal acquisition passage, portable brain magnetic signal detection device of the present invention has multiple signal sampling channel, can have 2～257
Individual, wherein 1 is reference channel, and remaining is Measurement channel.
Owing to the signal that optics atom magnetometer is measured containing many interference factors such as earth's magnetic field, power frequency magnetic field,
Using differential signal to be offset by noise section signal collected for two brain magnetic signal acquisition passages, obtain is two and leads to
The difference of signal between road.During actual application, the position of the optics atom magnetometer in reference channel is at the brain Magnetic testi helmet
Edge, such as left ear side.At this moment it is believed that the signal that optics atom magnetometer in reference channel collects does not contains brain magnetic
Signal, only noise information.The signal that optics atom magnetometer in Measurement channel collects has brain magnetic information simultaneously and makes an uproar
Acoustic intelligence.The signal that so the optics atom magnetometer in Measurement channel records all is surveyed with optics atom magnetometer in reference channel
The signal subtraction obtained, thus filter noise, useful signal is retained.Differentiated signal input signal memorizer, in case brain magnetic
Signal post-processing, and various analysis.
The signal differential function of device of the present invention is completed by the difference engine array in storage system, difference engine battle array
Row are made up of the difference engine that multiple structures are identical, and the quantity of difference engine is equal with the quantity of Measurement channel, with Measurement channel one by one
Corresponding.Each difference engine is by the outfan of the phase-sensitive detection circuit in two inputs, first input end and place Measurement channel
Connecting, the second input is connected with the phase-sensitive detection circuit outfan of reference channel.Outfan is connected with signal storage.If
The signal of the phase-sensitive detection circuit output of one Measurement channel is Vm, and the signal of the phase-sensitive detection circuit output of Measurement channel is
Vref, then the difference engine corresponding to this Measurement channel is output as Vm-Vref.
1 brain magnetic signal acquisition passage includes chip-scale optics atom magnetometer and peripheral components two large divisions.Chip-scale
Optics atom magnetometer is the core component of brain magnetic signal detection device.One chip-scale optics atom magnetometer volume is less than
2 cubic centimetres, include rubidium steam chamber, heater, temperature sensor, modulation coil, incident optical, entrance prism, outgoing rib
Mirror, lens, outgoing optical fiber and shell.Rubidium steam chamber, heater, temperature sensor, modulation coil, entrance prism, outgoing prism
With lens packages portion in the enclosure.1 chip-scale optics atom magnetometer has five ports, first input port, the second input
Port, the 3rd input port, the first output port and the second output port, these ports are positioned at housing exterior.Incident optical
Input is connected with first input port, and incident optical passes shell, the outfan of incident optical and the plane of incidence of entrance prism
Connecting, the outfan of outgoing optical fiber and the first delivery outlet end connect, and outgoing optical fiber passes shell, and the input of outgoing optical fiber is with saturating
The exit facet of mirror connects, and the plane of incidence of lens is connected with the exit facet of outgoing prism, and heater and the second input port connect, and adjust
Coil processed and the 3rd input port connect, and temperature sensor and the second output port connect.
Peripheral components includes LASER Light Source, heater constant-current source, modulated Field constant-current source, temperature-control circuit, photodetection
Device, phase-sensitive detection circuit, and signal storage.LASER Light Source is connected with the first input port of optics atom magnetometer, adds
The outfan of hot device constant-current source is connected with the second input port of optics atom magnetometer, modulated Field constant-current source and optics nonmagnetic atom
3rd input port of strong meter connects, and the input of photodetector is connected with the first output port of optics atom magnetometer,
The input of temperature-control circuit is connected with the second output port of optics atom magnetometer, the input of heater constant-current source with
The outfan of temperature-control circuit connects.The outfan of photodetector is connected with the input of phase-sensitive detection circuit, and phase sensitivity is examined
The outfan of wave circuit is connected with signal storage.
One signal sampling channel functionally can be divided into temperature control system, optical system and additional modulation magnetic field system
System, they act on the core component rubidium steam chamber of optics atom magnetometer respectively with heat, light, the form of magnetic.The present invention
The rubidium steam chamber used is cylindrical, and side is transparent surface.Except natural rubidium in rubidium steam chamber, also it is filled with buffer gas with dimension
Holding the polarized state of rubidium atom, the buffer gas being filled with is neon, and pressure is about 133Pa.
The optical system of optics atom magnetometer includes incident optical, entrance prism, outgoing prism, lens and emergent light
Fine.Wherein entrance prism and outgoing prism are fixed on the outer surface of heater, and heater is having a common boundary with entrance prism, outgoing prism
Perforate at face, in order to laser can pass in hole and irradiate rubidium steam chamber.Lens are arranged between outgoing prism and outgoing optical fiber,
Can converge to get up to enter back into outgoing optical fiber by emergent light.It is the left-handed of 795nm or right-hand circular polarization that LASER Light Source sends wavelength
Light, laser enters optical fiber, then arrives entrance prism, is irradiated rubidium steam chamber by the perforate on heater after prismatic decomposition,
Laser passes through the transmission light after rubidium steam chamber again by outgoing prismatic decomposition, after the emergent light of outgoing prism is by lens collection, focusing on
Enter outgoing optical fiber, finally detected final emergent light by photodetector.Rubidium atom in rubidium steam chamber is under laser irradiates
Absorbing photon, energy level transition occurs, by " pumping " to high level state, optical pumping makes atom integrated distribution higher in certain energy level
Sub-energy level on.Owing to the energy of laser changes, the transmission light of rubidium steam chamber contains the information of rubidium state of atom.
