CN105193426B - Non-invasive blood glucose meter - Google Patents

Non-invasive blood glucose meter Download PDF

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Publication number
CN105193426B
CN105193426B CN201510749831.3A CN201510749831A CN105193426B CN 105193426 B CN105193426 B CN 105193426B CN 201510749831 A CN201510749831 A CN 201510749831A CN 105193426 B CN105193426 B CN 105193426B
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China
Prior art keywords
signal
insulin
voltage
equipment
oxygen saturation
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CN201510749831.3A
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CN105193426A (en
Inventor
徐宝华
李本然
李平
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Shandong Big Data Medical Technology Co., Ltd.
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Shandong Big Data Medical Technology Co Ltd
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Priority to CN201510749831.3A priority Critical patent/CN105193426B/en
Publication of CN105193426A publication Critical patent/CN105193426A/en
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Publication of CN105193426B publication Critical patent/CN105193426B/en
Priority to CN201680035616.XA priority patent/CN107949326A/en
Priority to PCT/CN2016/096038 priority patent/WO2017076104A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps

Abstract

The present invention relates to a kind of non-invasive blood glucose meter, described blood glucose meter includes Automatic insulin injection equipment, blood oxygen saturation detection equipment, non-invasive blood sugar test equipment and DSP process chip, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment are respectively used to extract blood oxygen saturation data and the blood glucose level data of tested personnel, described DSP processes chip and described Automatic insulin injection equipment, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment connect respectively, the blood oxygen supply state of tested personnel is determined based on described blood oxygen saturation data, it is additionally based upon described blood glucose level data and determines the injection parameters of described Automatic insulin injection equipment.Pass through the present invention, on the one hand, can automatically detect the blood oxygen supply situation of tested personnel, on the other hand, it is possible to the self adaptation injection realizing insulin controls.

Description

Non-invasive blood glucose meter
Technical field
The present invention relates to injection of insulin control field, particularly relate to a kind of non-invasive blood glucose meter.
Background technology
Blood sugar, refers to glucose contained in blood.Postdigestive glucose is entered blood by small intestine, And each cell being transported in body, it is the main energy sources of cell.The blood sugar of normal person is dense Spend the most stable, fall within a confirmable blood glucose range.
Blood sugar must keep certain level could maintain each organ internal and the needs of tissue.Blood sugar Concentration is general to be raised after one to two hours on the feed, and is preferably minimized at breakfast.Blood sugar concentration is lacked of proper care Can cause multiple disease, hyperglycaemia and too low hypoglycemia that continuation blood sugar concentration is too high all can give people Health cause serious impact, and the Persistent hyperglycemia caused by many reasons will cause glycosuria Disease, this is also the most significant disease that blood sugar concentration is relevant.
Prior art exists Medical Instruments of some detection blood sugar, but below these blood glucose meter all exist Defect: (1) detection pattern is single, can only detect blood sugar concentration;(2) testing mechanism falls behind, knot Structure redundancy is too high, and precision can not meet the accuracy requirement increasingly increased;(3) there is no blood sugar test Controlling mechanism with insulin supply, it is impossible to the blood-sugar content self-adaptative adjustment according to tested human body is tested The supply parameter of the insulin of personnel, such as, feed speed, quantity delivered etc., in addition it is also necessary to manual observation Blood-sugar content, manual decision's insulin supply parameter, automatization level falls behind;(4) radio communication Interface is deficient, it is impossible to the parameters relevant to blood sugar is timely fed back to medical server end, even if There is some simple wireless communication interfaces, such as bluetooth communication interface, its matching mechanisms and connection machine Inefficiency processed, can not meet the requirement of the high speed transmission data of medical device.
To this end, the present invention proposes a kind of non-invasive blood glucose meter, it is possible to improve the knot of the blood glucose meter fallen behind Structure, is dissolved into blood oxygen saturation detection in blood glucose meter, widens the scope of the physiological parameter of detection, carry The precision of hyperglycaemia detection, it is possible to set up the insulin delivery system that blood sugar automatically controls, reduces artificial Participate in, in addition it is possible to improve existing Bluetooth communication mechanism, improve the speed of Wireless Data Transmission And efficiency.
