CN106037756A - Noninvasive glucometer - Google Patents
Noninvasive glucometer Download PDFInfo
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- CN106037756A CN106037756A CN201610424022.XA CN201610424022A CN106037756A CN 106037756 A CN106037756 A CN 106037756A CN 201610424022 A CN201610424022 A CN 201610424022A CN 106037756 A CN106037756 A CN 106037756A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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Abstract
The invention relates to a noninvasive glucometer, which comprises insulin automatic injection equipment, blood oxygen saturation detection equipment, invasive blood glucose detection equipment and a DSP (digital signal processor) processing chip, wherein the blood oxygen saturation detection equipment and the noninvasive blood glucose detection equipment are used for extracting blood oxygen saturation data and blood glucose data of a detected person; the DSP processing chip is connected to the insulin automatic injection equipment, the blood oxygen saturation detection equipment and the noninvasive blood glucose detection equipment; a blood oxygen supply state of the detected person is determined based on the blood oxygen saturation data; and in addition, injection parameters of the insulin automatic injection equipment are determined based on the blood glucose data. With the implementation of the noninvasive glucometer, the blood oxygen supply situation of the detected person can be automatically detected on one side, and on the other side, self-adaptive injection control of insulin can be achieved.
Description
The present invention is Application No. 201510747401.8, filing date on November 5th, 2015, invention entitled " a kind of
The using method of non-invasive blood glucose meter " the divisional application of patent.
Technical field
The present invention relates to injection of insulin control field, particularly relate to a kind of non-invasive blood glucose meter.
Background technology
Blood glucose, refers to glucose contained in blood.Postdigestive glucose is entered blood by small intestinal, and is transported to
Each cell in body, is the main energy sources of cell.The blood sugar concentration of normal person is the most stable, falls and can determine that at one
Blood glucose range within.
Blood glucose must keep certain level could maintain each organ internal and the needs of tissue.Blood sugar concentration typically exists
Raise after taking food one to two hours, and be preferably minimized at breakfast.Blood sugar concentration imbalance can cause multiple disease, persistence blood glucose
The hyperglycemia of excessive concentration and too low hypoglycemia cause serious impact all can to people's health, and caused by many reasons
Persistent hyperglycemia will cause diabetes, and this is also the most significant disease that blood sugar concentration is relevant.
Prior art exists the Medical Instruments of some detection blood glucose, but these blood glucose meter all exist following defect: (1) is examined
Survey pattern is single, can only detect blood sugar concentration；(2) testing mechanism falls behind, and structural redundancy is too high, and precision can not meet and increasingly increases
The accuracy requirement added；(3) there is no blood sugar test and the control mechanism of insulin supply, it is impossible to according to the blood sugar content of tested human body
The supply parameter of the insulin of self-adaptative adjustment tested personnel, such as, feed speed, quantity delivered etc., in addition it is also necessary to manual observation blood
Sugar content, manual decision's insulin supply parameter, automatization level falls behind；(4) wireless communication interface is deficient, it is impossible to will be with blood glucose
Relevant parameters is timely fed back to medical server end, even if there are some simple wireless communication interfaces, such as bluetooth
Communication interface, its matching mechanisms and connection mechanism inefficiency, can not meet the requirement of the high speed transmission data of medical device.
To this end, the present invention proposes a kind of non-invasive blood glucose meter, it is possible to improve the structure of the blood glucose meter fallen behind, blood oxygen is satisfied
It is dissolved in blood glucose meter with degree detection, widens the scope of the physiological parameter of detection, improve the precision of blood sugar test, it is possible to set up blood
The insulin delivery system that sugar automatically controls, reduces artificial participation, in addition it is possible to improve existing Bluetooth communication mechanism, carries
The speed of high wireless data transmission and efficiency.
Summary of the invention
In order to solve the technical problem that prior art exists, the invention provides a kind of non-invasive blood glucose meter, blood oxygen is satisfied
Work in concentrating on a detecting instrument with degree detection equipment and blood sugar test equipment simultaneously, optimize existing blood sugar test equipment
Structure, improve blood sugar test precision, meanwhile, add insulin pump and insulin supply control mechanism, it is achieved blood sugar concentration
Automatically control, particular, it is important that by improving the matching mechanisms of existing bluetooth communication interface and connection mechanism, improve blood glucose
The communication performance of instrument wireless connections.