In order to strengthen the effect of optical pumping, it is necessary to improved the number of gaseous state rubidium atom by heating.The optical pumping letter of rubidium
Number the most sensitive to variations in temperature, the temperature constant of rubidium steam chamber must be kept during measurement.In the present invention, heater, temperature
Degree sensor, heater constant-current source and temperature-control circuit constitute the closed loop thermal control system of rubidium steam chamber, it is possible to by rubidium
The temperature of steam chamber controls between 45～55 DEG C.In the closed loop thermal control system of this rubidium steam chamber, rubidium steam chamber quilt
Heater wraps up, and hot device outward appearance is cube, and there is the resistance wire for heating inside, and remainder is made from a material that be thermally conductive.With
Time rubidium steam chamber surface be mounted with temperature sensor, rubidium steam chamber temperature can be measured in real time.The closed loop thermal of rubidium steam chamber controls
During system work, rubidium steam chamber is heated by heater, and stabilizes it in work by the electric current that heater constant-current source produces
Making temperature, 45～55 DEG C, temperature sensor simultaneously is started working, by measurement to rubidium steam chamber temperature information be sent to temperature in real time
Degree control circuit, temperature-control circuit adjusts the output electric current of heater constant-current source according to the temperature of rubidium steam chamber, if rubidium steams
The temperature of air chamber is less than 47 DEG C, then the output electric current of heater constant-current source, heats rubidium steam chamber until temperature sensor
Detect that rubidium steam chamber temperature is increased to 53 DEG C, be then shut off heater constant-current source.
The additional modulation field system of optics atom magnetometer includes modulation coil and modulated Field constant-current source.Modulation coil is
To coaxial circular coil, it is arranged on heater outer surface a pair or three, the modulation magnetic field in one or three direction can be produced.Modulation
Coil is driven by modulated Field constant-current source, and modulated Field constant-current source can produce the electric current that frequency is hundreds of hertz to hundreds of megahertz,
Electric current flows through modulation coil, produces modulation magnetic field, the electric current difference that every pair of modulation coil passes through, in order to filter different modulating magnetic field
Between interfere.Modulation magnetic field acts on rubidium atom jointly with optical pumping, and atom aligns.
During the work of optics atom magnetometer, closed loop thermal control system, optical system and additional modulation field system are common
Acting on rubidium steam chamber, atom aligns, and the absorption of rubidium atom pair photon simultaneously will cause rubidium steam chamber emergent light
Changing, photodetector output will be stable sine wave, and frequency is identical with modulation field frequency.Modulated Field constant-current source with add
Hot device constant-current source frequency is different.If brain magnetic signal also acts on rubidium steam chamber, the emergent light of rubidium steam chamber will carry tune simultaneously
Magnetic field processed and the information of brain magnetic signal, photodetector output will be the sine wave after modulating, and phase-sensitive detection circuit can be by electricity
The garbages such as the modulation magnetic field carried in signal filter.Owing to modulated Field constant-current source is different from heater constant-current source frequency, phase
The magnetic field that heater produces can also be filtered by quick detecting circuit, is then stored by signal storage, in case software section
Process.
Portable brain magnetic detection device work process of the present invention is as follows:
The first step, the preheating of optics atom magnetometer array.Drive system is started working, and heater constant current source array exports
Optics atom magnetometer is heated by electric current, and temperature-control circuit is by the temperature sensing within optics atom magnetometer array simultaneously
Device detection temperature, all optics atom magnetometers stop heating after reaching operating temperature.
Second step, self-check of device.Laser source array sends incident laser, and modulated Field constant current source array sends electric current, light
Learn atom magnetometer and enter duty, the shoot laser of photodetector array detection optics atom magnetometer array, phase sensitivity
The output signal of photodetector array is filtered by detecting circuit array, and difference engine array is by corresponding for each Measurement channel
The phase-sensitive detection circuit output phase-sensitive detection circuit corresponding with reference channel exports and subtracts each other, and obtains differential signal and is stored in signal and deposits
Reservoir.If the signal in memory element is zero in detection signal storage, show that device is working properly, if abnormal,
Need device is proofreaded.
3rd step, subjects wears the brain Magnetic testi helmet, setup test.
4th step, formally detects.Optics atom magnetometer collects subjects's brain magnetic signal, and stores signal storage
Device.
5th step, detection of end.Subjects removes the brain Magnetic testi helmet.
Device of the present invention compared with prior art, has the advantage that
First, device of the present invention uses optics atom magnetometer to be sensor measurement brain magnetic signal, compared to tradition
The brain magnetic detection system with superconducting quantum interference device (SQUID) as sensor, its simple in construction, it is not necessary to low-temperature superconducting system, do not dropping
On the premise of low certainty of measurement, reduce cost.
Second, device of the present invention have employed differential configuration, deducts reference channel with the signal that Measurement channel is gathered
The signal gathered is as actual brain magnetic signal output, compared to the method for traditional passive screening building screened room, or
The active shield method of the additional shielded coil of person, this denoising method low cost, volume are little, it is adaptable to mancarried device.
3rd, the method that present invention employs closed loop thermal control carries out temperature control to rubidium steam chamber so that it is temperature can be steady
It is scheduled between 45～55 DEG C, improves the stability of optics atom magnetometer critical component, thus improve the measurement of whole device
Precision.
4th, comprehensive three above advantage, device volume of the present invention is little, lightweight, is a kind of portable brain magnetic survey
Amount device, compared to traditional brain magnetic measuring device, it is not necessary to screened room, low-temperature superconducting system, is following development trend.
Accompanying drawing explanation
Fig. 1 portable brain of the present invention magnetic detection device example structure block diagram；
Fig. 2 is the structure chart of one brain magnetic signal Measurement channel of the present invention；
Fig. 3 is the schematic diagram of storage system of the present invention.
Detailed description of the invention
The present invention is further illustrated below in conjunction with the drawings and specific embodiments.
As it is shown in figure 1, the embodiment of portable brain magnetic detection device of the present invention includes that the brain magnetic measurement helmet 100, optics are former
Sub-magnetometer array, drive system 103, signal detection system 104 and storage system 105.Optics atom magnetometer array
Being embedded on the brain magnetic measurement helmet 100, optics atom magnetometer array is made up of 8 optics atom magnetometer 101a～101h,
It is distributed on the brain magnetic measurement helmet 100.The input of optics atom magnetometer array is connected with the outfan of drive system 103,
The outfan of optics atom magnetometer is connected with the input of signal detection system 104, the first output of signal detection system 104
End is connected with storage system 105, and the second outfan of signal detection system 104 is connected with the input of drive system 103.
Described drive system 103 includes laser source array 106, heater constant current source array 107 and modulated Field constant current
Source array 108.Laser source array 106 is connected with the first input end 102a of optics atom magnetometer array, heater constant current
The outfan of source array 107 is connected with the second input 102b of optics atom magnetometer array, modulated Field constant current source array 108
It is connected with the 3rd input 102c of optics atom magnetometer array.Laser source array 106 is optics atom magnetometer array
Thering is provided incident laser, the heating that heater constant current source array 107 is optics atom magnetometer array provides and adds thermocurrent, modulated Field
Constant current source array 108 provides the electric current producing modulation magnetic field for optics atom magnetometer array.
