Esophagus impedance detection circuit
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of esophagus impedance detection circuit.
Background technology
Esophageal pH-impedance detection is a kind of a kind of aided detection method being directed to gastroesophageal reflux disease (GERD), stomach oesophagus
Reflux disease (GERD) is a kind of common chronic, the digestion dyskinesis disease that easily recurs of clinic, refers to stomach or duodenum
Content reflux causes multiple complications to oesophagus, compromises the quality of life of patient.Most common clinical symptoms be it is heartburn,
Retrosternal pain and sour regurgitation.Serious patients with gastroesophageal reflux there is also the outer symptom of oesophagus, show as chronic pharyngitis, sound is neighed
Mute, tracheitis, asthma etc., clinically constant error examine as bronchitis, pneumonia or asthma, lead to long-term mistaken diagnosis and misdiagnosis.
Now common impedance detection is realized by external special impedance collection chip, this special chip is a kind of high
The direct transformation system of precision impedance number, is mainly made of frequency generator and an on piece analog-digital converter (ADC), frequency
Generator can generate the external complex impedance of signal excitation of specific frequency, and the response signal of complex impedance is by piece analog-digital converter
(ADC) after sampling, then pass through digital signal processor progress Discrete Fourier Transform (DFT) on piece.In each output frequency,
A real value (R) and dummy values (I) can be all returned to after Discrete Fourier Transform (DFT) calculation process, the method is of high cost, power consumption
Greatly, detection speed is low, poor expandability.
Invention content
It, can be quickly the object of the present invention is to provide a kind of at low cost in order to overcome above-mentioned defect existing in the prior art
Detect the esophagus impedance detection circuit of esophagus impedance value.
In order to realize the above-mentioned purpose of the present invention, the present invention provides a kind of esophagus impedance detection circuits, including MCU to control
Device, exiting signal generating circuit, signal processing circuit and channel switching circuit, the MCU controllers include channel switch logic
Unit;
First output end of MCU controllers connects the exiting signal generating circuit input terminal, the pumping signal hair
Raw circuit activation signal output end connects the channel switching circuit pumping signal input terminal, the exiting signal generating circuit
Trigger signal output end connects the signal processing circuit trigger signal input terminal, and the channel switching logic unit output end connects
The channel switching circuit control terminal is connect, the channel switching circuit is connect with esophagus impedance detection conduit, realizes that signal is two-way
Transmission, the impedance signal input terminal of the esophagus impedance detection conduit are connected with pull-up resistor, are made not using channel switching circuit
Same esophagus impedance forms access with pull-up resistor, and the channel switching circuit output end connects the signal processing circuit impedance
Signal input part, the signal processing circuit output end connect the MCU controllers input terminal;
The MCU controllers output square-wave signal is given to the exiting signal generating circuit, the exiting signal generating circuit
The impedance that the square-wave signal is converted into after sine wave signal being output to by channel switching circuit in esophagus impedance detection conduit
Element and pull-up resistor form closed loop, the conduit middle impedance element of the signal processing circuit receiving channel switching circuit output
Impedance signal, exiting signal generating circuit trigger the signal processing circuit and handle impedance signal, the signal processing
Circuit will it is processed after impedance signal be sent in the MCU controllers and carry out analog-to-digital conversion, obtain impedance value.
Pumping signal is formed by channel switching circuit with esophagus impedance and pull-up resistor in the esophagus impedance detection circuit
Access makes the pumping signal generate different decaying to carry out the measurement of impedance, the resistance detected by the variation of esophagus impedance
Antinoise signal is sent to signal processing circuit, and the effect of the toggled signal of synchronous signal processing circuit triggers it to receiving
Impedance signal such as is filtered at the processing, then carries out analog-to-digital conversion to the impedance signal after processed by MCU controllers again, to
Obtain impedance value.Because when detecting esophagus impedance, the impedance of different location in esophagus, therefore esophagus impedance detection conduit need to be detected
It is usually necessary to use multiple channels to be detected to the impedance of different location in esophagus, using channel switching logic unit and lead to
Road switching circuit to carry out impedance value acquisition to each channel of esophagus impedance detection conduit, to more comprehensively and accurately obtain
To real-time impedance value.The esophagus impedance detection circuit is simple in structure, and production cost is low, and can fast and accurately detect that esophagus hinders
Anti- value.
