CN106029060A - 哌啶和哌啶衍生物及其在治疗病毒感染和癌症中的用途 - Google Patents

哌啶和哌啶衍生物及其在治疗病毒感染和癌症中的用途 Download PDF

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CN106029060A
CN106029060A CN201480074026.9A CN201480074026A CN106029060A CN 106029060 A CN106029060 A CN 106029060A CN 201480074026 A CN201480074026 A CN 201480074026A CN 106029060 A CN106029060 A CN 106029060A
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mixture
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连·展扬·杰克
马克·费勒
何山杉
胡新
胡宗义
胡安·何塞·马鲁甘
诺埃尔·特伦斯·索撒尔
肖静波
郑伟
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US Department of Health and Human Services
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CN201480074026.9A 2013-11-27 2014-11-20 哌啶和哌啶衍生物及其在治疗病毒感染和癌症中的用途 Pending CN106029060A (zh)

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US201361909414P 2013-11-27 2013-11-27
US61/909,414 2013-11-27
PCT/US2014/066680 WO2015080949A1 (en) 2013-11-27 2014-11-20 Piperidine and piperazine derivatives and their use in treating viral infections and cancer

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106727574A (zh) * 2016-12-28 2017-05-31 中国科学院武汉病毒研究所 马尼地平在制备治疗黄病毒科病毒感染药物中的应用
CN113549092A (zh) * 2020-04-23 2021-10-26 山东轩竹医药科技有限公司 三并环类激酶抑制剂
CN116023395A (zh) * 2021-10-25 2023-04-28 山东轩竹医药科技有限公司 三环类激酶抑制剂的晶型

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201503750YA (en) * 2012-11-16 2015-06-29 Univ Cardiff Process for preparing nucleoside prodrugs
US12187687B2 (en) 2017-06-26 2025-01-07 University Of Virginia Patent Foundation Compositions and uses thereof
AU2018354418B2 (en) * 2017-10-27 2025-09-11 Immunebridge Inc. Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene
US20250074907A1 (en) * 2021-12-22 2025-03-06 The Texas A&M University System Inhibitors of sars-cov-2

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154078C (da) * 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
GB8914040D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
CA2285264A1 (en) * 1997-04-25 1998-11-05 Michiyo Gyoten Condensed pyridazine derivatives, their production and use
ES2278729T3 (es) * 2000-03-06 2007-08-16 Acadia Pharmaceuticals Inc. Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina.
US6977301B1 (en) * 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
KR101561707B1 (ko) * 2007-03-12 2015-10-19 넥타르 테라퓨틱스 올리고머―항히스타민제 컨주게이트
WO2010046908A2 (en) * 2008-09-17 2010-04-29 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010101649A2 (en) * 2009-03-05 2010-09-10 Pablo Gastaminza Sigma 1 receptor inhibition as a novel therapeutical approach against hepatitis c virus infection
EP2714081A4 (en) * 2011-05-27 2015-09-09 Cytocure Llc METHODS, COMPOSITIONS AND KIT FOR CREAM TREATMENT
AU2014233757B2 (en) * 2013-03-18 2017-12-21 Genoscience Pharma Quinolines derivatives as novel anticancer agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DEREK A. PFLUM,ET AL.: "A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 *
HEA-YOUNG PARK CHOO,ET AL.: "Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
J. N. NARENDRA SHARATH CHANDRA,ET AL.: "Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
L. MISHACK MONENE,ET AL.: "Percutaneous absorption of cyclizine and its alkyl analogues", 《EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES》 *
YU- HSIANG HO,ET AL.: "Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine,and meclizine by capillary electrophoresis", 《ANAL BIOANAL CHEM》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106727574A (zh) * 2016-12-28 2017-05-31 中国科学院武汉病毒研究所 马尼地平在制备治疗黄病毒科病毒感染药物中的应用
CN106727574B (zh) * 2016-12-28 2019-05-03 中国科学院武汉病毒研究所 马尼地平在制备治疗黄病毒科病毒感染药物中的应用
CN113549092A (zh) * 2020-04-23 2021-10-26 山东轩竹医药科技有限公司 三并环类激酶抑制剂
CN116023395A (zh) * 2021-10-25 2023-04-28 山东轩竹医药科技有限公司 三环类激酶抑制剂的晶型
CN116023395B (zh) * 2021-10-25 2025-07-15 山东轩竹医药科技有限公司 三环类激酶抑制剂的晶型

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CA2931804A1 (en) 2015-06-04
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