Summary of the invention
In order to solve the technical problem that prior art exists, the invention provides a kind of non-invasive blood sugar Instrument, detects equipment by blood oxygen saturation and blood sugar test equipment concentrates in a detecting instrument work simultaneously Make, optimize the structure of existing blood sugar test equipment, improve the precision of blood sugar test, add meanwhile Insulin pump and insulin supply controlling mechanism, it is achieved automatically controlling of blood sugar concentration, particularly important Be, by improving the matching mechanisms of existing bluetooth communication interface and connection mechanism, improve blood sugar instrument without The communication performance that line connects.
According to an aspect of the present invention, it is provided that a kind of non-invasive blood glucose meter, described blood glucose meter includes pancreas At island element automatic injection device, blood oxygen saturation detection equipment, non-invasive blood sugar test equipment and DSP Reason chip, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment are respectively used to carry Taking blood oxygen saturation data and the blood glucose level data of tested personnel, described DSP processes chip and described pancreas islet Element automatic injection device, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment divide Do not connect, determine the blood oxygen supply state of tested personnel based on described blood oxygen saturation data, be additionally based upon Described blood glucose level data determines the injection parameters of described Automatic insulin injection equipment.
More specifically, in described non-invasive blood glucose meter, including: Direct Digital Frequency Synthesizers, use Make being used as mixing as rf frequency source in producing sine wave signal that frequency and phase place can adjust With;Pulse-series generator, is used for producing pulse train;Frequency mixer, with described Direct Digital frequency Synthesizer and described pulse-series generator connect respectively, use pulse train to carry out sine wave signal Mixed modulated;Power amplifier, is connected with described frequency mixer, for being entered by the signal after mixed modulated Row amplifies;Switching Power Supply, is used as the interface circuit between probe and power amplifier, after amplifying Signal loading to probe radio-frequency receiving-transmitting coil in;Nd-Fe-B permanent magnetic type magnet structure, tested accommodating A uniform static magnetic field of field intensity is produced in the space of personnel's finger;Probe, is placed on tested personnel Finger position, is wound around radio-frequency receiving-transmitting coil and sends into described Nd-Fe-B permanent magnetic type magnet with the signal that will load In structure, produce nmr phenomena, be additionally operable to after Hydrogen Proton resonance in tested personnel's finger The deamplification obtained is sent;Light emitting diode, is arranged on tested personnel's finger fingertip capillary position Put, be connected with light source driving circuit, for the LED control signal sent based on light source driving circuit, Alternate emission infrared light and ruddiness;Light source driving circuit, built-in timer, for described luminous two Pole pipe sends LED control signal;Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at The relative position of described light emitting diode, after being used for receiving transmission tested personnel's finger fingertip capillary Infrared light and ruddiness, and transmitted infrared light and transmission ruddiness are respectively converted into analog current signal, To obtain simulation infrared light electric current and simulation ruddiness electric current;Current-to-voltage converting circuit, with described photoelectricity Converter connects, for simulation infrared light electric current and simulation ruddiness electric current are carried out Current Voltage respectively and turned Change, to obtain simulation infrared light voltage and simulation red voltages respectively;Signal amplifier, with described electricity Stream voltage conversion circuit connects, for putting simulation infrared light voltage and simulation red voltages respectively Greatly, voltage is amplified to obtain to simulate infrared light amplification voltage and simulate ruddiness;Signal deteching circuit, with Described signal amplifier connects, including direct current signal detection electronic circuit and alternating current signal detection electronic circuit, For detecting the flip-flop in simulation infrared light voltage and alternating component, using as the first DC voltage With first alternating voltage output, be additionally operable to detection simulation red voltages in flip-flop with exchange into Point, to export as the second DC voltage and the second alternating voltage;Analog-digital converter, with described signal Testing circuit connects, for the first DC voltage, the first alternating voltage, the second DC voltage and the Two alternating voltages carry out analog-to-digital conversion respectively, to obtain the first Digital DC voltage, the first digitlization Alternating voltage, the second Digital DC voltage and the second Digital AC voltage;Blood oxygen saturation computing Circuit, is connected with described analog-digital converter, by the second Digital AC voltage and the second Digital DC The ratio of voltage divided by the ratio of the first Digital AC voltage and the first Digital DC voltage to obtain The light ratio factor must be absorbed, and calculate blood oxygen saturation, wherein, blood oxygen based on absorbing the