CN104306171A - Multivitamin solid lipid particles and preparation method thereof - Google Patents
Multivitamin solid lipid particles and preparation method thereof Download PDFInfo
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- CN104306171A CN104306171A CN201410611742.8A CN201410611742A CN104306171A CN 104306171 A CN104306171 A CN 104306171A CN 201410611742 A CN201410611742 A CN 201410611742A CN 104306171 A CN104306171 A CN 104306171A
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Abstract
The invention discloses multivitamin solid lipid particles and a preparation method thereof. The multivitamin solid lipid particles are loaded with vitamin A, vitamin A acetate, vitamin B, vitamin C, vitamin E and vitamin E acetate, and comprise the following components in percentage by weight: 1-2% of vitamin A, 1-5% of vitamin A acetate, 1-5% of vitamin B, 1-5% of vitamin C, 1-2% of vitamin E, 1-2% of vitamin E acetate, 20-28% of a solvent, 20-25% of an emulsifier and 36-50% of lipid material. The preparation method comprises the following steps: mixing the lipid material with the emulsifier as an oil phase; adding water-soluble vitamins into the solvent as an internal aqueous phase; adding the internal aqueous phase into a mixture of the liquid oil phase and oil-soluble vitamins, pre-emulsifying, performing ultrasonic emulsification, performing high shearing dispersion or high pressure homogenization, adding the oil-in-water emulsifier, stirring uniformly to obtain the lipid system, cooling to room temperature, and solidifying to obtain the solid lipid particles loaded with multivitamins.
Description
Technical field
The invention belongs to the carrier system technical field in cosmetics technology of preparing, relate to a kind of preparation method of micro/nano level carrier, particularly a kind of take multivitamin as micro and nano powders lipid particles of active component and preparation method thereof.
Background technology
Vitamin maintains the required type organic matter of human life activity, is also the important active substances keeping health.Vitamin content is in vivo less, but plays an important role in growth in humans, metabolism, growth course.Corresponding avitaminosis will be caused once lack, health is worked the mischief.
Lipid nanoparticle technology be a kind of matrix material of natural origin that adopts as carrier material, the nano carrier system that can be used for carrying active ingredients adopting modern nanotechnology to prepare.Lipid nanoparticle has following characteristics: can facilitate the introduction of lipophilic drugs, but parcel hydrophilic drugs ability is more weak; Improve the stability of medicine; Drug loading is higher; The biocompatibility of carrier is better; Avoid the use of organic solvent; The advantage such as large-scale production and sterilizing can be carried out.
Wrap up fat-soluble and that water-soluble active thing is conventional dosage form simultaneously and have liposome, multiple emulsion and water-in-oil emulsion.Loading liposomes active matter limited amount, and structure is relatively unstable; Multiple emulsion is a kind of system of thermodynamic instability, easily occurs layering, breakdown of emulsion etc.; The outer aqueous phase of water in oil emulsion is oils and fats, is of limited application.
Summary of the invention
Technical problem: technical problem to be solved by this invention is conbined usage multiple emulsion and lipid nanoparticle technology, provides a kind of compound vitamin solid lipid microgranule.
Another technical problem to be solved by this invention is the preparation method providing the multivitamin solid lipid microgranule of above-mentioned load.
Technical scheme: the lipid particles of compound vitamin of the present invention comprises following component by its percentage by weight:
Vitamin A | 1-2% |
Vitamin A acetate (GWS) | 1-5% |
Vitamin B | 1-5% |
Vitamin C | 1-5% |
Vitamin E | 1-2% |
Vitamin E acetate | 1-2% |
Solvent | 20-28% |
Emulsifying agent | 20-25% |
Matrix material | 36-50% |
Described matrix material is the solidliquid mixture of liquid lipoid material and solid lipid material; liquid lipoid material is one or both in Semen Maydis oil, Oleum Cocois, aloe or glycerol; described solid lipid material is one or both of glyceryl monostearate or acetylation monoglyceride, and described solvent is deionized water.
In described matrix material, liquid lipoid material accounts for the 30-39% of lipid particles percentage by weight; Solid lipid material accounts for the 11-15% of lipid particles percentage by weight.
Described emulsifier package draws together water-in-oil emulsifier and oil-water emulsifiers.
Described water-in-oil emulsifier is one or both of polyglycerol polyricinoleate or sorbitan monostearate, accounts for the 8-10% of lipid particles percentage by weight.
Described oil-water emulsifiers is one or both in ten polyglycereol monolaurates, six polyglycereol monolaurates or polyoxyethylene sorbitan fatty acid ester, accounts for the 12-15% of lipid particles percentage by weight.
