CN106031705A - High-content stable prinsepia utilis royle oil microemulsion and preparation method thereof - Google Patents
High-content stable prinsepia utilis royle oil microemulsion and preparation method thereof Download PDFInfo
- Publication number
- CN106031705A CN106031705A CN201610318421.8A CN201610318421A CN106031705A CN 106031705 A CN106031705 A CN 106031705A CN 201610318421 A CN201610318421 A CN 201610318421A CN 106031705 A CN106031705 A CN 106031705A
- Authority
- CN
- China
- Prior art keywords
- parts
- princepia utilis
- mixture
- utilis oil
- oil microemulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses high-content stable prinsepia utilis royle oil microemulsion and a preparation method thereof, and belongs to the technical field of oil microemulsification. The prinsepia utilis royle oil microemulsion is prepared from 10-20 parts of prinsepia utilis royle oil, 3-7 parts of tween-65, 2-7 parts of span-80, 2-6 parts of sodium diethylhexyl sulfosuccinate, 3-7 parts of carboxymethyl-beta-cyclodextrin, 4-8 parts of cocamidopropyl betaine, 5-12 parts of glycerin, 2-4 parts of n-butyl alcohol, 0.1-0.3 part of a preservative and 130-160 parts of deionized water. The preparation method of the prinsepia utilis royle oil microemulsion comprises the steps of mixing, stirring, shearing and the like. The prepared prinsepia utilis royle oil microemulsion has the advantages of being small in particle size, good in storage stability property and excellent in dissolving property.
Description
Technical field
The invention belongs to oils and fats micro-emulsion technology field, be specifically related to a kind of high-load stable type Princepia utilis oil micro-
Emulsion and preparation method thereof.
Background technology
The fatty acid of Princepia utilis oil forms based on unsaturated fatty acids pinolenic acid and linoleic acid, wherein oleic acid
Content 33.38%, linoleic acid content be 40.82%；It addition, also contain the Palmic acid of 17.2% and 6% hard
Fat acid, and contain the multivitamins such as vitamin A, vitamin D, vitamin E and vitamin K, every 100
G Princepia utilis oil contains 3.5mg vitamin A, 2.1mg vitamin D, 11.2mg vitamin E and 0.30mg
Vitamin K, possibly together with constant and trace such as very abundant calcium, sulfur, manganese, magnesium, potassium, phosphorus, zinc and ferrum
Element, compared with other edible oil, the element that wherein content is the highest is potassium, and content is 9.8mg/kg.Blue or green thorn
Fruit oil and other plant oil phase ratio, containing abundant monounsaturated fatty acid.Princepia utilis oil is burst at treatment skin
The aspects such as rotten, chilblain, skin protection are respectively provided with the best value.
Princepia utilis oil has, as a kind of, the natural plant grease that better nutritivity is worth, and it has the best
Medicinal function, needs it to have good water solublity.But Princepia utilis oil is as a kind of oils and fats, and it is in aqueous
Dissolubility under system is excessively poor, and after its preservation for a long time of single Princepia utilis oil, quality declines very fast
It is thus desirable to developed as microemulsion or emulsion.Microemulsion compare emulsion have better dissolubility and
Bin stability, the most effectively develops and has good stability energy and the Princepia utilis of high Princepia utilis oil content
Oil Microemulsions For Use, is the most important research direction.
Summary of the invention
It is an object of the invention to provide a kind of high-load stable type Princepia utilis oil microemulsion and preparation method thereof,
This Princepia utilis oil microemulsion can effectively solve the problem that Princepia utilis oil is insoluble in the problem of water-based system, preparation method letter
Single easy, it is suitable for industrialized production.
The present invention is to be achieved through the following technical solutions:
A kind of high-load stable type Princepia utilis oil microemulsion, in terms of mass fraction, including: 10～20 parts of Princepia utilis
Oil, 3～7 parts of polysorbate65s, 2～7 parts of sorbester p17s, 2～6 parts of dioctyl sodium sulfosuccinates, 3～7 parts of poly-second two
Alcohol list ricinoleate ester, 4～8 parts of cocamido propyl betaine, 5～12 parts of glycerol, 2～4 parts of n-butyl alcohol,
0.1～0.3 portion of preservative, 130～160 parts of deionized waters.
