CN106029060A - 哌啶和哌啶衍生物及其在治疗病毒感染和癌症中的用途 - Google Patents
哌啶和哌啶衍生物及其在治疗病毒感染和癌症中的用途 Download PDFInfo
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- CN106029060A CN106029060A CN201480074026.9A CN201480074026A CN106029060A CN 106029060 A CN106029060 A CN 106029060A CN 201480074026 A CN201480074026 A CN 201480074026A CN 106029060 A CN106029060 A CN 106029060A
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- 0 C*(CC1)CC*1C(c1ccccc1)c(cc1)ccc1N Chemical compound C*(CC1)CC*1C(c1ccccc1)c(cc1)ccc1N 0.000 description 3
- IOMRUVGLZCUFRT-UHFFFAOYSA-O COc1cc(OC)c(C[NH+](CC2)CCC2N(CCc2ccccc2)Cc2ccccc2)cc1 Chemical compound COc1cc(OC)c(C[NH+](CC2)CCC2N(CCc2ccccc2)Cc2ccccc2)cc1 IOMRUVGLZCUFRT-UHFFFAOYSA-O 0.000 description 1
- UZKBSZSTDQSMDR-UHFFFAOYSA-N Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1 Chemical compound Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1 UZKBSZSTDQSMDR-UHFFFAOYSA-N 0.000 description 1
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
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- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361909414P | 2013-11-27 | 2013-11-27 | |
| US61/909,414 | 2013-11-27 | ||
| PCT/US2014/066680 WO2015080949A1 (en) | 2013-11-27 | 2014-11-20 | Piperidine and piperazine derivatives and their use in treating viral infections and cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106029060A true CN106029060A (zh) | 2016-10-12 |
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| CN201480074026.9A Pending CN106029060A (zh) | 2013-11-27 | 2014-11-20 | 哌啶和哌啶衍生物及其在治疗病毒感染和癌症中的用途 |
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| US (1) | US20170001988A1 (https=) |
| EP (1) | EP3074001A1 (https=) |
| JP (1) | JP2016538306A (https=) |
| KR (1) | KR20160079846A (https=) |
| CN (1) | CN106029060A (https=) |
| AU (1) | AU2014354957A1 (https=) |
| CA (1) | CA2931804A1 (https=) |
| SG (1) | SG11201604301VA (https=) |
| TW (1) | TW201605813A (https=) |
| WO (1) | WO2015080949A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106727574A (zh) * | 2016-12-28 | 2017-05-31 | 中国科学院武汉病毒研究所 | 马尼地平在制备治疗黄病毒科病毒感染药物中的应用 |
| CN113549092A (zh) * | 2020-04-23 | 2021-10-26 | 山东轩竹医药科技有限公司 | 三并环类激酶抑制剂 |
| CN116023395A (zh) * | 2021-10-25 | 2023-04-28 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201503750YA (en) * | 2012-11-16 | 2015-06-29 | Univ Cardiff | Process for preparing nucleoside prodrugs |
| US12187687B2 (en) | 2017-06-26 | 2025-01-07 | University Of Virginia Patent Foundation | Compositions and uses thereof |
| AU2018354418B2 (en) * | 2017-10-27 | 2025-09-11 | Immunebridge Inc. | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene |
| US20250074907A1 (en) * | 2021-12-22 | 2025-03-06 | The Texas A&M University System | Inhibitors of sars-cov-2 |
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| DK154078C (da) * | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
| GB8914040D0 (en) * | 1989-06-19 | 1989-08-09 | Wellcome Found | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
| CA2285264A1 (en) * | 1997-04-25 | 1998-11-05 | Michiyo Gyoten | Condensed pyridazine derivatives, their production and use |
| ES2278729T3 (es) * | 2000-03-06 | 2007-08-16 | Acadia Pharmaceuticals Inc. | Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina. |
| US6977301B1 (en) * | 2001-05-29 | 2005-12-20 | Ucb, S.A. | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| TW200831105A (en) * | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| KR101561707B1 (ko) * | 2007-03-12 | 2015-10-19 | 넥타르 테라퓨틱스 | 올리고머―항히스타민제 컨주게이트 |
| WO2010046908A2 (en) * | 2008-09-17 | 2010-04-29 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
| WO2010101649A2 (en) * | 2009-03-05 | 2010-09-10 | Pablo Gastaminza | Sigma 1 receptor inhibition as a novel therapeutical approach against hepatitis c virus infection |
| EP2714081A4 (en) * | 2011-05-27 | 2015-09-09 | Cytocure Llc | METHODS, COMPOSITIONS AND KIT FOR CREAM TREATMENT |
| AU2014233757B2 (en) * | 2013-03-18 | 2017-12-21 | Genoscience Pharma | Quinolines derivatives as novel anticancer agents |
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- 2014-11-20 EP EP14809235.6A patent/EP3074001A1/en not_active Withdrawn
- 2014-11-20 SG SG11201604301VA patent/SG11201604301VA/en unknown
- 2014-11-20 JP JP2016534890A patent/JP2016538306A/ja not_active Abandoned
- 2014-11-20 AU AU2014354957A patent/AU2014354957A1/en not_active Abandoned
- 2014-11-20 WO PCT/US2014/066680 patent/WO2015080949A1/en not_active Ceased
- 2014-11-20 CN CN201480074026.9A patent/CN106029060A/zh active Pending
- 2014-11-20 US US15/039,781 patent/US20170001988A1/en not_active Abandoned
- 2014-11-20 CA CA2931804A patent/CA2931804A1/en not_active Abandoned
- 2014-11-20 KR KR1020167014314A patent/KR20160079846A/ko not_active Withdrawn
- 2014-11-26 TW TW103141004A patent/TW201605813A/zh unknown
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| DEREK A. PFLUM,ET AL.: "A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 * |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727574A (zh) * | 2016-12-28 | 2017-05-31 | 中国科学院武汉病毒研究所 | 马尼地平在制备治疗黄病毒科病毒感染药物中的应用 |
| CN106727574B (zh) * | 2016-12-28 | 2019-05-03 | 中国科学院武汉病毒研究所 | 马尼地平在制备治疗黄病毒科病毒感染药物中的应用 |
| CN113549092A (zh) * | 2020-04-23 | 2021-10-26 | 山东轩竹医药科技有限公司 | 三并环类激酶抑制剂 |
| CN116023395A (zh) * | 2021-10-25 | 2023-04-28 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
| CN116023395B (zh) * | 2021-10-25 | 2025-07-15 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201605813A (zh) | 2016-02-16 |
| JP2016538306A (ja) | 2016-12-08 |
| WO2015080949A1 (en) | 2015-06-04 |
| AU2014354957A1 (en) | 2016-06-16 |
| CA2931804A1 (en) | 2015-06-04 |
| SG11201604301VA (en) | 2016-07-28 |
| EP3074001A1 (en) | 2016-10-05 |
| KR20160079846A (ko) | 2016-07-06 |
| US20170001988A1 (en) | 2017-01-05 |
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