Described signal detection system 104 includes photodetector array 109, temperature-control circuit array 110 and phase sensitivity
Detecting circuit array 111.The input of photodetector array 109 and the first outfan 102d of optics atom magnetometer array
Connecting, the input of temperature-control circuit array 110 is connected with the second outfan 102e of optics atom magnetometer array, photoelectricity
The outfan of detector array 109 is connected with the input of phase-sensitive detection circuit array 111, temperature-control circuit array 110
Outfan is connected with the input of heater constant current source array 107 in drive system 103.Photodetector array 109 is used for examining
The emergent light of photometry atom magnetometer array output, carries brain magnetic signal in emergent light.Temperature-control circuit array 110 can
The temperature of optics atom magnetometer array to be detected, and adjust heater constant-current source in drive system 103 according to design temperature
The duty of array 107, if the temperature of optics atom magnetometer array is less than design temperature, heater constant current source array
107 start working, and output adds thermocurrent, and otherwise heater constant current source array 107 does not works.Phase-sensitive detection circuit array 110 is used
In filtering, the noise filtering that can will mix in photodetector array 109 output signal.
Described storage system 105 includes difference engine array 112 and signal storage 113.Signal storage 113 is used
Storage in signal.The input of difference engine array 112 and phase-sensitive detection circuit array 111 defeated in signal detection system 106
Going out end to connect, the outfan of difference engine array 112 is connected with signal storage 113.The function of difference engine array 112 is to calculate
Difference between different optics atom magnetometers are signal collected.
Laser source array 106 is made up of the LASER Light Source that 8 structures are identical.Heater constant current source array 107 is by 8 knots
The heater constant-current source composition that structure is identical.Modulated Field constant current source array 108 is made up of the modulated Field constant-current source that 8 structures are identical.
Photodetector array 109 is become by the photoelectricity group detector that 8 structures are identical.Temperature-control circuit array 110 is by 8 structure phases
Same temperature-control circuit composition.Phase-sensitive detection circuit array 111 is made up of 8 phase-sensitive detection circuits.LASER Light Source, heater
The quantity of constant-current source, modulated Field constant-current source, photodetector, temperature-control circuit and phase-sensitive detection circuit and optics atom magnetic strength
The quantity of meter is equal, and optics atom magnetometer one_to_one corresponding.In modulated Field constant current source array 108, each modulated Field constant-current source is adopted
With different power frequencies, different from the frequency of heater constant current source array 107, in order to adjacent signals can be filtered during filtering and adopt
The electromagnetic interference caused by modulation magnetic field or heater between collection passage.
1 LASER Light Source in laser source array 106,1 heater constant current in heater constant current source array 107
1 modulated Field constant-current source in source, modulated Field constant current source array 108,1 photodetector in photodetector array 109,
1 temperature-control circuit in temperature-control circuit array 110 and 1 phase sensitive detection electricity in phase-sensitive detection circuit array 111
Road constitutes the peripheral components of optics atom magnetometer, 1 chip-scale optics atom magnetometer and peripheral components thereof and constitutes a brain
Magnetic signal acquisition passage.The present embodiment has 8 brain magnetic signal acquisition passages, and wherein 1 is reference channel, and remaining 7 for measuring
Passage.
The work process of the present embodiment is as follows:
The first step, the preheating of optics atom magnetometer.Optics atom magnetometer drive system 103 is started working, heater
Constant current source array 107 exports electric current and heats optics atom magnetometer, temperature-control circuit 110 channel optical atom magnetic strength simultaneously
Temperature sensor detection temperature within Ji, optics atom magnetometer 101a～101h stops heating after all reaching operating temperature.
Second step, self-check of device.Laser source array 106 sends incident laser, and modulated Field constant current source array 108 sends electricity
Stream, optics atom magnetometer 101a～101h enters duty.Photodetector array 109 detects optics atom magnetometer battle array
The shoot laser of row, the output signal of photodetector array 109 is filtered by phase-sensitive detection circuit array 111, difference engine
Array 112 is by phase-sensitive detection circuit output corresponding with reference channel for the output of phase-sensitive detection circuit corresponding for each Measurement channel
Subtract each other, obtain differential signal and be stored in signal storage 113.If the signal in memory element in detection signal storage 113
It is zero, shows that device is working properly, if abnormal, need device is proofreaded.
3rd step, subjects wears the brain Magnetic testi helmet 100, setup test.
4th step, formally detects.Optics atom magnetometer 101a～101h collects subjects's brain magnetic signal, and storage is arrived
Signal storage 113.
5th step, detection of end, subjects removes the brain Magnetic testi helmet 100.
Fig. 2 show the structure chart of 1 brain magnetic signal acquisition passage of the present invention.As in figure 2 it is shown, 1 brain magnetic signal acquisition
Passage includes chip-scale optics atom magnetometer and peripheral components two large divisions.Chip-scale optics atom magnetometer includes rubidium steam
Room 200, heater 201, temperature sensor 202, modulation coil 203, incident optical 204, entrance prism 205, outgoing prism
206, lens 207, outgoing optical fiber 208 and shell 209.Rubidium steam chamber 200, heater 201, temperature sensor 202, modulation coil
203, entrance prism 205, outgoing prism 206 and lens 207 are encapsulated in shell 209 inside.Chip-scale optics atom magnetometer has
Five ports: first input port the 211, second input port the 212, the 3rd input port the 213, first output port 214, and
Second output port 215, it is outside that these ports are positioned at shell 209, is connected with the parts within shell 209 by extended line 210.