light ratio factor Saturation degree is linear with the absorption light ratio factor;DSP processes chip, is connected with described probe, Receive described deamplification, analyze the spectral line of described deamplification, and calculate wherein glucose institute accounting Example, thus obtain the blood sugar concentration of tested personnel, described DSP processes chip and also transports with blood oxygen saturation Calculate circuit to connect to obtain blood oxygen saturation;Described DSP processes chip when described blood sugar concentration is default During blood sugar upper concentration, send blood sugar concentration too high identification signal, when described blood sugar concentration is at default blood During sugar least concentration, send blood sugar concentration too low identification signal;When described blood oxygen saturation is at default blood During oxygen saturation upper concentration, send blood oxygen saturation too high identification signal, when described blood oxygen saturation When default blood oxygen saturation least concentration, send blood oxygen saturation too low identification signal;Insulin is deposited Storage equipment, for prestoring the insulin of preset capacity;Liquid level detection device, is positioned at described pancreas islet In element storage device, the insulin liquid level in detection insulin storage device in real time, and at pancreas islet When element liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, described liquid level Detection equipment also processes chip and is connected to send described insufficient insulin alarm signal with described DSP Chip is processed to described DSP;Insulin drives equipment, processes chip with described DSP and is connected, when When receiving described blood sugar concentration too high identification signal, process, according to described DSP, the blood sugar that chip forwards The difference of concentration and described default blood sugar upper concentration determines insulin pump drive signal, described insulin Pump drive signal determines value and the speed of the supply insulin of insulin pump;Insulin pump, with institute State insulin storage device and insulin infusion device connects respectively, drive equipment even with described insulin Connect, under the control driving equipment at described insulin, by the pancreas in described insulin storage device Island element is expelled in tested personnel's body by insulin infusion device;Insulin infusion device, detachably Formula is embedded in tested personnel's body, for tested personnel's insulin injection;Serial communication circuit, position Process between chip and Bluetooth matching communication equipment in DSP, for by described blood sugar concentration and described pancreas Island element deficiency alarm signal is sent to Bluetooth matching communication equipment;Bluetooth matching communication equipment, being used for will Described blood sugar concentration and described insufficient insulin alarm signal are wirelessly transmitted to the target Bluetooth connected Equipment;Described Bluetooth matching communication equipment include the first search subset, second search subset and Join connexon equipment;Wherein, the first search subset is dense according to MAC Address in Bluetooth Scatternet Degree determine micro bluetooth network that Bluetooth MAC address concentration is the highest as target piconet, a bluetooth Scatternet is made up of multiple micro bluetooth networks;Second search subset, with described first search subset Connect, in described target piconet, find, quantity preceding by signal strength signal intensity ranking and be not more than 7 One or more Bluetooth matching communication equipments as one or more target Bluetooth devices;Equipment connects Subset, is connected with described second search subset, starts and set with the one or more target Bluetooth Standby Bluetooth communication connects;Wherein, described optical-electrical converter is a photodiode;Wherein, described The wavelength of the infrared light that light emitting diode is launched is 940nm, the ruddiness that described light emitting diode is launched Wavelength is 660nm;Wherein, also set up between described signal amplifier and described signal deteching circuit Signal filter circuit, amplifies in voltage for filtering simulation infrared light amplification voltage and simulation ruddiness respectively Noise contribution;Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage coil, spiral pipeline One in circle, saddle-shaped coils, phased array coils and annulus;Wherein, Direct Digital frequency The frequency synthesis that synthesizer is used is selected in direct digital synthesizers, analog phase-locked look and digital phase-locked loop One;Wherein, when the quantity of the Bluetooth matching communication equipment having signal in described target piconet it is During more than or equal to 7, the quantity of the one or more target Bluetooth devices is 7, when described target Piconet has signal Bluetooth matching communication equipment quantity for less than 7 time, the one or more The quantity of target Bluetooth devices is to have the Bluetooth matching communication equipment of signal in described target piconet Quantity.
More specifically, in described non-invasive blood glucose meter: the built-in storage that described DSP processes chip is single It is dense that unit has prestored described default blood oxygen saturation upper concentration, described default blood oxygen saturation lower limit Degree, described preset reference liquid level, described default blood sugar upper concentration and described default blood sugar least concentration.