The preparation method of compound vitamin solid lipid microgranule of the present invention comprises the steps:
The first step: by fat soluble vitamin, matrix material mixes with water-in-oil emulsifier, and 60-70 DEG C dissolves and stir, as oil phase; Water soluble vitamins is added solvent, and 60-70 DEG C stirs, as interior aqueous phase;
Second step: add interior aqueous phase in liquid oil phase, after pre-emulsification mix homogeneously, ultrasonic emulsification, high shear dispersion or high pressure homogenize;
3rd step: add oil-water emulsifiers, 50-60 DEG C stirs and obtains lipid system, and cool to room temperature solidifies, and obtains the multivitamin lipid particles of load.
On the basis of such scheme, the particle loaded multivitamin weight percentage of described solid lipid is 1-15%.
Beneficial effect: the present invention is as a kind of new preparation technique, conbined usage multiple emulsion and lipid nanoparticle technology thereof, namely the oil phase in multiple emulsion selects solid oil, the fluid oil that the mixture replacing of fluid oil and fat soluble vitamin is traditional, interior aqueous phase is multiple water-soluble vitamin solution, and the multiple emulsion that this structure is more traditional is more stable, and the multivitamin solid lipid microgranule of the load obtained can as raw material, be added among food, effectively solve existing applied defect.
Accompanying drawing explanation
Fig. 1 is the preparation method flow chart containing the multivitamin solid lipid microgranule of load.
Detailed description of the invention
Below in conjunction with specific embodiment, such scheme is described further.These embodiments are not limited to for illustration of the present invention limit the scope of the invention.The implementation condition adopted in embodiment can do further adjustment according to the condition of concrete producer, and not marked implementation condition is generally the condition in normal experiment.
Embodiment 1
Be combined as formula:
The preparation method of the solid lipid microgranule of load compound vitamin:
The first step: take 5g vitamin C, 1g vitamin A acetate and 25g deionized water, 70 DEG C of heating in water bath also stir and make it dissolve completely and stir, and form the aqueous solution of containing water-soluble vitamin, as interior aqueous phase;
Take 1g Vitamin E acetate, 29.9g Semen Maydis oil, 5g glycerol, 10g polyglycereol Semen Ricini alcohol ester, 11g glyceryl monostearate, 70 DEG C of heating in water bath also stir and make it dissolve completely and stir, as oil phase;
Second step: slowly poured in oil phase by interior aqueous phase, carries out stirring 10 minutes simultaneously, after mix homogeneously, and 16000rpm high shear 5 minutes;
3rd step: drop into 12.1g ten polyglycereol monolaurate in mixture, 50 DEG C of heating in water bath, and stirring makes its mix homogeneously obtain lipid system, cool to room temperature solidifies, and obtains the multivitamin lipid particles of load.
By lipid particles dispersion in deionized water, it is 1.22 μm that this dispersion liquid records its mean diameter by particle size analyzer.
Embodiment 2
Be combined as formula:
The preparation method of the solid lipid microgranule of load compound vitamin:
The first step: take 2g vitamin C, 1g vitamin A acetate and 22g deionized water, 70 DEG C of heating in water bath also stir and make it dissolve completely and stir, and form the aqueous solution of containing water-soluble vitamin, as interior aqueous phase;
Take 2g Vitamin E acetate, 35g Oleum Cocois, 5g glycerol, 10g polyglycereol Semen Ricini alcohol ester, 11g acetylation monoglyceride, 70 DEG C of heating in water bath also stir and make it dissolve completely and stir, as oil phase;
Second step: slowly poured in oil phase by interior aqueous phase, carries out stirring 10 minutes, mix homogeneously simultaneously, 600bar high pressure homogenize 3 circulation;
3rd step: drop into 12g polyoxyethylene sorbitan fatty acid ester in mixture, 50 DEG C of heating in water bath, and stirring makes its mix homogeneously obtain lipid system, cool to room temperature solidifies, and obtains the multivitamin lipid particles of load.
By lipid particles dispersion in deionized water, it is 0.97 μm that this dispersion liquid records its mean diameter by particle size analyzer.
Embodiment 3
Be combined as formula:
The preparation method of the solid lipid microgranule of load compound vitamin:
The first step: take 2g vitamin C, 2g vitamin B and 26g deionized water, 70 DEG C of heating in water bath also stir and make it dissolve completely and stir, and form the aqueous solution of containing water-soluble vitamin, as interior aqueous phase;
Take 1g vitamin E, 1g vitamin A, 29.9g Semen Maydis oil, 5g glycerol, 10g sorbitan monostearate, 11g glyceryl monostearate, 70 DEG C of heating in water bath also stir and make it dissolve completely and stir, as oil phase;
Second step: slowly poured in oil phase by interior aqueous phase, carries out stirring 10 minutes, mix homogeneously simultaneously, ultrasonic 15 minutes;
3rd step: drop into 12.1g six polyglycereol monolaurate in mixture, 50 DEG C of heating in water bath, and stirring makes its mix homogeneously obtain lipid system, cool to room temperature solidifies, and obtains the multivitamin lipid particles of load.
By lipid particles dispersion in deionized water, it is 2.10 μm that this dispersion liquid records its particle diameter by particle size analyzer.
Claims (7)
1. a compound vitamin solid lipid microgranule, is characterized in that, this lipid particles comprises by its percentage by weight: retinol1-2%; Vitamin A acetate 1-5%; Vitamin B1-5%; Vitamin C 1-5%; Vitamin e1-2%; Vitamin E acetate 1-2%; Solvent 20-28%; Emulsifying agent 20-25%; Matrix material 36-50%.
2. compound vitamin solid lipid microgranule according to claim 1; it is characterized in that; described matrix material is the solidliquid mixture of liquid lipoid material and solid lipid material; liquid lipoid material is one or both in Semen Maydis oil, Oleum Cocois, aloe or glycerol; described solid lipid material is one or both of glyceryl monostearate or acetylation monoglyceride, and described solvent is deionized water.
3. the multivitamin solid lipid microgranule of the load according to right 2, it is characterized in that: in described matrix material, liquid lipoid material accounts for the 30-39% of lipid particles percentage by weight; Solid lipid material accounts for the 11-15% of lipid particles percentage by weight.
4. compound vitamin solid lipid microgranule according to claim 1, is characterized in that: described emulsifier package draws together water-in-oil emulsifier and oil-water emulsifiers.
5. compound vitamin solid lipid microgranule according to claim 4, is characterized in that: described water-in-oil emulsifier is one or both of polyglycerol polyricinoleate or sorbitan monostearate, accounts for the 8-10% of lipid particles percentage by weight.
6. compound vitamin solid lipid microgranule according to claim 4, it is characterized in that: described oil-water emulsifiers is one or both in ten polyglycereol monolaurates, six polyglycereol monolaurates or polyoxyethylene sorbitan fatty acid ester, accounts for the 12-15% of lipid particles percentage by weight.
7., according to a preparation method for the compound vitamin solid lipid microgranule one of claim 1 to 6 Suo Shu, it is characterized in that this preparation method comprises the steps:
The first step: by fat soluble vitamin, matrix material mixes with water-in-oil emulsifier, and 60-70 DEG C dissolves and stir, as oil phase; Water soluble vitamins is added solvent, and 60-70 DEG C stirs, as interior aqueous phase;
Second step: add interior aqueous phase in liquid oil phase, after pre-emulsification mix homogeneously, ultrasonic emulsification, high shear dispersion or high pressure homogenize;
3rd step: add oil-water emulsifiers, 50-60 DEG C stirs and obtains lipid system, and cool to room temperature solidifies, and obtains the multivitamin lipid particles of load.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106943395A (en) * | 2017-04-18 | 2017-07-14 | 扬州大学 | The preparation method of anti-oxidant nanoemulsions containing vitamin C and E |
CN107549801A (en) * | 2017-08-24 | 2018-01-09 | 福格森(武汉)生物科技股份有限公司 | A kind of multilayer embeds solid lipid calcium particulate |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1546016A (en) * | 2003-12-04 | 2004-11-17 | 东南大学 | Nanometer preparation of natural vitamin E and its preparation |
CN102552058A (en) * | 2011-12-27 | 2012-07-11 | 东南大学 | Compound vitamin lipid nanoparticle and preparation method thereof |
CN103976901A (en) * | 2014-05-22 | 2014-08-13 | 东南大学 | Coenzyme Q10 and tea polyphenol loaded micro-nano carrier, as well as preparation and application methods thereof |
-
2014
- 2014-11-04 CN CN201410611742.8A patent/CN104306171A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1546016A (en) * | 2003-12-04 | 2004-11-17 | 东南大学 | Nanometer preparation of natural vitamin E and its preparation |
CN102552058A (en) * | 2011-12-27 | 2012-07-11 | 东南大学 | Compound vitamin lipid nanoparticle and preparation method thereof |
CN103976901A (en) * | 2014-05-22 | 2014-08-13 | 东南大学 | Coenzyme Q10 and tea polyphenol loaded micro-nano carrier, as well as preparation and application methods thereof |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106943395A (en) * | 2017-04-18 | 2017-07-14 | 扬州大学 | The preparation method of anti-oxidant nanoemulsions containing vitamin C and E |
CN107549801A (en) * | 2017-08-24 | 2018-01-09 | 福格森(武汉)生物科技股份有限公司 | A kind of multilayer embeds solid lipid calcium particulate |
CN107549801B (en) * | 2017-08-24 | 2020-11-13 | 福格森(武汉)生物科技股份有限公司 | Multilayer embedded solid lipid calcium particle |
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