The input of incident optical 204 is connected with first input port 211, and incident optical 204 passes shell 209, incident optical 204
Outfan is connected with the plane of incidence of entrance prism 205, and the outfan of outgoing optical fiber 208 connects the first outfan 214 mouthfuls, emergent light
Fine 208 through shell 209, and the input of outgoing optical fiber 208 is connected with the exit facet of lens 207, the plane of incidence of lens 207 with go out
The exit facet penetrating prism 206 connects, and heater 201 is connected with the second input port 212, modulation coil 203 and the 3rd input
Mouth 213 connects, and temperature sensor 202 connects the second output port 215.The volume of one chip-scale optics atom magnetometer is less than
2 cubic centimetres, the length of extended line 210 is between 30 centimetres to 2 meters.Peripheral components includes LASER Light Source 216, heater constant current
Source 219, modulated Field constant-current source 218, temperature-control circuit 217, photodetector 220, phase-sensitive detection circuit 221, and signal
Memorizer 222.LASER Light Source 216 is connected with first input port 211, the outfan of heater constant-current source 219 and the second input
Port 212 connects, and modulated Field constant-current source 218 is connected with the 3rd input port 213, and the input of photodetector 220 is connected to
First output port 214, input and second output port 215 of temperature-control circuit 217 connect.Heater constant-current source 219
Input be connected with the outfan of temperature-control circuit 217.The outfan of photodetector 220 and phase-sensitive detection circuit 221
Input connect, the outfan of phase-sensitive detection circuit 221 is connected with the input of signal storage 222.
Rubidium steam chamber 200 is the core component of optics atom magnetometer, and what the present invention used rubidium steam chamber is cylinder
Shape, side is transparent surface.Except natural rubidium in rubidium steam chamber, also it is filled with the buffer gas polarized state with maintenance rubidium atom,
The buffer gas being filled with is neon, and pressure is about 133Pa.In order to strengthen the effect of optical pumping, it is necessary to improve gas by heating
The number of state rubidium atom.The oplical pumping signal of rubidium is the most sensitive to variations in temperature, must keep rubidium steam chamber during measurement
Temperature constant.Rubidium steam chamber 200 is wrapped up by heater 201, and heater 201 outward appearance is cube, and there is the electricity for heating inside
Resistance silk, remainder is made from a material that be thermally conductive.Rubidium steam chamber 200 surface is mounted with temperature sensor 202 simultaneously, can measure in real time
Rubidium steam chamber temperature.Modulation coil 203 be a pair or three to coaxial circular coil, be arranged on heater outer surface, one can be produced
Individual or the modulation magnetic field in three directions.Incident optical 204, entrance prism 205 and outgoing prism 206, lens 207, outgoing optical fiber
208 light paths constituting optics atom magnetometer, wherein entrance prism 205 and outgoing prism 206 are fixed on outside heater 201
Surface, heater 201 with entrance prism 205, outgoing prism 206 interface at perforate, in order to laser can pass in hole
And irradiate rubidium steam chamber 200.Lens 207 are arranged between outgoing prism 206 and outgoing optical fiber 208, can be converged by emergent light
Get up to enter back into outgoing optical fiber 208.
The operation principle of following description optics atom magnetometer.
The first step, rubidium steam chamber is heated by heater 201, and makes by the electric current that heater constant-current source 219 produces
It is stable in operating temperature, and 45～55 DEG C, temperature sensor simultaneously 202 is started working, rubidium steam chamber 200 temperature measurement arrived
Information is sent to temperature-control circuit 217 in real time, and temperature-control circuit 217 adjusts heater according to the temperature of rubidium steam chamber 200
The output electric current of constant-current source 219, if the temperature of rubidium steam chamber 200 is less than 47 DEG C, then increases the output of heater constant-current source 219
Electric current, heats rubidium steam chamber 200 until temperature is increased to 53 DEG C, is then shut off heater constant-current source 219.
Second step, it is the left-handed of 795nm or right-circularly polarized light that LASER Light Source 216 sends wavelength, and laser enters incident illumination
Fine 204, then arrive entrance prism 205, after entrance prism 205 light splitting, irradiated rubidium steam chamber by the perforate on heater
200, laser by after rubidium steam chamber 200 again by outgoing prism 206 light splitting, the emergent light of outgoing prism 206 is received by lens 207
Enter emergent light fibre 208 after collection, focusing, finally detected final emergent light by photodetector 220.In rubidium steam chamber 200
There is energy level transition in rubidium atom under laser irradiates, by " pumping " to high level state, optical pumping makes atom integrated distribution in certain
On the sub-energy level that individual energy level is higher.
3rd step, modulated Field constant-current source 219 produces the electric current that frequency is hundreds of hertz to hundreds of megahertz, and electric current flows through tune
Coil 203 processed, produces modulation magnetic field, and modulation magnetic field acts on jointly with optical pumping, and atom aligns.
4th step, during measurement, brain magnetic signal, to the atom generation effect in rubidium steam chamber 200, affects its suction to photon
Receive, thus change the transmission light of rubidium steam chamber 200, counter can push away brain magnetic signal from the change of transmission light.
5th step, photodetector 220 detects the emergent light carrying brain magnetic signal, is translated into the signal of telecommunication, and passes
Delivering to phase-sensitive detection circuit 221, garbages such as carrying modulation magnetic field in the signal of telecommunication is filtered, afterwards by phase-sensitive detection circuit 221
The useful signal storage 222 that is sent to store.
Fig. 3 show storage system schematic diagram of the present invention.
In conjunction with Fig. 1, Fig. 2, Fig. 3, storage system principle is described.Storage system include 7 difference engine 301a～
301g and 1 signal storage 300.Each difference engine has two inputs, first input end and difference engine place Measurement channel
Phase-sensitive detection circuit outfan connect, the second input is connected with the phase-sensitive detection circuit outfan of reference channel.7 differences
The output dividing device is all connected to signal storage 300.Such as in Fig. 1 optics atom magnetometer 101h place brain magnetic signal acquisition passage
It is Measurement channel for reference channel, optics atom magnetometer 101a～101g place signal sampling channel, optics atom magnetometer
The signal that 101a～101h measures is exported, often by 8 identical phase-sensitive detection circuits in phase-sensitive detection circuit array 113
Individual phase-sensitive detection circuit all has structure and the function of photodetector 221 in Fig. 2.So first input end of 7 difference engines
The signal detected corresponding to optics atom magnetometer 101a～101g, the second input of 7 difference engines is former corresponding to optics
The signal that sub-gaussmeter 101h detects.The outfan of 7 difference engines is that optics atom magnetometer 101a～101g detects
The difference of the signal that signal detects with optics atom magnetometer 101h.