More specifically, in described non-invasive blood glucose meter, described blood glucose meter also includes: Compact Flash, For having prestored described default blood oxygen saturation upper concentration, described default blood oxygen saturation lower limit Concentration, described preset reference liquid level, described default blood sugar upper concentration and described default blood sugar lower limit are dense Degree.
More specifically, in described non-invasive blood glucose meter: described DSP processes chip and satisfies sending blood oxygen Signal, blood oxygen saturation too low identification signal, blood sugar too high identification signal or blood sugar is identified with spending height During too low identification signal, being simultaneously emitted by abnormality signal, otherwise, described DSP processes chip simultaneously Send normal state signal.
More specifically, in described non-invasive blood glucose meter: described serial communication circuit is RS485 serial Communication interface.
Accompanying drawing explanation
Below with reference to accompanying drawing, embodiment of the present invention are described, wherein:
Fig. 1 is the block diagram of the first embodiment of the non-invasive blood glucose meter of the present invention.
Reference: 1 Automatic insulin injection equipment;2 blood oxygen saturation detection equipment;3 is noninvasive Formula blood sugar test equipment;4 DSP process chip
Detailed description of the invention
Below with reference to accompanying drawings the embodiment of the non-invasive blood glucose meter of the present invention is described in detail.
Sugar in blood is referred to as blood sugar, is the most all glucose.Internal each histocyte Energy major part needed for activity is from glucose, so blood sugar preferably must be held in certain level and could tie up Hold internal each organ and the demand of tissue.
The concentration of the blood sugar in human body is generally controlled in a scope the narrowest, and blood sugar is too high or mistake Low all can affect to people.In order to effectively detect the blood sugar concentration in human body, on the market Occur in that multiple blood glucose meter, especially favored by suffering from the patient of hypertension.
But, blood glucose meter of the prior art detection parameter is single, testing mechanism falls behind, and lacks blood sugar What detection and insulin supplied automatically controls mechanism, and meanwhile, the wireless communication interface being furnished with mates and connects Connect inefficiency, can not meet the existing requirement of hospital and patient.
To this end, the present invention has built a kind of non-invasive blood glucose meter, high-precision by through structure optimization Blood oxygen saturation monitoring device and blood glucose monitoring device are integrated in a detecting instrument, use blood simultaneously Bluetooth communication interface after the sugared automatic control mode detected with insulin supply and optimization, thus square Just patient and the use of hospital.
Fig. 1 is the block diagram of the first embodiment of the non-invasive blood glucose meter of the present invention, described blood sugar Instrument includes that Automatic insulin injection equipment, blood oxygen saturation detect equipment, non-invasive blood sugar test equipment Processing chip with DSP, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment divide Yong Yu not extract blood oxygen saturation data and the blood glucose level data of tested personnel, described DSP process chip with Described Automatic insulin injection equipment, described blood oxygen saturation detection equipment and the inspection of described non-invasive blood sugar Measurement equipment connects respectively, determines the blood oxygen supply shape of tested personnel based on described blood oxygen saturation data State, is additionally based upon described blood glucose level data and determines the injection parameters of described Automatic insulin injection equipment.
Then, continue the concrete structure of the second embodiment of the non-invasive blood glucose meter of the present invention is entered The explanation of one step.
Described blood glucose meter includes: Direct Digital Frequency Synthesizers, is used for producing frequency and phase place can be adjusted Whole sine wave signal to be used as mixing use as rf frequency source;Pulse-series generator, is used for Produce pulse train;Frequency mixer, occurs with described Direct Digital Frequency Synthesizers and described pulse train Device connects respectively, uses pulse train that sine wave signal is carried out mixed modulated;Power amplifier, with Described frequency mixer connects, for being amplified by the signal after mixed modulated.
