CN106072515A - The health-care food composition of a kind of auxiliary improvement of memory containing Armeniaca mume Sieb. and preparation method - Google Patents
The health-care food composition of a kind of auxiliary improvement of memory containing Armeniaca mume Sieb. and preparation method Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to field of health care food, relate to health-care food composition and the preparation method of a kind of auxiliary improvement of memory containing Armeniaca mume Sieb..This health-care food composition includes following raw material of preparing: Armeniaca mume Sieb., Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Polygonati and Fructus Jujubae.The health-care food composition composition of the present invention rationally, make a distinction between the important and the lesser one, mutual gain.Each component coordinate mutually and, there is tonifying kidney and nourishing yin, strengthening the spleen and nourishing the stomach, QI invigorating mind calming, the effect of intelligent promoting and the mind tranquilizing, find through test, the health-care food composition that the present invention provides has the effect of significant auxiliary improvement of memory power.
Description
Technical field
The present invention relates to field of health care products, particularly relate to the health food combination of a kind of auxiliary improvement of memory containing Armeniaca mume Sieb.
Thing and preparation method.
Background technology
Cognitive and memory is the basic activity of the mankind.Increased by life stress, aged tendency of population, the aspect such as living environment
Impact, the phenomenon that cognitive and memory function declines is more and more universal, and orthobiosis causes increasing puzzlement.
Cognition as basic function is related to the every aspect of human lives with memory.Research shows, after stepping into old age,
Cognitive and memory function there will be a certain degree of decline.Under the increase of natality and the promotion of life, world's model
Enclose interior aging population and increase not seen before occurs.For China, by the end of the year 2013,60 one full year of life and above population about 200,000,000,
Account for the 14.9% of total population, 65 one full year of life and above population about 1.3 hundred million, account for the 9.7% of total population, step into aging society already.
Under this trend, in addition to normal amnesia, the Memory and Cognition obstacle number that the age is correlated with also dramatically increases, the most often
The i.e. Alzheimer (Alzheimer disease, AD) seen.The U.S.'s existing 5,300,000 patients with Alzheimer disease in 2003,
And number increases considerably year by year.According to estimates, China's patients with Alzheimer disease nearly 6,000,000 in 2011, will to the middle of this century
Reach 20,000,000.The more Patients with Mild Cognitive Impairment of the most promising number, this stage is eventually changed into Alzheimer.A Er
The function serious loss such as Ci Haimo patient's life, certainly will more and more be paid close attention to by society and pay attention to.Additionally, parkinson,
Vascular conditions, meals, fatigue etc. can cause the cognitive decline with memory function equally.In view of the foregoing, memory class is improved
Health food is more and more paid attention to.
In China's Chinese medicine, early having the relevant record of amnesia, as " the forgetful door of dialectical record " is loaded with, " people has year
Old and forgetter, nearly thing is many not to be remembered, though people states front thing, if still ignorant, this most forgetful pole is also " description.Comprehensive forefathers'
Discussing, Chinese medicine learning memory function declines can be attributed to void, silt, 3 aspects of expectorant.Void is function and goes down, vital essence
Insufficiency of blood.Become silted up and hinder heart and brain, irritability, palpitation and insomnia, forgetful dementia, the quiet language of coma for addiction.Expectorant is the turbid upper criminal's head of expectorant, blinds
Clear sun, brain god's apraxia.
Chinese patent application 201410182314.8 discloses a kind of health food improving memory, this health food bag
Include following component: walnut powder 20-25 part, dried Fructus Vitis viniferae 5-8 part, Semen sojae atricolor powder 20-30 part, Antarctic krill shell 3-5 part, oatmeal 20-
30 parts, tea pigment 2-4 part, milk powder 5-8 part, sodium glutamate 5-6 part, this health food has a sweet taste, and has the work improving memory
With, but effect is the most notable.
Summary of the invention
It is an object of the invention to provide health-care food composition and the preparation side of a kind of auxiliary improvement of memory containing Armeniaca mume Sieb.
Method, this health-care food composition has good effect in terms of auxiliary improvement of memory power.