According to an aspect of the present invention, it is provided that a kind of non-invasive blood glucose meter, described blood glucose meter includes that insulin is noted automatically
Jet device, blood oxygen saturation detection equipment, non-invasive blood sugar test equipment and DSP process chip, and described blood oxygen saturation detects
Equipment and described non-invasive blood sugar test equipment are respectively used to extract blood oxygen saturation data and blood glucose level data, the institute of tested personnel
State DSP and process chip and described Automatic insulin injection equipment, described blood oxygen saturation detection equipment and described non-invasive blood glucose
Detection equipment connects respectively, determines the blood oxygen supply state of tested personnel based on described blood oxygen saturation data, is additionally based upon described
Blood glucose level data determines the injection parameters of described Automatic insulin injection equipment.
More specifically, in described non-invasive blood glucose meter, including Direct Digital Frequency Synthesizers, be used for producing frequency and
The sine wave signal that phase place can adjust to be used as mixing use as rf frequency source；Pulse-series generator, is used for producing
Pulse train；Frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, uses pulse
Sequence pair sine wave signal carries out mixed modulated；Power amplifier, is connected with described frequency mixer, for by the letter after mixed modulated
Number it is amplified；Switching Power Supply, is used as the interface circuit between probe and power amplifier, and the signal loading after amplifying is to visiting
In the radio-frequency receiving-transmitting coil of head；Nd-Fe-B permanent magnetic type magnet structure, produces a field in the space accommodating tested personnel's finger
Strong uniform static magnetic field；Probe, is placed on tested personnel's finger position, is wound around radio-frequency receiving-transmitting coil to be sent by the signal of loading
Enter in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, be additionally operable to hydrogen matter in tested personnel's finger
The deamplification obtained after sub-resonance is sent；Light emitting diode, is arranged on tested personnel's finger fingertip blood capillary position, with light
Source driving circuit connects, for the LED control signal sent based on light source driving circuit, alternate emission infrared light and HONGGUANG；Light
Source driving circuit, built-in timer, for sending LED control signal to described light emitting diode；Optical-electrical converter, is arranged on
On tested personnel's finger fingertip, it is positioned at the relative position of described light emitting diode, is used for receiving transmission tested personnel's finger fingertip
Infrared light after blood capillary and HONGGUANG, and transmitted infrared light and transmission HONGGUANG are respectively converted into analog current signal, to obtain
Infrared light electric current and simulation HONGGUANG electric current must be simulated；Current-to-voltage converting circuit, is connected with described optical-electrical converter, for mould
Intend infrared light electric current and simulation HONGGUANG electric current carries out current/voltage conversion respectively, to obtain simulation infrared light voltage and simulation respectively
Red voltages；Signal amplifier, is connected with described current-to-voltage converting circuit, for simulation infrared light voltage and simulation HONGGUANG
Voltage is amplified respectively, amplifies voltage to obtain to simulate infrared light amplification voltage and simulate HONGGUANG；Signal deteching circuit, with institute
State signal amplifier to connect, including direct current signal detection electronic circuit and alternating current signal detection electronic circuit, be used for detecting simulation infrared
Flip-flop in photovoltage and alternating component, to export as the first DC voltage and the first alternating voltage, be additionally operable to detection
Flip-flop in simulation red voltages and alternating component, to export as the second DC voltage and the second alternating voltage；Modulus
Transducer, is connected with described signal deteching circuit, for the first DC voltage, the first alternating voltage, the second DC voltage and
Second alternating voltage carries out analog digital conversion respectively, with obtain the first Digital DC voltage, the first Digital AC voltage, second
Digital DC voltage and the second Digital AC voltage；Blood oxygen saturation computing circuit, is connected with described analog-digital converter, will
The ratio of the second Digital AC voltage and the second Digital DC voltage is divided by the first Digital AC voltage and the first numeral
Change DC voltage ratio to obtain the absorbing light ratio factor, and based on the absorbing light ratio factor calculating blood oxygen saturation, wherein,
Blood oxygen saturation is linear with the absorbing light ratio factor；DSP processes chip, is connected with described probe, receives described decay
Signal, analyzes the spectral line of described deamplification, and calculates wherein glucose proportion, thus the blood glucose obtaining tested personnel is dense
Degree, described DSP processes chip and also is connected to obtain blood oxygen saturation with blood oxygen saturation computing circuit；Described DSP processes chip
When described blood sugar concentration is at default blood glucose upper concentration, send blood sugar concentration too high identification signal, when described blood sugar concentration exists
When presetting blood glucose least concentration, send blood sugar concentration too low identification signal；When described blood oxygen saturation is in default blood oxygen saturation
During upper concentration, send blood oxygen saturation too high identification signal, when described blood oxygen saturation is dense at default blood oxygen saturation lower limit
When spending, send blood oxygen saturation too low identification signal；Insulin storage device, for prestoring the insulin of preset capacity；