Described blood glucose meter includes: Switching Power Supply, is used as the interface circuit between probe and power amplifier, Will amplify after signal loading to probe radio-frequency receiving-transmitting coil in;Nd-Fe-B permanent magnetic type magnet structure, A uniform static magnetic field of field intensity is produced in the space accommodating tested personnel's finger;Probe, places At tested personnel's finger position, it is wound around radio-frequency receiving-transmitting coil and sends into described neodymium iron boron with the signal that will load In permanent-magnet type magnet structure, produce nmr phenomena, be additionally operable to hydrogen in tested personnel's finger The deamplification obtained after proton resonance is sent;Light emitting diode, is arranged on tested personnel's finger fingertip Capillary position, is connected with light source driving circuit, for the luminescence sent based on light source driving circuit Control signal, alternate emission infrared light and ruddiness.
Described blood glucose meter includes: light source driving circuit, built-in timer, for described light-emitting diodes Pipe sends LED control signal;Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at institute State the relative position of light emitting diode, after receiving transmission tested personnel's finger fingertip capillary Infrared light and ruddiness, and transmitted infrared light and transmission ruddiness are respectively converted into analog current signal, with Obtain simulation infrared light electric current and simulation ruddiness electric current;Current-to-voltage converting circuit, turns with described photoelectricity Parallel operation connects, for simulation infrared light electric current and simulation ruddiness electric current are carried out Current Voltage respectively and turned Change, to obtain simulation infrared light voltage and simulation red voltages respectively.
Described blood glucose meter includes: signal amplifier, is connected with described current-to-voltage converting circuit, is used for Simulation infrared light voltage and simulation red voltages are amplified respectively, amplify with acquisition simulation infrared light Voltage and simulation ruddiness amplify voltage;Signal deteching circuit, is connected with described signal amplifier, including Direct current signal detection electronic circuit and alternating current signal detection electronic circuit, be used for detecting in simulation infrared light voltage Flip-flop and alternating component, to export as the first DC voltage and the first alternating voltage, also use Flip-flop in detection simulation red voltages and alternating component, using as the second DC voltage and the Two alternating voltage outputs.
Described blood glucose meter includes: analog-digital converter, is connected with described signal deteching circuit, for the One DC voltage, the first alternating voltage, the second DC voltage and the second alternating voltage carry out modulus respectively Conversion, to obtain the first Digital DC voltage, the first Digital AC voltage, the second digitlization directly Stream voltage and the second Digital AC voltage;Blood oxygen saturation computing circuit, with described analog-digital converter Connect, by the ratio of the second Digital AC voltage and the second Digital DC voltage divided by the first numeral The ratio changing alternating voltage and the first Digital DC voltage absorbs the light ratio factor to obtain, and based on Absorbing the light ratio factor and calculate blood oxygen saturation, wherein, blood oxygen saturation becomes with absorbing the light ratio factor Linear relationship.
Described blood glucose meter includes: DSP processes chip, is connected with described probe, receives described decay letter Number, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain quilt The blood sugar concentration of survey personnel, described DSP processes chip and also is connected to obtain with blood oxygen saturation computing circuit Obtain blood oxygen saturation;Described DSP processes chip when described blood sugar concentration is at default blood sugar upper concentration Time, send blood sugar concentration too high identification signal, when described blood sugar concentration is at default blood sugar least concentration, Send blood sugar concentration too low identification signal;When described blood oxygen saturation is dense in the default blood oxygen saturation upper limit When spending, send blood oxygen saturation too high identification signal, when described blood oxygen saturation is at default blood oxygen saturation During degree least concentration, send blood oxygen saturation too low identification signal.
Described blood glucose meter includes: insulin storage device, for prestoring the insulin of preset capacity; Liquid level detection device, is positioned at described insulin storage device, sets for detection insulin storage in real time Standby interior insulin liquid level, and when insulin liquid level is equal to or less than preset reference liquid level, send pancreas Island element deficiency alarm signal, described liquid level detection device also processes chip with described DSP and is connected with by institute State insufficient insulin alarm signal and be sent to described DSP process chip.
Described blood glucose meter includes: insulin drives equipment, processes chip with described DSP and is connected, when connecing When receiving described blood sugar concentration too high identification signal, the blood sugar processing chip forwarding according to described DSP is dense The difference of degree and described default blood sugar upper concentration determines insulin pump drive signal, described insulin pump Drive value and the speed of the supply insulin of signal deciding insulin pump;Insulin pump, with described Insulin storage device and insulin infusion device connect respectively, drive equipment even with described insulin Connect, under the control driving equipment at described insulin, by the pancreas in described insulin storage device Island element is expelled in tested personnel's body by insulin infusion device.