Preferably, in terms of mass fraction, including: 12～18 parts of Princepia utilis oil, 4～6 parts of polysorbate65s, 3～5 parts
Sorbester p17,3～5 parts of dioctyl sodium sulfosuccinates, 4～6 parts of polyethyleneglycol ricinoleate esters, 5～7 portions of coconut palms
Oleamide CAB, 6～10 parts of glycerol, 3～4 parts of n-butyl alcohol, 0.1～0.2 portion of preservative, 140～150
Part deionized water.
Preferably, in terms of mass fraction, including: 15 parts of Princepia utilis oil, 5 parts of polysorbate65s, 4 parts of sorbester p17s,
4 parts of dioctyl sodium sulfosuccinates, 5 parts of polyethyleneglycol ricinoleate esters, 6 portions of cocamidopropyl propyl amide Radix Betaes
Alkali, 8 parts of glycerol, 3 parts of n-butyl alcohol, 0.1 portion of preservative, 145 parts of deionized waters.
Preferably, 1～3 part of sucrose stearate and 1～3 part of sodium stearoyl lactate are also included.
Described preservative is one or more in potassium sorbate, sodium benzoate or sodium lactate.
The invention also discloses the preparation method of a kind of high-load stable type Princepia utilis oil microemulsion, including following
Step:
1) in terms of mass fraction, 10～20 parts of Princepia utilis oil are taken, 3～7 parts of polysorbate65s, 2～7 parts of sorbester p17s,
2～6 parts of dioctyl sodium sulfosuccinates, 3～7 parts of polyethyleneglycol ricinoleate esters, 4～8 parts of coconut oleoyl amines third
Base glycine betaine, 5～12 parts of glycerol, 2～4 parts of n-butyl alcohol, 0.1～0.3 portion of preservative, 130～160 parts of deionizations
Water；
2) by polysorbate65, sorbester p17, dioctyl sodium sulfosuccinate, polyethyleneglycol ricinoleate ester,
Cocamido propyl betaine, glycerol and n-butyl alcohol, at room temperature stir, and is subsequently adding blue or green thorn
Fruit oil, continues to stir, and prepares mixture A；
3) preservative is dissolved in deionized water, mixing, prepares mixture B；
4) under room temperature, mixture B is poured in mixture A while stirring, stirs, prepare mixed
Compound C；
5) mixture C is carried out mechanical shearing, prepare Princepia utilis oil microemulsion.
Step 2) in, at room temperature stirring is under conditions of rotating speed is 300～500rpm, stirs
Mix 10～20min；Continuing to stir is under conditions of rotating speed is 300～500rpm, stirs 5～10min.
Step 4) in, mixing speed is 300～500rpm.
Step 5) in, use high-speed shearing machine that mixture C carries out mechanical shearing, shearing rotating speed is
5000～7000rpm, shear time is 12～18min.
Described preservative is one or more in potassium sorbate, sodium benzoate or sodium lactate.
Compared with prior art, the present invention has a following useful technique effect:
Princepia utilis oil microemulsion disclosed by the invention success solves Princepia utilis oil and is insoluble in asking of water-based system
Topic, by emulsifying agent carrying out substantial amounts of screening and compounding, optimizes kind and the ratio of emulsifying agent in microemulsion
Example, prepare Princepia utilis oil microemulsion can further in water-based system, in water can with water with
Arbitrary proportion mixes, and considerably improves stability and the dissolubility of Princepia utilis oil, the Princepia utilis prepared
In oil Microemulsions For Use, the content of Princepia utilis oil has reached 6wt%-12wt%, is tested by particle diameter, Princepia utilis oil microemulsion
The particle diameter of liquid is all at below 100nm, and has the best dewatering ability and bin stability.
Preparation method disclosed by the invention, first by polysorbate65, sorbester p17, dioctyl sodium sulfosuccinate, poly-
Ethylene glycol list ricinoleate ester, cocamido propyl betaine, glycerol and n-butyl alcohol mix homogeneously, prepare mixed
Fit A, then preservative is dissolved in deionized water, prepare mixture B, then mixture A, B are mixed
After, through mechanical shearing, prepare Princepia utilis oil microemulsion.Each component is successively added suitable by this preparation method
Sequence and stir speed (S.S.) require strict, and operating process is simple, are suitable for industrialization large-scale production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, described in the present invention
Explain rather than limit.