Liquid level detection device, is positioned at described insulin storage device, the insulin liquor in detection insulin storage device in real time
Position, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, described Level Detection
Equipment also processes chip and is connected described insufficient insulin alarm signal is sent to described DSP process chip with described DSP；Pancreas
Island element drives equipment, processes chip with described DSP and is connected, when receiving described blood sugar concentration too high identification signal, according to institute
The difference stating blood sugar concentration and described default blood glucose upper concentration that DSP processes chip forwarding determines insulin pump drive signal,
Described insulin pump drives value and the speed of the supply insulin of signal deciding insulin pump；Insulin pump, with described pancreas
Island element storage device and insulin infusion device connect respectively, drive equipment to be connected with described insulin, at described islets of langerhans
Under the control of element driving equipment, the insulin in described insulin storage device is expelled to tested by insulin infusion device
In personnel's body；Insulin infusion device, detachable is embedded in tested personnel's body, for tested personnel's insulin injection；
Serial communication circuit, processes between chip and Bluetooth matching communication equipment at DSP, for by described blood sugar concentration and described pancreas
Island element deficiency alarm signal is sent to Bluetooth matching communication equipment；Bluetooth matching communication equipment, for by described blood sugar concentration and
Described insufficient insulin alarm signal is wirelessly transmitted to the target Bluetooth devices connected；Described Bluetooth matching communication equipment includes
First search subset, the second search subset and coupling connexon equipment；Wherein, the first search subset, dissipate according to bluetooth
Penetrating micro bluetooth network that MAC Address concentration in net determines that Bluetooth MAC address concentration is the highest as target piconet, a bluetooth dissipates
Penetrate net to be made up of multiple micro bluetooth networks；Second search subset, is connected with described first search subset, micro-in described target
In microgrid, find, quantity preceding by signal intensity ranking and be not more than one or more Bluetooth matching communication equipments of 7 as one
Individual or multiple target Bluetooth devices；Equipment connexon equipment, with described second search subset is connected, start and one or
The Bluetooth communication of multiple target Bluetooth devices connects；Wherein, described optical-electrical converter is a photodiode；Wherein, described
The wavelength of the infrared light that optical diode is launched is 940nm, and the wavelength of the HONGGUANG that described light emitting diode is launched is 660nm；Wherein,
Signal filter circuit is also set up between described signal amplifier and described signal deteching circuit, infrared for filtering simulation respectively
Light amplification voltage and simulation HONGGUANG amplify the noise contribution in voltage；Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is bird
One in cage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus；Wherein, Direct Digital frequency is closed
The one in direct digital synthesizers, analog phase-locked look and digital phase-locked loop is selected in the frequency synthesis growing up to be a useful person used；Wherein, institute is worked as
State the quantity of the Bluetooth matching communication equipment having signal in target piconet for during more than or equal to 7, the one or more target
The quantity of bluetooth equipment is 7, when the quantity of the Bluetooth matching communication equipment having signal in described target piconet is less than 7
Time, the quantity of the one or more target Bluetooth devices is to have the Bluetooth matching communication equipment of signal in described target piconet
Quantity.
More specifically, in described non-invasive blood glucose meter: described DSP processes the built-in storage unit of chip and prestores
Described default blood oxygen saturation upper concentration, described default blood oxygen saturation least concentration, described preset reference liquid level, described pre-
If blood glucose upper concentration and described default blood glucose least concentration.
More specifically, in described non-invasive blood glucose meter, described blood glucose meter also includes: Compact Flash, it is used for prestoring
Described default blood oxygen saturation upper concentration, described default blood oxygen saturation least concentration, described preset reference liquid level, described
Preset blood glucose upper concentration and described default blood glucose least concentration.
More specifically, in described non-invasive blood glucose meter: described DSP processes chip and is sending the too high identification of blood oxygen saturation
When signal, blood oxygen saturation too low identification signal, blood glucose too high identification signal or hypoglycemia identification signal, it is simultaneously emitted by exception
Status signal, otherwise, described DSP processes chip and is simultaneously emitted by normal state signal.
More specifically, in described non-invasive blood glucose meter: described serial communication circuit is RS485 serial communication interface.
Accompanying drawing explanation
Below with reference to accompanying drawing, embodiment of the present invention are described, wherein:
Fig. 1 is the block diagram of the first embodiment of the non-invasive blood glucose meter of the present invention.
Reference: 1 Automatic insulin injection equipment；2 blood oxygen saturation detection equipment；3 non-invasive blood sugar test equipment；
4DSP processes chip
Detailed description of the invention
Below with reference to accompanying drawings the embodiment of the non-invasive blood glucose meter of the present invention is described in detail.