Described blood glucose meter includes: insulin infusion device, detachable is embedded in tested personnel's body, For to tested personnel's insulin injection.
Described blood glucose meter includes: serial communication circuit, is positioned at DSP and processes chip and Bluetooth matching communication Between equipment, for described blood sugar concentration and described insufficient insulin alarm signal are sent to bluetooth Join communication equipment.
Described blood glucose meter includes: Bluetooth matching communication equipment, for by described blood sugar concentration and described pancreas Island element deficiency alarm signal is wirelessly transmitted to the target Bluetooth devices connected;Described Bluetooth matching communication Equipment includes the first search subset, the second search subset and coupling connexon equipment;Wherein, According to MAC Address concentration in Bluetooth Scatternet, one search subset, determines that Bluetooth MAC address is dense Spending the highest micro bluetooth network as target piconet, a Bluetooth Scatternet is by multiple micro bluetooth networks Composition;Second search subset, is connected, at described target piconet with described first search subset In, find, quantity preceding by signal strength signal intensity ranking and be not more than one or more Bluetooth matchings of 7 and lead to Letter equipment is as one or more target Bluetooth devices;Equipment connexon equipment, with described second search Subset connects, and starts and is connected with the Bluetooth communication of the one or more target Bluetooth devices;Wherein, Described optical-electrical converter is a photodiode.
Wherein, the wavelength of the infrared light that described light emitting diode is launched is 940nm, described light-emitting diodes The wavelength of the ruddiness that pipe is launched is 660nm;Wherein, in described signal amplifier and described signal detection Also set up signal filter circuit between circuit, amplify voltage and simulation for filtering simulation infrared light respectively Ruddiness amplifies the noise contribution in voltage;Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage One in coil, toroidal winding, saddle-shaped coils, phased array coils and annulus;Wherein, Frequency synthesis that Direct Digital Frequency Synthesizers is used select direct digital synthesizers, analog phase-locked look and One in digital phase-locked loop.
Wherein, when described target piconet having the quantity of Bluetooth matching communication equipment of signal for being more than During equal to 7, the quantity of the one or more target Bluetooth devices is 7, when described target is slight Net has signal Bluetooth matching communication equipment quantity for less than 7 time, the one or more target The quantity of bluetooth equipment is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
Alternatively, in described blood glucose meter: described DSP processes the built-in storage unit of chip and deposits in advance Store up described default blood oxygen saturation upper concentration, described default blood oxygen saturation least concentration, described Preset reference liquid level, described default blood sugar upper concentration and described default blood sugar least concentration;Described blood Sugar instrument also includes: Compact Flash, be used for having prestored described default blood oxygen saturation upper concentration, Described default blood oxygen saturation least concentration, described preset reference liquid level, the described default blood sugar upper limit are dense Degree and described default blood sugar least concentration;Described DSP processes chip and is sending the too high knowledge of blood oxygen saturation Level signal, blood oxygen saturation too low identification signal, blood sugar too high identification signal or hypoglycemia identification letter Number time, be simultaneously emitted by abnormality signal, otherwise, described DSP processes chip and is simultaneously emitted by normal shape State signal;Described serial communication circuit is RS485 serial communication interface.
It addition, dsp chip, also referred to as digital signal processor, it is that one is particularly suitable for carrying out numeral The microprocessor of signal transacting computing, it is mainly applied is to realize real-time at various data signal Adjustment method.
According to the requirement of Digital Signal Processing, dsp chip typically has a following main feature: (1) A multiplication and a sub-addition can be completed within an instruction cycle;(2) program and data space divides Open, can simultaneously access instruction and data;(3) there is quick RAM in sheet, generally can be by solely Vertical data/address bus accesses in two pieces simultaneously;(4) there is low overhead or without overhead loop and redirect Hardware supported;(5) quickly interrupt processing and Hardware I/O support;(6) have in the monocycle Multiple hardware address generators of interior operation;(7) can be with the multiple operation of executed in parallel;(8) support Pile line operation, makes fetching, decodes and the operation such as execution can be with Overlapped Execution.
Use the non-invasive blood glucose meter of the present invention, fall behind and nothing for blood sugar apparatus structure in prior art The technical problem of line communication function difference, optimizes the structure of existing blood sugar instrument, adds the detection of blood oxygen and sets Standby and blood sugar concentration automatic control equipment, the most also improves the communication performance of existing bluetooth communication interface, Thus improve the intelligence degree of medical detecting Instrument.
Although it is understood that the present invention discloses as above with preferred embodiment, but above-mentioned enforcement Example is not limited to the present invention.For any those of ordinary skill in the art, without departing from Under technical solution of the present invention ambit, all may utilize the technology contents of the disclosure above to the technology of the present invention Scheme makes many possible variations and modification, or is revised as the Equivalent embodiments of equivalent variations.Therefore, Every content without departing from technical solution of the present invention, the technical spirit of the foundation present invention is to above example Any simple modification, equivalent variations and the modification done, all still falls within technical solution of the present invention protection In the range of.

Claims (1)

1. a non-invasive blood glucose meter, described blood glucose meter includes Automatic insulin injection equipment, blood oxygen Saturation degree detection equipment, non-invasive blood sugar test equipment and DSP process chip, described blood oxygen saturation Detection equipment and described non-invasive blood sugar test equipment are respectively used to extract the blood oxygen saturation of tested personnel Degrees of data and blood glucose level data, described DSP processes chip and described Automatic insulin injection equipment, described Blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment connect, respectively based on described blood oxygen Saturation data determines the blood oxygen supply state of tested personnel, is additionally based upon described blood glucose level data and determines described The injection parameters of Automatic insulin injection equipment;
Described blood glucose meter includes:
Direct Digital Frequency Synthesizers, for produce frequency and sine wave signal that phase place can adjust with It is used as mixing as rf frequency source to use;
Pulse-series generator, is used for producing pulse train;
Frequency mixer, connects respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator Connect, use pulse train that sine wave signal is carried out mixed modulated;
Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated;
Switching Power Supply, is used as the interface circuit between probe and power amplifier, the signal after amplifying It is loaded in the radio-frequency receiving-transmitting coil of probe;
Nd-Fe-B permanent magnetic type magnet structure, produces a field intensity in the space accommodating tested personnel's finger Uniform static magnetic field;
Probe, is placed on tested personnel's finger position, is wound around radio-frequency receiving-transmitting coil with the signal that will load Send in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, be additionally operable to through quilt The deamplification obtained after Hydrogen Proton resonance in survey personnel's finger is sent;
Light emitting diode, is arranged on tested personnel's finger fingertip capillary position, drives electricity with light source Road connect, for based on light source driving circuit send LED control signal, alternate emission infrared light and Ruddiness;
Light source driving circuit, built-in timer, for sending light emitting control letter to described light emitting diode Number;
Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at the phase of described light emitting diode To position, it is used for the infrared light after receiving transmission tested personnel's finger fingertip capillary and ruddiness, and Transmitted infrared light and transmission ruddiness are respectively converted into analog current signal, to obtain simulation infrared electro Stream and simulation ruddiness electric current;
Current-to-voltage converting circuit, is connected with described optical-electrical converter, for simulation infrared light electric current Current Voltage conversion is carried out respectively, to obtain simulation infrared light voltage and mould respectively with simulation ruddiness electric current Intend red voltages;
Signal amplifier, is connected with described current-to-voltage converting circuit, for simulation infrared light voltage It is amplified respectively with simulation red voltages, amplifies voltage with acquisition simulation infrared light and simulation ruddiness is put Big voltage;
Signal deteching circuit, is connected with described signal amplifier, including direct current signal detection electronic circuit and Alternating current signal detection electronic circuit, for detect simulation infrared light voltage in flip-flop with exchange into Point, to export as the first DC voltage and the first alternating voltage, it is additionally operable to detection simulation red voltages In flip-flop and alternating component, to export as the second DC voltage and the second alternating voltage;
Analog-digital converter, is connected with described signal deteching circuit, for the first DC voltage, first Alternating voltage, the second DC voltage and the second alternating voltage carry out analog-to-digital conversion respectively, to obtain first Digital DC voltage, the first Digital AC voltage, the second Digital DC voltage and the second numeral Change alternating voltage;