Embodiment 1
Step 1: according to the mass fraction, take respectively polysorbate65 be 7 parts, sorbester p17 be 2 parts, succinic acid two
Dioctyl sodium sulfosuccinate 6 parts, polyethyleneglycol ricinoleate ester 3 parts, cocamido propyl betaine 8 parts, sweet
Above-mentioned various compositions are first stirred at room temperature by oil 5 parts, n-butyl alcohol 4 parts, and speed of agitator is 500rpm,
Mixing time is 10min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 20 parts in the mixture of step 1, then
Keep rotating speed constant stirring 5min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.3 part, deionized water 160 parts, is dissolved by preservative
In deionized water, for mixture B；Described preservative be 0.1 part of potassium sorbate, 0.1 part of sodium benzoate and
The mixture of 0.1 part of sodium lactate；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 500rpm, until all pouring into complete；Step 5: use high-speed shearing machine to step
The mixture of rapid 4 carries out mechanical shearing, and cutter rotating speed is 8000rpm, and shear time is 20min, preparation
Obtain Princepia utilis oil microemulsion.
Embodiment 2
Step 1: according to the mass fraction, take respectively polysorbate65 be 3 parts, sorbester p17 be 7 parts, succinic acid two
Dioctyl sodium sulfosuccinate 2 parts, polyethyleneglycol ricinoleate ester 7 parts, cocamido propyl betaine 4 parts, sweet
Above-mentioned various compositions are first stirred at room temperature by oil 12 parts, n-butyl alcohol 2 parts, and speed of agitator is 300rpm,
Mixing time is 20min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 10 parts in the mixture of step 1, then
Keep rotating speed constant stirring 10min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.1 part, deionized water 130 parts, is dissolved by preservative
In deionized water, for mixture B；Preservative used is sodium benzoate；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 300rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
4000rpm, shear time is 10min, prepares Princepia utilis oil microemulsion.
Embodiment 3
Step 1: according to the mass fraction, take respectively polysorbate65 be 6 parts, sorbester p17 be 3 parts, succinic acid two
Dioctyl sodium sulfosuccinate 5 parts, polyethyleneglycol ricinoleate ester 4 parts, cocamido propyl betaine 5 parts, sweet
Above-mentioned various compositions are first stirred at room temperature by oil 10 parts, n-butyl alcohol 4 parts, and speed of agitator is 500rpm,
Mixing time is 10min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 12 parts in the mixture of step 1, then
Keep rotating speed constant stirring 5min, for mixture A；
Step 3: mass fraction meter, takes preservative 0.2 part, deionized water 140 parts, is dissolved in by preservative
In deionized water, for mixture B；Preservative is 0.1 part of sodium lactate and 0.1 part of sodium benzoate；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 500rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
7000rpm, shear time is 12min, prepares Princepia utilis oil microemulsion.
Embodiment 4
Step 1: according to the mass fraction, take respectively polysorbate65 be 4 parts, sorbester p17 be 5 parts, succinic acid two
Dioctyl sodium sulfosuccinate 3 parts, polyethyleneglycol ricinoleate ester 6 parts, cocamido propyl betaine 7 parts, sweet
Above-mentioned various compositions are first stirred at room temperature by oil 6 parts, n-butyl alcohol 3 parts, and speed of agitator is 300rpm,
Mixing time is 20min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 18 parts in the mixture of step 1, then
Keep rotating speed constant stirring 10min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.1 part, deionized water 150 parts, is dissolved by preservative
In deionized water, for mixture B；Preservative is sodium lactate；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 300rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
5000rpm, shear time is 18min, prepares Princepia utilis oil microemulsion.