Sugar in blood is referred to as blood glucose, is the most all glucose.Needed for internal each histiocyte activity
Energy major part is from glucose, so blood glucose preferably must be held in certain level and could maintain internal each organ and the need of tissue
Ask.
The concentration of the blood glucose in human body is generally controlled in a scope the narrowest, and blood glucose is too high or too low all can give people
Affect.In order to effectively detect the blood sugar concentration in human body, occur in that multiple blood glucose meter on the market, especially for suffering from
The patient having hypertension is favored.
But, blood glucose meter of the prior art detection parameter is single, testing mechanism falls behind, and lacks blood sugar test and insulin
Supply automatically controls mechanism, and meanwhile, the wireless communication interface coupling being furnished with and joint efficiency are low, can not meet hospital
Existing requirement with patient.
To this end, the present invention has built a kind of non-invasive blood glucose meter, by the high-precision blood oxygen saturation through structure optimization
Monitoring device and blood glucose monitoring device are integrated in a detecting instrument, simultaneously use blood sugar test and insulin supply automatic
Bluetooth communication interface after control model and optimization, thus facilitate the use of patient and hospital.
Fig. 1 is the block diagram of the first embodiment of the non-invasive blood glucose meter of the present invention, and described blood glucose meter includes islets of langerhans
Element automatic injection device, blood oxygen saturation detection equipment, non-invasive blood sugar test equipment and DSP process chip, and described blood oxygen is satisfied
It is respectively used to extract blood oxygen saturation data and the blood of tested personnel with degree detection equipment and described non-invasive blood sugar test equipment
Sugar data, described DSP processes chip and described Automatic insulin injection equipment, described blood oxygen saturation detection equipment and described nothing
Wound formula blood sugar test equipment connects respectively, determines the blood oxygen supply state of tested personnel based on described blood oxygen saturation data, also
The injection parameters of described Automatic insulin injection equipment is determined based on described blood glucose level data.
Then, continue the concrete structure of the second embodiment of the non-invasive blood glucose meter of the present invention is carried out further
Bright.
Described blood glucose meter includes: Direct Digital Frequency Synthesizers, for the sine wave producing frequency and phase place can adjust
Signal to be used as mixing use as rf frequency source；Pulse-series generator, is used for producing pulse train；Frequency mixer, with institute
State Direct Digital Frequency Synthesizers and described pulse-series generator connects respectively, use pulse train that sine wave signal is carried out
Mixed modulated；Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated.
Described blood glucose meter includes: Switching Power Supply, is used as the interface circuit between probe and power amplifier, after amplifying
Signal loading to probe radio-frequency receiving-transmitting coil in；Nd-Fe-B permanent magnetic type magnet structure, in the space accommodating tested personnel's finger
One uniform static magnetic field of field intensity of interior generation；Probe, is placed on tested personnel's finger position, is wound around radio-frequency receiving-transmitting coil to incite somebody to action
The signal loaded is sent in described Nd-Fe-B permanent magnetic type magnet structure, produces nmr phenomena, is additionally operable to through tested person
The deamplification obtained after Hydrogen Proton resonance in member's finger is sent；Light emitting diode, is arranged on tested personnel's finger fingertip capillary
Vessel position, is connected with light source driving circuit, and for the LED control signal sent based on light source driving circuit, alternate emission is red
Outer light and HONGGUANG.
Described blood glucose meter includes: light source driving circuit, built-in timer, for sending luminescence control to described light emitting diode
Signal processed；Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at the relative position of described light emitting diode, is used for
Receive the infrared light after transmission tested personnel's finger fingertip blood capillary and HONGGUANG, and by transmitted infrared light and transmission HONGGUANG difference
Be converted to analog current signal, to obtain simulation infrared light electric current and simulation HONGGUANG electric current；Current-to-voltage converting circuit, with described
Optical-electrical converter connects, for simulation infrared light electric current and simulation HONGGUANG electric current are carried out current/voltage conversion respectively, with respectively
Obtain simulation infrared light voltage and simulation red voltages.
Described blood glucose meter includes: signal amplifier, is connected with described current-to-voltage converting circuit, for simulation infrared light
Voltage and simulation red voltages are amplified respectively, amplify voltage and simulation HONGGUANG amplification voltage with acquisition simulation infrared light；Letter
Number testing circuit, is connected with described signal amplifier, including direct current signal detection electronic circuit and alternating current signal detection electronic circuit, uses
Flip-flop in detection simulation infrared light voltage and alternating component, using defeated as the first DC voltage and the first alternating voltage
Go out, be additionally operable to the flip-flop in detection simulation red voltages and alternating component, using as the second DC voltage and the second exchange
Voltage exports.
