CN106038416A - 一种清凉组合物及含有清凉组合物的药品和化妆品 - Google Patents
一种清凉组合物及含有清凉组合物的药品和化妆品 Download PDFInfo
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Abstract
本发明涉及一种清凉组合物及含有清凉组合物的药品和化妆品。本发明的清凉组合物包含下述重量份的组分：根瘤菌胶0.2‑1.0份、赤藓醇0.5‑10份、岩藻糖0.1‑2.0份和生物糖胶‑2 0.4‑10份；本发明的药品或化妆品含有所述清凉组合物。本发明所提供的组合物是一种具有清凉效果的组合物，其适用于消费者享受清新、凉爽愉悦的皮肤感觉或者帮助消费者缓解皮肤不适的热感。
Description
技术领域
本发明涉及一种组合物及其含有该组合物的药品和化妆品，具体涉及一种清凉组合物及其含有清凉组合物的药品和化妆品。
背景技术
我们的身体中有各种各样的感受器或感觉器官，它们接受各种信息并传达到大脑，产生感觉和知觉，并形成我们对世界的认识。一般认为皮肤感觉主要有四种，即触觉、冷觉、热觉和痛觉。每一种感觉是由皮肤内相应的感受器所引起的。
温度感受器为温度刺激的感受器，是温度觉(包括冷觉和热觉)的受体。它们将皮肤及外界环境的温度变化传递给体温调节中枢。热敏感性瞬时受体电位离子通道(简称TRPs或热敏TRPs)被分子克隆并证实为主要的细胞温度感受器，它们在初级感觉神经末梢被表达，并感知环境温度变化。目前已知的有6种哺乳类热敏感性瞬时受体电位通道，在从冷痛到热伤的某一特定温度它们被激活、表达。其中TRPV1和TRPV2是由伤害性热刺激(≥42℃)活化；TRPV3和TRPV4被非痛温觉激活；TRPM8由非痛冷刺激活化；TRPA1由引发伤害性冷刺激(≤4℃)活化。每个TRP可由不同的天然化合物以及合成化合物激活，这些化合物通常会诱发人体的热感和痛感，表1列出这些激活剂。
表1TRP通道与温度敏感性、非热激活剂及功能
引起热敏感性瞬时受体电位通道受体变化的温度称为热阈值，很多热敏感性瞬时受体的热阈值是由损伤的组织或炎性反应释放的细胞外介质来调节的，如缓激肽、前列腺素和生长因子等。
TRPV1通常被认为介导伴随炎症的热痛觉过敏，TRPV4在热痛觉过敏过程中具有一定的作用。TRPM8，曾被称为“寒冷与薄荷醇受体1”(CMR1)，在活化时它允许钠离子和钾离子进入细胞内，这导致细胞的去极化以及产生一个动作电位，并最终将导致生物感受到冷的感觉。
在感觉神经元上表达的这种TRPM8蛋白，会被温度降低或者诸如薄荷醇、冰素(icilin)和桉油精等冷感剂激活。已实验验证和通常使用的薄荷醇受体激活剂(非热激活剂)包括芳樟醇、香叶醇、羟基香茅醛、薄荷酰胺(WS-3、WS-23)、薄荷酮甘油缩酮(FrescolatMGA)、薄荷醇乳酸酯(Frescolat ML)、对薄荷基-3,8-二醇(PMD 38)、异胡薄荷醇(CoolactP)和薄荷氧基丙二醇(Cooling Agent 10)。
利用热敏感性瞬时受体的作用原理，在化妆品中可以使用两种不同类型的清凉剂。例如薄荷醇作为非痛性冷感受器TRPM8的激活剂可以提供清凉的感觉，达到愉悦的感官体验，尽管皮肤的温度并没有降低。另外，非堵塞性制品中聚二甲基硅氧烷、乙醇(同时也是TRPV1通道的非热激活剂)和水等挥发性成分从皮肤表面蒸发过程消耗的热量使皮肤温度下降，这种制冷效果通常十分短暂。