Further, the MCU controllers further include excitation square-wave generator and analog-digital converter, the excitation letter
It includes square wave-sawtooth conversion circuit, sawtooth wave-sine wave conversion circuit number circuit to occur, and the signal processing circuit includes anti-
Shifting circuit, all-wave Acquisition Circuit and filter circuit;
The excitation square-wave generator output end connects the square wave-sawtooth conversion circuit input terminal, the square wave-sawtooth
The first output end of conversion circuit connects the sawtooth wave-sine wave conversion circuit first input end, the square wave-sawtooth conversion electricity
Road second output terminal connects the all-wave Acquisition Circuit first input end, and the sawtooth wave-sine wave conversion circuit output end connects
The channel switching circuit pumping signal input terminal is connect, the channel switching circuit output end connects the circuit for reversing impedance letter
The positive signal output end of number input terminal, the circuit for reversing connects second input terminal of all-wave Acquisition Circuit, the reversion
Circuit inversion signal output end connects the all-wave Acquisition Circuit third input terminal, and the all-wave Acquisition Circuit output end connects institute
Filter circuit input terminal is stated, the filter circuit output end connects the analog-digital converter input terminal.
The excitation square-wave generator output square-wave signal of MCU controllers is converted into sawing by square wave-sawtooth wave conversion circuit
Then tooth wave is converted to sine wave via sawtooth wave-sine wave conversion circuit.The sine of a positive is exported by circuit for reversing
Wave, while the sine wave of a reverse phase is exported again, to obtain the sine wave that 2 phases differ 180 °, square wave-sawtooth conversion electricity
The sine wave that road triggering all-wave Acquisition Circuit differs the two phases 180 ° samples, and only retains respective upper half waveform,
An all-wave is obtained, then by filter circuit all-wave is filtered to obtain our analog signal, is then turned via analog to digital
Parallel operation carries out analog-to-digital conversion to analog signal, obtains real-time impedance value, this makes finally obtained impedance value more accurate.
Further, the exiting signal generating circuit further includes biasing clamp circuit, the biasing clamp circuit output
End is connected to the sawtooth wave-the second input terminal of sine wave conversion circuit.It biases clamp circuit and electricity is converted to sawtooth wave-sine wave
The sine wave of road conversion carries out voltage bias and clamper.
Further, the square wave-sawtooth conversion circuit includes field-effect tube, first resistor, second resistance, third electricity
Resistance, the 4th resistance, the 5th resistance, the 6th resistance, the 7th resistance, the first capacitance, the second capacitance, the first operational amplifier and second
Operational amplifier;
The grid of the field-effect tube connects the excitation square-wave generator output end, source electrode ground connection, and drain electrode passes through
The second resistance is connected to the first operational amplifier reverse side, and the reverse side of first operational amplifier is described in
First resistor is connected to power supply, and the positive terminal of first operational amplifier is connected to power supply by the 3rd resistor, passes through
4th resistance eutral grounding, the reverse side of first operational amplifier connect one end of first capacitance, first electricity
The other end of appearance connects the output end of first operational amplifier, and institute is parallel to after the 5th resistance and the series connection of the 6th resistance
The both ends of the first capacitance are stated, one end of second capacitance is connected at the tie point between the 5th resistance and the 6th resistance,
The second capacitance other end ground connection, first operational amplifier output terminal connect the sawtooth wave-sine wave conversion circuit
(input terminal, the positive terminal of the second operational amplifier connect the output end of first operational amplifier, second fortune
The reverse side for calculating amplifier connects power supply, and output end connects the all-wave Acquisition Circuit input terminal.
The square wave that MCU controllers are sent out quickly and accurately can be converted to sawtooth wave by the square wave-sawtooth conversion circuit, and be tied
Structure is simple, and production cost is low, convenient for promoting.
Further, the sawtooth wave-sine wave conversion circuit includes third capacitance, the 8th resistance, the 9th resistance, the tenth
Resistance, third operational amplifier and four-operational amplifier;
Third capacitance one end connects square wave-first output end of sawtooth conversion circuit, and the third capacitance is another
End connects the positive terminal of the third operational amplifier, and the positive terminal of the third operational amplifier is connected by the 8th resistance
It is connected to power supply, reverse side is connected to power supply by the 9th resistance, and reference edge is connected to the four-operational amplifier
Reverse side, output end connects one end of the tenth resistance, and the other end of the tenth resistance connects the 4th operation
The positive terminal of amplifier positive terminal, the four-operational amplifier connects the channel switching circuit output end, and the 4th operation is put
The reverse side of big device is connected with output end.
Sawtooth wave quickly and accurately can be converted to sine wave by the sawtooth wave-sine wave conversion circuit, and simple in structure, raw
Produce it is at low cost, convenient for promote.
Further, the circuit for reversing includes the 5th operational amplifier, the 6th operational amplifier, eleventh resistor and the
12 resistance;
The positive terminal of 5th operational amplifier connects the channel switching circuit output end, and reverse side is exported with it
End connection, output end connect two branches, and connection second input terminal of all-wave Acquisition Circuit, another by described
Eleventh resistor is connected to the reverse side of the 6th operational amplifier, and the positive terminal of the 6th operational amplifier is connected to electricity
The connection twelfth resistor of source, reverse side and output end, it is defeated that output end is connected to the all-wave Acquisition Circuit second
Enter end.
The output end of 5th operational amplifier is connected to all-wave Acquisition Circuit by two lines, wherein one is other one
Anti-phase output, this for all-wave Acquisition Circuit realize all-wave acquisition provide the foundation, all-wave Acquisition Circuit takes two lines to export
The waveform of the upper half of signal, you can composition all-wave.The circuit for reversing is simple in structure, and production cost is low, convenient for promoting.
Further, the filter circuit include thirteenth resistor, the 14th resistance, the 15th resistance, the 16th resistance,
4th capacitance, the 5th capacitance, the 6th capacitance, the 7th capacitance, the 7th operational amplifier and the 8th operational amplifier;
The all-wave Acquisition Circuit output end connects the 7th fortune by concatenated thirteenth resistor with the 14th resistance
The positive terminal of amplifier is calculated, one end of the 4th capacitance is connected at the thirteenth resistor and the tie point of the 14th resistance,
The other end of 4th capacitance connects the reverse side of the 7th operational amplifier, and the 14th resistance is transported with the described 7th
One end that the 5th capacitance is connected at the tie point of the positive terminal of amplifier is calculated, the 5th capacitance other end ground connection is described
The reverse side of 7th operational amplifier is connected with output end, and the output end of the 7th operational amplifier passes through the described 15th
Resistance is connected to the positive terminal of the 8th operational amplifier, the positive of the 15th resistance and the 8th operational amplifier
By the 6th capacity earth at the tie point at end, the 8th operational amplifier reverse side is connected with output end, defeated
Outlet is connected to the analog-digital converter input terminal, the 16th resistance and the simulation by the 16th resistance
Pass through the 7th capacity earth at the tie point of digital quantizer input terminal.The filter circuit construction is simple, good wave filtering effect,
Production cost is low, convenient for promoting.
Beneficial effects of the present invention have:
The esophagus impedance detection circuit generates pumping signal using peripheral analog circuit, and is carried out by external analog circuitry
Filtering and conversion, and data acquisition is carried out by analog-to-digital conversion, and realize the acquisition of impedance without dedicated integrated chip, have
There is at low cost, small power consumption, detection speed is high, the strong advantage of scalability.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Description of the drawings
The above-mentioned and/or additional aspect and advantage of the present invention will become in the description from combination following accompanying drawings to embodiment
Obviously and it is readily appreciated that, wherein:
Fig. 1 is the principle of the present invention block diagram;
Fig. 2 is square wave-sawtooth wave conversion circuit figure;
Fig. 3 is sawtooth wave-dextrorotation wave conversion circuit figure;
Fig. 4 is circuit for reversing figure;
Fig. 5 is filter circuit figure.
Specific implementation mode
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, and is only used for explaining the present invention, and is not considered as limiting the invention.
In the description of the present invention, unless otherwise specified and limited, it should be noted that term " installation ", " connected ",
" connection " shall be understood in a broad sense, for example, it may be mechanical connection or electrical connection, can also be the connection inside two elements, it can
, can also indirectly connected through an intermediary, for the ordinary skill in the art to be to be connected directly, it can basis
Concrete condition understands the concrete meaning of above-mentioned term.
As shown in Figure 1, the present invention provides a kind of esophagus impedance detection circuit, including MCU controllers 1, pumping signal hair
Raw circuit 2, signal processing circuit 3 and channel switching circuit 4, MCU controllers 1 include channel switching logic unit 1-3.
1 first output end of MCU controllers connects 2 input terminal of exiting signal generating circuit, and exiting signal generating circuit 2 swashs
Encourage the pumping signal input terminal of signal output end interface channel switching circuit 4, the trigger signal output of exiting signal generating circuit 2
Hold 3 trigger signal input terminal of connection signal processing circuit, channel switching logic unit 1-3 output end interface channels switching circuit 4
Control terminal, the channel switching circuit 4 are connect with esophagus impedance detection conduit, realize signal transmitted in both directions, the esophagus impedance
Detection conduit impedance signal input terminal be connected with pull-up resistor R, using channel switching circuit 4 make different esophagus impedances with it is upper
Pull-up resistor R forms access, and 4 output end of the channel switching circuit connects the 3 impedance signal input terminal of signal processing circuit, institute
It states 3 output end of signal processing circuit and connects 1 input terminal of MCU controllers.
In order to be detected to the impedance of different location in esophagus, it is logical which is provided with multiple detections
The channel switching logic unit 1-3 control channels switching circuit 4 in road, MCU controllers 1 is sequentially switched to last from first passage
A channel carries out impedance detection, wherein channel switching circuit to the corresponding position in each channel of esophagus impedance detection conduit
4 can be, but not limited to, analog switch, by channel switching logic unit 1-3 control its from different impedance detection channels into
Row connection.
When detecting each channel, MCU controllers 1 export square-wave signal and are given to exiting signal generating circuit 2, excitation letter
Number occur circuit 2 square-wave signal is converted into be output to esophagus impedance detection by channel switching circuit 4 after sine wave signal
Impedor and pull-up resistor R in conduit form closed loop, the conduit of 3 receiving channel switching circuit 4 of signal processing circuit output
The impedance signal of middle impedance element, 2 trigger signal processing circuit 3 of exiting signal generating circuit handle impedance signal, letter
Number processing circuit 3 will it is processed after impedance signal be sent in MCU controllers 1 and carry out analog-to-digital conversion, obtain impedance value.
As the preferred embodiment of the present embodiment, MCU controllers 1 further include that excitation square-wave generator 1-1 and simulation numeral turn
Parallel operation 1-2, exiting signal generating circuit 2 include square wave-sawtooth conversion circuit 2-1, sawtooth wave-sine wave conversion circuit 2-2 and
Clamp circuit 2-3 is biased, signal processing circuit 3 includes circuit for reversing 3-1, all-wave Acquisition Circuit 3-2 and filter circuit 3-3.
Square-wave generator 1-1 output ends are encouraged to connect square wave-sawtooth conversion circuit 2-1 input terminals, square wave-sawtooth conversion electricity
2-1 the first output ends in road connect sawtooth wave-sine wave conversion circuit 2-2 first input ends, square wave-sawtooth conversion circuit 2-1 the
Two output ends connect all-wave Acquisition Circuit 3-2 first input ends, and biasing clamp circuit 2-3 output ends are connected to sawtooth wave-sine
Wave conversion circuit the second input terminals of 2-2, the sawtooth wave-excitation letter of sine wave conversion circuit 2-2 output end interface channels switching circuit 4
Number input terminal, 4 output end of channel switching circuit connect circuit for reversing 3-1 impedance signal input terminals, and circuit for reversing 3-1's just believes
Number output end connects all-wave Acquisition Circuit the second input terminals of 3-2, and the circuit for reversing 3-1 inversion signal output ends connection is described complete
Wave Acquisition Circuit 3-2 third input terminals, all-wave Acquisition Circuit 3-2 output ends connect filter circuit 3-3 input terminals, filter circuit 3-
3 output ends connect analog-digital converter 1-2 input terminals.Here excitation square-wave generator 1-1 output ends are MCU controllers
1 the first output end is also the excitation square-wave signal output end of excitation square-wave generator 1-1.
Wherein, as shown in Fig. 2, square wave-sawtooth conversion circuit 2-1 includes field-effect tube Q, first resistor R1, second resistance
R2,3rd resistor R3, the 4th resistance R4, the 5th resistance R5, the 6th resistance R6, the 7th resistance R7, the first capacitance C1, the second capacitance
C2, the first operational amplifier U1 and second operational amplifier U2.
The grid connection excitation square-wave generator 1-1 output ends of field-effect tube Q, source electrode ground connection, drain electrode pass through second
Resistance R2 is connected to the first operational amplifier U1 reverse side, and the reverse side of the first operational amplifier U1 is connected by first resistor R1
To power supply, the positive terminal of the first operational amplifier U1 is connected to power supply by 3rd resistor R3, is grounded by the 4th resistance R4, the
The reverse side of one operational amplifier U1 connects one end of the first capacitance C1, and the other end of the first capacitance C1 connects the first operation amplifier
Be parallel to the both ends of the first capacitance C1 after the output end of device U1, the 5th resistance R5 and the 6th resistance R6 series connection, the 5th resistance R5 and
One end of the second capacitance C2, second capacitance C2 other ends ground connection are connected at tie point between 6th resistance R6, the first operation is put
The input terminal of big device U1 output ends connection sawtooth wave-sine wave conversion circuit 2-2, the positive terminal connection of second operational amplifier U2
The reverse side of the output end of first operational amplifier U1, second operational amplifier U2 connects power supply, and output end connection all-wave is adopted
Collector 3-2 input terminals.
As shown in figure 3, sawtooth wave-sine wave conversion circuit 2-2 includes third capacitance C3, the 8th resistance R8, the 9th resistance
R9, the tenth resistance R10, third operational amplifier U3 and four-operational amplifier U4.
The one end third capacitance C3 connects square wave-sawtooth conversion circuit the first output ends of 2-1, the connection of the third capacitance C3 other ends
The positive terminal of the positive terminal of third operational amplifier U3, third operational amplifier U3 is connected to power supply by the 8th resistance R8,
Reverse side is connected to power supply by the 9th resistance R9, and reference edge is connected to the reverse side of four-operational amplifier U4, output
The other end of one end of the tenth resistance R10 of end connection, the tenth resistance R10 connects four-operational amplifier U4 positive terminals, the 4th fortune
The positive terminal for calculating amplifier U4 is separately connected 4 output end of the channel switching circuit and biases clamp circuit 2-3 output ends, and the 4th
The reverse side of operational amplifier U4 is connected with output end.
As shown in figure 4, circuit for reversing 3-1 includes the 5th operational amplifier U5, the 6th operational amplifier U6, eleventh resistor
R11 and twelfth resistor R12.
4 output end of positive terminal interface channel switching circuit of 5th operational amplifier U5, reverse side connect with its output end
It connects, output end connects two branches, and connection all-wave Acquisition Circuit second input terminal of 3-2, another article passes through the 11st electricity
Resistance R11 is connected to the reverse side of the 6th operational amplifier U6, and the positive terminal of the 6th operational amplifier U6 is connected to power supply, reverse phase
The connection twelfth resistor R12 at end and output end, output end are connected to all-wave Acquisition Circuit the second input terminals of 3-2.
As shown in figure 5, filter circuit 3-3 includes thirteenth resistor R13, the 14th resistance R14, the 15th resistance R15,
16 resistance R16, the 4th capacitance C4, the 5th capacitance C5, the 6th capacitance C6, the 7th capacitance C7, the 7th operational amplifier U7 and
Eight operational amplifier U8.
All-wave Acquisition Circuit 3-2 output ends are transported by concatenated thirteenth resistor R13 and the 14th resistance R14 connections the 7th
The one of the 4th capacitance C4 is connected at the tie point of the positive terminal of calculation amplifier U7, thirteenth resistor R13 and the 14th resistance R14
End, the other end of the 4th capacitance C4 connect the reverse side of the 7th operational amplifier U7, the 14th resistance R14 and the 7th operation amplifier
One end of the 5th capacitance C5, the 5th capacitance C5 other ends ground connection, the 7th operation amplifier are connected at the tie point of the positive terminal of device U7
The reverse side of device U7 is connected with output end, and the output end of the 7th operational amplifier U7 is connected to by the 15th resistance R15
Pass through at the positive terminal of eight operational amplifier U8, the 15th resistance R15 and the tie point of the positive terminal of the 8th operational amplifier U8
6th capacitance C6 ground connection, the 8th operational amplifier U8 reverse side are connected with output end, and output end passes through the 16th resistance R16
It is connected to analog-digital converter 1-2 input terminals, the tie point of the 16th resistance R16 and analog-digital converter 1-2 input terminals
Place passes through the 7th capacitance C7 ground connection.
MCU controllers 1 are low-power scm, and square wave and analogue-to-digital converters 1-2 is encouraged to be controlled by MCU controllers 1
System generates.Biasing clamp circuit 2-3 is made of a pull-up resistor and clamp diode.
MCU controllers 1 export square-wave signal be converted into sawtooth wave by square wave-sawtooth wave conversion circuit 2-1, then via
Sawtooth wave-sine wave conversion circuit 2-2 is converted to sine wave, and inclined to sine wave progress voltage by biasing clamp circuit 2-3
It sets and clamper.Obtained sine wave is output in esophagus impedance detection conduit by channel switching circuit 4 and pull-up resistor R shapes
At closed loop, the impedance for the conduit middle impedance element that circuit for reversing 3-1 receiving channels switching circuit 4 exports in signal processing circuit 3
Signal, and the signal is inverted, the sine wave for exporting 2 180 ° of phases differences is given to all-wave Acquisition Circuit 3-2, swashs simultaneously
The all-wave Acquisition Circuit 3-2 of square wave-sawtooth conversion circuit 2-1 trigger signals processing circuit 3 in signal generating circuit 2 is encouraged to institute
The impedance signal received is handled, and 2 phases are differed with 180 ° of sine wave and is sampled, respective upper half waveform is only retained,
To obtain an all-wave, then analogue-to-digital converters 1- is sent to after being filtered to the all-wave by filter circuit 3-3
2 carry out analog-to-digital conversion, obtain real-time impedance value.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
Centainly refer to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be any
One or more embodiments or example in can be combined in any suitable manner.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that:Not
In the case of being detached from the principle of the present invention and objective a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The range of invention is limited by claim and its equivalent.