The function of difference engine is to calculate the difference of two channel signals.The signal arrived due to optics atom magnetometer measurement
In contain many interference factors such as earth's magnetic field, power frequency magnetic field, use the differential signal can be by two optics atom magnetometers
Identical noise section subtracts each other, and obtain is the difference of signal between two passages.During actual application, can be by 8 brain magnetic letters
In number acquisition channel one, as in Fig. 1, optics atom magnetometer 101h place brain magnetic signal acquisition passage is set to reference channel,
Its position is at the edge of the brain magnetic measurement helmet 100, such as left ear side.At this moment it is believed that optics atom magnetometer 101h gathers
To signal do not contain brain magnetic signal, only noise information.The signal that remaining optics atom magnetometer collects has brain simultaneously
Magnetic information and noise information.The signal phase that the signal that so optics atom magnetometer 101a～101g records all records with 101h
Subtract, thus filter noise.
Claims (10)
1. a portable brain magnetic detection device, is characterized in that: described portable brain magnetic detection device includes brain magnetic measurement head
Helmet (100), optics atom magnetometer array, drive system (103), signal detection system (104) and storage system
(105)；Optics atom magnetometer array is uniformly embedded on the brain magnetic measurement helmet (100)；Optics atom magnetometer array defeated
Enter end to be connected with the outfan of drive system (103), the outfan of optics atom magnetometer array and signal detection system (104)
Input connect, the first outfan of signal detection system (104) is connected with storage system (105), signal detection system
Second outfan of system (104) is connected with the input of drive system (103)；Optics atom magnetometer array is adopted as sensor
Collection brain magnetic signal；The effect of drive system (103) is to maintain optics atom magnetometer normal operating conditions；Signal detection system
(104) for identifying the output signal of optics atom magnetometer, the storage of storage system (105) complete pair signals.
2. according to the portable brain magnetic detection device described in claim 1, it is characterized in that: described drive system (103) includes
Laser source array (106), heater constant current source array (107) and modulated Field constant current source array (108)；Laser source array
(106) it is connected with the first input end (102a) of optics atom magnetometer array, the outfan of heater constant current source array (107)
It is connected with second input (102b) of optics atom magnetometer array, modulated Field constant current source array (108) and optics nonmagnetic atom
3rd input (102c) of strong meter array connects；Laser source array (106) provides incidence for optics atom magnetometer array
Laser, the heating that heater constant current source array (107) is optics atom magnetometer array provides and adds thermocurrent, modulated Field constant-current source
Array (108) provides the electric current producing modulation magnetic field for optics atom magnetometer array.
3. according to the portable brain magnetic detection device described in claim 1, it is characterized in that: described signal detection system (104)
Including photodetector array (109), temperature-control circuit array (110) and phase-sensitive detection circuit array (111)；Photodetection
The input of device array (109) is connected with first outfan (102d) of optics atom magnetometer array, temperature-control circuit battle array
The input of row (110) is connected with second outfan (102e) of optics atom magnetometer array, photodetector array (109)
Outfan be connected with the input of phase-sensitive detection circuit array (111), the outfan of temperature-control circuit array (110) with drive
In dynamic system (103), the input of heater constant current source array (107) connects；Photodetector array (109) is used for detecting light
Learn the emergent light of atom magnetometer array output, emergent light carries brain magnetic signal；Temperature-control circuit array (110) detects
The temperature of optics atom magnetometer array, and adjust heater constant current source array in drive system (103) according to the temperature set
(107) duty, if the temperature of optics atom magnetometer array is less than design temperature, heater constant current source array
(107) starting working, output adds thermocurrent, and otherwise heater constant current source array (107) does not works；Phase-sensitive detection circuit array
(110) it is used for filtering, the noise filtering that will mix in photodetector array (109) output signal.
4. according to the portable brain magnetic detection device described in claim 1, it is characterized in that: described storage system (105)
Including difference engine array (112) and signal storage (113)；The input of difference engine array (112) and signal detection system
(106) in, the outfan of phase-sensitive detection circuit array (111) connects, the outfan of difference engine array (112) and signal storage
(113) connect；Difference engine array (112) calculate between the signal that different optics atom magnetometer measurement is arrived difference, signal
Memorizer (113) stores for signal.
5. according to the portable brain magnetic detection device described in claim 1, it is characterized in that: described optics atom magnetometer array
It is made up of multiple identical chip-scale optics atom magnetometers；Laser source array (106) is by the identical laser light of multiple structures
Source forms；Described heater constant current source array (107) is made up of the heater constant-current source that multiple structures are identical；Modulated Field constant current
Source array (108) is made up of the modulated Field constant-current source that multiple structures are identical；Photodetector array (109) is identical by multiple structures
Photodetector composition；Temperature-control circuit array (110) is made up of the temperature-control circuit that multiple structures are identical；Phase sensitivity is examined
Wave circuit array (111) is made up of the phase-sensitive detection circuit that multiple structures are identical；LASER Light Source, heater constant-current source, modulated Field
The quantity of constant-current source, photodetector, temperature-control circuit and phase-sensitive detection circuit is equal with the quantity of optics atom magnetometer,
And with optics atom magnetometer one_to_one corresponding；1 LASER Light Source, 1 heater constant-current source, 1 modulated Field constant-current source, 1 light
Electric explorer, 1 temperature-control circuit, 1 phase-sensitive detection circuit constitute the peripheral components of optics atom magnetometer, 1 chip
Level optics atom magnetometer and peripheral components thereof constitute a brain magnetic signal acquisition passage.
6. according to the portable brain magnetic detection device described in claim 4 or 5, it is characterized in that: described difference engine array (112)
The difference engine identical by multiple structures forms, and each difference engine has two inputs, first input end to adopt with place brain magnetic signal
The outfan of the phase-sensitive detection circuit in the Measurement channel of collection passage connects, the second input and place brain magnetic signal acquisition passage
Reference channel phase-sensitive detection circuit outfan connect；The outfan of difference engine and the signal of place brain magnetic signal acquisition passage
Memorizer connects.
7. according to the portable brain magnetic detection device described in claim 1, it is characterized in that: a described brain magnetic signal acquisition leads to
Road includes a chip-scale optics atom magnetometer and peripheral components two large divisions；One chip-scale optics atom magnetometer includes
Rubidium steam chamber (200), heater (201), temperature sensor (202), modulation coil (203), incident optical (204), incident rib
Mirror (205), outgoing prism (206), lens (207), outgoing optical fiber (208), shell (209) and extended line (210), rubidium steam chamber
(200), heater (201), temperature sensor (202), modulation coil (203), entrance prism (205), outgoing prism (206) and
It is internal that lens (207) are encapsulated in shell (209), and a chip-scale optics atom magnetometer has five ports: first input port
(211), the second input port (212), the 3rd input port (213), the first output port (214) and the second output port
(215), it is outside that these ports are positioned at shell (209), and the parts internal with shell (209) by extended line (210) are connected；Incident
The input of optical fiber (204) is connected with first input port (211), and incident optical (204) passes shell (209), incident optical
(204) outfan is connected with the plane of incidence of entrance prism (205), and the outfan of outgoing optical fiber (208) connects the first outfan
Mouth (214), outgoing optical fiber (208) passes shell (209), and the input of outgoing optical fiber (208) connects with the exit facet of lens (207)
Connect；The plane of incidence of lens (207) is connected with the exit facet of outgoing prism (206), heater (201) and the second input port
(212) connecting, modulation coil (203) is connected with the 3rd input port (213), and temperature sensor (202) connects the second outfan
Mouth (215)；Described peripheral components include LASER Light Source (216), heater constant-current source (219), modulated Field constant-current source (218),
Temperature-control circuit (217), photodetector (220), phase-sensitive detection circuit (221) and signal storage (222)；LASER Light Source
(216) being connected with first input port (211), the outfan of heater constant-current source (219) and the second input port (212) are even
Connecing, modulated Field constant-current source (218) is connected with the 3rd input port (213), the input of photodetector (220) and the first output
Port (214) connects, and the input of temperature-control circuit (217) and the second output port (215) connect；Heater constant-current source
(219) input is connected with the outfan of temperature-control circuit (217)；The outfan of photodetector (220) is examined with phase sensitivity
The input of wave circuit (221) connects, and the outfan of phase-sensitive detection circuit (221) connects with the input of signal storage (222)
Connect.
8. according to the portable brain magnetic detection device described in claim 7, it is characterized in that: described rubidium steam chamber (200) is circle
Cylindricality, side is transparent surface；Except natural rubidium in rubidium steam chamber (200), also it is filled with buffer gas to maintain the pole of rubidium atom
Change state, the buffer gas being filled with is neon, and pressure is 133Pa；Described heater (201), temperature sensor (202), add
Hot device constant-current source (219) and temperature-control circuit (217) constitute the closed loop thermal control system of rubidium steam chamber (200)；Described
Rubidium steam chamber (200) wrapped up by heater (201), the internal resistance wire having for heating of heater (201), remainder by
Heat Conduction Material is made；Rubidium steam chamber (200) surface is provided with temperature sensor, measures the temperature of rubidium steam chamber (200) in real time；Institute
Heater (201), temperature sensor (202), heater constant-current source (219) and the temperature-control circuit (217) stated constitute rubidium
The closed loop thermal control system of steam chamber (200)；When the closed loop thermal control system of rubidium steam chamber (200) works, heater is permanent
Rubidium steam chamber (200) is heated by the electric current that stream source (219) produces by heater (201), and stabilizes it in operating temperature 45
～55 DEG C, temperature sensor simultaneously (202) is started working, by measurement to rubidium steam chamber (200) temperature information be sent in real time
Temperature-control circuit (217), temperature-control circuit (217) adjusts heater constant-current source according to the temperature of rubidium steam chamber (200)
(219) output electric current, if the temperature of rubidium steam chamber (200) is less than 47 DEG C, then increases the output of heater constant-current source (219)
Electric current, heats until temperature is increased to 53 DEG C rubidium steam chamber (200), is then shut off heater constant-current source (219)；Measure
Time, brain magnetic signal, to the atom generation effect in described rubidium steam chamber (200), affects its absorption to photon, thus changes
The transmission light of rubidium steam chamber (200), change from transmission light is counter pushes away brain magnetic signal；Photodetector (220) detects and carries brain
The emergent light of magnetic signal, is translated into the signal of telecommunication, and is sent to phase-sensitive detection circuit (221), and phase-sensitive detection circuit (221) will
The garbages such as the modulated Field carried in the signal of telecommunication filter, and useful information is sent to signal storage (222) storage.
9. according to the portable brain magnetic detection device described in claim 7, it is characterized in that: described incident optical (204), incident
Prism (205), outgoing prism (206), lens (207), outgoing optical fiber (208) constitute the light path of optics atom magnetometer；Incident
Prism (205) and outgoing prism (206) are fixed on the outer surface of heater (201), heater (201) with entrance prism
(205) and outgoing prism rib (206) interface perforate, laser in hole through and irradiate rubidium steam chamber (200)；Lens (207)
It is arranged between outgoing prism (206) and outgoing optical fiber (208), converges to get up to enter back into outgoing optical fiber (208) by emergent light；Swash
It is the left-handed of 795nm or right-circularly polarized light that radiant (216) sends wavelength, and laser enters incident optical (204), then arrives
Entrance prism (205), is irradiated rubidium steam chamber (200) by the perforate on heater (201) after entrance prism (205) light splitting,
Laser by the transmission light after rubidium steam chamber (200) again by outgoing prism (206) light splitting, the emergent light of outgoing prism (206) by
Lens (207) collect, focus on after to enter emergent light fine (208), finally detected final emergent light by photodetector (220)；
Rubidium atom in rubidium steam chamber (200) absorbs photon under laser irradiates, and energy level transition occurs, by " pumping " to high level shape
State, optical pumping makes atom integrated distribution on the sub-energy level that certain energy level is higher.Owing to the energy of laser changes, rubidium steams
The transmission light of air chamber (200) contains the information of rubidium state of atom.
10. according to the portable brain magnetic detection device described in claim 7, it is characterized in that: described modulation coil (203) is one
To or three to coaxial circular coil, be arranged on the outer surface of heater (201), modulation coil (203) produces one or three sides
To modulation magnetic field；Described modulated Field constant-current source (218) produces the electric current that frequency is hundreds of hertz to hundreds of megahertz, electric current
Flowing through modulation coil (203), produce modulation magnetic field, modulated Field acts on jointly with optical pumping, makes rubidium atom align.Modulation lines
Circle is driven by modulated Field constant-current source, and the electric current that modulated Field constant-current source produces flows through modulation coil, produces modulation magnetic field, modulates magnetic field
Jointly act on rubidium atom with optical pumping, make rubidium atom align；The electric current difference that every pair of modulation coil passes through, in order to
Interfering between different modulating magnetic field is filtered during Filtering Processing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610367559.7A CN106073751B (en) | 2016-05-30 | 2016-05-30 | A kind of portable brain magnetic detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610367559.7A CN106073751B (en) | 2016-05-30 | 2016-05-30 | A kind of portable brain magnetic detection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106073751A true CN106073751A (en) | 2016-11-09 |
| CN106073751B CN106073751B (en) | 2019-06-04 |
Family
ID=57230279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610367559.7A Active CN106073751B (en) | 2016-05-30 | 2016-05-30 | A kind of portable brain magnetic detection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106073751B (en) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106725342A (en) * | 2017-01-09 | 2017-05-31 | 上海理工大学 | Magneticencephalogram detection means based on vector whirlpool light beam |
| CN106859599A (en) * | 2017-01-23 | 2017-06-20 | 上海理工大学 | Magneticencephalogram system and acquisition methods based on the detection of full light atomic magnetic force |
| CN108459282A (en) * | 2018-01-30 | 2018-08-28 | 中国科学院生物物理研究所 | Magneticencephalogram detection device and method based on atom magnetometer/gradometer |
| CN109567785A (en) * | 2018-12-05 | 2019-04-05 | 北京昆迈生物医学研究院有限公司 | A kind of quantum magneticencephalogram system and method based on magnetic shielding cylinder |
| CN109567784A (en) * | 2018-12-05 | 2019-04-05 | 北京昆迈生物医学研究院有限公司 | A kind of wearable portable quantum magneticencephalogram system and method |
| CN110477898A (en) * | 2019-08-28 | 2019-11-22 | 张海军 | A kind of wearable medical monitoring device and system based on weak magnetic detection |
| WO2020060652A1 (en) * | 2018-09-18 | 2020-03-26 | Hi Llc | Dynamic magnetic shielding and beamforming using ferrofluid for compact magnetoencephalography (meg) |
| US10627460B2 (en) | 2018-08-28 | 2020-04-21 | Hi Llc | Systems and methods including multi-mode operation of optically pumped magnetometer(s) |
| CN111035386A (en) * | 2018-10-12 | 2020-04-21 | 中国科学院物理研究所 | Miniature SERF type magnetometer, use method and application thereof |
| US10976386B2 (en) | 2018-07-17 | 2021-04-13 | Hi Llc | Magnetic field measurement system and method of using variable dynamic range optical magnetometers |
| US10983177B2 (en) | 2018-08-20 | 2021-04-20 | Hi Llc | Magnetic field shaping components for magnetic field measurement systems and methods for making and using |
| CN113093065A (en) * | 2021-03-23 | 2021-07-09 | 北京未磁科技有限公司 | Atomic magnetometer and magnetic field detection device |
| CN113171098A (en) * | 2021-05-06 | 2021-07-27 | 中国科学院上海光学精密机械研究所 | Detection device and detection method for magnetoencephalography signals in cerebral oscillation |
| CN113311369A (en) * | 2021-05-28 | 2021-08-27 | 清华大学 | Microminiature atomic magnetometer and magnetic imaging system based on optical fiber circulator |
| CN113827246A (en) * | 2021-11-25 | 2021-12-24 | 北京航空航天大学杭州创新研究院 | Magnetoencephalography data acquisition and analysis method and system |
| US11262420B2 (en) | 2018-08-17 | 2022-03-01 | Hi Llc | Integrated gas cell and optical components for atomic magnetometry and methods for making and using |
| US11294008B2 (en) | 2019-01-25 | 2022-04-05 | Hi Llc | Magnetic field measurement system with amplitude-selective magnetic shield |
| CN115932677A (en) * | 2022-12-22 | 2023-04-07 | 中科知影(北京)科技有限公司 | Local magnetic field compensation device, magnetic field compensation system and method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102316799A (en) * | 2009-02-11 | 2012-01-11 | 皇家飞利浦电子股份有限公司 | Method and system of tracking and mapping in a medical procedure |
| CN103188992A (en) * | 2010-09-10 | 2013-07-03 | 柯尼卡美能达先进多层薄膜株式会社 | Biomagnetism measuring device, biomagnetism measuring system, and biomagnetism measuring method |
| CN103744034A (en) * | 2013-12-30 | 2014-04-23 | 浙江大学 | Difference method for improving sensitivity and absolute precision of CPT (Coherent Population Trapping) atom magnetometer |
| CN105147289A (en) * | 2015-08-18 | 2015-12-16 | 高家红 | MEG system and method based on atom magnetometer |
| CN105223524A (en) * | 2015-11-06 | 2016-01-06 | 无锡清杨机械制造有限公司 | A kind of optically pumped magnetometer |
-
2016
- 2016-05-30 CN CN201610367559.7A patent/CN106073751B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102316799A (en) * | 2009-02-11 | 2012-01-11 | 皇家飞利浦电子股份有限公司 | Method and system of tracking and mapping in a medical procedure |
| CN103188992A (en) * | 2010-09-10 | 2013-07-03 | 柯尼卡美能达先进多层薄膜株式会社 | Biomagnetism measuring device, biomagnetism measuring system, and biomagnetism measuring method |
| CN103744034A (en) * | 2013-12-30 | 2014-04-23 | 浙江大学 | Difference method for improving sensitivity and absolute precision of CPT (Coherent Population Trapping) atom magnetometer |
| CN105147289A (en) * | 2015-08-18 | 2015-12-16 | 高家红 | MEG system and method based on atom magnetometer |
| CN105223524A (en) * | 2015-11-06 | 2016-01-06 | 无锡清杨机械制造有限公司 | A kind of optically pumped magnetometer |
Non-Patent Citations (1)
| Title |
