CN106072602A - Nurse one's health and strengthen compositions and the preparation thereof of human detoxification beautifying function - Google Patents
Nurse one's health and strengthen compositions and the preparation thereof of human detoxification beautifying function Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of conditioning and strengthen the compositions of human detoxification beautifying function, described compositions is mainly prepared from by the raw material of following weight portion is processed: lycopene, monascus, Semen Persicae, Fructus Mume, Flos abelmoschi manihot, water Medulla Junci, taurine, Semen Coicis, Herba Pogostemonis, Rhizoma Polygonati Odorati, Radix Puerariae and Flos Chrysanthemi.Said composition is used for being prepared as chewable tablet and eats, and convenient, mouthfeel is good, has the health maintenance effect of fabulous eliminating toxin and beautifying the skin.
Description
Technical field
The invention belongs to field of health care food, particularly to a kind of conditioning and the compositions of enhancing human detoxification beautifying function
And preparation and preparation method.
Background technology
Along with the raising of people's living standard, the high protein daily intaked, high heat oiliness food too much, city in addition
The operating pressure of working clan is big, and rhythm of life is fast, life style not science, and fast food is taken in too much, has increased the weight of the negative of liver
Load, affects the liver function of people, cause that complexion is gloomy, lassitude, dizzy tinnitus, hypomnesis, inappetence, four
How myasthenia of limbs, improve this situation, cures the disease in not sick, though the most famous kind of nutrient and healthcare products, specific aim is equal
The strongest, it is difficult to meet liver and be in the demand of sub-health state crowd.Traditional Chinese medical science aspect then has the magistral medicines of Various Complex, has pin
The health maintenance effect of the eliminating toxin and beautifying the skin stronger to property.But people are difficult to have the time to adhere to conditioning health of taking medicine, and medicine mouthfeel is not
Good also have certain side effect.How organically to be combined by Chinese medicine and food and carry out dietetic therapy, still there is well spy
Suo Yiyi；Applicant, according to this problem, develops conditioning and strengthens compositions and the health food of human detoxification beautifying function, no
Only instant is quick, also has the health-care effect of conditioning health.
Summary of the invention
In order to solve above-mentioned technical problem, the present invention provides a kind of conditioning and strengthens the combination of human detoxification beautifying function
Thing, has the health maintenance effect of eliminating toxin and beautifying the skin.
The concrete technical scheme of the present invention is as follows:
The present invention provides a kind of conditioning and strengthens the compositions of human detoxification beautifying function, and described crude drug is by following weight
The raw material of part is prepared from:
Further improving, described crude drug is made up of the component of following parts by weight:
Wherein, the lycopene in described crude drug is powder, and the lycopene in described compositions is by adding microcapsule
Change adjuvant and make the lycopene microcapsule that particle size range is 1-50 μm.By lycopene is made microcapsule, play and carry further
The stability of high medicine, improves bioavailability.
For realizing above-mentioned purpose further, described microencapsulation adjuvant includes Rhizoma Atractylodis oil 2-8 weight portion, polypropylene acid resin
0.8-1.4 weight portion and sodium lauryl sulphate 0.2-1.2 weight portion.Wherein, polypropylene acid resin and the mixing of Rhizoma Atractylodis oil
Thing, as capsule material, improves the stability of medicine, and its microcapsule structure prepared can also control sustained drug release, can reduce use
Medicine frequency；And the auxiliary use in sodium lauryl sulphate further enhancing the dispersion of capsule material.
Described microencapsulation adjuvant also includes maltose alcohol 0.2-0.8 weight portion and polyvinylpyrrolidone 0.4-1 weight
Part.Maltose alcohol and polyvinylpyrrolidone are used in conjunction with for completely cutting off intergranular the most chimeric, reduce intergranular rubbing
Wiping power, thus reach to improve raising mobility purpose；Meanwhile, polyvinylpyrrolidone can improve microencapsulation effect, reduces granule
Between adhesion, be beneficial to molding.