Embodiment 5
Step 1: according to the mass fraction, take respectively polysorbate65 be 5 parts, sorbester p17 be 4 parts, succinic acid two
Dioctyl sodium sulfosuccinate 4 parts, polyethyleneglycol ricinoleate ester 5 parts, cocamido propyl betaine 6 parts, sweet
Above-mentioned various compositions are first stirred at room temperature by oil 8 parts, n-butyl alcohol 3 parts, and speed of agitator is 400rpm,
Mixing time is 15min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 15 parts in the mixture of step 1, then
Keep rotating speed constant stirring 7min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.1 part, deionized water 145 parts, is dissolved by preservative
In deionized water, for mixture B；Preservative is sodium benzoate；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 400rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
6000rpm, shear time is 15min, prepares Princepia utilis oil microemulsion.
Embodiment 6
Step 1: according to the mass fraction, take respectively polysorbate65 be 5 parts, sorbester p17 be 4 parts, succinic acid two
Dioctyl sodium sulfosuccinate 4 parts, polyethyleneglycol ricinoleate ester 5 parts, cocamido propyl betaine 6 parts, sugarcane
Sugar stearate 2 parts, sodium stearoyl lactate 2 parts, glycerol 8 parts, n-butyl alcohol 3 parts, by above-mentioned various
Composition is first stirred at room temperature, and speed of agitator is 400rpm, and mixing time is 15min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 15 parts in the mixture of step 1, then
Keep rotating speed constant stirring 7min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.3 part, deionized water 145 parts, is dissolved by preservative
In deionized water, for mixture B；Preservative used is potassium sorbate；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 400rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
6000rpm, shear time is 15min, prepares Princepia utilis oil microemulsion.
Comparative example 1
Step 1: according to the mass fraction, take respectively polysorbate65 be 7 parts, sorbester p17 be 2 parts, glycerol 5 parts,
Above-mentioned various compositions are first stirred at room temperature by n-butyl alcohol 4 parts, and speed of agitator is 500rpm, during stirring
Between be 10min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 20 parts in the mixture of step 1, then
Keep rotating speed constant stirring 5min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.3 part, deionized water 160 parts, is dissolved by preservative
In deionized water, for mixture B；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 500rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
8000rpm, shear time is 20min, prepares Princepia utilis oil emulsion.
Comparative example 2
Step 1: according to the mass fraction, take respectively polysorbate65 be 7 parts, sorbester p17 be 2 parts, coconut oleoyl amine
Above-mentioned various compositions are first stirred at room temperature by CAB 8 parts, glycerol 5 parts, n-butyl alcohol 4 parts,
Speed of agitator is 500rpm, and mixing time is 10min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 20 parts in the mixture of step 1, then
Keep rotating speed constant stirring 5min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.3 part, deionized water 160 parts, is dissolved by preservative
In deionized water, for mixture B；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 500rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
8000rpm, shear time is 20min, prepares Princepia utilis oil emulsion.
Comparative example 3
Step 1: according to the mass fraction, take respectively polysorbate65 be 7 parts, sorbester p17 be 2 parts, succinic acid two
Dioctyl sodium sulfosuccinate 6 parts, polyethyleneglycol ricinoleate ester 3 parts, glycerol 5 parts, n-butyl alcohol 4 parts, by upper
The various compositions stated first are stirred at room temperature, and speed of agitator is 500rpm, and mixing time is 10min；
Step 2: according to the mass fraction, then addition Princepia utilis oil is 20 parts in the mixture of step 1, then
Keep rotating speed constant stirring 5min, for mixture A；
Step 3: according to the mass fraction, takes preservative 0.3 part, deionized water 160 parts, is dissolved by preservative
In deionized water, for mixture B；
Step 4: be poured slowly in the mixture A of step 2 by mixture B under room temperature, pours into while carry out
Stirring, speed of agitator is 500rpm, until all pouring into complete；
Step 5: using high-speed shearing machine that the mixture of step 4 is carried out mechanical shearing, cutter rotating speed is
8000rpm, shear time is 20min, prepares Princepia utilis oil emulsion.