Blood oxygen saturation computing circuit, is connected with described analog-digital converter, by the second Digital AC electricity Pressure digitizes divided by the first Digital AC voltage and first with the ratio of the second Digital DC voltage The ratio of DC voltage absorbs the light ratio factor to obtain, and calculates blood oxygen based on absorbing the light ratio factor Saturation degree, wherein, blood oxygen saturation is linear with the absorption light ratio factor;
DSP processes chip, is connected with described probe, receives described deamplification, analyze described decay The spectral line of signal, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel, Described DSP processes chip and also is connected to obtain blood oxygen saturation with blood oxygen saturation computing circuit;Described DSP process chip, when described blood sugar concentration is at default blood sugar upper concentration, sends blood sugar concentration too high Identify signal, when described blood sugar concentration is at default blood sugar least concentration, send the too low knowledge of blood sugar concentration Level signal;When described blood oxygen saturation is at default blood oxygen saturation upper concentration, send blood oxygen saturation Spend high identification signal, when described blood oxygen saturation is at default blood oxygen saturation least concentration, send Blood oxygen saturation too low identification signal;
Insulin storage device, for prestoring the insulin of preset capacity;
Liquid level detection device, is positioned at described insulin storage device, deposits for detection insulin in real time Insulin liquid level in storage equipment, and when insulin liquid level is equal to or less than preset reference liquid level, send out Go out insufficient insulin alarm signal, described liquid level detection device also with described DSP process chip be connected with Described insufficient insulin alarm signal is sent to described DSP and processes chip;
Insulin drives equipment, processes chip with described DSP and is connected, when receiving described blood sugar concentration During too high identification signal, process, according to described DSP, blood sugar concentration and the described default blood sugar that chip forwards The difference of upper concentration determines insulin pump drive signal, and described insulin pump drives signal deciding pancreas The value of the supply insulin of island element pump and speed;
Insulin pump, connects respectively with described insulin storage device and insulin infusion device, with institute Stating insulin drives equipment to connect, under the control driving equipment at described insulin, by described pancreas Insulin in the element storage device of island is expelled in tested personnel's body by insulin infusion device;
Insulin infusion device, detachable is embedded in tested personnel's body, for noting to tested personnel Penetrate insulin;
Serial communication circuit, processes between chip and Bluetooth matching communication equipment at DSP, and being used for will Described blood sugar concentration and described insufficient insulin alarm signal are sent to Bluetooth matching communication equipment;
Bluetooth matching communication equipment, for by described blood sugar concentration and described insufficient insulin alarm signal It is wirelessly transmitted to the target Bluetooth devices on connecting;Described Bluetooth matching communication equipment includes the first search Subset, the second search subset and coupling connexon equipment;Wherein, the first search subset, root Determine that the bluetooth that Bluetooth MAC address concentration is the highest is slight according to MAC Address concentration in Bluetooth Scatternet Net is as target piconet, and a Bluetooth Scatternet is made up of multiple micro bluetooth networks;Second search Equipment, is connected with described first search subset, and in described target piconet, it is strong that signal is pressed in searching Ranking is preceding for degree, quantity be not more than one or more Bluetooth matching communication equipments of 7 as one or Multiple target Bluetooth devices;Equipment connexon equipment, is connected with described second search subset, starts It is connected with the Bluetooth communication of the one or more target Bluetooth devices;
Wherein, described optical-electrical converter is a photodiode;
Wherein, the wavelength of the infrared light that described light emitting diode is launched is 940nm, described light-emitting diodes The wavelength of the ruddiness that pipe is launched is 660nm;
Wherein, between described signal amplifier and described signal deteching circuit, also set up signal filtering electricity Road, the noise amplified in voltage with simulation ruddiness for filtering simulation infrared light amplification voltage respectively becomes Point;
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage coil, toroidal winding, saddle One in coil, phased array coils and annulus;
Wherein, direct digital synthesizers, mould are selected in the frequency synthesis that Direct Digital Frequency Synthesizers is used Intend the one in phaselocked loop and digital phase-locked loop;
Wherein, when described target piconet having the quantity of Bluetooth matching communication equipment of signal for being more than During equal to 7, the quantity of the one or more target Bluetooth devices is 7, when described target is slight Net has signal Bluetooth matching communication equipment quantity for less than 7 time, the one or more target The quantity of bluetooth equipment is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
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