Health-care food composition of the present invention includes the raw material of preparing of following parts by weight:
Armeniaca mume Sieb. 16-28 part, Fructus Schisandrae Chinensis 12-20 part, Radix Ophiopogonis 8-14 part, Fructus Lycii 8-12 part, Rhizoma Dioscoreae 6-10 part, Radix Rehmanniae Preparata
6-12 part, Arillus Longan 4-8 part, Radix Salviae Miltiorrhizae 6-13 part, Rhizoma Polygonati 5-10 part and Fructus Jujubae 4-10 part.
Further, described health-care food composition includes the raw material of preparing of following parts by weight:
16 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 12 parts, Radix Ophiopogonis 8 parts, Fructus Lycii 8 parts, Rhizoma Dioscoreae 6 parts, Radix Rehmanniae Preparata 6 parts, Arillus Longan 4 parts, pellet
Join 6 parts, Rhizoma Polygonati 5 parts and 4 parts of Fructus Jujubae.
Further, described health-care food composition includes the raw material of preparing of following parts by weight:
28 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 20 parts, Radix Ophiopogonis 14 parts, Fructus Lycii 12 parts, Rhizoma Dioscoreae 10 parts, Radix Rehmanniae Preparata 12 parts, Arillus Longan 8
Part, Radix Salviae Miltiorrhizae 13 parts, Rhizoma Polygonati 10 parts and 10 parts of Fructus Jujubae.
Further, described health-care food composition includes the raw material of preparing of following parts by weight:
22 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 16 parts, Radix Ophiopogonis 11 parts, Fructus Lycii 10 parts, Rhizoma Dioscoreae 8 parts, Radix Rehmanniae Preparata 9 parts, Arillus Longan 6 parts,
Radix Salviae Miltiorrhizae 9 parts, Rhizoma Polygonati 7 parts and 7 parts of Fructus Jujubae.
Further, described health-care food composition is made into capsule, tablet, pill or oral liquid.
Correspondingly, the present invention also provides for the preparation method of described health-care food composition, comprises the steps of
S1, take the Armeniaca mume Sieb. of Maturity uniformity, enucleation, smash into Armeniaca mume Sieb. slurry-mud to pieces, add above-mentioned Armeniaca mume Sieb. slurry-mud 2-5 times amount
Ethanol solution, mechanical shaking extraction 2-3 time at 40-60 DEG C, each 2-4h, filter, merging filtrate, obtain filtrate I；
S2, take Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Polygonati and Fructus Jujubae, clean respectively,
It is ground into coarse powder, mix homogeneously, adds the ethanol solution of above-mentioned 2-4 times of weight of coarse powder, reflux, extract, 2-4 time, each 3-4h, mistake
Filter, merging filtrate, both obtained filtrate II；
S3, step S1 gained filtrate I and step S2 gained filtrate II being sufficiently mixed, drying under reduced pressure becomes extractum, by extractum
Attrition grinding, crosses 80-100 mesh sieve, obtains health-care food composition fine powder, adds adjuvant toward above-mentioned fine powder, uses modern crafts
It is prepared as required dosage form.
Health-care food composition Armeniaca mume Sieb. of the present invention and Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, kidney calming；Radix Ophiopogonis, Rhizoma Dioscoreae and Fructus Lycii
Clear away heart-fire relieving restlessness, kidney and spleen invigorating, lung benefiting promotes the production of body fluid；Radix Rehmanniae Preparata, Arillus Longan, Radix Salviae Miltiorrhizae and Rhizoma Polygonati nourishing YIN and supplementing blood, promoting blood circulation to restore menstrual flow, calming the nerves clears away heart-fire；
Fructus Jujubae is in harmonious proportion, and between each component, collaborative promotion, complements each other, and is finally reached tonifying kidney and nourishing yin, strengthening the spleen and nourishing the stomach, QI invigorating mind calming, Fructus Alpiniae Oxyphyllae peace
The effects such as god, have significant effect to auxiliary improvement of memory power.