Determine the mean diameter of the Princepia utilis oil microemulsion of embodiment 1 to 6 and comparative example 1 to 3, result
As shown in table 1 below:
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Mean diameter (nm) | 67 | 59 | 35 | 39 | 28 | 24 |
The particle diameter of the Princepia utilis oil emulsion of comparative example such as table 2:
Table 2
| Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Mean diameter (nm) | 187 | 132 | 119 |
It can be seen that the most single due to emulsifying agent in comparative example 1 in from the above, it prepares
Princepia utilis oil does not form microemulsion, but emulsion, its particle diameter is the biggest, in comparative example 2 and comparative example 3
Owing to having lacked emulsifying agent the most important in the present invention respectively, its mean diameter have also been obtained and significantly increases,
Show the importance that the emulsifying agent of the present invention is compounding.
Additionally, embodiment 1 to 6 and the microemulsion of comparative example 1 to 3 or emulsion high speed centrifuge are carried out
High speed centrifugation, result is as shown in table 3:
Table 3
| Dewatering ability | |
| Embodiment 1 | Separation situation is not had to produce after centrifugal 10min under rotating speed is 5000rpm |
| Embodiment 2 | Separation situation is not had to produce after centrifugal 10min under rotating speed is 5000rpm |
| Embodiment 3 | Separation situation is not had to produce after centrifugal 10min under rotating speed is 6000rpm |
| Embodiment 4 | Separation situation is not had to produce after centrifugal 10min under rotating speed is 6000rpm |
| Embodiment 5 | Separation situation is not had to produce after centrifugal 10min under rotating speed is 7000rpm |
| Embodiment 6 | Separation situation is not had to produce after centrifugal 15min under rotating speed is 7000rpm |
| Comparative example 1 | Under rotating speed is 4000rpm, after centrifugal 10min, emulsion is substantially layered |
| Comparative example 2 | Under rotating speed is 5000rpm, after centrifugal 10min, emulsion is substantially layered |
| Comparative example 3 | Under rotating speed is 5000rpm, after centrifugal 10min, emulsion is substantially layered |
It addition, after embodiment and the microemulsion of comparative example or emulsion being sealed, at room temperature place 3
Month, after 3 months, the microemulsion of embodiment 1 to 6 keeps uniform state the most completely, without lamination.Right
The emulsion of ratio 1 to 3, after placed 3 months, all there occurs the most serious creaming of emulsion phenomenon, tool
There is poor bin stability.
Claims (10)
1. a high-load stable type Princepia utilis oil microemulsion, it is characterised in that in terms of mass fraction, including:
10～20 parts of Princepia utilis oil, 3～7 parts of polysorbate65s, 2～7 parts of sorbester p17s, 2～6 parts of dioctyl sodium sulfosuccinates,
3～7 parts of polyethyleneglycol ricinoleate esters, 4～8 parts of cocamido propyl betaine, 5～12 parts of glycerol, 2～4
Part n-butyl alcohol, 0.1～0.3 portion of preservative, 130～160 parts of deionized waters.
High-load stable type Princepia utilis oil microemulsion the most according to claim 1, it is characterised in that with
Mass fraction meter, including: 12～18 parts of Princepia utilis oil, 4～6 parts of polysorbate65s, 3～5 parts of sorbester p17s, 3～5 parts
Dioctyl sodium sulfosuccinate, 4～6 parts of polyethyleneglycol ricinoleate esters, 5～7 portions of cocamidopropyl propyl amide Radix Betaes
Alkali, 6～10 parts of glycerol, 3～4 parts of n-butyl alcohol, 0.1～0.2 portion of preservative, 140～150 parts of deionized waters.
High-load stable type Princepia utilis oil microemulsion the most according to claim 1, it is characterised in that with
Mass fraction meter, including: 15 parts of Princepia utilis oil, 5 parts of polysorbate65s, 4 parts of sorbester p17s, 4 parts of succinic acid two
Dioctyl sodium sulfosuccinate, 5 parts of polyethyleneglycol ricinoleate esters, 6 parts of cocamido propyl betaine, 8 parts of glycerol,
3 parts of n-butyl alcohol, 0.1 portion of preservative, 145 parts of deionized waters.
High-load stable type Princepia utilis oil microemulsion the most according to claim 1, it is characterised in that also
Including 1～3 part of sucrose stearate and 1～3 part of sodium stearoyl lactate.