Described blood glucose meter includes: analog-digital converter, is connected with described signal deteching circuit, for the first DC voltage,
First alternating voltage, the second DC voltage and the second alternating voltage carry out analog digital conversion respectively, to obtain the first Digital DC
Voltage, the first Digital AC voltage, the second Digital DC voltage and the second Digital AC voltage；Blood oxygen saturation computing
Circuit, is connected with described analog-digital converter, by the ratio of the second Digital AC voltage and the second Digital DC voltage divided by
The ratio of the first Digital AC voltage and the first Digital DC voltage is to obtain the absorbing light ratio factor, and based on absorbing light
The ratio factor calculates blood oxygen saturation, and wherein, blood oxygen saturation is linear with the absorbing light ratio factor.
Described blood glucose meter includes: DSP processes chip, is connected with described probe, receives described deamplification, decline described in analysis
The spectral line of cut signal, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel, described DSP process
Chip also is connected to obtain blood oxygen saturation with blood oxygen saturation computing circuit；Described DSP processes chip when described blood sugar concentration
When default blood glucose upper concentration, send blood sugar concentration too high identification signal, when described blood sugar concentration is dense at default blood glucose lower limit
When spending, send blood sugar concentration too low identification signal；When described blood oxygen saturation is at default blood oxygen saturation upper concentration, send
Blood oxygen saturation too high identification signal, when described blood oxygen saturation is at default blood oxygen saturation least concentration, sends blood oxygen and satisfies
With spend low identification signal.
Described blood glucose meter includes: insulin storage device, for prestoring the insulin of preset capacity；Level Detection sets
Standby, it is positioned at described insulin storage device, the insulin liquid level in detection insulin storage device in real time, and at islets of langerhans
Element liquid level equal to or less than preset reference liquid level time, send insufficient insulin alarm signal, described liquid level detection device also with institute
State DSP and process chip connection described insufficient insulin alarm signal to be sent to described DSP process chip.
Described blood glucose meter includes: insulin drives equipment, processes chip with described DSP and is connected, when receiving described blood glucose
During excessive concentration identification signal, process, according to described DSP, blood sugar concentration and the described default blood glucose upper concentration that chip forwards
Difference determines insulin pump drive signal, and described insulin pump drives the value of the supply insulin of signal deciding insulin pump
And speed；Insulin pump, connects respectively with described insulin storage device and insulin infusion device, drives with described insulin
Equipment connects, and under the control driving equipment at described insulin, is passed through by the insulin in described insulin storage device
Insulin infusion device is expelled in tested personnel's body.
Described blood glucose meter includes: insulin infusion device, detachable is embedded in tested personnel's body, for tested person
Member's insulin injection.
Described blood glucose meter includes: serial communication circuit, processes between chip and Bluetooth matching communication equipment at DSP, uses
In described blood sugar concentration and described insufficient insulin alarm signal are sent to Bluetooth matching communication equipment.
Described blood glucose meter includes: Bluetooth matching communication equipment, for by described blood sugar concentration and described insufficient insulin report
Alert signal is wirelessly transmitted to the target Bluetooth devices connected；Described Bluetooth matching communication equipment include the first search subset,
Second search subset and coupling connexon equipment；Wherein, the first search subset is dense according to MAC Address in Bluetooth Scatternet
Degree determine micro bluetooth network that Bluetooth MAC address concentration is the highest as target piconet, a Bluetooth Scatternet is by multiple bluetooths
Piconet forms；Second search subset, is connected with described first search subset, and in described target piconet, searching is pressed
Signal intensity ranking is preceding, quantity is not more than one or more Bluetooth matching communication equipments of 7 as one or more targets
Bluetooth equipment；Equipment connexon equipment, is connected with described second search subset, starts and the one or more target Bluetooth
The Bluetooth communication of equipment connects；Wherein, described optical-electrical converter is a photodiode.
Wherein, the wavelength of the infrared light that described light emitting diode is launched is 940nm, the HONGGUANG that described light emitting diode is launched
Wavelength be 660nm；Wherein, between described signal amplifier and described signal deteching circuit, also set up signal filter circuit,
The noise contribution in voltage and simulation HONGGUANG amplification voltage is amplified for filtering simulation infrared light respectively；Wherein, described probe twines
Around radio-frequency receiving-transmitting coil be in birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus
Kind；Wherein, direct digital synthesizers, analog phase-locked look and digital phase-locking are selected in the frequency synthesis that Direct Digital Frequency Synthesizers is used
The one of Xiang Huanzhong.
Wherein, when being more than or equal to 7 when described target piconet has the quantity of Bluetooth matching communication equipment of signal, institute
The quantity stating one or more target Bluetooth devices is 7, when the Bluetooth matching communication having signal in described target piconet sets
When standby quantity is less than 7, the quantity of the one or more target Bluetooth devices is to have signal in described target piconet
The quantity of Bluetooth matching communication equipment.
Alternatively, in described injection platform: described DSP processes the built-in storage unit of chip and prestored described pre-
If blood oxygen saturation upper concentration, described default blood oxygen saturation least concentration, described preset reference liquid level, described default blood glucose
Upper concentration and described default blood glucose least concentration；Described injection platform also includes: Compact Flash, is used for having prestored described
Preset blood oxygen saturation upper concentration, described default blood oxygen saturation least concentration, described preset reference liquid level, described default blood
Sugar upper concentration and described default blood glucose least concentration；Described DSP process chip send blood oxygen saturation too high identification signal,
When blood oxygen saturation too low identification signal, blood glucose too high identification signal or hypoglycemia identification signal, it is simultaneously emitted by abnormality
Signal, otherwise, described DSP processes chip and is simultaneously emitted by normal state signal；Described serial communication circuit is RS485 serial communication
Interface.
It addition, dsp chip, also referred to as digital signal processor, it is that one is particularly suitable for carrying out Digital Signal Processing computing
Microprocessor, it is mainly applied is to realize various digital signal processing algorithm real-time.
According to the requirement of Digital Signal Processing, dsp chip typically has following main feature: (1) is an instruction cycle
In can complete a multiplication and a sub-addition；(2) program and data space is separately, can access instruction and data simultaneously；(3) sheet
Inside there is quick RAM, generally can be accessed in two pieces by independent data/address bus simultaneously；(4) there is low overhead or without expense
Circulation and the hardware supported redirected；(5) quickly interrupt processing and Hardware I/O support；(6) there is operation within the monocycle many
Individual hardware address generator；(7) can be with the multiple operation of executed in parallel；(8) support pile line operation, make fetching, decode and perform
Can be with Overlapped Execution Deng operation.
Use the non-invasive blood glucose meter of the present invention, fall behind and radio communication function for blood glucose apparatus structure in prior art
The technical problem of difference, optimizes the structure of existing blood glucose instrument, adds blood oxygen detection equipment and blood sugar concentration automatic controlling device,
The most also improve the communication performance of existing bluetooth communication interface, thus improve the intelligence degree of medical detecting Instrument.
Although it is understood that the present invention discloses as above with preferred embodiment, but above-described embodiment being not used to
Limit the present invention.For any those of ordinary skill in the art, without departing under technical solution of the present invention ambit,
Technical solution of the present invention is made many possible variations and modification by the technology contents that all may utilize the disclosure above, or is revised as
Equivalent embodiments with change.Therefore, every content without departing from technical solution of the present invention, according to the technical spirit pair of the present invention
Any simple modification made for any of the above embodiments, equivalent variations and modification, all still fall within the scope of technical solution of the present invention protection
In.
Claims (2)
1. a non-invasive blood glucose meter, described blood glucose meter includes that Automatic insulin injection equipment, blood oxygen saturation detect equipment, nothing
Wound formula blood sugar test equipment and DSP process chip, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment
Being respectively used to extract blood oxygen saturation data and the blood glucose level data of tested personnel, described DSP processes chip with described insulin certainly
Dynamic injection device, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment connect, respectively based on described blood
Oxygen saturation data determine the blood oxygen supply state of tested personnel, are additionally based upon described blood glucose level data and determine that described insulin is noted automatically
The injection parameters of jet device.
2. non-invasive blood glucose meter as claimed in claim 1, it is characterised in that described blood glucose meter includes:
Direct Digital Frequency Synthesizers, for producing frequency and sine wave signal that phase place can adjust is using as rf frequency source
It is used as mixing to use；
Pulse-series generator, is used for producing pulse train；
Frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, uses pulse train
Sine wave signal is carried out mixed modulated；
Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated；
Switching Power Supply, is used as the interface circuit between probe and power amplifier, signal loading the penetrating to probe after amplifying
Frequently in dispatch coil；
Nd-Fe-B permanent magnetic type magnet structure, produces a uniform static-magnetic of field intensity in the space accommodating tested personnel's finger
?；
Probe, is placed on tested personnel's finger position, is wound around radio-frequency receiving-transmitting coil and sends into described neodymium iron boron with the signal that will load
In permanent-magnet type magnet structure, produce nmr phenomena, be additionally operable to through obtaining after Hydrogen Proton resonance in tested personnel's finger
Deamplification send；
Light emitting diode, is arranged on tested personnel's finger fingertip blood capillary position, is connected with light source driving circuit, for based on
The LED control signal that light source driving circuit sends, alternate emission infrared light and HONGGUANG；
Light source driving circuit, built-in timer, for sending LED control signal to described light emitting diode；
Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at the relative position of described light emitting diode, is used for receiving
Infrared light after transmission tested personnel's finger fingertip blood capillary and HONGGUANG, and transmitted infrared light and transmission HONGGUANG are changed respectively
For analog current signal, simulate infrared light electric current and simulation HONGGUANG electric current to obtain；
Current-to-voltage converting circuit, is connected with described optical-electrical converter, for simulation infrared light electric current and simulation HONGGUANG electric current
Carry out current/voltage conversion respectively, to obtain simulation infrared light voltage and simulation red voltages respectively；
Signal amplifier, is connected with described current-to-voltage converting circuit, for simulation infrared light voltage and simulation red voltages
It is amplified respectively, amplifies voltage to obtain to simulate infrared light amplification voltage and simulate HONGGUANG；
Signal deteching circuit, is connected with described signal amplifier, including direct current signal detection electronic circuit and alternating current signal detection
Circuit, for detecting the flip-flop in simulation infrared light voltage and alternating component, to hand over as the first DC voltage and first
Stream voltage output, is additionally operable to the flip-flop in detection simulation red voltages and alternating component, using as the second DC voltage and
Second alternating voltage output；
Analog-digital converter, is connected with described signal deteching circuit, for the first DC voltage, the first alternating voltage, second straight
Stream voltage and the second alternating voltage carry out analog digital conversion, respectively to obtain the first Digital DC voltage, the first Digital AC
Voltage, the second Digital DC voltage and the second Digital AC voltage；
Blood oxygen saturation computing circuit, is connected with described analog-digital converter, by the second Digital AC voltage and the second digitized
The ratio of DC voltage divided by the ratio of the first Digital AC voltage and the first Digital DC voltage to obtain absorbing light ratio
The value factor, and calculate blood oxygen saturation based on the absorbing light ratio factor, wherein, blood oxygen saturation becomes line with the absorbing light ratio factor
Sexual relationship；
DSP processes chip, is connected with described probe, receives described deamplification, analyze the spectral line of described deamplification, and calculate
Wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel, described DSP processes chip and also transports with blood oxygen saturation
Calculate circuit to connect to obtain blood oxygen saturation；Described DSP process chip when described blood sugar concentration is at default blood glucose upper concentration,
Send blood sugar concentration too high identification signal, when described blood sugar concentration is at default blood glucose least concentration, send blood sugar concentration too low
Identify signal；When described blood oxygen saturation is at default blood oxygen saturation upper concentration, sends too high identification of blood oxygen saturation and believe
Number, when described blood oxygen saturation is at default blood oxygen saturation least concentration, send blood oxygen saturation too low identification signal；
Insulin storage device, for prestoring the insulin of preset capacity；
Liquid level detection device, is positioned at described insulin storage device, the islets of langerhans in detection insulin storage device in real time
Element liquid level, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, described liquid level
Detection equipment also processes chip and is connected described insufficient insulin alarm signal is sent to described DSP process core with described DSP
Sheet；
Insulin drives equipment, processes chip with described DSP and is connected, when receiving described blood sugar concentration too high identification signal,
The blood sugar concentration forwarded according to described DSP process chip and the difference of described default blood glucose upper concentration determine that insulin pump drives
Signal, described insulin pump drives value and the speed of the supply insulin of signal deciding insulin pump；
Insulin pump, connects respectively with described insulin storage device and insulin infusion device, drives with described insulin and sets
