CN102068463B - Preparation method of traditional Chinese medicine emulsion - Google Patents
Preparation method of traditional Chinese medicine emulsion Download PDFInfo
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- CN102068463B CN102068463B CN200910226225A CN200910226225A CN102068463B CN 102068463 B CN102068463 B CN 102068463B CN 200910226225 A CN200910226225 A CN 200910226225A CN 200910226225 A CN200910226225 A CN 200910226225A CN 102068463 B CN102068463 B CN 102068463B
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine emulsion, which comprises the steps of: (1) extracting grease ingredients and water-soluble ingredients in raw material drugs to obtain grease and water-soluble extract; (2) dissolving sucrose stearate which is used an emulsifying agent in water, stirring, heating by water bath, stirring to dissolve uniformly to obtainsucrose stearate aqueous solution; subjecting the grease to water-bath heating and then pouring the grease to the sucrose stearate aqueous solution, uniformly stirring, emulsifying at normal pressureat first, and then emulsifying by increasing the pressure to obtain oil-in-water emulsion; (3) uniformly mixing the oil-in-water emulsion with syrup having the same weight; and (4) mixing the water-soluble extract with the oil-in-water emulsion syrup to obtain the traditional Chinese medicine emulsion. The method of the invention enhances the utilization rate of grease ingredients in the traditional Chinese medicines, improves the appearance of emulsified preparation and settles the problems of low utilization rate of grease, easy separation between oil and water, instability and the like during traditional Chinese medicine emulsion preparation.
Description
Technical field
The present invention relates to a kind of method for preparing of Chinese medicine preparation, relate in particular to the method for preparing of Chinese medicine Emulsion, belong to field of traditional Chinese.
Background technology
Effective Components of Chinese Herb can be divided into water soluble ingredient and liposoluble constituent, and oils and fats belongs to fatty oil property composition effective ingredient, and oils and fats mainly exists in the seed class Chinese medicine, like Semen Armeniacae Amarum, Semen Sesami Nigrum, Semen Persicae etc., has intestine moistening, lung moistening, effects such as tonification.
At present to the oils and fats in the seed class Chinese medicine; Two kinds of processing modes are arranged, the one, with the water soluble ingredient of water extraction seed class Chinese medicine, and the oils and fats major part also exists in the seed medicinal residues; The one, press with milling process and to get oils and fats or with the little solvent extraction of polarity; But oils and fats and aqueous soluble active constituent can not dissolve each other, and the profit layering occurs, do not meet the requirement of preparation even.In addition, the phenomenon that is prone to the dispersed phase drop come-up in the Emulsion put procedure or sinks.
Summary of the invention
Technical problem to be solved by this invention is the deficiency that overcomes prior art; A kind of method for preparing of new Chinese medicine Emulsion is provided; This method for preparing can make Chinese medicine water soluble ingredient and fat-soluble lubricant component fully mix, and prepared Chinese medicine emulsion stability is good, the profit layering do not occur; Improve Chinese medicine oils and fats components utilising rate, improved the outward appearance of Chinese medicine emulsion preparations.
Technical problem to be solved by this invention realizes through following technical scheme:
A kind of method for preparing of Chinese medicine Emulsion may further comprise the steps:
(1), extract lubricant component and water soluble ingredient in the crude drug, obtain oils and fats and water solubility extract respectively;
(2), the emulsifying agent sucrose stearate is soluble in water, stir, heating in water bath, stirring and dissolving is even, obtains the sucrose stearate aqueous solution of ester; In impouring sucrose stearate aqueous solution behind the oils and fats heating in water bath, stir; Emulsifying; Get oil-in-water emulsion;
(3), with oil-in-water emulsion and syrup mix homogeneously, obtain the oil-in-water emulsion liquid syrup, subsequent use;
(4), with water solubility extract and oil-in-water emulsion liquid syrup mix homogeneously, promptly get.
In order to reach better preparation effect, preferred in the step (1), resultant oils and fats and water solubility extract are carried out following processing respectively: oils and fats is filtered, heats and anhydrate; Water solubility extract is concentrated; Because the density of Emulsion is lower than water, be prone to and the water soluble ingredient layering, in order to increase denseness, stop the come-up of Emulsion, preferably water soluble ingredient is concentrated into relative density more than 1.30.
Preferably, the weight proportion of oils and fats, water and sucrose stearate is 8-12: 8-12: 0.8-1.2 in the step (2); More preferably: 10: 10: 1; Wherein, the hydrophilic hydrophobic balance value (HLB) of described sucrose stearate is preferably 10-14;
Emulsifying described in the step (2) is preferably: first normal pressure emulsifying 1 time is forced into 20-30MPa emulsifying 2 to 3 times again;
The temperature of the heating in water bath described in the step (2) is preferably 50-70 ℃;
Preferably; Adopting the equivalent incremental method to mix water solubility extract and oil-in-water emulsion liquid syrup in the step (5) (is the quality of oil-in-water emulsion liquid syrup much smaller than water solubility extract; Get with the water solubility extract of oil-in-water emulsion liquid syrup equimultiple and mix, get 2 times of amount mixture, get 2 times of water gaging dissolubility extracts again and mix with mixture with the oil-in-water emulsion liquid syrup; Get 4 times of amount mixture, increase progressively successively and mix fully.) can make the oil and the miscible effect of water reach best like this.
The present invention tests with drug prescriptions such as Decoction for Reliving Dryness of the Lung promulgated by the ministries or commissions of the Central Government, zhigancao decoction and Fructus Cannabis mixture; Adopt the method for preparing of Chinese medicine Emulsion of the present invention, prepared even one, stable Decoction for Reliving Dryness of the Lung Emulsion, zhigancao decoction Emulsion and Fructus Cannabis mixture Emulsion respectively.
Preferably, a kind of method for preparing Decoction for Reliving Dryness of the Lung Emulsion may further comprise the steps:
(1), the oil expression of Semen Armeniacae Amarum and Semen Sesami Nigrum is filtered, with oils and fats filter, heating anhydrates, and obtains oils and fats, and is subsequent use; With Gypsum Fibrosum, Folium Mori, Folium Eriobotryae, Radix Ginseng, Radix Ophiopogonis, Radix Glycyrrhizae and Colla Corii Asini mixing and water adding, decoct, decoction liquor is filtered, and it is more than 1.30, to obtain water solubility extract that filtrating is concentrated into relative density, subsequent use;
(2), the emulsifying agent sucrose stearate is soluble in water, stir, heating in water bath, stirring and dissolving is even, obtains the sucrose stearate aqueous solution of ester; In impouring sucrose stearate aqueous solution behind the oils and fats heating in water bath, stir; Emulsifying; Get oil-in-water emulsion;
(3), with oil-in-water emulsion and syrup mix homogeneously, obtain the oil-in-water emulsion liquid syrup, subsequent use;
(4), with water solubility extract and oil-in-water emulsion liquid syrup mix homogeneously, promptly get.
The present invention with Chinese medicine lubricant component and water, emulsifying agent with the emulsifying of high pressure homogenization machine; Get oil-in-water emulsion; Dissolve each other with water solublity Chinese medicine extraction composition again, process even one, stable emulsification preparation, improved Chinese medicine oils and fats components utilising rate; Improved the emulsification preparation outward appearance, solved that oils and fats utilization rate of the prior art is few, the easily separated problem of unstable of profit.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment with form or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall in protection scope of the present invention the details of technical scheme of the present invention.
The preparation of embodiment 1 Decoction for Reliving Dryness of the Lung Emulsion
(1), the oil expression of Semen Armeniacae Amarum and Semen Sesami Nigrum is filtered, with oils and fats filter, heating anhydrates, and obtains oils and fats, and is subsequent use; Gypsum Fibrosum, Folium Mori, Folium Eriobotryae, Radix Ginseng, Radix Ophiopogonis, Radix Glycyrrhizae and Colla Corii Asini mixing are added 4 times of weight water, decoct 3 times, decoction liquor is filtered, merging filtrate, and being concentrated into relative density is 1.31 (60 ℃), obtains water solubility extract, subsequent use;
(2), take by weighing following component by following weight portion proportioning: oils and fats: water: sucrose stearate (hydrophilic hydrophobic balance value HLB=12)=10: 10: 1; The sucrose stearate emulsifying agent is soluble in water, stir, 60 ℃ of heating in water bath, stirring and dissolving is even; The oils and fats water-bath is added in 60 ℃ of impouring sucrose stearate aqueous solution of ester, stirs, and with the even matter emulsifying of high pressure homogenization machine elder generation normal pressure 1 time, is forced into the even matter emulsifying of 25MPa 3 times, gets oil-in-water emulsion;
(3), with water solubility extract with etc. the syrup mix homogeneously of weight, obtain the oil-in-water emulsion liquid syrup, subsequent use;
(4), adopt the equivalent incremental method to mix water solubility extract and oil-in-water emulsion liquid syrup, promptly get.
The prepared Emulsion of present embodiment is shallow sepia, and easy to be mobile, evenly fine and smooth, relative density is 1.35; The profit lamination does not appear in centrifugal 30 minutes of the rotating speed that changes with per minute 4000.Place after 3 months the phenomenon that the dispersed phase drop come-up do not occur or sink.
Embodiment 2
(1), the oil expression of Semen Armeniacae Amarum and Semen Sesami Nigrum is filtered, with oils and fats filter, heating anhydrates, and obtains oils and fats, and is subsequent use; Gypsum Fibrosum, Folium Mori, Folium Eriobotryae, Radix Ginseng, Radix Ophiopogonis, Radix Glycyrrhizae and Colla Corii Asini mixing are added 5 times of weight water, decoct 2 times, decoction liquor is filtered, merging filtrate, and being concentrated into relative density is 1.31 (60 ℃), obtains water solubility extract, subsequent use;
(2), take by weighing following component by following weight portion proportioning: oils and fats: water: sucrose stearate (hydrophilic hydrophobic balance value HLB=10)=8: 12: 1.2; The sucrose stearate emulsifying agent is soluble in water, stir, 50 ℃ of heating in water bath, stirring and dissolving is even; The oils and fats water-bath is added in 60 ℃ of impouring sucrose stearate aqueous solution of ester, stirs, and with the even matter emulsifying of high pressure homogenization machine elder generation normal pressure 1 time, is forced into the even matter emulsifying of 25MPa 3 times, gets oil-in-water emulsion;
(3), with water solubility extract with etc. the syrup mix homogeneously of weight, obtain the oil-in-water emulsion liquid syrup, subsequent use;
(4), adopt the equivalent incremental method to mix water solubility extract and oil-in-water emulsion liquid syrup, promptly get.
The prepared Emulsion of present embodiment is shallow sepia, and easy to be mobile, evenly fine and smooth, relative density is 1.30; The profit lamination does not appear in centrifugal 15 minutes of the rotating speed that changes with per minute 4000.Place after 3 months the phenomenon that the dispersed phase drop come-up do not occur or sink.
Embodiment 3
(1), the oil expression of Semen Armeniacae Amarum and Semen Sesami Nigrum is filtered, with oils and fats filter, heating anhydrates, and obtains oils and fats, and is subsequent use; Gypsum Fibrosum, Folium Mori, Folium Eriobotryae, Radix Ginseng, Radix Ophiopogonis, Radix Glycyrrhizae and Colla Corii Asini mixing are added 3 times of weight water, decoct 3 times, decoction liquor is filtered, merging filtrate, and being concentrated into relative density is 1.31 (60 ℃), obtains water solubility extract, subsequent use;
(2), take by weighing following component by following weight portion proportioning: oils and fats: water: sucrose stearate (hydrophilic hydrophobic balance value HLB=14)=12: 8: 0.8; The sucrose stearate emulsifying agent is soluble in water, stir, 70 ℃ of heating in water bath, stirring and dissolving is even; The oils and fats water-bath is added in 60 ℃ of impouring sucrose stearate aqueous solution of ester, stirs, and with the even matter emulsifying of high pressure homogenization machine elder generation normal pressure 1 time, is forced into the even matter emulsifying of 25MPa 3 times, gets oil-in-water emulsion;
(3), with water solubility extract with etc. the syrup mix homogeneously of weight, obtain the oil-in-water emulsion liquid syrup, subsequent use;
(4), adopt the equivalent incremental method to mix water solubility extract and oil-in-water emulsion liquid syrup, promptly get.
The prepared Emulsion of present embodiment is shallow sepia, and easy to be mobile, evenly fine and smooth, relative density is 1.30; The profit lamination does not appear in centrifugal 20 minutes of the rotating speed that changes with per minute 4000.Place after 3 months the phenomenon that the dispersed phase drop come-up do not occur or sink.
Claims (4)
1. the method for preparing of a Chinese medicine Emulsion may further comprise the steps:
(1), extract lubricant component and water soluble ingredient in the crude drug, obtain oils and fats and water solubility extract respectively; Oils and fats is filtered, heats and anhydrate; It is more than 1.30 that water solubility extract is concentrated into relative density;
(2), the sucrose stearate emulsifying agent is soluble in water, stir, heating in water bath, temperature is 50-70 ℃, stirring and dissolving is even, obtains the sucrose stearate aqueous solution of ester; In impouring sucrose stearate aqueous solution behind the oils and fats heating in water bath, stir, emulsifying gets oil-in-water emulsion; The hydrophilic hydrophobic balance value of described sucrose stearate is 10-14;
(3), be 1: 1 mix homogeneously with oil-in-water emulsion and syrup according to weight proportion, obtain the oil-in-water emulsion liquid syrup, subsequent use;
(4), with water solubility extract and oil-in-water emulsion liquid syrup mix homogeneously, promptly get;
Wherein, the weight proportion of oils and fats, water and sucrose stearate is 8-12: 8-12: 0.8-1.2 in the step (2);
Wherein, the emulsifying described in the step (2) comprises: first normal pressure emulsifying is forced into 20-30MPa emulsifying for 1 time 2 to 3 times again.
2. according to the described method of claim 1, it is characterized in that: described Chinese medicine Emulsion is extract oral Emulsion.
3. by claim 1 or the prepared product that obtains of 2 described methods.
4. according to the described method of claim 1, it is characterized in that described Chinese medicine Emulsion is Decoction for Reliving Dryness of the Lung Emulsion, the preparation of concrete described Decoction for Reliving Dryness of the Lung Emulsion may further comprise the steps:
(1), with the oil expression of Semen Armeniacae Amarum and Semen Sesami Nigrum, with oils and fats filter, heating anhydrates, and obtains oils and fats, and is subsequent use; With Gypsum Fibrosum, Folium Mori, Folium Eriobotryae, Radix Ginseng, Radix Ophiopogonis, Radix Glycyrrhizae and Colla Corii Asini mixing and water adding, decoct, decoction liquor is filtered, and it is more than 1.30, to obtain water solubility extract that filtrating is concentrated into relative density, subsequent use;
(2), the emulsifying agent sucrose stearate is soluble in water, stir, heating in water bath, stirring and dissolving is even, obtains the sucrose stearate aqueous solution of ester; In impouring sucrose stearate aqueous solution behind the oils and fats heating in water bath, stir; Emulsifying; Get oil-in-water emulsion;
(3), with oil-in-water emulsion and syrup mix homogeneously, obtain the oil-in-water emulsion liquid syrup, subsequent use;
(4), with water solubility extract and oil-in-water emulsion liquid syrup mix homogeneously, promptly get.
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| CN200910226225A CN102068463B (en) | 2009-11-20 | 2009-11-20 | Preparation method of traditional Chinese medicine emulsion |
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| CN102871155B (en) * | 2012-10-16 | 2015-07-15 | 福建安井食品股份有限公司 | Method for increasing whiteness of minced fillet product |
| CN107349375B (en) * | 2017-06-01 | 2021-03-23 | 江西广恩和药业股份有限公司 | Preparation method of traditional Chinese medicine oral microemulsion and traditional Chinese medicine oral microemulsion |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1785315A (en) * | 2005-11-07 | 2006-06-14 | 苏州长征－欣凯制药有限公司 | Hemp-leaved ritet emulsion used for phlegm dispelling cough suppressing and panting calming, and preparing process thereof |
| CN1903228A (en) * | 2006-07-03 | 2007-01-31 | 李颖 | Prepn. of self-emulsion of glossy ganoderma spore oil, and its prepn. method |
| CN101028461A (en) * | 2007-03-30 | 2007-09-05 | 吴敏 | Job's tears nut oil self-emusifying preparation and its making method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1785315A (en) * | 2005-11-07 | 2006-06-14 | 苏州长征－欣凯制药有限公司 | Hemp-leaved ritet emulsion used for phlegm dispelling cough suppressing and panting calming, and preparing process thereof |
| CN1903228A (en) * | 2006-07-03 | 2007-01-31 | 李颖 | Prepn. of self-emulsion of glossy ganoderma spore oil, and its prepn. method |
| CN101028461A (en) * | 2007-03-30 | 2007-09-05 | 吴敏 | Job's tears nut oil self-emusifying preparation and its making method |
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