For having preferably edible taste and mode, the conditioning of the present invention and the compositions of enhancing human detoxification beautifying function
Preparation made by adjuvant, and the most described preparation is chewable tablet, and described compositions is 1:0.3-1 with the ratio of weight and number of pharmaceutical adjunct:
4；Described pharmaceutical adjunct include aspartame 6-18 weight portion, xylitol 10-30 weight portion, Radix Dauci Sativae essence 10-20 weight portion and
Microcrystalline Cellulose 20-55 weight portion.Make preparation have good mouthfeel by the pharmaceutical adjunct added, be effectively improved this granule
Bitter taste, makes people be prone to receive the mouthfeel of this medicine.And the molding adding beneficially tablet of microcrystalline Cellulose, improve medicine
Stability, improves the disintegrating property of tablet simultaneously.
Further pharmaceutical adjunct of the present invention also includes colloidality silica 1 0-20 weight portion, sodium starch glycol 6-
20 weight portions and triolein 2-10 weight portion.Further by sodium starch glycol and microcrystalline Cellulose in the program
Being used in conjunction with improving the collaborative disintegration of tablet, disintegrating property is more preferably；The interpolation of triolein then increases the cunning of granule
Dynamic property, makes that filling is good, tablet Density Distribution is uniform, it is ensured that release the complete of tablet.
Further in improvement project, described crude drug is mainly made up of following parts by weight of component:
Described microencapsulation adjuvant includes Rhizoma Atractylodis oil 6.6 weight portion, polyacrylic resin 1.2 weight portion, lauryl sulphate acid
Sodium 0.8 weight portion, maltose alcohol 0.45 weight portion and polyvinylpyrrolidone 0.8 weight portion；
Described pharmaceutical adjunct includes aspartame 12 weight portion, xylitol 23 weight portion, Radix Dauci Sativae essence 18 weight portion, micro-
Crystalline cellulose 45 weight portion, colloidality silica 13 weight portion, sodium starch glycol 16 weight portion and triolein 8 weight
Amount part.Conditioning that this formula position applicant is developed by mental work and strengthen the chewable tablet of human detoxification beautifying function
Good scheme.
Another aspect of the present invention provides the preparation method of the compositions of conditioning and enhancing human detoxification beautifying function, the party
Method comprises the steps:
1) lycopene microencapsulation:
1.1) lycopene powder is added in Rhizoma Atractylodis oil, after ultrasonic mixing, be dissolved in second together with polyacrylic resin
In acetoacetic ester, obtain oil phase；
1.2) by soluble in water to sodium lauryl sulphate, maltose alcohol and polyvinylpyrrolidone, acetic acid second is added
Ester, makes ethyl acetate saturated solution, filters, obtains aqueous phase；
1.3) under the conditions of aqueous phase is stirred, oil phase is at the uniform velocity instilled aqueous phase, crosslinked and solidification 2 hours, then add
Enter 500ml water, remove solvent, be then spray-dried, inlet temperature 110 DEG C, leaving air temp 55 DEG C, charging rate 10ml/
Min, atomisation pressure is 0.45MPa, crosses 40 mesh sieves and i.e. obtain lycopene microcapsule after blood pressure lowering cooling；
2) weigh the Semen Persicae of formula ratio, Fructus Mume, Flos abelmoschi manihot, water Medulla Junci, Semen Coicis, Herba Pogostemonis, Rhizoma Polygonati Odorati, Radix Puerariae and Flos Chrysanthemi, add water
Decoct three times, each 1h；Amount of water is add raw material gross weight 12 times for the first time；Amount of water is to add raw material gross weight for the second time
10 times；Amount of water is add raw material gross weight 8 times for the third time；Decoction liquor merges, and is concentrated into paste, is cooled to room temperature, adds second
Alcohol makes alcohol content be 65%, stirring, stands 24 hours, takes supernatant and reclaims ethanol and be concentrated into when temperature 80 DEG C,
Relative density is the clear paste of 1.03-1.35, is dried, pulverizes, obtains powder；
3) by prepared lycopene microcapsule, step 2) prepare powder and the monascus of formula ratio and taurine mixing
Uniformly, cross 80 mesh sieves, obtain present invention conditioning and strengthen the compositions of human detoxification beautifying function.