Health-care food composition of the present invention, comes from the achievement in research of China's Chinese medical theory and modern pharmacology, through drug effect
Learn experimentation, it was demonstrated that its treatment hypomnesis in terms of determined curative effect, have no adverse reaction, have tonifying kidney and nourishing yin, strengthening the spleen and nourishing the stomach,
The effects such as QI invigorating mind calming, intelligent promoting and the mind tranquilizing, pharmacodynamic experiment shows that it has and significantly reduces what caused Rats With Memory power tired out declined
Degree, increases the memory of rat tired out, declines auxiliary improvement of memory power and has significant curative effect, has no side effect.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.At this
In bright scope or without departing from present disclosure, spirit and scope, change that the present invention is carried out, combine or replace
Change, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment l
The embodiment of the present invention 1 health-care food composition includes the raw material of preparing of following parts by weight:
16 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 12 parts, Radix Ophiopogonis 8 parts, Fructus Lycii 8 parts, Rhizoma Dioscoreae 6 parts, Radix Rehmanniae Preparata 6 parts, Arillus Longan 4 parts, pellet
Join 6 parts, Rhizoma Polygonati 5 parts and 4 parts of Fructus Jujubae；
Preparation method is as follows:
S1, take the Armeniaca mume Sieb. of Maturity uniformity, enucleation, smash into Armeniaca mume Sieb. slurry-mud to pieces, add above-mentioned Armeniaca mume Sieb. slurry-mud 3 times amount
Ethanol solution, mechanical shaking extraction 3 times at 50 DEG C, each 3h, filters, merging filtrate, obtains filtrate I；
S2, take Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Polygonati and Fructus Jujubae, clean respectively,
It is ground into coarse powder, mix homogeneously, adds the ethanol solution of above-mentioned 3 times of weight of coarse powder, reflux, extract, 3 times, each 3h, filter, close
And filtrate, both obtained filtrate II；
S3, step S1 gained filtrate I and step S2 gained filtrate II being sufficiently mixed, drying under reduced pressure becomes extractum, by extractum
Attrition grinding, crosses 100 mesh sieves, obtains health-care food composition fine powder, adds adjuvant toward above-mentioned fine powder, uses modern crafts to prepare
Become soft capsule.
Embodiment 2:
The embodiment of the present invention 2 health-care food composition includes the raw material of preparing of following parts by weight:
28 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 20 parts, Radix Ophiopogonis 14 parts, Fructus Lycii 12 parts, Rhizoma Dioscoreae 10 parts, Radix Rehmanniae Preparata 12 parts, Arillus Longan 8
Part, Radix Salviae Miltiorrhizae 13 parts, Rhizoma Polygonati 10 parts and 10 parts of Fructus Jujubae；
Preparation method is with embodiment 1.
Embodiment 3
The embodiment of the present invention 3 health-care food composition includes the raw material of preparing of following parts by weight:
22 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 16 parts, Radix Ophiopogonis 11 parts, Fructus Lycii 10 parts, Rhizoma Dioscoreae 8 parts, Radix Rehmanniae Preparata 9 parts, Arillus Longan 6 parts,
Radix Salviae Miltiorrhizae 9 parts, Rhizoma Polygonati 7 parts and 7 parts of Fructus Jujubae；
Preparation method is with embodiment 1.
Comparative example 1
Comparative example 1 health-care food composition of the present invention includes the raw material of preparing of following parts by weight:
22 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 16 parts, Radix Ophiopogonis 11 parts, Fructus Lycii 10 parts, Rhizoma Dioscoreae 8 parts, Radix Rehmanniae Preparata 9 parts, Arillus Longan 6 parts,
Radix Salviae Miltiorrhizae 12 parts, Rhizoma Polygonati 7 parts and 7 parts of Fructus Jujubae；
Preparation method is with embodiment 1.
Comparative example 1 is with the difference of embodiment 3: add the parts by weight of Radix Salviae Miltiorrhizae in comparative example 1.