Standby connection, under the control driving equipment at described insulin, passes through pancreas by the insulin in described insulin storage device
Island element injection device is expelled in tested personnel's body；
Insulin infusion device, detachable is embedded in tested personnel's body, for tested personnel's insulin injection；
Serial communication circuit, processes between chip and Bluetooth matching communication equipment at DSP, for by described blood sugar concentration and institute
State insufficient insulin alarm signal and be sent to Bluetooth matching communication equipment；
Bluetooth matching communication equipment, for being wirelessly transmitted to connection by described blood sugar concentration and described insufficient insulin alarm signal
On target Bluetooth devices；Described Bluetooth matching communication equipment includes the first search subset, the second search subset and coupling
Connexon equipment；Wherein, the first search subset, determine Bluetooth MAC address concentration according to MAC Address concentration in Bluetooth Scatternet
The highest micro bluetooth network is as target piconet, and a Bluetooth Scatternet is made up of multiple micro bluetooth networks；Second search
Equipment, is connected with described first search subset, and in described target piconet, it is preceding, several that signal intensity ranking is pressed in searching
Amount is not more than one or more Bluetooth matching communication equipments of 7 as one or more target Bluetooth devices；Equipment connexon sets
Standby, it is connected with described second search subset, starts and be connected with the Bluetooth communication of the one or more target Bluetooth devices；
Wherein, described optical-electrical converter is a photodiode；
Wherein, the wavelength of the infrared light that described light emitting diode is launched is 940nm, the ripple of the HONGGUANG that described light emitting diode is launched
A length of 660nm；
Wherein, between described signal amplifier and described signal deteching circuit, also set up signal filter circuit, for filtering respectively
Amplify voltage except simulation infrared light and simulation HONGGUANG amplifies the noise contribution in voltage；
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage coil, toroidal winding, saddle-shaped coils, phased array alignment
One in circle and annulus；
Wherein, direct digital synthesizers, analog phase-locked look and numeral are selected in the frequency synthesis that Direct Digital Frequency Synthesizers is used
One in phaselocked loop；
Wherein, when being more than or equal to 7 when described target piconet has the quantity of Bluetooth matching communication equipment of signal, described one
Individual or multiple target Bluetooth devices quantity is 7, when the Bluetooth matching communication equipment having signal in described target piconet
When quantity is less than 7, the quantity of the one or more target Bluetooth devices is the bluetooth having signal in described target piconet
The quantity of matched communicating devices；
Described DSP processes the built-in storage unit of chip and has prestored described default blood oxygen saturation upper concentration, described pre-
If blood oxygen saturation least concentration, described preset reference liquid level, described default blood glucose upper concentration and described default blood glucose lower limit
Concentration；
Compact Flash, is used for having prestored described default blood oxygen saturation upper concentration, described default blood oxygen saturation lower limit
Concentration, described preset reference liquid level, described default blood glucose upper concentration and described default blood glucose least concentration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610424022.XA CN106037756A (en) | 2015-11-05 | 2015-11-05 | Noninvasive glucometer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610424022.XA CN106037756A (en) | 2015-11-05 | 2015-11-05 | Noninvasive glucometer |
| CN201510747401.8A CN105193425A (en) | 2015-11-05 | 2015-11-05 | Use method of noninvasive glucometer |
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| CN201510747401.8A Division CN105193425A (en) | 2015-11-05 | 2015-11-05 | Use method of noninvasive glucometer |
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| CN201510747401.8A Withdrawn CN105193425A (en) | 2015-11-05 | 2015-11-05 | Use method of noninvasive glucometer |
| CN201610424022.XA Pending CN106037756A (en) | 2015-11-05 | 2015-11-05 | Noninvasive glucometer |
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| CN201510747401.8A Withdrawn CN105193425A (en) | 2015-11-05 | 2015-11-05 | Use method of noninvasive glucometer |
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Cited By (2)
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| CN108784710A (en) * | 2018-06-27 | 2018-11-13 | 常州市第人民医院 | A kind of blood oxygen saturation monitoring instrument based on Radio Transmission Technology |
| WO2020073958A1 (en) * | 2018-10-11 | 2020-04-16 | 京东方科技集团股份有限公司 | Contact lenses, and glucose monitoring system and monitoring method |
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| CN105193426B (en) * | 2015-11-05 | 2016-08-17 | 山东大数据医疗科技有限公司 | Non-invasive blood glucose meter |
| CN105411551A (en) * | 2016-01-02 | 2016-03-23 | 无锡桑尼安科技有限公司 | Human-body-state detecting device |
| CN105549511A (en) * | 2016-01-02 | 2016-05-04 | 无锡桑尼安科技有限公司 | Multifunctional electric control system disposed on bus |
| CN105549441A (en) * | 2016-01-02 | 2016-05-04 | 无锡桑尼安科技有限公司 | Intelligent electric control system |
| CN107714049A (en) * | 2017-09-08 | 2018-02-23 | 上海乐糖信息科技有限公司 | Noninvasive Blood Glucose Detection Methods, system and device based on Multi-information acquisition |
| CN108852330A (en) * | 2018-05-08 | 2018-11-23 | 广东小天才科技有限公司 | Biological signal detection method and device based on TWS earphone |
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| CN105193425A (en) | 2015-12-30 |
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