CN1060359C - Complete Chinese medical preparation for chronic fatigue syndrome and process thereof - Google Patents
Complete Chinese medical preparation for chronic fatigue syndrome and process thereof Download PDFInfo
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- CN1060359C CN1060359C CN96112990A CN96112990A CN1060359C CN 1060359 C CN1060359 C CN 1060359C CN 96112990 A CN96112990 A CN 96112990A CN 96112990 A CN96112990 A CN 96112990A CN 1060359 C CN1060359 C CN 1060359C
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Abstract
The present invention provides a pure Chinese medicine preparation for treating chronic fatigue syndromes and a preparation method thereof. The pure Chinese medicine preparation is mainly characterized in that Chinese medicinal materials of pilose asiabell root, achyranthes root, rehmannia root, motherwort and chuanxiong rhizome are adopted; ethanol is used for extracting and drying; and a pure Chinese medicine capsule is manufactured through liquid decocting, extracting, drying and pulverizing. The pure Chinese medicine capsule is an effective medicine with the functions of reducing fatigue, enhancing organism antifatigue capability, improving the immune function, supplementing qi, nourishing yin and promoting blood circulation to remove obstruction in collaterals. Compared with the prior art, the pure Chinese medicine capsule has the obvious advantages of conspicuous curative effect, no side effect, easy reception by patients, etc.
Description
The invention belongs to medical technical field, is a kind of pure Chinese medicinal preparation and preparation method for the treatment of chronic fatigue syndrome.
Along with the science and technology of fierceness and the market competition and the high efficiency that occurs, allegro work cause people's spirit, psychological burden to increase the weight of day by day.Because long-term excessively busy, nervous, people often are in the state of fatigue, dispirited, immunologic hypofunction, and often with corresponding symptom.The typical clinical manifestation of patient is that confirmed fatigue and movable back fatigue increase the weight of, but can not check tangible organic disease again clinically, and this is to be in " being overworked for a very long period " stage, once " one-tenth disease ", rather thorny organic disease in the treatment often.A large amount of studies show that, is in fatigue state and hurt in spirits repeatedly for a long time, with the hypertension of body, arteriosclerosis, must cerebrovascular disease, generation, the development of diabetes, immunologic function disorder even malignant tumor all have comparatively confidential relation.Numeral shows according to the relevent statistics, and fatigue patient male accounts for 19% among the adult, and the women accounts for 24%, and is higher than the male.Recently, according to the Center for Disease Control prediction, chronic fatigue syndrome (CSF) will become one of subject matter of 21 century human health, be to threaten human new killer.Therefore, CSF has become the fashionable diagnosis of some developed countries of current west, becomes the important topic of foreign medical science circle research in recent years.In China, according to clinical observation, the patient who suffers from chronic fatigue syndrome is not rarely seen, and sickness rate is in rising trend and cause the great attention of domestic the world of medicine.But prior treatment method mainly is to use western medical treatment, promptly use antiviral agents (acycloguanosine), antidepressants, Mg supplementation and use psychostimulant etc., yet curative effect is all not ideal enough, at present, still lacks really effectively medicine.
The objective of the invention is to develop a kind ofly resist fatigue damage, the pure Chinese medicinal preparation of the symptom that lessens fatigue, thereby can play the better protect effect to the overwork crowd.
For reaching above-mentioned purpose, the main technical schemes that the present invention taked is to select Radix Codonopsis, Radix Achyranthis Bidentatae, Radix Rehmanniae, Herba Leonuri, Rhizoma Chuanxiong Chinese medicine of the five flavours for use, Radix Achyranthis Bidentatae, Rhizoma Chuanxiong, Herba Leonuri are adopted ethanol extraction, medicinal liquid is made fine powder through concentrated, dry, and medicinal residues and Radix Codonopsis, Radix Rehmanniae after extracting are decocted with water, extract medicinal liquid through concentrated, dry, make fine powder, after with two kinds of fine powder mixings, make a kind of be used for the treatment of chronic fatigue syndrome pure Chinese medicinal preparation.
