CN106029661B - 吡唑并[1,5‑a]吡啶衍生物及其使用方法 - Google Patents

吡唑并[1,5‑a]吡啶衍生物及其使用方法 Download PDF

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Publication number
CN106029661B
CN106029661B CN201480075903.4A CN201480075903A CN106029661B CN 106029661 B CN106029661 B CN 106029661B CN 201480075903 A CN201480075903 A CN 201480075903A CN 106029661 B CN106029661 B CN 106029661B
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China
Prior art keywords
fluoro
pyrazolo
pyridin
phenyl
compound
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Expired - Fee Related
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CN201480075903.4A
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English (en)
Chinese (zh)
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CN106029661A (zh
Inventor
罗伯特·L·赫德金斯
艾利森·L·祖利
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Ignyta Inc
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Ignyta Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201480075903.4A 2013-12-26 2014-12-18 吡唑并[1,5‑a]吡啶衍生物及其使用方法 Expired - Fee Related CN106029661B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361920819P 2013-12-26 2013-12-26
US61/920,819 2013-12-26
PCT/US2014/071040 WO2015100117A1 (en) 2013-12-26 2014-12-18 Pyrazolo[1,5-a]pyridine derivatives and methods of their use

Publications (2)

Publication Number Publication Date
CN106029661A CN106029661A (zh) 2016-10-12
CN106029661B true CN106029661B (zh) 2017-11-03

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CN201480075903.4A Expired - Fee Related CN106029661B (zh) 2013-12-26 2014-12-18 吡唑并[1,5‑a]吡啶衍生物及其使用方法

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Country Link
US (2) US9914731B2 (https=)
EP (2) EP3087070B1 (https=)
JP (1) JP2017500362A (https=)
KR (1) KR20160110390A (https=)
CN (1) CN106029661B (https=)
AU (1) AU2014370186A1 (https=)
BR (1) BR112016015057A2 (https=)
CA (1) CA2934667A1 (https=)
CL (1) CL2016001604A1 (https=)
DK (1) DK3087070T3 (https=)
EA (2) EA029757B1 (https=)
ES (1) ES2654931T3 (https=)
HU (1) HUE037579T2 (https=)
IL (1) IL246311A0 (https=)
MX (1) MX2016008445A (https=)
NO (1) NO3014707T3 (https=)
PH (1) PH12016501232A1 (https=)
PL (1) PL3087070T3 (https=)
PT (1) PT3087070T (https=)
SG (1) SG11201605207PA (https=)
SI (1) SI3087070T1 (https=)
WO (1) WO2015100117A1 (https=)

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CN106543145B (zh) * 2016-10-28 2019-07-19 山西医科大学 c-Met激酶抑剂3-(4-氟苯基)嘧啶酮-5-甲酸酰胺衍生物、制备方法与应用
EP3558991A2 (en) * 2016-12-23 2019-10-30 Plexxikon Inc. Compounds and methods for cdk8 modulation and indications therefor
WO2018136661A1 (en) 2017-01-18 2018-07-26 Andrews Steven W SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
US11623923B2 (en) * 2017-11-24 2023-04-11 Medshine Discovery, Inc. Uracil compound as c-MET/AXL inhibitor
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
JP7060694B2 (ja) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
EP3740490A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
ES2985569T3 (es) * 2018-08-24 2024-11-06 Transthera Sciences Nanjing Inc Nuevo inhibidor de derivado de quinolina
UY38349A (es) * 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
CN112996794A (zh) 2018-09-10 2021-06-18 阿雷生物药品公司 作为ret激酶抑制剂的稠合杂环化合物
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN110467616B (zh) * 2019-07-01 2021-12-21 江西科技师范大学 含杂芳基取代哒嗪酮结构的三唑并吡嗪类化合物的制备及应用
CN110330479A (zh) * 2019-07-19 2019-10-15 南京华威医药科技集团有限公司 一种用作axl抑制剂的抗肿瘤化合物及其用途
JP7542613B2 (ja) * 2019-09-06 2024-08-30 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ Ａｘｌとｃ－Ｍｅｔキナーゼ阻害活性を有する化合物およびその製造と使用
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
BR112022019517A2 (pt) 2020-03-30 2022-12-06 Hutchison Medipharma Ltd Compostos de amida e usos dos mesmos
JP7802077B2 (ja) * 2021-07-13 2026-01-19 日本曹達株式会社 ウラシル化合物の製造方法
IT202100022682A1 (it) * 2021-09-01 2023-03-01 Luigi Frati Derivati pirimidinici e loro uso nel trattamento di tumori
CN116655626B (zh) * 2023-05-24 2025-03-11 遵义医科大学 一种含咪唑并[l，2-a]吡啶骨架的环丙二酰胺化合物及其制备方法和用途
AU2024319770A1 (en) 2023-08-07 2026-02-19 Cogent Biosciences, Inc. Compounds for fgfr inhibition
WO2025111224A1 (en) * 2023-11-21 2025-05-30 Fmc Corporation Linked bicyclic compounds for controlling and combating invertebrate pests

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CN101611041A (zh) * 2006-12-12 2009-12-23 武田药品工业株式会社 稠合杂环化合物
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途
WO2013180949A1 (en) * 2012-05-27 2013-12-05 Ning Xi Substituted quinoline compounds and methods of use

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PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7547782B2 (en) * 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
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EP1972628A1 (en) 2007-03-21 2008-09-24 Schwarz Pharma Ag Indolizines and aza-analog derivatives thereof as CNS active compounds
JP2011530511A (ja) 2008-08-05 2011-12-22 メルク・シャープ・エンド・ドーム・コーポレイション 治療用化合物
EA030141B1 (ru) * 2009-12-31 2018-06-29 Хатчисон Медифарма Лимитед Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения
MA34969B1 (fr) * 2011-02-25 2014-03-01 Irm Llc Composes et compositions en tant qu inibiteurs de trk
WO2013022519A1 (en) * 2011-08-10 2013-02-14 Merck Patent Gmbh Pyrido-pyrimidine derivatives
SG11201400724SA (en) * 2011-09-19 2014-04-28 Genentech Inc Combination treatments comprising c-met antagonists and b-raf antagonists
SG11201402004YA (en) * 2011-11-14 2014-05-29 Cephalon Inc Uracil derivatives as axl and c-met kinase inhibitors

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CN101611041A (zh) * 2006-12-12 2009-12-23 武田药品工业株式会社 稠合杂环化合物
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途
WO2013180949A1 (en) * 2012-05-27 2013-12-05 Ning Xi Substituted quinoline compounds and methods of use

Also Published As

Publication number Publication date
US9914731B2 (en) 2018-03-13
AU2014370186A1 (en) 2016-07-14
US20160318929A1 (en) 2016-11-03
PL3087070T3 (pl) 2018-03-30
SG11201605207PA (en) 2016-07-28
WO2015100117A1 (en) 2015-07-02
ES2654931T3 (es) 2018-02-15
EP3087070B1 (en) 2017-11-08
CA2934667A1 (en) 2015-07-02
CL2016001604A1 (es) 2017-05-26
IL246311A0 (en) 2016-08-02
SI3087070T1 (en) 2018-01-31
KR20160110390A (ko) 2016-09-21
PH12016501232A1 (en) 2016-08-15
BR112016015057A2 (pt) 2017-08-08
EP3309160A1 (en) 2018-04-18
DK3087070T3 (en) 2017-12-04
MX2016008445A (es) 2016-10-28
HUE037579T2 (hu) 2018-09-28
EA201890061A2 (ru) 2018-05-31
EP3087070A1 (en) 2016-11-02
JP2017500362A (ja) 2017-01-05
EA029757B1 (ru) 2018-05-31
EA201691164A1 (ru) 2016-12-30
NO3014707T3 (https=) 2018-01-06
AU2014370186A2 (en) 2016-07-21
EA201890061A3 (ru) 2018-09-28
CN106029661A (zh) 2016-10-12
PT3087070T (pt) 2018-01-30
US20180148447A1 (en) 2018-05-31

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Termination date: 20181218