Comparative example 2
Comparative example 2 health-care food composition of the present invention includes the raw material of preparing of following parts by weight:
22 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 16 parts, Radix Ophiopogonis 11 parts, Fructus Lycii 10 parts, Rhizoma Dioscoreae 8 parts, Radix Rehmanniae Preparata 9 parts, Arillus Longan 6 parts,
Radix Salviae Miltiorrhizae 9 parts, Rhizoma Polygonati 7 parts and 7 parts of Radix Glycyrrhizae；
Preparation method is with embodiment 1.
Comparative example 2 is with the difference of embodiment 3: comparative example 2 has changed Fructus Jujubae into Radix Glycyrrhizae.
Health-care food composition of the present invention is to improving the research experiment that caused Rats With Memory power tired out declines
1, experimental subject: choose 80 SD rats, male and female half and half, body weight is 260 ± 20g, by the experiment of Beijing dimension tonneau China
Company of Animals Ltd. provides.
2, experiment material: embodiment 1, embodiment 2, embodiment 3, comparative example 1 and the soft capsule of comparative example 2 preparation；Positive
Comparison medicine is ANSHEN BUNAO YE (being purchased from Lunan Pharmaceutical Co., Ltd., traditional Chinese medicines quasi-word Z37021354), and blank group is made a living
Reason saline.
3, model is set up: takes above-mentioned wherein 7 groups of rats and is trained, during training, begins with swimming exercise and add not
The method that breath is deprived.The swimming depth of water is 2 times of rat body length, and water temperature is maintained at 33-36 DEG C, each swimming pool random assortment
6 rats.Every day, 8:00 started to train 60min, experiment modeling 7 days.During swimming, under animal movement harmony is obvious
Fall, when occurring repeatedly sinking, takes out rest 1-3 minute by animal, places into pond relaying reforwarding and moves, and makes rat in training process
In remain kinestate.During testing, rat is placed on sleep deprivation platform by non-swimming time, carries out sleep deprivation
7 days.Environment continuous light, in tank, water is changed every day.
During one trains, often group starts Y maze learning training after having swum, and experiment is in quiet environment, without photostimulation
Diagnostics of Chinese Medicine behavior room in carry out.Rat is put into Y type fan. after palace case adapts to 3-5min, give suitably to shock by electricity, to it
Till 3 arms are all explored entrance.With trained rat, place of safety with random order conversions, distinguishes that light stimulates and clearing bearing
Ability.After rat runs away to place of safety after being shocked by electricity, light continuation effect 10-15s, terminates after light-off once to test, rat place
Support arm is just as the starting point tested next time, and twice test interval is 30s or gives the 2nd test after rest 1min again,
Being repeated in, test 30 times, period continuously reaches the rat of 10/30 for reaching study standard.During training, often group is carried out altogether
Three Y maze learnings are trained, and eliminate the rat being unable to reach learning and memory standard, after formal experiment terminates, proceed by Y fan
Palace memory evaluation test, observe rat after learning training terminates, the situation of learning and memory.Rat reaches standard institute of association
The testing time needed, represents the ability of learning and memory of its space reaction explanation.Desired times is more saved your breath the speed of bright learning and memory
The fastest or ability of learning and memory is the strongest, when required number of times is the most, then point out the ability of learning and memory of rat to decline.
4, test method: above-mentioned 70 rats after modeling are randomly divided into 7 groups, respectively model group, Anshen Bunao
Liquid group, embodiment 1 group, embodiment 2 groups, embodiment 3 groups, comparative example 1 group and comparative example, often group 10, another set rat is not
Making any process as blank group, the dosage of each group is as follows:
Blank group: the isopyknic normal saline of gavage；
Model group: the isopyknic normal saline of gavage；
ANSHEN BUNAO YE group: the ANSHEN BUNAO YE of gavage 15ml/kg；
Embodiment 1 group: after embodiment 1 soft capsule adds the water dissolution of equal volume, gavage 15ml/kg；
Embodiment 2 groups: after embodiment 2 soft capsule adds the water dissolution of equal volume, gavage 15ml/kg；
Embodiment 3 groups: after embodiment 3 soft capsule adds the water dissolution of equal volume, gavage 15ml/kg；
Comparative example 1 group: after comparative example 1 soft capsule adds the water dissolution of equal volume, gavage 15ml/kg；
Comparative example 2 groups: after comparative example 2 soft capsule adds the water dissolution of equal volume, gavage 15ml/kg；
Each group medication every day 1 time, continuous use one week.
