CN113876816A - Oil-soluble plant extract emulsion - Google Patents
Oil-soluble plant extract emulsion Download PDFInfo
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- CN113876816A CN113876816A CN202010631555.1A CN202010631555A CN113876816A CN 113876816 A CN113876816 A CN 113876816A CN 202010631555 A CN202010631555 A CN 202010631555A CN 113876816 A CN113876816 A CN 113876816A
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- 239000000839 emulsion Substances 0.000 title claims abstract description 60
- 239000000419 plant extract Substances 0.000 title claims abstract description 34
- 239000007788 liquid Substances 0.000 claims abstract description 48
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 36
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 36
- 239000002245 particle Substances 0.000 claims abstract description 35
- 239000012528 membrane Substances 0.000 claims description 27
- 238000004945 emulsification Methods 0.000 claims description 18
- 241000222336 Ganoderma Species 0.000 claims description 16
- 238000010008 shearing Methods 0.000 claims description 9
- 238000000265 homogenisation Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000008346 aqueous phase Substances 0.000 claims description 7
- 230000001804 emulsifying effect Effects 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 3
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 3
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 claims description 3
- 229960000502 poloxamer Drugs 0.000 claims description 3
- 229920001983 poloxamer Polymers 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000136 polysorbate Polymers 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- -1 homogenizing Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims 2
- 239000012071 phase Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 5
- 239000011148 porous material Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 229960001701 chloroform Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000012982 microporous membrane Substances 0.000 description 2
- 210000004492 nuclear pore Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 208000037823 Cerebral ischemia/reperfusion injury Diseases 0.000 description 1
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
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- 238000000227 grinding Methods 0.000 description 1
- 231100000171 higher toxicity Toxicity 0.000 description 1
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- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention provides an oil-soluble plant extract emulsion, which comprises a water phase and liquid droplets dispersed in the water phase, wherein the particle size of the liquid droplets is 0.1-100 microns, the liquid droplets comprise an emulsifier and ganoderma lucidum spore oil coated in the emulsifier, and in the oil-soluble plant extract emulsion, the number of the liquid droplets with the particle size deviating from the average particle size by 10-30% accounts for 80-95% of the total number of the liquid droplets. The oil-soluble plant extract emulsion provided by the embodiment of the invention has uniform droplet size.
Description
Technical Field
The invention belongs to the technical field of ganoderma lucidum spore oil preparations, and particularly relates to oil-soluble plant extract emulsion.
Background
The Ganoderma spore oil is oily lipid extracted from wall-broken Ganoderma spore by supercritical carbon dioxide fluid extraction technology, and integrates multiple active ingredients of Ganoderma spore. The ganoderma lucidum spore oil is yellow transparent liquid, the main components are saturated fatty acid, unsaturated fatty acid and the like, and the ganoderma lucidum spore oil contains a small amount of ganoderma lucidum acid components and has the effects of resisting cerebral ischemia/reperfusion injury, resisting oxidation and eliminating free radicals.
Although the ganoderma spore oil can be used for various purposes, the use effect is not obvious. The effect is obviously limited by its own characteristics: is fat-soluble. Because of being fat-soluble (oil) substances, the ganoderma lucidum spore oil is insoluble in water and only soluble in trichloromethane, and the trichloromethane is a substance with higher toxicity. The characteristic of poor solubility ensures that although the ganoderma lucidum spore oil is difficult to absorb in the digestive system, the ganoderma lucidum spore oil needs to enter the liver for metabolism and absorption after being taken, and further plays the physiological function of the ganoderma lucidum spore oil, so that a certain part of the ganoderma lucidum spore oil is inevitably excreted in the digestive system, and even the part of the ganoderma lucidum spore oil entering the liver cannot be completely absorbed.
In order to ensure the absorption of the ganoderma lucidum spore oil by human body, the ganoderma lucidum spore oil needs to be made into water-soluble. The current technical proposal is that the water phase (containing water, emulsifier, emulsification assistant and other water-soluble substances) and the oil phase (ganoderma spore oil/other oil-soluble substances needing to be added) are respectively heated, dissolved, prepared and mixed for emulsification, and the emulsification method is emulsification by a high-speed shearing machine or direct emulsification by a high-pressure homogenizer. However, the existing ganoderma spore oil emulsion emulsifier needs to ensure more emulsifier dosage to realize better emulsification effect, and the existing ganoderma spore oil emulsion product has unstable quality and is easy to have the phenomena of oil and water stratification, cracking, phase inversion, flocculation, corruption and the like during storage.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the oil-soluble plant extract emulsion with uniform liquid drop particle size.
The invention provides an oil-soluble plant extract emulsion, which comprises an aqueous phase and liquid droplets dispersed in the aqueous phase, wherein the particle size of the liquid droplets is 0.1-100 microns, the liquid droplets comprise an emulsifier and ganoderma lucidum spore oil coated in the emulsifier, and the number of the liquid droplets with the particle size deviating from the average particle size by 10-30% in the oil-soluble plant extract emulsion accounts for 80-95% of the total number of the liquid droplets.
Preferably, in the oil-soluble plant extract emulsion, the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (2-20): 1.
preferably, the weight ratio of the water to the ganoderma lucidum spore oil is (1-10): 1.
preferably, the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (5-15): 1.
preferably, the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (5-10): 1.
preferably, the weight ratio of the water to the ganoderma lucidum spore oil is (1-5): 1.
preferably, the weight ratio of the water, the ganoderma lucidum spore oil and the emulsifier is (10-50): (5-10): 1.
preferably, the liquid droplets have a particle size of 0.1 to 50 microns.
Preferably, in the oil-soluble plant extract emulsion, the number of liquid droplets having a particle size which deviates from the average particle size by 10% to 20% is 80% to 95% of the total number of liquid droplets.
Preferably, the emulsifier is an aqueous emulsifier, and the hydrophilic-lipophilic value of the aqueous emulsifier is more than 10.
Preferably, the emulsifier comprises one or more of tween 20, tween 40, tween 60, tween 80, glycerol monooleate, poloxamer and monoglycerides.
The invention also provides a preparation method of the oil-soluble plant extract emulsion, which comprises the following steps:
(1) dissolving the emulsifier in water to form an aqueous phase;
(2) mixing the ganoderma spore oil and water, homogenizing, and membrane emulsifying the homogenized emulsion.
Preferably, in the step (2), the homogenized emulsion is subjected to membrane emulsification within 5 minutes, and the method for homogenizing comprises the following steps: the homogenization is carried out by using a high-speed shearing machine, the rotating speed of the high-speed shearing machine is 7000-.
The oil-soluble plant extract emulsion provided by the embodiment of the invention has uniform droplet size and is beneficial to absorption by a human body.
Drawings
The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings. Like reference numerals refer to like parts throughout the drawings, and the drawings are not intended to be drawn to scale in actual dimensions, emphasis instead being placed upon illustrating the principles of the invention.
Fig. 1 is a schematic structural diagram of an oil-soluble plant extract emulsion provided in example 1 of the present invention under an electron microscope (SEM).
Detailed Description
The technical solutions of the present invention are further described in detail with reference to specific examples so that those skilled in the art can better understand the present invention and can implement the present invention, but the examples are not intended to limit the present invention.
The embodiment of the invention provides an oil-soluble plant extract emulsion, which comprises a water phase and liquid droplets dispersed in the water phase, wherein the particle size of the liquid droplets is 0.1-100 microns, the liquid droplets comprise an emulsifier and ganoderma lucidum spore oil coated in the emulsifier, and in the oil-soluble plant extract emulsion, the number of the liquid droplets with the particle size deviating from the average particle size by 10-30% accounts for 80-95% of the total number of the liquid droplets. The average particle size of the liquid droplets in this example is 0.1-100 microns and the percentage deviation of the liquid droplet particle size from the average particle size is calculated as: (liquid droplet particle size-average particle size of liquid droplet)/average particle size of liquid droplet) 100%. For example: the average particle size of the liquid droplets is 10 microns, with one liquid droplet having a particle size of 12 microns, then the percentage deviation of the liquid droplet particle size from the average particle size is calculated as: (12-10)/10) × 100% ═ 20%. Further, in a preferred embodiment, the oil-soluble plant extract emulsion contains 80% to 95% of the total number of liquid droplets having a particle size which deviates from the average particle size by 10% to 20%.
The oil-soluble plant extract emulsion provided by the embodiment has the advantages of good stability, less emulsifier dosage, uniform liquid droplet particle size in the emulsion and good stability.
In a preferred embodiment, the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (2-20): 1, the weight ratio of water to ganoderma lucidum spore oil is (1-10): 1.
the oil-soluble plant extract emulsion provided in this example was obtained by a membrane emulsification method.
In a preferred embodiment, the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (5-15): 1. in a further preferred embodiment, the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (5-10): 1.
in a preferred embodiment, the weight ratio of the water to the ganoderma lucidum spore oil is (1-5): 1. the water content in the water phase in a certain proportion is ensured, the membrane passing is smoother after the water phase and the oil phase are combined, the membrane passing of one liquid drop after homogenization can be realized, and the blockage of micropores of the membrane is avoided.
In a preferred embodiment, the weight ratio of the water, the ganoderma lucidum spore oil and the emulsifier is (10-50): (5-10): 1. in a preferred embodiment, the oil-soluble plant extract emulsion is composed of water, ganoderma lucidum spore oil and an emulsifier. The oil-soluble plant extract emulsion disclosed by the embodiment is simple in component, the liquid droplets are dispersed in water, the ganoderma lucidum spore oil is changed into water, and the bioavailability is high.
In a preferred embodiment, the liquid droplets have a particle size of 0.1 to 50 microns. The oil-soluble plant extract emulsion of the embodiment is obtained by a membrane emulsification method, and the uniformity of the particle size of liquid droplets is better.
In a preferred embodiment, the emulsifier is an aqueous emulsifier having a hydrophilic-lipophilic value of greater than 10.
In a preferred embodiment, the emulsifier comprises one or more of tween 20, tween 40, tween 60, tween 80, glycerol monooleate, poloxamer and monoglycerides. The emulsifier selected in this example is a food grade emulsifier.
The invention also provides a preparation method of the oil-soluble plant extract emulsion, which comprises the following steps:
(1) dissolving an emulsifier in water to form an aqueous phase;
(2) mixing Ganoderma spore oil and water, and emulsifying the homogenized emulsion with membrane.
In the embodiment, the homogenized emulsion is subjected to membrane filtration to realize membrane emulsification, the preparation method is simple, and the uniform droplet size of the obtained oil-soluble plant extract emulsion is realized; the size of emulsion liquid drops is controllable; the emulsion state is more stable, the emulsion is not easy to break and delaminate, and the storage stability is better. The emulsion has high bioavailability.
In a preferred embodiment, the membrane emulsification is performed by using a microporous membrane, an ultrafiltration membrane, a nuclear pore membrane or a ceramic membrane, wherein the microporous membrane, the ultrafiltration membrane, the nuclear pore membrane or the ceramic membrane is provided with a plurality of micropores, and the pore diameter of each micropore is 0.01-100 microns. The membrane emulsification mode can realize controllable emulsion droplet size, the pore diameter of the micropores is 0.01-100 microns, the particle diameter of the liquid droplets after membrane emulsification can be controlled between 0.1-100 microns, and the bioavailability is high.
In a preferred embodiment, the homogenized emulsion is subjected to membrane emulsification in step (2) within 5 minutes. Ensures that the membrane emulsification is carried out under the best dispersion state, and can ensure that the emulsion droplets formed after the membrane emulsification have better effect. Avoid the phenomenon that the water and the water of the emulsion oil are layered or liquid drops are gathered from small to large due to long-time standing after homogenization. In a further preferred embodiment, the grinding emulsification is performed within 5 minutes after homogenization, more preferably within 2 minutes after homogenization.
In a preferred embodiment, in step (2), the homogenization method is: the homogenization is carried out by using a high-speed shearing machine, the rotating speed of the high-speed shearing machine is 7000-.