On the other hand, present invention also offers the preparation method of chewable tablet, the method comprises the steps:
A) conditioning prepared and the composition powder strengthening human detoxification beautifying function；
B) diluting aspartame, xylitol and Radix Dauci Sativae essence with ethanol solution, stirring, to being completely dissolved, prepares mixed
Close liquid；
C) by the colloidality dioxy of the microcrystalline Cellulose of 3/4 formula ratio, the sodium starch glycol of 1/2 formula ratio and formula ratio
SiClx, triolein are placed in mortar, grind 1h, add the prepared composition powder of step a), mix homogeneously, add step
Rapid b) prepared mixed liquor, soft material processed, cross 80 mesh sieves and pelletize, be spray-dried, obtain granule；
D) adding in granule by the microcrystalline Cellulose of 1/4 formula ratio and the sodium starch glycol of 1/2 formula ratio, mixing is all
After even, granulate, tabletting machine, prepare chewable tablet.
Present invention conditioning and the compositions of enhancing human detoxification beautifying function, be especially used for the health care of spot-removing beautifying face in preparation
The application effect of food is notable.
The source of raw material of the present invention is as follows:
Lycopene: use the tomato red that commercially available powder, such as Hubei Sheng Tianhengchuan bio tech ltd are sold
Element.
Monascus: another name Monas cuspurpureus Went, red wine dregs, red rice.A genus ascomycetes Aspergillaceae fungus in Eurotiale.
Semen Persicae: this product is rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana
(Carr.) dry mature seed of Franch..
Fructus Mume: this product is the dry near mellow fruit of rose department plant plum Prunus mume (Sieh.) Sieb.et Zucc.
Real.
Flos abelmoschi manihot: medical material Ji Yuan: for root, leaf, flower or the seed of Malvaceae plant Abelmoschus esculentus.
Water Medulla Junci: for the dry stem pith of rush family plant Medulla Junci Juncus effusus L..
Taurine: this product is feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz., alkali ground Pu is public
English Taraxacum sinicum Kitag. or belong to the dry herb of several plants together.
Semen Coicis: this product is grass Semen Coicis Coix lacryma-jobi L.var.ma-yuen (Roman.)
The dry mature kernal of Stapf.
Herba Pogostemonis: for labiate Herba Pogostemonis or the herb of Herba Pogostemonis.
Rhizoma Polygonati Odorati: this product is the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce.
Radix Puerariae: this product is legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae rattan Pueraria
The dry root of thomsonii Benth..
Flos Chrysanthemi: this product is the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..
Conditioning provided by the present invention and strengthen human detoxification beautifying function compositions by the lycopene of microencapsulation,
Monascus and Flos abelmoschi manihot etc. tens taste medicine be prepared from, composition is simple, and its effect effect substantially and for eliminating toxin and beautifying the skin is splendid, supports
Raw effective.
The chewable tablet of the present invention has good mouthfeel, and prepared tablet compactibility is good, in tablet add correctives with
And essence can reduce chewable tablet bitterness in mouth and other offending tastes, comfortable taste, compliance is good；Additionally, pass through
Important functional component is embedded by microcapsule controlled-release technology, makes microcapsule be difficult to be destroyed, scatter and disappear, improves the stability of product；In medication
After, medicine discharges in vivo and penetrates into cyst wall, medicine dissolution and a series of process of diffusion through body fluid, thus reaches long-acting slow-release
Effect.