5, experimental result:
Experimental result is as shown in table 1.
The change in table 1 experimental rat Y labyrinth
Note: compared with blank groupΔP ＜ 0.05,ΔΔP ＜ 0.01；Compared with model group,*P ＜ 0.05,**P ＜ 0.01；
Compared with ANSHEN BUNAO YE group#P ＜ 0.05,##P ＜ 0.01.
As shown in Table 1, compared with model group, embodiment 1 group, embodiment 2 groups and embodiment 3 groups can pole (P ＜ significantly
0.01) increase the memory ability of mice, and therapeutic effect notable (P ＜ 0.05) be better than ANSHEN BUNAO YE group, comparative example 1 group with
Embodiment 3 groups is compared, and removes, adds the parts by weight of Radix Salviae Miltiorrhizae, and its therapeutic effect is not so good as embodiment 3；Fructus Jujubae is changed by comparative example 2 groups
Having become Radix Glycyrrhizae, its therapeutic effect decreases compared with Example 3, and this illustrates each composition tool in health-care food composition of the present invention
There is the effect of Synergistic.Wherein, the most pronounced effects improving mouse memory power of embodiment 3, therefore embodiment 3 be the present invention
Good embodiment.In sum, the health food compatibility improving memory that the present invention provides is reasonable, science, it is possible to collaborative enhancing
Improve memory.
Claims (7)
1. the health-care food composition of auxiliary improvement of memory containing Armeniaca mume Sieb., it is characterised in that include preparing as follows raw material and
Its parts by weight:
Armeniaca mume Sieb. 16-28 part, Fructus Schisandrae Chinensis 12-20 part, Radix Ophiopogonis 8-14 part, Fructus Lycii 8-12 part, Rhizoma Dioscoreae 6-10 part, Radix Rehmanniae Preparata 6-12
Part, Arillus Longan 4-8 part, Radix Salviae Miltiorrhizae 6-13 part, Rhizoma Polygonati 5-10 part and Fructus Jujubae 4-10 part.
2. contain the health-care food composition of the auxiliary improvement of memory of Armeniaca mume Sieb. as claimed in claim 1, it is characterised in that include
Prepare raw material and parts by weight thereof as follows:
16 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 12 parts, Radix Ophiopogonis 8 parts, Fructus Lycii 8 parts, Rhizoma Dioscoreae 6 parts, Radix Rehmanniae Preparata 6 parts, Arillus Longan 4 parts, Radix Salviae Miltiorrhizae 6
Part, Rhizoma Polygonati 5 parts and 4 parts of Fructus Jujubae.
3. contain the health-care food composition of the auxiliary improvement of memory of Armeniaca mume Sieb. as claimed in claim 1, it is characterised in that include
Prepare raw material and parts by weight thereof as follows:
28 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 20 parts, Radix Ophiopogonis 14 parts, Fructus Lycii 12 parts, Rhizoma Dioscoreae 10 parts, Radix Rehmanniae Preparata 12 parts, Arillus Longan 8 parts, pellet
Join 13 parts, Rhizoma Polygonati 10 parts and 10 parts of Fructus Jujubae.
4. contain the health-care food composition of the auxiliary improvement of memory of Armeniaca mume Sieb. as claimed in claim 1, it is characterised in that include
Prepare raw material and parts by weight thereof as follows:
22 parts of Armeniaca mume Sieb., Fructus Schisandrae Chinensis 16 parts, Radix Ophiopogonis 11 parts, Fructus Lycii 10 parts, Rhizoma Dioscoreae 8 parts, Radix Rehmanniae Preparata 9 parts, Arillus Longan 6 parts, Radix Salviae Miltiorrhizae 9
Part, Rhizoma Polygonati 7 parts and 7 parts of Fructus Jujubae.
5. the health-care food composition of the auxiliary improvement of memory containing Armeniaca mume Sieb. as described in as arbitrary in claims 1-4, its feature exists
In, described health-care food composition is made into capsule, tablet, pill or oral liquid.
6. the health-care food composition of the auxiliary improvement of memory containing Armeniaca mume Sieb. as described in as arbitrary in claims 1-4, its feature exists
In, described health-care food composition is prepared from by following steps:
S1, take the Armeniaca mume Sieb. of Maturity uniformity, enucleation, smash into Armeniaca mume Sieb. slurry-mud to pieces, add the second of above-mentioned Armeniaca mume Sieb. slurry-mud 2-5 times amount
Alcoholic solution, mechanical shaking extraction 2-3 time at 40-60 DEG C, each 2-4h, filters, merging filtrate, obtains filtrate I；
S2, take Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Polygonati and Fructus Jujubae, clean respectively, pulverize
Become coarse powder, mix homogeneously, add the ethanol solution of above-mentioned 2-4 times of weight of coarse powder, reflux, extract, 2-4 time, each 3-4h, filter,
Merging filtrate, had both obtained filtrate II；
S3, step S1 gained filtrate I and step S2 gained filtrate II being sufficiently mixed, drying under reduced pressure becomes extractum, is pulverized by extractum
Grind, cross 80-100 mesh sieve, obtain health-care food composition fine powder, add adjuvant toward above-mentioned fine powder, use modern crafts to prepare
Become required dosage form.
7. the preparation side of the health-care food composition of the auxiliary improvement of memory containing Armeniaca mume Sieb. as described in as arbitrary in claims 1-6
Method, it is characterised in that comprise the following steps:
S1, take the Armeniaca mume Sieb. of Maturity uniformity, enucleation, smash into Armeniaca mume Sieb. slurry-mud to pieces, add the second of above-mentioned Armeniaca mume Sieb. slurry-mud 2-5 times amount
Alcoholic solution, mechanical shaking extraction 2-3 time at 40-60 DEG C, each 2-4h, filters, merging filtrate, obtains filtrate I；
S2, take Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Polygonati and Fructus Jujubae, clean respectively, pulverize
Become coarse powder, mix homogeneously, add the ethanol solution of above-mentioned 2-4 times of weight of coarse powder, reflux, extract, 2-4 time, each 3-4h, filter,
Merging filtrate, had both obtained filtrate II；
S3, step S1 gained filtrate I and step S2 gained filtrate II being sufficiently mixed, drying under reduced pressure becomes extractum, is pulverized by extractum
Grind, cross 80-100 mesh sieve, obtain health-care food composition fine powder, add adjuvant toward above-mentioned fine powder, use modern crafts to prepare
Become required dosage form.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101543576A (en) * | 2008-03-28 | 2009-09-30 | 天科仁祥技术（北京）有限责任公司 | Medicine composition for preventing and curing senile dementia and preparation method thereof |
| CN102754834A (en) * | 2012-08-01 | 2012-10-31 | 北京港生药业科技有限公司 | Biological mixture for regulating emotion and relieving stress and preparation method thereof |
| CN103316207A (en) * | 2012-03-22 | 2013-09-25 | 曾杰 | Memory aging resistance nature drug compound prescription |
-
2016
- 2016-06-06 CN CN201610395548.XA patent/CN106072515A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101543576A (en) * | 2008-03-28 | 2009-09-30 | 天科仁祥技术（北京）有限责任公司 | Medicine composition for preventing and curing senile dementia and preparation method thereof |
| CN103316207A (en) * | 2012-03-22 | 2013-09-25 | 曾杰 | Memory aging resistance nature drug compound prescription |
| CN102754834A (en) * | 2012-08-01 | 2012-10-31 | 北京港生药业科技有限公司 | Biological mixture for regulating emotion and relieving stress and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张怡等: "青梅汁改善小鼠记忆障碍的研究", 《营养学报》 * |
| 缪希雍: "《神农本草经疏》", 31 December 2012 * |
| 陈德兴等: "《怎样进补最健康》", 31 January 2010 * |
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