This pure Chinese medicinal preparation inclusions is a chocolate brown powder, feeble QI, and mildly bitter flavor, toxicity test are hypotoxicity.
The present invention provides a kind of pure Chinese medicinal preparation and preparation method of ideal treatment chronic fatigue syndrome for medical technical field.Motherland medical science becomes thinks that fatigue is that declining of a kind of body function is tired, by tired and arrive and decline, forms disease by labor, and labor is impairment of QI then, the then cloudy consumption of void; Gas be blood it, the deficiency of vital energy and unable handsome blood is capable, blood fortune is sluggish, poly-then cause block up, the blood block up does not then have Tianjin and supports body, in the course of time, make the deficiency of vital energy more, the deficiency of YIN is stronger, and the blood block up is more acute, three's generation of meeting each other is opposed each other and yet also complement each other, and the meridians internal organs must not be transferred reach, the poly-retardance of qi-blood-body fluid knot, thus make body impaired, invade in the pathogenic factor, make the people lassitude occur, depressed, dizziness, cardiopalmus, insomnia, symptom such as forgetful.According to theory of Chinese medical science, in conjunction with modern medicine, long-term in tension overwork crowd has down been carried out a large amount of study on prevention, filtered out supplementing QI and nourishing YIN, promoting blood flow and remove blood stasis this prescription for the Therapeutic Principle.Radix Codonopsis among this side contains Radix Codonopsis Saponin, inulin, fructose, micro-alkaloid, plant sterol and the necessary aminoacid of multiple human body, pharmacological testing shows, Radix Codonopsis Saponin and Radix Codonopsis polysaccharide etc. have the effects such as content that promote cytophagy and improve body 17-ketone 17-hydroxy-11-dehydrocorticosterone, thus enhancing body immunologic function.With Radix Codonopsis as the monarch drug among this side, but invigorating the spleen and replenishing QI, strengthening the body resistance makes gas prosperous capable with handsome blood.Radix Achyranthis Bidentatae closes triterpenoid saponin, generates oleanolic acid after the hydrolysis, and contains volume potassium salt, and other contains Inokopolyose, hydroxy ecdysterone, and inokosterone etc., its pharmacological action is: shrinks the uterus, suppresses intestinal tube, blood pressure lowering, pain relieving, diuresis, improve immunologic function, antibiotic etc.; Radix Rehmanniae contains 10 kinds of iridoid glycosides, stachyose, multiple amino ester; And cupreol, mannitol etc., its pharmacological action is blood sugar lowering, boost, diuresis, the liver protecting, prevent liver glycogen reduce, antibiotic etc.But with Radix Achyranthis Bidentatae, Radix Rehmanniae is ministerial drug invigorating the liver and kidney, YIN nourishing and the production of body fluid promoting.Herba Leonuri contains multiple alkaloids such as leonurine, stachydrine, leonurinine, and its pharmacological action is excited isolated uterine, blood pressure lowering, antiadrenergic drug, excited respiratory center nerve etc.; Rhizoma Chuanxiong contains ligustrazine, chuanxingol, ferulic acid, chrysophanol etc., and its pharmacological action is calmness, blood pressure lowering, contraction smooth muscle, and is antibiotic etc.Herba Leonuri, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling are regulated the flow of vital energy and promoting blood circulation, with the effect of assistant the monarch and his subjects QI invigorating tonifying YIN, mend the deficiency that the monarch and his subjects' blood stasis dispelling is regulated the flow of vital energy again.Five medicines share, and the tool supplementing QI and nourishing YIN, the effect of blood circulation promoting and blood stasis dispelling is applicable to that cloudy two void of gas have the chronic fatigue syndrome of blood stasis syndrome concurrently.Process is to this kind pure Chinese medicinal preparation Pharmacodynamic test of active extract, and the result confirms to have following pharmacological action: (1) enhancing body stress ability.Comprise to swim fatigue stress, cold stress, high temperature stress, the tolerance of oxygen deprivation stress all is significantly increased.