Detailed description of the invention
Embodiment 1 compositions
A kind of conditioning and the compositions of enhancing human detoxification beautifying function, said composition is mainly by the crude drug of following weight
It is prepared from:
Embodiment 2 compositions
A kind of conditioning and the compositions of enhancing human detoxification beautifying function, said composition is mainly by the crude drug of following weight
It is prepared from:
Embodiment 3 compositions
A kind of conditioning and the compositions of enhancing human detoxification beautifying function, said composition is processed by the raw material of following weight
It is prepared from:
Wherein, the lycopene in described crude drug is powder, and the lycopene in described compositions is by adding microcapsule
Change adjuvant and make the lycopene microcapsule that particle size range is 50 μm.
Embodiment 4 compositions
A kind of conditioning and the compositions of enhancing human detoxification beautifying function, said composition is prepared by the crude drug of following weight
Form:
Wherein, the lycopene in described crude drug is powder, and the lycopene in described compositions is by adding microcapsule
Change adjuvant and make the lycopene microcapsule that particle size range is 10 μm；Microencapsulation adjuvant includes: Rhizoma Atractylodis oil 80g, polypropylene acid resin
8g and sodium lauryl sulphate 2g.Preparation method:
1) lycopene microencapsulation:
1.1) lycopene powder is added in Rhizoma Atractylodis oil, after ultrasonic mixing, be dissolved in second together with polyacrylic resin
In acetoacetic ester, obtain oil phase；
1.2) sodium lauryl sulphate is soluble in water, add ethyl acetate, make ethyl acetate saturated solution, mistake
Filter, obtains aqueous phase；
1.3) under the conditions of aqueous phase is stirred, oil phase is at the uniform velocity instilled aqueous phase, crosslinked and solidification 2 hours, then add
Enter 500ml water, remove solvent, be then spray-dried, inlet temperature 110 DEG C, leaving air temp 55 DEG C, charging rate 10ml/
Min, atomisation pressure is 0.45MPa, crosses 40 mesh sieves and i.e. obtain lycopene microcapsule after blood pressure lowering cooling；
2) weigh the Semen Persicae of formula ratio, Fructus Mume, Flos abelmoschi manihot, water Medulla Junci, Semen Coicis, Herba Pogostemonis, Rhizoma Polygonati Odorati, Radix Puerariae and Flos Chrysanthemi, add water
Decoct three times, each 1h；Amount of water is add raw material gross weight 12 times for the first time；Amount of water is to add raw material gross weight for the second time
10 times；Amount of water is add raw material gross weight 8 times for the third time；Decoction liquor merges, and is concentrated into paste, is cooled to room temperature, adds second
Alcohol makes alcohol content be 65%, stirring, stands 24 hours, takes supernatant and reclaims ethanol and be concentrated into when temperature 80 DEG C,
Relative density is the clear paste of 1.03-1.35, is dried, pulverizes, obtains powder；
3) by prepared lycopene microcapsule, step 2) prepare powder and the monascus of formula ratio and taurine mixing
Uniformly, cross 80 mesh sieves, obtain present invention conditioning and strengthen the compositions of human detoxification beautifying function.
Embodiment 5 compositions
A kind of conditioning and strengthen human detoxification beautifying function compositions, said composition by the crude drug of following weight through adding
Work is prepared from:
Wherein, the lycopene in described crude drug is powder, and the lycopene in described compositions is by adding microcapsule
Change adjuvant and make the lycopene microcapsule that particle size range is 10 μm；Microencapsulation adjuvant includes: Rhizoma Atractylodis oil 66g, polypropylene acid resin
12g, sodium lauryl sulphate 8g, maltose alcohol 4.5g and polyvinylpyrrolidone 8g.