|---|
| 李曙光: "原子磁力仪的研究", 《中国博士学位论文全文数据库 基础科学辑》 * |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106725342A (en) * | 2017-01-09 | 2017-05-31 | 上海理工大学 | Magneticencephalogram detection means based on vector whirlpool light beam |
| CN106859599A (en) * | 2017-01-23 | 2017-06-20 | 上海理工大学 | Magneticencephalogram system and acquisition methods based on the detection of full light atomic magnetic force |
| CN106859599B (en) * | 2017-01-23 | 2020-05-15 | 上海理工大学 | Magnetoencephalogram system based on all-optical atomic magnetic detection and acquisition method |
| CN108459282A (en) * | 2018-01-30 | 2018-08-28 | 中国科学院生物物理研究所 | Magneticencephalogram detection device and method based on atom magnetometer/gradometer |
| US10976386B2 (en) | 2018-07-17 | 2021-04-13 | Hi Llc | Magnetic field measurement system and method of using variable dynamic range optical magnetometers |
| US11262420B2 (en) | 2018-08-17 | 2022-03-01 | Hi Llc | Integrated gas cell and optical components for atomic magnetometry and methods for making and using |
| US10983177B2 (en) | 2018-08-20 | 2021-04-20 | Hi Llc | Magnetic field shaping components for magnetic field measurement systems and methods for making and using |
| US11307272B2 (en) | 2018-08-28 | 2022-04-19 | Hi Llc | Systems and methods including multi-mode operation of optically pumped magnetometer(s) |
| US10627460B2 (en) | 2018-08-28 | 2020-04-21 | Hi Llc | Systems and methods including multi-mode operation of optically pumped magnetometer(s) |
| US10877111B2 (en) | 2018-08-28 | 2020-12-29 | Hi Llc | Systems and methods including multi-mode operation of optically pumped magnetometer(s) |
| WO2020060652A1 (en) * | 2018-09-18 | 2020-03-26 | Hi Llc | Dynamic magnetic shielding and beamforming using ferrofluid for compact magnetoencephalography (meg) |
| US11237225B2 (en) | 2018-09-18 | 2022-02-01 | Hi Llc | Dynamic magnetic shielding and beamforming using ferrofluid for compact Magnetoencephalography (MEG) |
| CN111035386A (en) * | 2018-10-12 | 2020-04-21 | 中国科学院物理研究所 | Miniature SERF type magnetometer, use method and application thereof |
| CN111035386B (en) * | 2018-10-12 | 2024-03-22 | 中国科学院物理研究所 | Miniature SERF magnetometer, use method and application thereof |
| CN109567784A (en) * | 2018-12-05 | 2019-04-05 | 北京昆迈生物医学研究院有限公司 | A kind of wearable portable quantum magneticencephalogram system and method |
| CN109567785A (en) * | 2018-12-05 | 2019-04-05 | 北京昆迈生物医学研究院有限公司 | A kind of quantum magneticencephalogram system and method based on magnetic shielding cylinder |
| US11294008B2 (en) | 2019-01-25 | 2022-04-05 | Hi Llc | Magnetic field measurement system with amplitude-selective magnetic shield |
| CN110477898A (en) * | 2019-08-28 | 2019-11-22 | 张海军 | A kind of wearable medical monitoring device and system based on weak magnetic detection |
| CN113093065A (en) * | 2021-03-23 | 2021-07-09 | 北京未磁科技有限公司 | Atomic magnetometer and magnetic field detection device |
| CN113171098A (en) * | 2021-05-06 | 2021-07-27 | 中国科学院上海光学精密机械研究所 | Detection device and detection method for magnetoencephalography signals in cerebral oscillation |
| CN113311369A (en) * | 2021-05-28 | 2021-08-27 | 清华大学 | Microminiature atomic magnetometer and magnetic imaging system based on optical fiber circulator |
| CN113827246A (en) * | 2021-11-25 | 2021-12-24 | 北京航空航天大学杭州创新研究院 | Magnetoencephalography data acquisition and analysis method and system |
| CN115932677A (en) * | 2022-12-22 | 2023-04-07 | 中科知影(北京)科技有限公司 | Local magnetic field compensation device, magnetic field compensation system and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106073751B (en) | 2019-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106073751A (en) | A kind of portable brain magnetic detection device | |
| US11903713B2 (en) | Biofeedback for awareness and modulation of mental state using a non-invasive brain interface system and method | |
| US11022658B2 (en) | Neural feedback loop filters for enhanced dynamic range magnetoencephalography (MEG) systems and methods | |
| Knappe et al. | Optically pumped magnetometers for MEG | |
| CN109998519A (en) | A kind of magnetocardiogram measurement and magnetocardiogram generation system based on SERF atom magnetometer | |
| Shah et al. | A compact, high performance atomic magnetometer for biomedical applications | |
| Colombo et al. | Four-channel optically pumped atomic magnetometer for magnetoencephalography | |
| US20210139742A1 (en) | Methods and systems for homogenous optically-pumped vapor cell array assembly from discrete vapor cells | |
| CN107562188A (en) | Brain machine interface system and its application method based on atom magnetometer | |
| Nardelli et al. | A conformal array of microfabricated optically-pumped first-order gradiometers for magnetoencephalography | |
| CN102697487B (en) | System and method for using light modulation to measure physiological data | |
| US8334690B2 (en) | Atomic magnetometer and method of sensing magnetic fields | |
| CN103987316B (en) | Measurement equipment, measuring method | |
| CN105147289B (en) | MEG system and methods based on atomic magnetic force meter | |
| CN108459282A (en) | Magneticencephalogram detection device and method based on atom magnetometer/gradometer | |
| CN107044959B (en) | Micro- multi-modal fusion spectral detection system | |
| WO2011148948A1 (en) | Brain function measuring device | |
| CN103987317B (en) | Measurement equipment and method | |
| CN110123281A (en) | Actuated in parallel based on locking phase photon counting technique spreads optical tomography imaging device | |
| Li et al. | TDLAS tomography system for online imaging and dynamic process playback of temperature and gas mole fraction | |
| Schneiderman et al. | On-scalp MEG | |
| Coussens et al. | A modular optically pumped magnetometer system | |
| CN107422287B (en) | A kind of virtualization biscuit porcelain resonance signal synchronization motivationtheory and detection method and device | |
| Dawson et al. | Portable single-beam cesium zero-field magnetometer for magnetocardiography | |
| Limes et al. | Total-field atomic gradiometer for unshielded portable magnetoencephalography |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |