CN106029661B - 吡唑并[1,5‑a]吡啶衍生物及其使用方法 - Google Patents
吡唑并[1,5‑a]吡啶衍生物及其使用方法 Download PDFInfo
- Publication number
- CN106029661B CN106029661B CN201480075903.4A CN201480075903A CN106029661B CN 106029661 B CN106029661 B CN 106029661B CN 201480075903 A CN201480075903 A CN 201480075903A CN 106029661 B CN106029661 B CN 106029661B
- Authority
- CN
- China
- Prior art keywords
- fluoro
- pyrazolo
- pyridin
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)C(c1c(*)[n](*)nc1*)=O Chemical compound CC(C)C(c1c(*)[n](*)nc1*)=O 0.000 description 11
- SYOFUHAPVZZBBQ-QOYRCOFASA-O NC(C=C1Oc(ccc([N+](O)=O)c2)c2F)=CN/C1=C\C=[NH2+] Chemical compound NC(C=C1Oc(ccc([N+](O)=O)c2)c2F)=CN/C1=C\C=[NH2+] SYOFUHAPVZZBBQ-QOYRCOFASA-O 0.000 description 2
- ATGUQKUVXPKDGB-UHFFFAOYSA-N CC1OC1C1(CCC1)C(N)=O Chemical compound CC1OC1C1(CCC1)C(N)=O ATGUQKUVXPKDGB-UHFFFAOYSA-N 0.000 description 1
- WCYHWEQQYGDVHD-QXKUIIBYSA-N CN(CC1)CCN1c(nc1)ccc1C(CC=C1Oc(ccc(NC(C2=CC=CN(c(cc3)ccc3F)C2=O)=O)c2)c2F)=CN/C1=C\C=N Chemical compound CN(CC1)CCN1c(nc1)ccc1C(CC=C1Oc(ccc(NC(C2=CC=CN(c(cc3)ccc3F)C2=O)=O)c2)c2F)=CN/C1=C\C=N WCYHWEQQYGDVHD-QXKUIIBYSA-N 0.000 description 1
- FECJESLSVHHGFU-MGBGTMOVSA-N C[C@@](C1=CC=CN(C(CC2)=CC=C2F)C1=O)(Nc(cc1)cc(F)c1Oc1cc(Nc2ccccc2)c[n]2c1ccc2)O Chemical compound C[C@@](C1=CC=CN(C(CC2)=CC=C2F)C1=O)(Nc(cc1)cc(F)c1Oc1cc(Nc2ccccc2)c[n]2c1ccc2)O FECJESLSVHHGFU-MGBGTMOVSA-N 0.000 description 1
- FYKKAGXOQUOAEJ-HIJNHCMXSA-N Cc1ccc(CN(C=CC=C2C(Nc(cc3F)ccc3OC3=CC=CN/C3=C\C=N)=O)C2=O)cc1 Chemical compound Cc1ccc(CN(C=CC=C2C(Nc(cc3F)ccc3OC3=CC=CN/C3=C\C=N)=O)C2=O)cc1 FYKKAGXOQUOAEJ-HIJNHCMXSA-N 0.000 description 1
- ZASPZFPTMGXKTQ-UHFFFAOYSA-N Nc1c[n]2nccc2c(Oc(ccc([N+](O)=O)c2)c2F)c1 Chemical compound Nc1c[n]2nccc2c(Oc(ccc([N+](O)=O)c2)c2F)c1 ZASPZFPTMGXKTQ-UHFFFAOYSA-N 0.000 description 1
- QGPCRACKWAOEGL-KSEXSDGBSA-N [N-]=C/C=C(/C(Oc(ccc(NC(C1=CC=CN(c(cc2)ccc2F)C1=O)=O)c1)c1F)=C1)\N=C1N1CCCC1 Chemical compound [N-]=C/C=C(/C(Oc(ccc(NC(C1=CC=CN(c(cc2)ccc2F)C1=O)=O)c1)c1F)=C1)\N=C1N1CCCC1 QGPCRACKWAOEGL-KSEXSDGBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920819P | 2013-12-26 | 2013-12-26 | |
| US61/920,819 | 2013-12-26 | ||
| PCT/US2014/071040 WO2015100117A1 (en) | 2013-12-26 | 2014-12-18 | Pyrazolo[1,5-a]pyridine derivatives and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106029661A CN106029661A (zh) | 2016-10-12 |
| CN106029661B true CN106029661B (zh) | 2017-11-03 |
Family
ID=52293273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480075903.4A Expired - Fee Related CN106029661B (zh) | 2013-12-26 | 2014-12-18 | 吡唑并[1,5‑a]吡啶衍生物及其使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9914731B2 (https=) |
| EP (2) | EP3309160A1 (https=) |
| JP (1) | JP2017500362A (https=) |
| KR (1) | KR20160110390A (https=) |
| CN (1) | CN106029661B (https=) |
| AU (1) | AU2014370186A1 (https=) |
| BR (1) | BR112016015057A2 (https=) |
| CA (1) | CA2934667A1 (https=) |
| CL (1) | CL2016001604A1 (https=) |
| DK (1) | DK3087070T3 (https=) |
| EA (2) | EA201890061A3 (https=) |
| ES (1) | ES2654931T3 (https=) |
| HU (1) | HUE037579T2 (https=) |
| IL (1) | IL246311A0 (https=) |
| MX (1) | MX2016008445A (https=) |
| NO (1) | NO3014707T3 (https=) |
| PH (1) | PH12016501232A1 (https=) |
| PL (1) | PL3087070T3 (https=) |
| PT (1) | PT3087070T (https=) |
| SG (1) | SG11201605207PA (https=) |
| SI (1) | SI3087070T1 (https=) |
| WO (1) | WO2015100117A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018000808A2 (pt) * | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| CN106467541B (zh) * | 2015-08-18 | 2019-04-05 | 暨南大学 | 取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用 |
| CN106543145B (zh) * | 2016-10-28 | 2019-07-19 | 山西医科大学 | c-Met激酶抑剂3-(4-氟苯基)嘧啶酮-5-甲酸酰胺衍生物、制备方法与应用 |
| US10703757B2 (en) | 2016-12-23 | 2020-07-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
| WO2019101178A1 (zh) * | 2017-11-24 | 2019-05-31 | 南京明德新药研发股份有限公司 | 作为c-MET/AXL抑制剂的尿嘧啶类化合物 |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| WO2019143991A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
| AU2019323455B9 (en) * | 2018-08-24 | 2024-10-24 | Transthera Sciences (Nanjing), Inc. | Novel quinoline derivative inhibitor |
| UY38349A (es) * | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| EP3849986B1 (en) | 2018-09-10 | 2022-06-08 | Array Biopharma, Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110467616B (zh) * | 2019-07-01 | 2021-12-21 | 江西科技师范大学 | 含杂芳基取代哒嗪酮结构的三唑并吡嗪类化合物的制备及应用 |
| CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
| EP4029862A4 (en) * | 2019-09-06 | 2023-10-04 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences | Compound having axl and c-met kinase inhibitory activity, preparation thereof and application thereof |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN117720520A (zh) | 2020-03-30 | 2024-03-19 | 和记黄埔医药（上海）有限公司 | 酰胺类化合物及其用途 |
| US20240317692A1 (en) * | 2021-07-13 | 2024-09-26 | Nippon Soda Co., Ltd. | Method for producing uracil compound |
| IT202100022682A1 (it) * | 2021-09-01 | 2023-03-01 | Luigi Frati | Derivati pirimidinici e loro uso nel trattamento di tumori |
| CN116655626B (zh) * | 2023-05-24 | 2025-03-11 | 遵义医科大学 | 一种含咪唑并[l，2-a]吡啶骨架的环丙二酰胺化合物及其制备方法和用途 |
| WO2025034912A2 (en) * | 2023-08-07 | 2025-02-13 | Cogent Biosciences, Inc. | Compounds for fgfr inhibition |
| WO2025111224A1 (en) * | 2023-11-21 | 2025-05-30 | Fmc Corporation | Linked bicyclic compounds for controlling and combating invertebrate pests |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101611041A (zh) * | 2006-12-12 | 2009-12-23 | 武田药品工业株式会社 | 稠合杂环化合物 |
| CN102827186A (zh) * | 2011-06-16 | 2012-12-19 | 中国科学院上海药物研究所 | 一类吡啶并五元杂环衍生物及其制备方法和用途 |
| WO2013180949A1 (en) * | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7547782B2 (en) * | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| BRPI0708615A2 (pt) * | 2006-03-07 | 2011-06-07 | Array Biopharma Inc | compostos de pirazol heterobicìclicos e métodos de uso |
| EP1972628A1 (en) | 2007-03-21 | 2008-09-24 | Schwarz Pharma Ag | Indolizines and aza-analog derivatives thereof as CNS active compounds |
| AU2009279936A1 (en) | 2008-08-05 | 2010-02-11 | Banyu Pharmaceutical Co., Ltd. | Therapeutic compounds |
| EP3795573B1 (en) * | 2009-12-31 | 2022-07-06 | Hutchison Medipharma Limited | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| WO2012116217A1 (en) * | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
| WO2013022519A1 (en) * | 2011-08-10 | 2013-02-14 | Merck Patent Gmbh | Pyrido-pyrimidine derivatives |
| AU2012312515A1 (en) * | 2011-09-19 | 2014-03-13 | Genentech, Inc. | Combination treatments comprising c-met antagonists and B-raf antagonists |
| EP2780338B1 (en) * | 2011-11-14 | 2016-11-09 | Ignyta, Inc. | Uracil derivatives as axl and c-met kinase inhibitors |
-
2014
- 2014-12-18 KR KR1020167019605A patent/KR20160110390A/ko not_active Withdrawn
- 2014-12-18 BR BR112016015057A patent/BR112016015057A2/pt not_active IP Right Cessation
- 2014-12-18 JP JP2016542956A patent/JP2017500362A/ja active Pending
- 2014-12-18 EP EP17196014.9A patent/EP3309160A1/en not_active Withdrawn
- 2014-12-18 EA EA201890061A patent/EA201890061A3/ru unknown
- 2014-12-18 PL PL14824711T patent/PL3087070T3/pl unknown
- 2014-12-18 US US15/108,400 patent/US9914731B2/en not_active Expired - Fee Related
- 2014-12-18 MX MX2016008445A patent/MX2016008445A/es unknown
- 2014-12-18 HU HUE14824711A patent/HUE037579T2/hu unknown
- 2014-12-18 PT PT148247117T patent/PT3087070T/pt unknown
- 2014-12-18 EP EP14824711.7A patent/EP3087070B1/en not_active Not-in-force
- 2014-12-18 AU AU2014370186A patent/AU2014370186A1/en not_active Abandoned
- 2014-12-18 SI SI201430533T patent/SI3087070T1/en unknown
- 2014-12-18 ES ES14824711.7T patent/ES2654931T3/es active Active
- 2014-12-18 CA CA2934667A patent/CA2934667A1/en not_active Abandoned
- 2014-12-18 CN CN201480075903.4A patent/CN106029661B/zh not_active Expired - Fee Related
- 2014-12-18 DK DK14824711.7T patent/DK3087070T3/en active
- 2014-12-18 EA EA201691164A patent/EA029757B1/ru not_active IP Right Cessation
- 2014-12-18 SG SG11201605207PA patent/SG11201605207PA/en unknown
- 2014-12-18 WO PCT/US2014/071040 patent/WO2015100117A1/en not_active Ceased
-
2015
- 2015-06-23 NO NO15745380A patent/NO3014707T3/no unknown
-
2016
- 2016-06-19 IL IL246311A patent/IL246311A0/en unknown
- 2016-06-21 CL CL2016001604A patent/CL2016001604A1/es unknown
- 2016-06-22 PH PH12016501232A patent/PH12016501232A1/en unknown
-
2018
- 2018-01-24 US US15/879,175 patent/US20180148447A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101611041A (zh) * | 2006-12-12 | 2009-12-23 | 武田药品工业株式会社 | 稠合杂环化合物 |
| CN102827186A (zh) * | 2011-06-16 | 2012-12-19 | 中国科学院上海药物研究所 | 一类吡啶并五元杂环衍生物及其制备方法和用途 |
| WO2013180949A1 (en) * | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| HUE037579T2 (hu) | 2018-09-28 |
| EA201691164A1 (ru) | 2016-12-30 |
| PL3087070T3 (pl) | 2018-03-30 |
| KR20160110390A (ko) | 2016-09-21 |
| AU2014370186A1 (en) | 2016-07-14 |
| DK3087070T3 (en) | 2017-12-04 |
| JP2017500362A (ja) | 2017-01-05 |
| SG11201605207PA (en) | 2016-07-28 |
| BR112016015057A2 (pt) | 2017-08-08 |
| US20180148447A1 (en) | 2018-05-31 |
| SI3087070T1 (en) | 2018-01-31 |
| EA201890061A2 (ru) | 2018-05-31 |
| US9914731B2 (en) | 2018-03-13 |
| EA201890061A3 (ru) | 2018-09-28 |
| CA2934667A1 (en) | 2015-07-02 |
| ES2654931T3 (es) | 2018-02-15 |
| MX2016008445A (es) | 2016-10-28 |
| AU2014370186A2 (en) | 2016-07-21 |
| PH12016501232A1 (en) | 2016-08-15 |
| EP3309160A1 (en) | 2018-04-18 |
| US20160318929A1 (en) | 2016-11-03 |
| NO3014707T3 (https=) | 2018-01-06 |
| WO2015100117A1 (en) | 2015-07-02 |
| CN106029661A (zh) | 2016-10-12 |
| EP3087070B1 (en) | 2017-11-08 |
| PT3087070T (pt) | 2018-01-30 |
| EA029757B1 (ru) | 2018-05-31 |
| IL246311A0 (en) | 2016-08-02 |
| CL2016001604A1 (es) | 2017-05-26 |
| EP3087070A1 (en) | 2016-11-02 |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171103 Termination date: 20181218 |