1) lycopene microencapsulation:
1.1) lycopene powder is added in Rhizoma Atractylodis oil, after ultrasonic mixing, be dissolved in second together with polyacrylic resin
In acetoacetic ester, obtain oil phase；
1.2) by soluble in water to sodium lauryl sulphate, maltose alcohol and polyvinylpyrrolidone, acetic acid second is added
Ester, makes ethyl acetate saturated solution, filters, obtains aqueous phase；
1.3) under the conditions of aqueous phase is stirred, oil phase is at the uniform velocity instilled aqueous phase, crosslinked and solidification 2 hours, then add
Enter 500ml water, remove solvent, be then spray-dried, inlet temperature 110 DEG C, leaving air temp 55 DEG C, charging rate 10ml/
Min, atomisation pressure is 0.45MPa, crosses 40 mesh sieves and i.e. obtain lycopene microcapsule after blood pressure lowering cooling；
2) weigh the Semen Persicae of formula ratio, Fructus Mume, Flos abelmoschi manihot, water Medulla Junci, Semen Coicis, Herba Pogostemonis, Rhizoma Polygonati Odorati, Radix Puerariae and Flos Chrysanthemi, add water
Decoct three times, each 1h；Amount of water is add raw material gross weight 12 times for the first time；Amount of water is to add raw material gross weight for the second time
10 times；Amount of water is add raw material gross weight 8 times for the third time；Decoction liquor merges, and is concentrated into paste, is cooled to room temperature, adds second
Alcohol makes alcohol content be 65%, stirring, stands 24 hours, takes supernatant and reclaims ethanol and be concentrated into when temperature 80 DEG C,
Relative density is the clear paste of 1.03-1.35, is dried, pulverizes, obtains powder；
3) by prepared lycopene microcapsule, step 2) prepare powder and the monascus of formula ratio and taurine mixing
Uniformly, cross 80 mesh sieves, obtain present invention conditioning and strengthen the compositions of human detoxification beautifying function.
Embodiment 6 compositions
A kind of conditioning and strengthen human detoxification beautifying function compositions, said composition by the crude drug of following weight through adding
Work is prepared from:
Wherein, the lycopene in described crude drug is powder, and the lycopene in described compositions is by adding microcapsule
Change adjuvant and make the lycopene microcapsule that particle size range is 5 μm；Microencapsulation adjuvant includes: Rhizoma Atractylodis oil 20g, polypropylene acid resin
14g, sodium lauryl sulphate 12g, maltose alcohol 2g and polyvinylpyrrolidone 10g.
Preparation method: prepare according to the preparation method described in embodiment 5.
Embodiment 7 chewable tablet
Preparation method:
A) it is prepared into conditioning and strengthens the composition powder of human detoxification beautifying function；
B) diluting aspartame, xylitol and Radix Dauci Sativae essence with ethanol solution, stirring, to being completely dissolved, prepares mixed
Close liquid；
C) by the colloidality dioxy of the microcrystalline Cellulose of 3/4 formula ratio, the sodium starch glycol of 1/2 formula ratio and formula ratio
SiClx, triolein are placed in mortar, grind 1h, add the prepared composition powder of step a), mix homogeneously, add step
Rapid b) prepared mixed liquor, soft material processed, cross 80 mesh sieves and pelletize, be spray-dried, obtain granule；
D) adding in granule by the microcrystalline Cellulose of 1/4 formula ratio and the sodium starch glycol of 1/2 formula ratio, mixing is all
After even, granulate, tabletting machine, prepare chewable tablet.
Embodiment 8 chewable tablet
Preparation method: prepare according to the preparation method described in embodiment 7.
Embodiment 9 chewable tablet
Preparation method: prepare according to the preparation method described in embodiment 7.
Comparative examples 1 compositions
A kind of conditioning and the compositions of enhancing human detoxification beautifying function, the crude drug weight of said composition and embodiment 5
Identical；Wherein, the lycopene in described crude drug is powder.
Preparation method: not by outside lycopene powder microencapsulation at preparation method, other are identical with preparation method described in embodiment 5.
Comparative examples 2 chewable tablet
Preparation method: being not added with at preparation method outside xylitol and Radix Dauci Sativae essence, other are identical with preparation method described in embodiment 7.
Comparative examples 3 chewable tablet
Preparation method: be not added with at preparation method outside Radix Dauci Sativae essence, other are identical with preparation method described in embodiment 7.
Comparative examples 4 chewable tablet
Preparation method: be not added with at preparation method outside colloidality silicon dioxide, other are identical with preparation method described in embodiment 7.
Comparative examples 5 chewable tablet
Preparation method: be not added with at preparation method outside sodium starch glycol, other are identical with preparation method described in embodiment 7.
Test example 1 mouthfeel is tested
Mouthfeel test uses embodiment 7-9 and comparative examples 2,5 kinds of chewable tablet of comparative examples 3, and test crowd is
Randomly drawing, test total 50 people, everyone gives a mark after tasting 5 kinds of samples respectively, and mark is 1-10, the highest expression of score value
Mouthfeel is the best, averages.By table 1 it can be seen that, the tablet ratio obatained score of embodiment 7-9 result of the test is the most prominent
Going out, the especially result of the test of embodiment 7 is the most prominent, it is possible to accepted by vast majority of people；And 2 scores of comparative examples
Number is worst, it is known that after adding xylitol and Radix Dauci Sativae essence, taste more preferably, more liked by people by this chewable tablet.
The taste score of table 1 embodiment 7-9 and comparative examples 2, comparative examples 3 compares
Test example 2 stability test
Example 7 and comparative examples 4, comparative examples 5 tablet as sample, carry out influence factor's test,
Including high humidity (RH92.5%), high temperature (60 DEG C) and highlight test (4500lx), character, dissolution and the disintegrate to selected tablet
The projects such as time limit are investigated；
(1) in 4500LX highlight test, above sample Continuous irradiation 10 days, in sampling in the 5th day and the 10th day, examine
Examine the inspection of project, the results are shown in Table 2；
(2) in 60 DEG C of hot tests, above-mentioned sample is placed 10 days continuously, in sampling in the 5th day and the 10th day, investigates
The detection of project, the results are shown in Table 3；
(3) in 92.5% high wet test, being individually positioned in exsiccator by above sample, the bottom of exsiccator is put into full
And KNO3Solution, is placed on exsiccator in biochemical cultivation case the most again, adjusts the temperature to 25 DEG C, and above-mentioned sample places 10 continuously
My god, in sampling in the 5th day and the 10th day, carry out the inspection of investigation project, the results are shown in Table 4；
Table 2 highlight test result
Table 3 hot test result
Table 4 high humidity result of the test
Can be seen that from table 2-4, the chewable tablet of embodiment 7 is in high light, high humidity or hot environment, and character is the most stable, respectively
Item index does not has significant change；Compared with comparative examples 4, character is more stable；Illustrate that colloidality silicon dioxide is fine with crystallite
Dimension element is used in conjunction with being remarkably improved the stability of tablet.The chewable tablet of embodiment 7 is compared with comparative examples 5, during disintegrate
Limit short；The collaborative use of sodium starch glycol and microcrystalline Cellulose is described, significantly improves the disintegration rate of tablet.
The speckle dispelling test of test example 3 compositions and tablet
1 tested crowd
18-65 age, experimenter 120 example year, being face has chloasma, for filbert to dark brown, well-defined speckle
Sheet, without inflammatory performance and squama；Without obvious subjective symptoms；Without obvious endocrinopathy, and get rid of the pigment that other diseases causes
Calm.
2 packet and test-meals
It is randomly divided into test-meal group 96 and matched group 24 by the color of the speckle of experimenter, area situation；Concrete test-meal group
For:
Group 1: the compositions of embodiment 5；
Group 2: the tablet of embodiment 7；
Group 1 is pressed 3g/ time, three times on the one, chews edible, the most edible 30 days.Group 2 is pressed 8g/ time, three times on the one, directly eats
With.Matched group is blank.Experimenter stops using other oral during testing and external is about the articles for use of face-beautifying and spot-removing.
Original dietary habit, normal diet is not changed during test.
3 efficiency indexes
3.1 facial area speckle size detections: with the area (mm of the tested whole facial area speckle front and back of tape measure2)；
3.2 facial area speckle shade detections: according to Institute of Geography, Academia Sinica's development and design, Mapping Press
The judge index that brown (Y+M+BK) colour atla is the chloasma depth in " use standard color card " (first edition) published for 1992:
I degree (15,20,5), II degree (30,40,10) III degree (40,60,15)；Meter 1 point, 2 points, 3 points respectively.
4 effect criterion
Effective: chloasma color declines I degree, area reduces more than 10%, and does not produce new chloasma；
Invalid: chloasma color and area are without significant change.
5 results
Experimenter's facial area speckle size situation is shown in Table 5；
The speckle size of table 5 experimenter's chloasma and the change of shade
As shown in Table 5, group 1, examination trencherman's area of chloasma of group 2 are more than 10%, and color integration is decreased obviously, before self
After compare and compare with matched group, difference all has the plant enzyme of significance, the i.e. present invention to have expelling toxin and dispelling freckle effect.
Test example 4 vitro release determination test
The drug release rate detection of the present composition: with reference to 2010 editions " Chinese Pharmacopoeia " annex XIXD vitro drug release
Degree checks.
Take the compositions of above example 5, the compositions of comparative examples 1 respectively, put in medicament dissolution instrument, in 1h, 2h,
4h, 6h, 12h, 16h, 24h are separately sampled, detect dissolution percentage rate by high performance liquid chromatography, and the accumulation of calculation composition is released
Put percentage rate, the results are shown in Table 6.
The cumulative release percentage rate result of table 6 compositions
Embodiment 5, the compositions of comparative examples 1 as can be seen from the table, it discharges sustainable 24h, in vitro release
Performance meets slow releasing agent feature.Wherein embodiment 5 reaches the effect of long-acting slow-release.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: not
These embodiments can be carried out multiple change in the case of departing from the principle of the present invention and objective, revise, replace and modification, this
The scope of invention is limited by claim and equivalent thereof.
Claims (10)
1. a conditioning and the compositions of enhancing human detoxification beautifying function, it is characterised in that described crude drug is by following weight
The raw material of part is prepared from:
2. conditioning as claimed in claim 1 and the compositions of enhancing human detoxification beautifying function, it is characterised in that described raw material
Medicine is made up of the component of following parts by weight:
Wherein, the lycopene in described crude drug is powder, and the lycopene in described compositions is auxiliary by adding microencapsulation
The lycopene microcapsule that particle size range is 1-50 μm made by material.
3. conditioning as claimed in claim 2 and the compositions of enhancing human detoxification beautifying function, it is characterised in that described microcapsule
Change adjuvant and include Rhizoma Atractylodis oil 2-8 weight portion, polypropylene acid resin 0.8-1.4 weight portion and sodium lauryl sulphate 0.2-1.2
Weight portion.
4. conditioning as claimed in claim 3 and the compositions of enhancing human detoxification beautifying function, it is characterised in that described microcapsule
Change adjuvant and also include maltose alcohol 0.2-0.8 weight portion and polyvinylpyrrolidone 0.4-1 weight portion.
5. conditioning and strengthen the preparation of human detoxification beautifying function, by compositions according to any one of claim 1-4 and
Pharmaceutical adjunct is made, it is characterised in that described preparation is chewable tablet, and described compositions is 1 with the ratio of weight and number of pharmaceutical adjunct:
0.3-1:4；Described pharmaceutical adjunct includes aspartame 6-18 weight portion, xylitol 10-30 weight portion, Radix Dauci Sativae essence 10-20 weight
Amount part and microcrystalline Cellulose 20-55 weight portion.
6. preparation as claimed in claim 5, it is characterised in that described pharmaceutical adjunct also includes colloidality silica 1 0-20 weight
Amount part, sodium starch glycol 6-20 weight portion and triolein 2-10 weight portion.
7. preparation as claimed in claim 6, it is characterised in that described crude drug is mainly made up of following parts by weight of component:
Described microencapsulation adjuvant includes Rhizoma Atractylodis oil 6.6 weight portion, polyacrylic resin 1.2 weight portion, sodium lauryl sulphate 0.8
Weight portion, maltose alcohol 0.45 weight portion and polyvinylpyrrolidone 0.8 weight portion；
Described pharmaceutical adjunct includes that aspartame 12 weight portion, xylitol 23 weight portion, Radix Dauci Sativae essence 18 weight portion, crystallite are fine
Tie up plain 45 weight portions, colloidality silica 13 weight portion, sodium starch glycol 16 weight portion and triolein 8 weight
Part.
8. conditioning described in claim 4 and strengthen the preparation method of compositions of human detoxification beautifying function, it is characterised in that
Described method comprises the steps:
1) lycopene microencapsulation:
1.1) lycopene powder is added in Rhizoma Atractylodis oil, after ultrasonic mixing, be dissolved in acetic acid second together with polyacrylic resin
In ester, obtain oil phase；
1.2) by soluble in water to sodium lauryl sulphate, maltose alcohol and polyvinylpyrrolidone, ethyl acetate is added, system
Become ethyl acetate saturated solution, filter, obtain aqueous phase；
1.3) under the conditions of aqueous phase is stirred, oil phase is at the uniform velocity instilled aqueous phase, crosslinked and solidification 2 hours, add
500ml water, removes solvent, is then spray-dried, inlet temperature 110 DEG C, leaving air temp 55 DEG C, charging rate 10ml/
Min, atomisation pressure is 0.45MPa, crosses 40 mesh sieves and i.e. obtain lycopene microcapsule after blood pressure lowering cooling；
2) Semen Persicae of formula ratio, Fructus Mume, Flos abelmoschi manihot, water Medulla Junci, Semen Coicis, Herba Pogostemonis, Rhizoma Polygonati Odorati, Radix Puerariae and Flos Chrysanthemi, boiling are weighed
Three times, each 1h；Amount of water is add raw material gross weight 12 times for the first time；Amount of water is add raw material gross weight 10 for the second time
Times；Amount of water is add raw material gross weight 8 times for the third time；Decoction liquor merges, and is concentrated into paste, is cooled to room temperature, adds ethanol
Making alcohol content is 65%, stirring, stands 24 hours, takes supernatant and reclaims ethanol and be concentrated into when temperature 80 DEG C, phase
It is the clear paste of 1.03-1.35 to density, is dried, pulverizes, obtain powder；
3) by prepared lycopene microcapsule, step 2) powder for preparing and the monascus of formula ratio and taurine mixing are all
Even, cross 80 mesh sieves, obtain present invention conditioning and strengthen the compositions of human detoxification beautifying function.
9. the preparation method of the preparation described in claim 7, described method comprises the steps:
A) conditioning prepared and the composition powder strengthening human detoxification beautifying function；
B) diluting aspartame, xylitol and Radix Dauci Sativae essence with ethanol solution, stirring, to being completely dissolved, prepares mixed liquor；
C) by the colloidality silicon dioxide of the microcrystalline Cellulose of 3/4 formula ratio, the sodium starch glycol of 1/2 formula ratio and formula ratio
It is placed in mortar with triolein, grinds 1h, add the prepared composition powder of step a), mix homogeneously, add step
B) mixed liquor prepared, soft material processed, cross 80 mesh sieves and pelletize, be spray-dried, obtain granule；
D) microcrystalline Cellulose of 1/4 formula ratio and the sodium starch glycol of 1/2 formula ratio are added in granule, mix homogeneously
After, granulate, tabletting machine, prepare chewable tablet.
10. the purposes of the compositions according to any one of claim 1-4, it is characterised in that described compositions is in preparation
Application for the health food of spot-removing beautifying face.
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