5. according to the high-load stable type Princepia utilis oil microemulsion described in any one in Claims 1 to 4, its
Being characterised by, described preservative is one or more in potassium sorbate, sodium benzoate or sodium lactate.
6. the preparation method of a high-load stable type Princepia utilis oil microemulsion, it is characterised in that include following
Step:
1) in terms of mass fraction, 10～20 parts of Princepia utilis oil are taken, 3～7 parts of polysorbate65s, 2～7 parts of sorbester p17s,
2～6 parts of dioctyl sodium sulfosuccinates, 3～7 parts of polyethyleneglycol ricinoleate esters, 4～8 parts of coconut oleoyl amines third
Base glycine betaine, 5～12 parts of glycerol, 2～4 parts of n-butyl alcohol, 0.1～0.3 portion of preservative, 130～160 parts of deionizations
Water；
2) by polysorbate65, sorbester p17, dioctyl sodium sulfosuccinate, polyethyleneglycol ricinoleate ester,
Cocamido propyl betaine, glycerol and n-butyl alcohol, at room temperature stir, and is subsequently adding blue or green thorn
Fruit oil, continues to stir, and prepares mixture A；
3) preservative is dissolved in deionized water, mixing, prepares mixture B；
4) under room temperature, mixture B is poured in mixture A while stirring, stirs, prepare mixed
Compound C；
5) mixture C is carried out mechanical shearing, prepare Princepia utilis oil microemulsion.
The preparation method of high-load stable type Princepia utilis oil microemulsion the most according to claim 6, it is special
Levy and be, step 2) in, at room temperature stirring is under conditions of rotating speed is 300～500rpm,
Stirring 10～20min；Continuing to stir is under conditions of rotating speed is 300～500rpm, stirs 5～10min.
The preparation method of high-load stable type Princepia utilis oil microemulsion the most according to claim 6, it is special
Levy and be, step 4) in, mixing speed is 300～500rpm.
The preparation method of high-load stable type Princepia utilis oil microemulsion the most according to claim 6, it is special
Levy and be, step 5) in, use high-speed shearing machine that mixture C carries out mechanical shearing, shearing rotating speed is
5000～7000rpm, shear time is 12～18min.
The preparation method of high-load stable type Princepia utilis oil microemulsion the most according to claim 6, its
Being characterised by, described preservative is one or more in potassium sorbate, sodium benzoate or sodium lactate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610318421.8A CN106031705B (en) | 2016-05-13 | 2016-05-13 | A kind of high-content stable type prinsepia utilis royle oil microemulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610318421.8A CN106031705B (en) | 2016-05-13 | 2016-05-13 | A kind of high-content stable type prinsepia utilis royle oil microemulsion and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106031705A true CN106031705A (en) | 2016-10-19 |
| CN106031705B CN106031705B (en) | 2019-02-22 |
Family
ID=57149549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610318421.8A Active CN106031705B (en) | 2016-05-13 | 2016-05-13 | A kind of high-content stable type prinsepia utilis royle oil microemulsion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106031705B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684529A (en) * | 2017-08-21 | 2018-02-13 | 上海相宜本草化妆品股份有限公司 | A kind of microemulsified facial mask liquid and preparation method thereof |
| CN109589278A (en) * | 2018-10-10 | 2019-04-09 | 昆明贝泰妮生物科技有限公司 | The preparation process of high stable prinsepia utilis royle oil liposome and its application in cosmetics |
| CN110051626A (en) * | 2018-01-18 | 2019-07-26 | 杜权 | A kind of two-phase oil formulation and its application |
| CN111631297A (en) * | 2020-06-03 | 2020-09-08 | 陕西科技大学 | Stable microemulsion based on modified perilla seed protein and preparation method thereof |
| CN115152949A (en) * | 2022-07-12 | 2022-10-11 | 合肥工业大学 | Low-fat pork ball with prinsepia utilis protein high internal phase emulsion as fat substitute and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040209795A1 (en) * | 2003-04-21 | 2004-10-21 | Vlad Florin Joseph | VOC-free microemulsions |