(2) human body immunity improving function.Comprise non-specific immunity to body, humoral immune function, cellular immune functions etc. all are significantly improved.(3) generation of minimizing free radical increases the ability that body is eliminated free radical.(4) microcirculation improvement reduces hemorheological property, and the organ-tissue that anti-stress is caused damages.Observe (oral this product 3 times/day by 132 routine chronic fatigue syndrome patients being carried out clinical trial with said preparation, 2/time) 30 days be a course of treatment, symptoms such as result's proof is forgetful to lassitude, the fatigue and asthenia that reduction of patient showed, the cardiopalmus of breathing hard, headache, insomnia and dreamful sleep have significant curative effect.Rheology test index determining result before and after treatment, whole blood viscosity behind the patient treatment, plasma viscosity, packed cell volume, Fibrinogen, whole blood reduced viscosity, erythrocyte accumulation index etc. all has remarkable reduction, illustrates that this pure Chinese medicinal preparation has the effect of blood viscosity lowering significantly.Cellular immunology index determining result before and after treatment, immunocyte CD behind the patient treatment
3, CD
4, CD
8Rising is all arranged, show that this medicine has the immunologic function of enhancing body cell significantly.Patient's routine blood test before and after treatment, routine urinalysis, stool routine examination and hepatic and renal function detect, and there is no unusually, illustrate that this medicine clinical practice is safe.Thereby can assert that this kind pure Chinese medicinal preparation is a kind of active drug for the treatment of chronic fatigue syndrome, compared with prior art, have evident in efficacyly, have no side effect that taking convenience is easy to the patient and accepts, and is convenient to remarkable advantages such as popularization.
In conjunction with example, further specify a kind of pure Chinese medicinal preparation and preparation method for the treatment of chronic fatigue syndrome of the present invention.
A kind of pure Chinese medicinal preparation and preparation method for the treatment of chronic fatigue syndrome of the present invention, wherein each constituent content is in the prescription: Radix Codonopsis 20-28%, Radix Achyranthis Bidentatae 18-26%, Herba Leonuri 18-26%, Radix Rehmanniae 8-16%, Rhizoma Chuanxiong 6-16%.
Its preparation method adds 6 times of amounts of ethanol for getting Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, Herba Leonuri, reflux, extract, twice, and each 2 hours, filter, complete and filtrate is reclaimed ethanol, is concentrated into the clear paste of relative density 1.30 (55-60 ℃), behind vacuum drying, is ground into fine powder.Get Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, Herba Leonuri medicinal residues behind the ethanol extraction, add 10 times of water gagings with Radix Codonopsis, the Radix Rehmanniae, decoct 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and filtrate is concentrated into about 1.6 (50C) of relative density, add ethanol and make that to contain alcohol amount be 50%, stir evenly, left standstill 24 hours, get supernatant.Reclaim ethanol, be concentrated into the clear paste that relative density is 1.3 (55-60C), behind vacuum drying, be ground into fine powder, with the fine powder mixing of ethanol extraction part, sieve incapsulate in, make every pure Chinese medicine capsule that contains 0.6 gram medicated powder.