薄荷醇及其衍生物(薄荷醇PCA酯例外)带有气味，与化妆品香味会有冲突。另外，对于敏感皮肤和过敏体质的使用者，使用薄荷醇及其衍生物成分的化妆品还要留意可能带来的皮肤刺激和过敏反应。
由于一些炎症介质激活热痛觉过敏，在化妆品中可以应用具有舒缓抗敏的成分，配合清凉剂的冷介导镇痛，帮助消费者缓解皮肤不适的热感。
发明内容
本发明的目的在于克服现有技术的不足之处而提供一种具有清凉效果的组合物，该组合物可为提供清新、凉爽愉悦的皮肤感觉或者帮助消费者缓解皮肤不适的热感。
为实现上述目的，本发明采取的技术方案为：一种清凉组合物，包含下述重量份的组分：根瘤菌胶0.2-1.0份、赤藓醇0.5-10份、岩藻糖0.1-2.0份和生物糖胶-2 0.4-10.0份。
根瘤菌胶是由含根瘤菌的小麦麦麸培养基经过发酵形成的支链多聚糖，其为粉末状，分子量800，000道尔顿，由下列成分组成的连续单元：吡喃糖形式的6个中性糖(3个葡萄糖分子和3个半乳糖分子)和1个带电荷的葡萄糖醛酸分子，并且带有乙酰基和丙酮酸基，因此成为带有电荷的多聚糖。在皮肤上，根瘤菌胶由于释放水分发生分子结构变化，呈现螺旋结构。根瘤菌胶能够显著降低皮肤温度，效果持久且能使皮肤保持清爽。
赤藓醇为白色结晶的四碳多元醇类化合物，化学名称为1，2，3，4-丁四醇，是小分子湿润剂，天然糖醇的一种，其溶解热为-97.4J/g。由于溶解热较大，溶于水时会吸收较多的能量，有很强的制冷作用。实验表明，将10g赤藓糖醇溶解于90g水中，温度下降约4.8℃。赤藓醇用于化妆品中，保湿性能优于海藻糖、甜菜碱、甘油和山梨醇等，肤感更好，可带来清爽、清新、清凉的肤感。
岩藻糖为L(-)岩藻糖，六碳糖的一种，可刺激人体皮肤纤维母细胞增殖，有细胞保护作用；可抑制某些引发皮肤过敏反应的淋巴因子的活性，对过敏性接触性皮炎有明显的抑制作用，减少人体皮肤的过敏反应，有抗过敏作用。
生物糖胶-2是通过菌类发酵获得植物支链聚多糖，分子量60，000道尔顿，由下列成分组成的连续单元：3个鼠李糖分子、2个半乳糖分子和1个葡萄糖醛酸分子，富含L-鼠李糖。生物糖胶-2不同于其他生物多糖胶，如生物糖胶-1为线性聚多糖，含有L-岩藻糖、D-半乳糖和半乳糖醛酸，主要的起保湿作用，生物糖胶-4为平均分子量达2，000，000道尔顿支链聚多糖，含有D-葡萄糖、L-岩藻糖和葡萄糖醛酸，主要作用形成生物保护膜，而生物糖胶-2主要作用是抗过敏。角质细胞含有鼠李糖的特殊受体，对角质细胞有很高的亲和力，通过将自身固定在受袭角质细胞的细胞膜受体上和限制角质细胞释放炎症信使来减少炎症，舒缓炎症的反应；通过角质细胞促进减少疼痛感的愉悦分子β-内啡肽的释放，增加舒适感和愉悦感。
本发明的上述组合物，其是一种温和、有效、无气味的清凉组合物。
作为本发明所述清凉组合物的优选实施方式，所述清凉组合物还包含以下(a)-(d)所述重量份组分中的至少一项：(a)β-葡聚糖0.1-10份；(b)泛醇0.1-5份；(c)甘油葡糖苷0.1-5.0份；(d)芦荟提取物0.01-1.0份。