| CN101002827A (en) * | 2006-12-15 | 2007-07-25 | 江南大学 | Micro-emulsion of mint oil with slow-releasing property, and its preparing method |
| CN104207145A (en) * | 2014-09-18 | 2014-12-17 | 苏州经贸职业技术学院 | Vitamin E nano-microemulsion and preparation method thereof |
-
2016
- 2016-05-13 CN CN201610318421.8A patent/CN106031705B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040209795A1 (en) * | 2003-04-21 | 2004-10-21 | Vlad Florin Joseph | VOC-free microemulsions |
| CN101002827A (en) * | 2006-12-15 | 2007-07-25 | 江南大学 | Micro-emulsion of mint oil with slow-releasing property, and its preparing method |
| CN104207145A (en) * | 2014-09-18 | 2014-12-17 | 苏州经贸职业技术学院 | Vitamin E nano-microemulsion and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684529A (en) * | 2017-08-21 | 2018-02-13 | 上海相宜本草化妆品股份有限公司 | A kind of microemulsified facial mask liquid and preparation method thereof |
| CN110051626A (en) * | 2018-01-18 | 2019-07-26 | 杜权 | A kind of two-phase oil formulation and its application |
| CN110051626B (en) * | 2018-01-18 | 2022-10-04 | 杜权 | Two-phase oil preparation and application thereof |
| CN109589278A (en) * | 2018-10-10 | 2019-04-09 | 昆明贝泰妮生物科技有限公司 | The preparation process of high stable prinsepia utilis royle oil liposome and its application in cosmetics |
| CN111631297A (en) * | 2020-06-03 | 2020-09-08 | 陕西科技大学 | Stable microemulsion based on modified perilla seed protein and preparation method thereof |
| CN115152949A (en) * | 2022-07-12 | 2022-10-11 | 合肥工业大学 | Low-fat pork ball with prinsepia utilis protein high internal phase emulsion as fat substitute and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106031705B (en) | 2019-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106031705A (en) | High-content stable prinsepia utilis royle oil microemulsion and preparation method thereof | |
| RU2732152C2 (en) | Nanoemulsions of beverage produced by high-shear treatment | |
| CN101861987B (en) | Method for preparing sweet almond oil microcapsules | |
| CN103815050A (en) | Sweet cream and its preparation method | |
| CN104492340B (en) | Emulsified composition | |
| CN112889938A (en) | Secondary embedding edible vegetable oil microcapsule powder and production method thereof | |
| CN106418131A (en) | Preparation method of oil-soluble natural pigment | |
| WO2013088971A1 (en) | Mixture of fats and/or oils for use in foamable oil-in-water emulsion and foamable oil-in-water emulsion containing said mixture | |
| CN105230811B (en) | The oily whey powder of height containing polyunsaturated fatty acid grease | |
| CN104921973A (en) | Liposome and preparation method thereof | |
| WO2018061723A1 (en) | Premix for preparing emulsion composition, and composition using same | |
| CN106617085A (en) | Preparation method of ulva fasciata polysaccharide-tween 20 compounded beta-carotene emulsion | |
| CN104277919A (en) | Method for preparing solid lipid by combination of oryzanol and phytosterin | |
| CN105345316A (en) | Novel solder paste production process | |
| US11000046B2 (en) | Method for manufacturing an oil-in-water emulsion from an oily active substance, for cosmetic, food, or pharmaceutical use | |
| CN107173839A (en) | A kind of oil phase suspension system based on single diglycerine fatty acid ester and glycerin/propylene glycol and preparation method and application | |
| CN100433993C (en) | Homogeneous liquid feed stuff additive and its preparation method | |
| CN103918958B (en) | The method of a kind of solid complex additive mixing | |
| CN105994345A (en) | Efficient cyfluthrin nano-emulsion composition and preparation method thereof | |
| CN113876817A (en) | Oil-soluble plant extract emulsion | |
| CN112655778A (en) | Preparation method of ester exchange rice bran solid ester mold release oil | |
| CN108210617B (en) | High-emulsion-stability xanthoceras sorbifolia bunge oil microemulsion and preparation method thereof | |
| CN113876816A (en) | Oil-soluble plant extract emulsion | |
| CN102068463B (en) | Preparation method of traditional Chinese medicine emulsion | |
| CN103271159B (en) | Liquid dairy food compound thickening agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |