CN105999363A - Method for preparing calcium alginate/silver nanoparticle fiber - Google Patents

Method for preparing calcium alginate/silver nanoparticle fiber Download PDF

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CN105999363A
CN105999363A CN201610484355.1A CN201610484355A CN105999363A CN 105999363 A CN105999363 A CN 105999363A CN 201610484355 A CN201610484355 A CN 201610484355A CN 105999363 A CN105999363 A CN 105999363A
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fiber
silver
nanocrystalline
mass concentration
solution
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郭迎庆
王龙
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D01F1/103—Agents inhibiting growth of microorganisms
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
    • D01F9/04—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of alginates
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4209—Inorganic fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Chemical & Material Sciences (AREA)
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  • Manufacturing & Machinery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention relates to a method for preparing calcium alginate/silver nanoparticle fiber and belongs to the technical field of medical antibacterial dressing. Silver nanoparticles prepared through a common method easily aggregate, and accordingly dispersity of the particles is not good. Besides, most nano silver trapping agents are non-biodegradable polymer or potential toxic chemical substances. According to the method for preparing the calcium alginate/silver nanoparticle fiber, degreased cotton serves as the raw material and is hydrolyzed with concentrated sulfuric acid, nanocrystalline fiber is obtained after centrifugal separation, the nanocrystalline fiber serves as a carrier, dopamine is coated on the surface of the nanocrystalline fiber in a polymerization mode, and by means of the reduction and chelation function of polydopamine on silver ions, silver is evenly loaded on the surface of nanocrystalline cellulose through the silver nitrate in-situ reduction method.

Description

A kind of filametntary preparation method of calcium alginate/Nano silver grain
Technical field
The present invention relates to a kind of filametntary preparation method of calcium alginate/Nano silver grain, belong to medical antibacterial dressing technical field.
Background technology
Medical dressing is a class medical protection material, before skin function is rebuild and recovered, wound surface can be carried out provisional covering; temporarily play barrier action; to reduce body fluid loss, protection human body is from alien bacteria and the infringement of harmful substance, for the microenvironment that the healing offer of wound surface is strong.Anti-microbial type dressing is to add some antimicrobial components on the basis of common dressing, and such as silver, iodine, oneself is fixed etc. so that it is have certain local antibacterial function while protection wound surface.Clinical research shows, compared with traditional gauze dressing, antiseptic dressing, in addition to the function with traditional dressing, also can shorten the time of wound healing, reduces infection rate, alleviates the misery of patient, and reduce medical expense.
Current widely used antiseptic dressing includes silver dressings, alginate medical dressing chitin and carapace amine medical dressing and the mixing antibacterial medical dressing of this different materials.Wherein alginate dressing quality is soft, its not only compliance good, and easily fold, paste, alginic acid fibre adds silver compound and can improve the anti-microbial property of calcium alginate medical dressing further, stop the breeding of antibacterial and issuable cross infection in lesion.It is different to the acquisition situation of silver that current silver dressings is broadly divided into colloid type, ion-type and nanocrystalline build, the release performance of the silver ion of different types of dressing and wound tissue, and the replacement frequency thus causing dressing is the most different.Wherein, nanometer silver type rate of release is the slowest, within every 7 days, changes 1 time；Colloid type silver dressings needs change for every 3 days 1 time；Silver ion type dressing absorbs the fastest, needs every day and changes 1 time.So nanometer silver type dressing has a extensive future, although the method preparing silver nano-grain has a lot, such as photoreduction met hod, silver mirror reaction.But the silver nano-grain prepared by common method is easy to assemble, cause particle dispersion bad.Therefore, in order to stop the gathering of nano-particle, obtain the silver nano-grain of high-specific surface area, preparation process typically can add trapping agent to stablize silver nano-grain.Although trapping agent kind is a lot, but major part is all non-biodegradable polymers or potential toxic chemical substance.
Summary of the invention
The technical problem to be solved: the silver nano-grain prepared for common method is easy to assemble, cause particle dispersion bad, and commonly using nanometer silver trapping agent major part is all non-biodegradable polymers or the problem of potential toxic chemical substance, the invention provides a kind of filametntary preparation method of calcium alginate/Nano silver grain, the present invention uses absorbent cotton as raw material, concentrated sulphuric acid is utilized to hydrolyze, nanocrystalline fiber is obtained after being performing centrifugal separation on, with nanocrystalline fiber as carrier, dopamine polymerization is coated on nanocrystalline fiber surface, by poly-dopamine to the reduction of silver ion and chelation, utilize the method for in-situ reducing silver nitrate by silver uniform load on the surface of nanocrystalline cellulose.Dispersibility good to significant for poly-dopamine absorbability and nanocrystalline cellulose is combined, makes to be supported on the silver nano-grain not only good dispersion of cellulose surface, but also there is good stability.
For solving above-mentioned technical problem, the technical solution used in the present invention is:
(1) 5.0 ~ 6.0g absorbent cotton is weighed, being soaked in 100 ~ 120mL mass concentration is in 64% sulphuric acid, agitating heating 45 ~ 50min at 45 ~ 50 DEG C, adds 0.8 ~ 1.0L deionized water, proceed to centrifuge, with 5000 ~ 5500r/min, centrifugal 10 ~ 12min, collects lower floor's turbid solution, repeat above-mentioned centrifugally operated 3 ~ 5 times, merge turbid solution, be 30% sodium hydroxide regulation pH to 7 ~ 8 by mass concentration, obtain nanocrystalline fiber turbid solution；
(2) above-mentioned nanocrystalline fiber turbid solution is taken, it is separately added into 3.0 ~ 5.0g dopamine hydrochloride, 1.8 ~ 2.0g sodium peroxide, maintain the temperature at 70 ~ 75 DEG C, after heating 90 ~ 96h, add 2.0 ~ 3.0g glycerol, shear dispersion with high-shearing dispersion emulsifying machine with 10000r/min, obtain the nanocrystalline fiber suspension that surface is modified；
(3) 12 ~ 15g sodium alginate is weighed, add in 100 ~ 200mL deionized water, after being uniformly mixed, add in the nanocrystalline fiber suspension that the above-mentioned surface of 200 ~ 300mL is modified, stirring 20 ~ 30min, being separately added into 100 ~ 200mL mass concentration is 20% silver nitrate solution, 20～30mL mass concentrations are 10% formalin, and with mass concentration be 17% ammonia regulation pH of mixed be 8.0～9.0, in the case of shading, stirring reaction 8 ~ 12min, mixed liquor is proceeded to high-shearing dispersion emulsifying machine again and shears dispersion with 10000r/min, after liquid to be mixed does not has bubble, obtain sodium alginate/Nano silver grain fiber spinning solution；
(4) above-mentioned sodium alginate/Nano silver grain fiber spinning solution is extruded by spinneret orifice, being immersed in mass concentration is 20 ~ 30min in 2% calcium chloride solution, takes out cellosilk, is washed with deionized 3 ~ 5 times, insert 60 ~ 65 DEG C of oven drying 1 ~ 2h, obtain calcium alginate/Nano silver grain cellosilk.
The application process of the present invention is: the calcium alginate present invention prepared/Nano silver grain cellosilk carding makes non-weaving cloth, it is coated on chronic wounds, within 10 ~ 12 days, changing once, speed of wound healing faster than common dressing 40 ~ 45%, wound healing rate improves 150 ~ 180%.
The method have the benefit that:
(1) calcium alginate prepared by the present invention/Nano silver grain cellosilk has the ability preferably absorbing wound exudate, has certain breathability, can maintain the moist environment of wound surface；
(2) calcium alginate prepared by the present invention/Nano silver grain cellosilk is nontoxic, to human body without harmful reaction and stimulation, antibacterial can be stoped to enter wound surface in case major structure becomes superinfection, avoid Wound contact particle and poisonous pollutant, hemostasis, pain relieving etc. is had to act on, wound healing can be accelerated, reduce disease trace；
(3) calcium alginate prepared by the present invention/Nano silver grain cellosilk storage stability is good, has degradability, and garbage does not produce pollution to environment, easy to use, easily removes and changes.
Detailed description of the invention
Weigh 5.0 ~ 6.0g absorbent cotton, being soaked in 100 ~ 120mL mass concentration is in 64% sulphuric acid, agitating heating 45 ~ 50min at 45 ~ 50 DEG C, adds 0.8 ~ 1.0L deionized water, proceed to centrifuge, with 5000 ~ 5500r/min, centrifugal 10 ~ 12min, collects lower floor's turbid solution, repeat above-mentioned centrifugally operated 3 ~ 5 times, merge turbid solution, be 30% sodium hydroxide regulation pH to 7 ~ 8 by mass concentration, obtain nanocrystalline fiber turbid solution；Take above-mentioned nanocrystalline fiber turbid solution, it is separately added into 3.0 ~ 5.0g dopamine hydrochloride, 1.8 ~ 2.0g sodium peroxide, maintain the temperature at 70 ~ 75 DEG C, after heating 90 ~ 96h, add 2.0 ~ 3.0g glycerol, shear dispersion with high-shearing dispersion emulsifying machine with 10000r/min, obtain the nanocrystalline fiber suspension that surface is modified；Weigh 12 ~ 15g sodium alginate, add in 100 ~ 200mL deionized water, after being uniformly mixed, add in the nanocrystalline fiber suspension that the above-mentioned surface of 200 ~ 300mL is modified, stirring 20 ~ 30min, being separately added into 100 ~ 200mL mass concentration is 20% silver nitrate solution, 20～30mL mass concentrations are 10% formalin, and with mass concentration be 17% ammonia regulation pH of mixed be 8.0～9.0, in the case of shading, stirring reaction 8 ~ 12min, mixed liquor is proceeded to high-shearing dispersion emulsifying machine again and shears dispersion with 10000r/min, after liquid to be mixed does not has bubble, obtain sodium alginate/Nano silver grain fiber spinning solution；Above-mentioned sodium alginate/Nano silver grain fiber spinning solution is extruded by spinneret orifice, being immersed in mass concentration is 20 ~ 30min in 2% calcium chloride solution, takes out cellosilk, is washed with deionized 3 ~ 5 times, insert 60 ~ 65 DEG C of oven drying 1 ~ 2h, obtain calcium alginate/Nano silver grain cellosilk.
Example 1
Weigh 5.0g absorbent cotton, being soaked in 100mL mass concentration is in 64% sulphuric acid, agitating heating 45min at 45 DEG C, adds 0.8L deionized water, proceed to centrifuge, with 5000r/min, centrifugal 10min, collects lower floor's turbid solution, repeat above-mentioned centrifugally operated 3 times, merge turbid solution, be 30% sodium hydroxide regulation pH to 7 by mass concentration, obtain nanocrystalline fiber turbid solution；Take above-mentioned nanocrystalline fiber turbid solution, be separately added into 3.0g dopamine hydrochloride, 1.8g sodium peroxide, maintain the temperature at 70 DEG C, after heating 90h, add 2.0g glycerol, shear dispersion with high-shearing dispersion emulsifying machine with 10000r/min, obtain the nanocrystalline fiber suspension that surface is modified；Weigh 12g sodium alginate, add in 100mL deionized water, after being uniformly mixed, add in the nanocrystalline fiber suspension that the above-mentioned surface of 200mL is modified, stirring 20min, being separately added into 100mL mass concentration is 20% silver nitrate solution, 20mL mass concentration is 10% formalin, and with mass concentration be 17% ammonia regulation pH of mixed be 8.0, in the case of shading, stirring reaction 8min, then mixed liquor is proceeded to high-shearing dispersion emulsifying machine with 10000r/min shearing dispersion, after liquid to be mixed does not has bubble, obtain sodium alginate/Nano silver grain fiber spinning solution；Above-mentioned sodium alginate/Nano silver grain fiber spinning solution is extruded by spinneret orifice, being immersed in mass concentration is 20min in 2% calcium chloride solution, takes out cellosilk, is washed with deionized 3 times, insert 60 DEG C of oven drying 1h, obtain calcium alginate/Nano silver grain cellosilk.
The application process of the present invention is: the calcium alginate present invention prepared/Nano silver grain cellosilk carding makes non-weaving cloth, is coated on chronic wounds, within 10 days, changes once, speed of wound healing faster than common dressing 40%, and wound healing rate improves 150%.
Example 2
Weigh 5..5g absorbent cotton, being soaked in 110mL mass concentration is in 64% sulphuric acid, agitating heating 48min at 48 DEG C, adds 0.9L deionized water, proceed to centrifuge, with 5200r/min, centrifugal 11min, collects lower floor's turbid solution, repeat above-mentioned centrifugally operated 4 times, merge turbid solution, be 30% sodium hydroxide regulation pH to 7 by mass concentration, obtain nanocrystalline fiber turbid solution；Take above-mentioned nanocrystalline fiber turbid solution, be separately added into 4g dopamine hydrochloride, 1.9g sodium peroxide, maintain the temperature at 72 DEG C, after heating 92h, add 2.5g glycerol, shear dispersion with high-shearing dispersion emulsifying machine with 10000r/min, obtain the nanocrystalline fiber suspension that surface is modified；Weigh 13g sodium alginate, add in 150mL deionized water, after being uniformly mixed, add in the nanocrystalline fiber suspension that the above-mentioned surface of 250mL is modified, stirring 25min, being separately added into 150mL mass concentration is 20% silver nitrate solution, 25mL mass concentration is 10% formalin, and with mass concentration be 17% ammonia regulation pH of mixed be 8.0, in the case of shading, stirring reaction 10min, then mixed liquor is proceeded to high-shearing dispersion emulsifying machine with 10000r/min shearing dispersion, after liquid to be mixed does not has bubble, obtain sodium alginate/Nano silver grain fiber spinning solution；Above-mentioned sodium alginate/Nano silver grain fiber spinning solution is extruded by spinneret orifice, being immersed in mass concentration is 25min in 2% calcium chloride solution, takes out cellosilk, is washed with deionized 4 times, insert 62 DEG C of oven drying 1.5h, obtain calcium alginate/Nano silver grain cellosilk.
The application process of the present invention is: the calcium alginate present invention prepared/Nano silver grain cellosilk carding makes non-weaving cloth, is coated on chronic wounds, within 11 days, changes once, speed of wound healing faster than common dressing 42%, and wound healing rate improves 160%.
Example 3
Weigh 6.0g absorbent cotton, being soaked in 120mL mass concentration is in 64% sulphuric acid, agitating heating 50min at 50 DEG C, adds 1.0L deionized water, proceed to centrifuge, with 5500r/min, centrifugal 12min, collects lower floor's turbid solution, repeat above-mentioned centrifugally operated 5 times, merge turbid solution, be 30% sodium hydroxide regulation pH to 8 by mass concentration, obtain nanocrystalline fiber turbid solution；Take above-mentioned nanocrystalline fiber turbid solution, be separately added into 5.0g dopamine hydrochloride, 2.0g sodium peroxide, maintain the temperature at 75 DEG C, after heating 96h, add 3.0g glycerol, shear dispersion with high-shearing dispersion emulsifying machine with 10000r/min, obtain the nanocrystalline fiber suspension that surface is modified；Weigh 15g sodium alginate, add in 200mL deionized water, after being uniformly mixed, add in the nanocrystalline fiber suspension that the above-mentioned surface of 300mL is modified, stirring 30min, being separately added into 200mL mass concentration is 20% silver nitrate solution, 30mL mass concentration is 10% formalin, and with mass concentration be 17% ammonia regulation pH of mixed be 9.0, in the case of shading, stirring reaction 12min, then mixed liquor is proceeded to high-shearing dispersion emulsifying machine with 10000r/min shearing dispersion, after liquid to be mixed does not has bubble, obtain sodium alginate/Nano silver grain fiber spinning solution；Above-mentioned sodium alginate/Nano silver grain fiber spinning solution is extruded by spinneret orifice, being immersed in mass concentration is 30min in 2% calcium chloride solution, takes out cellosilk, is washed with deionized 5 times, insert 65 DEG C of oven drying 2h, obtain calcium alginate/Nano silver grain cellosilk.
The application process of the present invention is: the calcium alginate present invention prepared/Nano silver grain cellosilk carding makes non-weaving cloth, is coated on chronic wounds, within 12 days, changes once, speed of wound healing faster than common dressing 45%, and wound healing rate improves 180%.

Claims (1)

1. the filametntary preparation method of calcium alginate/Nano silver grain, it is characterised in that concrete preparation process is:
(1) 5.0 ~ 6.0g absorbent cotton is weighed, being soaked in 100 ~ 120mL mass concentration is in 64% sulphuric acid, agitating heating 45 ~ 50min at 45 ~ 50 DEG C, adds 0.8 ~ 1.0L deionized water, proceed to centrifuge, with 5000 ~ 5500r/min, centrifugal 10 ~ 12min, collects lower floor's turbid solution, repeat above-mentioned centrifugally operated 3 ~ 5 times, merge turbid solution, be 30% sodium hydroxide regulation pH to 7 ~ 8 by mass concentration, obtain nanocrystalline fiber turbid solution；
(2) above-mentioned nanocrystalline fiber turbid solution is taken, it is separately added into 3.0 ~ 5.0g dopamine hydrochloride, 1.8 ~ 2.0g sodium peroxide, maintain the temperature at 70 ~ 75 DEG C, after heating 90 ~ 96h, add 2.0 ~ 3.0g glycerol, shear dispersion with high-shearing dispersion emulsifying machine with 10000r/min, obtain the nanocrystalline fiber suspension that surface is modified；
(3) 12 ~ 15g sodium alginate is weighed, add in 100 ~ 200mL deionized water, after being uniformly mixed, add in the nanocrystalline fiber suspension that the above-mentioned surface of 200 ~ 300mL is modified, stirring 20 ~ 30min, being separately added into 100 ~ 200mL mass concentration is 20% silver nitrate solution, 20～30mL mass concentrations are 10% formalin, and with mass concentration be 17% ammonia regulation pH of mixed be 8.0～9.0, in the case of shading, stirring reaction 8 ~ 12min, mixed liquor is proceeded to high-shearing dispersion emulsifying machine again and shears dispersion with 10000r/min, after liquid to be mixed does not has bubble, obtain sodium alginate/Nano silver grain fiber spinning solution；
(4) above-mentioned sodium alginate/Nano silver grain fiber spinning solution is extruded by spinneret orifice, being immersed in mass concentration is 20 ~ 30min in 2% calcium chloride solution, takes out cellosilk, is washed with deionized 3 ~ 5 times, insert 60 ~ 65 DEG C of oven drying 1 ~ 2h, obtain calcium alginate/Nano silver grain cellosilk.
CN201610484355.1A 2016-06-28 2016-06-28 Method for preparing calcium alginate/silver nanoparticle fiber Pending CN105999363A (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
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CN106581734A (en) * 2016-11-22 2017-04-26 孙祎 Preparation method of highly antibacterial alginate dressing
CN106924803A (en) * 2017-05-05 2017-07-07 江南大学 A kind of high-performance medical use liquid adhesive bandage and preparation method thereof
CN106962401A (en) * 2017-05-14 2017-07-21 常州力纯数码科技有限公司 A kind of preparation method of nano silver antimicrobials
CN109260512A (en) * 2018-11-23 2019-01-25 广州新诚生物科技有限公司 A kind of preparation method of antibacterial cement bracket
CN109331184A (en) * 2017-08-01 2019-02-15 复旦大学 A kind of lotus positively charged drug nano crystallization preparation and preparation method thereof
CN109381703A (en) * 2018-11-27 2019-02-26 五邑大学 Calcium alginate nanofiber and preparation method and application carry medicine calcium alginate nanofiber and preparation method
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