β-葡聚糖是β-1,3-D-葡聚糖，自然界常见的葡聚糖异构体有β-(1,3)/(1,4)-葡聚糖和β-(1,3)/(1,6)-葡聚糖，β-(1,3)/(1,4)-葡聚糖主要来源于燕麦或大麦等谷物，β-(1,3)/(1,6)-葡聚糖主要来源于酵母细胞壁或者蘑菇，优选为β-(1,3)/(1,6)-葡聚糖。β-葡聚糖是优良的免疫激活剂，能促进朗格罕氏细胞(皮肤的主动防御系统)增殖，增强皮肤的免疫能力；β-葡聚糖能激活免疫系统中的基础细胞---巨噬细胞，巨噬细胞产生表皮生长因子(EGF)，从而促进伤口愈合所必需的胶原蛋白产生，同时血管生成因子(AF)可促进伤口愈合必需的新血管形成，在敏感肌肤修复方面有独特的生物活性。
泛醇是泛酸的同效物，泛酸有促进细胞再生作用，对皮肤和头发的损伤有愈合作用。作为天然抗氧剂，泛酸可以减缓脂质的过氧化反应，减少自由基对肌肤的伤害。
甘油葡糖苷是通过蔗糖和甘油反应制得，能够增加肌肤保湿性、增强皮肤细胞活力、减轻皮肤发红、对抗红疹、加速皮肤伤口愈合以及增强皮肤细胞抗氧化能力。
芦荟提取物是库拉索芦荟叶的天然的水溶性活性成分，能够滋润干燥肌肤、恢复皮肤弹性、清除自由基、缓解发炎和修复受损皮肤。
作为本发明所述清凉组合物的优选实施方式，所述根瘤菌胶为0.4-0.5重量份，根瘤菌胶与赤藓醇的重量比为1:5-1:10。在所述重量份和重量比时，组合物的清凉效果和肤感达到最佳平衡。
本发明还提供了一种含有上述清凉组合物的药品和化妆品。本发明的组合物具有清凉的效果，可用于药品和化妆品，使得药品和化妆品也具有清凉效果。
作为本发明所述化妆品的优选实施方式，所述化妆品还包含辅料；优选地，所述化妆品为100重量份。其中，辅料指的是目前用于化妆品中的常规辅料，本领域技术人员可根据现有技术以及化妆品的剂型、用途等选择适宜含量的辅料，只要所选择的辅料不碍于本发明组合物所期望的功能就行。化妆品辅料可以在《已使用化妆品原料名称目录》找到。
作为本发明所述化妆品的优选实施方式，所述辅料为防腐剂、螯合剂、香精、油脂、保湿剂、增稠剂、表面活性剂、乳化剂、着色剂、抗氧化剂、助渗剂、肤感调节剂中的至少一种。本发明的化妆品可以采用一种或多种不同的防腐剂或具有防腐效果的成分。
作为本发明所述化妆品的优选实施方式，所述防腐剂为甲醛释放体类、尼泊金酯类、含卤素类、季铵盐类、有机酸类、醇类防腐剂中的至少一种，更优选地，所述防腐剂为有机酸类防腐剂或者醇类防腐剂；所述保湿剂为甘油、1,2-己二醇、丙二醇、吡咯烷酮羧酸钠、透明质酸钠、糖类、聚乙二醇中的至少一种；所述增稠剂为纤维素、黄原胶、卡拉胶、结冷胶、果胶、刺槐豆胶、卡波姆、聚丙烯酸类共聚物中的至少一种；所述抗氧化剂为生育酚、生育酚乙酸酯、丁羟甲苯、对羟基苯乙酮中的至少一种；所述助渗剂为月桂氮卓酮、乙氧基二甘醇、聚甘油-10二十碳二酸酯/十四碳二酸酯/甘油(NeosolueTM-AquaS)中的至少一种。防腐剂、保湿剂、增稠剂、抗氧化剂和助渗剂包括但不限于所述优选的物质。
作为本发明所述化妆品的优选实施方式，所述化妆品为液状、啫喱状、乳液状或膏霜状剂型。从使用性能方面来考虑，所述化妆品更优选为液状、啫喱状、或乳液状，最佳地，所述化妆品为液状或啫喱状。
作为本发明所述化妆品的优选实施方式，所述化妆品为液状剂型，其由下述重量份的组分组成：根瘤菌胶0.5份、赤藓醇5份、岩藻糖0.1份、生物糖胶-2 2.0份、泛醇0.5份、保湿剂3.4份、抗氧化剂0.5份、水92.6份；所述保湿剂由甘油和1,2-己二醇组成；所述抗氧化剂为对羟基苯乙酮。
作为本发明所述化妆品的优选实施方式，所述化妆品为液状剂型，其由下述重量份的组分组成：根瘤菌胶0.4份、赤藓醇2.0份、岩藻糖0.2份、生物糖胶-2 0.4份、β-葡聚糖5.0份、泛醇5.0份、甘油葡糖苷1.0份、芦荟提取物0.1份、保湿剂3.4份、抗氧化剂0.5份、水82.0份；所述保湿剂由甘油和1,2-己二醇组成；所述抗氧化剂为对羟基苯乙酮。
作为本发明所述化妆品的优选实施方式，所述化妆品为驻留类化妆品或者淋洗类化妆品。从使用性能方面来考虑，所述化妆品更优选为停留型的化妆品。
与现有技术相比，本发明的有益效果为：
(1)本发明所提供的组合物是一种具有清凉效果的组合物，其适用于消费者享受清新、凉爽愉悦的皮肤感觉或者帮助消费者缓解皮肤不适的热感；
(2)通过将本发明的清凉组合物制成不同的化妆品剂型，可提供清新、凉爽愉悦的皮肤感觉或者帮助缓解皮肤由于环境压力、过敏等导致的不适的热感。
附图说明
图1为实施例8中对志愿者晒后面部皮肤发红减少、灼热疼痛改善和清凉效果的评分结果图。
具体实施方式
为更好地说明本发明的目的、技术方案和优点，下面将结合附图和具体实施例对本发明作进一步说明。
实施例1
本发明清凉组合物的一种实施例，本实施例所述清凉组合物包含下述重量份的组分：根瘤菌胶0.5份、赤藓醇5份、岩藻糖0.1份和生物糖胶-2 2.0份、泛醇0.5份。
本实施例所述清凉组合物的制备方法为：将根瘤菌胶加入水中，搅拌加热，65℃-70℃保温搅拌30分钟，此为A相；70℃将泛醇加入到A相，成为B相；B相冷却降温；40℃将赤藓醇、岩藻糖和生物糖胶-2加入到B相，搅拌10分钟，成为C相；C相过滤出料，即为清凉组合物。
实施例2
本发明清凉组合物的一种实施例，本实施例所述清凉组合物包含下述重量份的组分：根瘤菌胶0.4份、赤藓醇2.0份、岩藻糖0.2份和生物糖胶-2 0.4份、β-葡聚糖5.0份、泛醇5.0份、甘油葡糖苷1.0份、芦荟提取物0.1份；其中芦荟提取物为芦荟粉。
本实施例所述清凉组合物的制备方法为：将根瘤菌胶加入水中，搅拌加热，65℃-70℃保温搅拌30分钟，此为A相；70℃将泛醇加入到A相，成为B相；B相冷却降温；40℃将赤藓醇、岩藻糖、生物糖胶-2、β-葡聚糖、甘油葡糖苷和芦荟提取物加入到B相，搅拌10分钟，成为C相；C相过滤出料，即为清凉组合物。
实施例3
本发明清凉组合物的一种实施例，本实施例所述清凉组合物包含下述重量份的组分：根瘤菌胶1.0份、赤藓醇0.5份、岩藻糖2.0份和生物糖胶-2 5.0份、β-葡聚糖0.1份、泛醇0.1份、甘油葡糖苷2.0份、芦荟提取物0.2份。
本实施例所述清凉组合物的制备方法同实施例2。
实施例4
本发明清凉组合物的一种实施例，本实施例所述清凉组合物包含下述重量份的组分：根瘤菌胶0.2份、赤藓醇10.0份、岩藻糖0.1份和生物糖胶-2 5.0份、β-葡聚糖10.0份、泛醇5.0份、甘油葡糖苷0.1份、芦荟提取物1.0份。
本实施例所述清凉组合物的制备方法同实施例2。
实施例5
本发明清凉组合物的一种实施例，本实施例所述清凉组合物包含下述重量份的组分：根瘤菌胶0.6份、赤藓醇10.0份、岩藻糖1.0份和生物糖胶-2 10.0份、β-葡聚糖5.0份、泛醇1.0份、甘油葡糖苷5.0份、芦荟提取物0.01份。
本实施例所述清凉组合物的制备方法同实施例2。
实施例6冰爽舒缓面膜液及其制备
本发明化妆品的一种实施例，本实施例所述化妆品为冰爽舒缓面膜液，其含有实施例1所述清凉组合物。本实施例所述冰霜舒缓面膜液的组成如表2所示。
表2冰爽舒缓面膜液组成
本实施例的冰爽舒缓面膜液的制备工艺如下：
1)将表2中的料序号为1号和2号原料搅拌加热，65℃-70℃保温搅拌30分钟，此为①相；
2)在70℃温度下，将序号为3号-7号的原料分别加入到①相，冷却降温，成为②相；
3)在40℃温度下，加入原料序号为8号和9号原料到②相，搅拌，成为③相；
4)将③相过滤出料，即成冰爽舒缓面膜液。
实施例7晒后修复清凉精华及其制备
本发明化妆品的一种实施例，本实施例所述化妆品为晒后修复清凉精华，其含有实施例2所述清凉组合物。本实施例所述晒后修复清凉精华的组成如表3所示。
表3晒后修复清凉精华组成
本实施例的晒后修复清凉精华的制备工艺如下：
1)将表3中的原料序号为1号和2号原料搅拌加热，65℃—75℃保温30分钟，此为①相；
2)在70℃温度下，将原料序号为3号—7号的原料加入到①相，冷却降温，成为②相；
3)在40℃温度下，加入序号为8号—12的号原料到②相，搅拌，成为③相；
4)将③相过滤出料，即成晒后修复清凉精华。
实施例8效果验证例
(1)应用测试例1
方法：80位健康皮肤志愿者，男性15位，女性65位，年龄从20岁—40岁，使用本发明实施例6的冰爽舒缓面膜液，每张无纺布巾用20克冰爽舒缓面膜液浸泡、润透，洁面后铺在面部，敷15分钟。敷毕，对志愿者进行问卷调查，评价使用感受。评价项目包括即时清凉效果(3分钟时)、持久清凉效果(15分钟时)、不良气味、刺痛感、灼热感和舒适性。结果统计如下表4所示。
表4
| 项目 | 人数 |
| 即时清凉效果(3分钟时) | 80 |
| 持久清凉效果(15分钟时) | 77 |
| 不良气味 | 0 |
| 刺痛感 | 0 |
| 灼热感 | 0 |
| 舒适性 | 78 |
从表4的统计结果可以看出，志愿者使用本发明实施例6的冰爽舒缓面膜液，所有志愿者都感受到即时清凉效果(80人/80人)，没有志愿者报告有不良气味、刺痛感和灼热感(0人/80人)，绝大多数志愿者感受到持久清凉效果(77人/78人)和认可冰爽舒缓面膜液的舒适性(78人/80人)。
(2)应用测试例2
方法：45位晒后面部皮肤发红、有灼热疼痛感的志愿者，男性15位，女性30位，年龄从20—40岁，洁面后，对照试验，左脸使用清水，右脸使用本发明实施例7的晒后修复清凉精华，测试结束时对志愿者进行问卷调查，对评价项目进行打分。评价项目包括面部发红减少、灼热疼痛改善和清凉效果，时间为3分钟时和120分钟，分别对应于即时效果和持续效果。对评价项目进行打分时分成5个等级，其中，对于面部发红减少而言，0分表示没有效果，1分表示面部发红稍有减少，2分表示面部发红减少效果良好，3分表示面部发红明显减少，4分表示面部发红基本完全减少；对于灼热疼痛改善而言，0分表示没有效果，1分表示灼热疼痛稍有改善，2份表示灼热疼痛改善效果良好，3分表示灼热疼痛明显改善，4分表示灼热疼痛基本完全改善；对于清凉效果而言，0分表示没有效果，1分表示稍有清凉效果，2分表示清凉效果良好，3分表示明显具有清凉效果，4分表示清凉效果最好。对志愿者晒后面部皮肤发红减少、灼热疼痛改善和清凉效果的评分结果如图1所示。
从图1的统计结果可以看出，测试者使用本发明实施例7的晒后修复清凉精华后，面部发红和灼热感持续改善，清凉效果持久。测试过程中，灼热感持续改善和清凉感明显好于清水对照，发红情况较使用清水效果好。
最后所应当说明的是，以上实施例仅用以说明本发明的技术方案而非对本发明保护范围的限制，尽管参照较佳实施例对本发明作了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的实质和范围。
Claims (10)
1.一种清凉组合物，其特征在于：包含下述重量份的组分：根瘤菌胶0.2-1.0份、赤藓醇0.5-10份、岩藻糖0.1-2.0份和生物糖胶-2 0.4-10份。
2.如权利要求1所述的清凉组合物，其特征在于：所述清凉组合物还包含以下(a)-(d)所述重量份组分中的至少一项：
(a)β-葡聚糖0.1-10份；(b)泛醇0.1-5份；(c)甘油葡糖苷0.1-5.0份；(d)芦荟提取物0.01-1.0份。
3.如权利要求1或2所述的清凉组合物，其特征在于：所述根瘤菌胶为0.4-0.5重量份，根瘤菌胶与赤藓醇的重量比为1:5-1:10。
4.一种含有如权利要求1～3任一项所述清凉组合物的药品或化妆品。
5.如权利要求4所述的化妆品，其特征在于：所述化妆品还包含辅料；优选地，所述辅料为防腐剂、螯合剂、香精、油脂、保湿剂、增稠剂、表面活性剂、乳化剂、着色剂、抗氧化剂、助渗剂、肤感调节剂中的至少一种。
6.如权利要求5所述的化妆品，其特征在于：如下的(1)-(5)项中的任意一项或者两项或者多项：
(1)所述防腐剂为甲醛释放体类、尼泊金酯类、含卤素类、季铵盐类、有机酸类、醇类防腐剂中的至少一种；
(2)所述保湿剂为甘油、1,2-己二醇、丙二醇、吡咯烷酮羧酸钠、透明质酸钠、糖类、聚乙二醇中的至少一种；
(3)所述增稠剂为纤维素、黄原胶、卡拉胶、结冷胶、果胶、刺槐豆胶、卡波姆、聚丙烯酸类共聚物中的至少一种；
(4)所述抗氧化剂为生育酚、生育酚乙酸酯、丁羟甲苯、对羟基苯乙酮中的至少一种；
(5)所述助渗剂为月桂氮卓酮、乙氧基二甘醇、聚甘油-10二十碳二酸酯/十四碳二酸酯/甘油中的至少一种。
7.如权利要求4～6任一项所述的化妆品，其特征在于：所述化妆品为液状、啫喱状、乳液状或膏霜状剂型。
8.如权利要求7所述的化妆品，其特征在于：所述化妆品为液状剂型，其由下述重量份的组分组成：根瘤菌胶0.5份、赤藓醇5份、岩藻糖0.1份、生物糖胶-2 2.0份、泛醇0.5份、保湿剂3.4份、抗氧化剂0.5份、水92.6份；所述保湿剂由甘油和1,2-己二醇组成；所述抗氧化剂为对羟基苯乙酮。
9.如权利要求7所述的化妆品，其特征在于：所述化妆品为液状剂型，其由下述重量份的组分组成：根瘤菌胶0.4份、赤藓醇2.0份、岩藻糖0.2份、生物糖胶-2 0.4份、β-葡聚糖5.0份、泛醇5.0份、甘油葡糖苷1.0份、芦荟提取物0.1份、保湿剂3.4份、抗氧化剂0.5份、水82.0份；所述保湿剂由甘油和1,2-己二醇组成；所述抗氧化剂为对羟基苯乙酮。
10.如权利要求4～6任一项所述的化妆品，其特征在于：所述化妆品为驻留型或者淋洗型。
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| CN114601748A (zh) * | 2021-12-21 | 2022-06-10 | 星智豫美(上海)生物科技有限公司 | 一种舒缓修复组合物及其应用 |
| CN116236429A (zh) * | 2023-03-23 | 2023-06-09 | 广州美思生物技术有限公司 | 一种舒缓压力疲倦提升心情愉悦感的洗沐产品及其制备方法 |
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