Example formulations one:
Radix Codonopsis 8.5g Radix Achyranthis Bidentatae 8g Herba Leonuri 8g Radix Rehmanniae 4.5g Rhizoma Chuanxiong 3g
Example formulations two:
Radix Codonopsis 8.5g Radix Achyranthis Bidentatae 8g Herba Leonuri 7.5g Radix Rehmanniae 5g Rhizoma Chuanxiong 3g
Example formulations three:
Radix Codonopsis 8.5g Radix Achyranthis Bidentatae 7.5g Herba Leonuri 7g Radix Rehmanniae 5g Rhizoma Chuanxiong 4g
List of references:
1, Sha Shiyan etc., " Chinese herbal medicine effective ingredients analytic process " (People's Health Publisher 1984)
2, the new medical college in Jiangsu " Chinese medicine voluminous dictionary " (the Shanghai People's Press 1977)
3, State Pharmaceutical Administration's Chinese herbal medicine information center station
" active ingredient of autonomic drug handbook (People's Health Publisher 1986)
4, Ke Mingqing etc. compiles " Chinese herbal medicine effective ingredients physics and chemistry pharmacological property " (Hunan science tech publishing house 1982)
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of chronic fatigue syndrome is characterized in that it is to make with following weight percentages: Radix Codonopsis 20-28%, Radix Achyranthis Bidentatae 18-26%, Herba Leonuri 18-26%, Radix Rehmanniae 8-16%, Rhizoma Chuanxiong 6-16%.
2, the preparation method of claim 1 Chinese medicine preparation, it is characterized in that described preparation method is for adopting the ethanol extraction drying with Radix Achyranthis Bidentatae, Rhizoma Chuanxiong, Herba Leonuri, make fine powder, medicinal residues after extracting and Radix Codonopsis, Radix Rehmanniae are added decocting liquid extraction drying, make fine powder, with two kinds of fine powder mixings, in incapsulating.
3, ask the preparation method of 2 Chinese medicine preparation as right, it is characterized in that described ethanol extraction is: with Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, Herba Leonuri adds 6 times of ethanol, reflux, extract, twice, each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the clear paste of relative density 1.3 (55-60 ℃), behind vacuum drying, be ground into fine powder, the described decocting liquid that adds is extracted as: with medicinal residues behind the ethanol extraction and Radix Codonopsis, Radix Rehmanniae adds 10 times of water gagings, decocts 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, filtrate is concentrated into about 1.16 (50 ℃) of relative density, adding ethanol, to make the alcohol amount of containing be 50% to stir evenly, and left standstill 24 hours, gets supernatant, reclaim ethanol, being concentrated into relative density is the clear paste of 1.30 (55-60 ℃), behind vacuum drying, is ground into fine powder.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN96112990A CN1060359C (en) | 1996-09-25 | 1996-09-25 | Complete Chinese medical preparation for chronic fatigue syndrome and process thereof |
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CN96112990A CN1060359C (en) | 1996-09-25 | 1996-09-25 | Complete Chinese medical preparation for chronic fatigue syndrome and process thereof |
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CN1148979A CN1148979A (en) | 1997-05-07 |
CN1060359C true CN1060359C (en) | 2001-01-10 |
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CN96112990A Expired - Fee Related CN1060359C (en) | 1996-09-25 | 1996-09-25 | Complete Chinese medical preparation for chronic fatigue syndrome and process thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107115363A (en) * | 2017-06-05 | 2017-09-01 | 青岛东海药业有限公司 | Application of the bacillus coagulans in prevention or treatment chronic fatigue syndrome preparation is prepared |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1060576A (en) * | 1990-10-15 | 1992-04-29 | 日本拜耳农药株式会社 | Fungicide and insecticides |
CN1088102A (en) * | 1992-12-16 | 1994-06-22 | 内蒙古轻纺技术经济开发公司商贸部 | The compound method of strong antifatigue liquid |
-
1996
- 1996-09-25 CN CN96112990A patent/CN1060359C/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1060576A (en) * | 1990-10-15 | 1992-04-29 | 日本拜耳农药株式会社 | Fungicide and insecticides |
CN1088102A (en) * | 1992-12-16 | 1994-06-22 | 内蒙古轻纺技术经济开发公司商贸部 | The compound method of strong antifatigue liquid |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107115363A (en) * | 2017-06-05 | 2017-09-01 | 青岛东海药业有限公司 | Application of the bacillus coagulans in prevention or treatment chronic fatigue syndrome preparation is prepared |
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CN1148979A (en) | 1997-05-07 |
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