The foregoing disclosure is illustrative of the present invention by specific examples in order to make the invention more comprehensible and practical and to highlight its progressive effects.
Example 1
Dissolving 2 g of Tween 20 in 50 g of water, and stirring and dissolving at 50 ℃ to form a water phase; mixing 16 g ganoderma spore oil and water, coarse emulsifying with high speed shearing machine at rotation speed of 10000 r/min, after 30 s emulsion is fully dispersed, passing through membrane equipment within 2 min, wherein the pore diameter of micropores on the membrane is 0.01-100 μm. The obtained Ganoderma spore oil emulsion has liquid droplet diameter of 0.1-100 μm.
Example 2
Dissolving 3 g of Tween 60 in 90 g of water, and stirring and dissolving at 50 ℃ to form a water phase; mixing 18 g ganoderma spore oil and water, coarse emulsifying with high speed shearing machine at rotation speed of 10000 r/min, after 30 s emulsion is fully dispersed, passing through membrane equipment within 2 min, wherein the pore diameter of micropores on the membrane is 0.01-100 μm. The obtained Ganoderma spore oil emulsion has liquid droplet diameter of 0.1-100 μm.
The relatively uniform droplet size of the ganoderma spore oil emulsions prepared in examples 1 and 2 was observed by electron microscopy (SEM). As shown in the accompanying FIG. 1, which is a schematic structural diagram of the ganoderma spore oil emulsion of example 1 under an electron microscope (SEM), it can be seen that the droplet size is relatively uniform. The ganoderma lucidum spore oil emulsion prepared in the embodiment 1 and the embodiment 2 can still keep a better liquid drop state after being placed for 6 months, is dispersed in a water phase in the liquid drop state, and is not demulsified.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. An oil-soluble plant extract emulsion comprising an aqueous phase and liquid droplets dispersed in the aqueous phase, wherein the liquid droplets have a particle size of 0.1 to 100 μm and comprise an emulsifier and ganoderma lucidum spore oil encapsulated in the emulsifier, and wherein the number of liquid droplets having a particle size of 10 to 30% of the average particle size accounts for 80 to 95% of the total number of liquid droplets in the oil-soluble plant extract emulsion.
2. The oil-soluble plant extract emulsion according to claim 1, wherein the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (2-20): 1; the weight ratio of the water to the ganoderma lucidum spore oil is (1-10): 1.
3. the oil-soluble plant extract emulsion according to claim 2, wherein the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (5-15): 1.
4. the oil-soluble plant extract emulsion according to claim 3, wherein the weight ratio of the ganoderma lucidum spore oil to the emulsifier is (5-10): 1.
5. the oil-soluble plant extract emulsion according to claim 2, wherein the weight ratio of the water to the ganoderma lucidum spore oil is (1-5): 1.
6. the oil-soluble botanical extract emulsion of claim 1 wherein the number of liquid droplets having a particle size which deviates from the average particle size by 10% to 30% is 80% to 95% of the total number of liquid droplets.
7. The oil-soluble botanical extract emulsion of claim 1 wherein the liquid droplets have a particle size of 0.1 to 50 microns.
8. The oil-soluble plant extract emulsion of claim 7, wherein the emulsifier is an aqueous emulsifier comprising one or more of Tween 20, Tween 40, Tween 60, Tween 80, glycerol monooleate, poloxamer and monoglycerides.
9. The method for preparing an oil-soluble plant extract emulsion according to any one of claims 1 to 8, comprising the steps of:
(1) dissolving the emulsifier in water to form an aqueous phase;
(2) mixing the ganoderma spore oil and water, homogenizing, and membrane emulsifying the homogenized emulsion to obtain oil-soluble plant extract emulsion.
10. The method for preparing an oil-soluble plant extract emulsion according to claim 9, wherein in the step (2), the homogenized emulsion is subjected to membrane emulsification within 5 minutes by: the homogenization is carried out by using a high-speed shearing machine, the rotating speed of the high-speed shearing machine is 7000-.
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