CN105999161A - Pharmaceutical composition for treating lung-derived hemoptysis and preparation method thereof - Google Patents
Pharmaceutical composition for treating lung-derived hemoptysis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a pharmaceutical composition for treating lung-derived hemoptysis and a preparation method thereof. The preparation method includes the steps that 3-6 parts of semen coicis, 2-5 parts of semen lepidii, 2-5 parts of radix stephaniae tetrandrae, 6-10 parts of rhizoma cyperi, 1-3 parts of flos Farfarae, 1-3 parts of bulbus lilii, 3-5 parts of dried ginger, 3-5 parts of herba agrimoniae, 3-5 parts of Taiwan beautyberry leaves, 2-5 parts of rhizoma bletillae, 2-5 parts of flowers of broadbeans, 1-3 parts of flowers of shepherdspurse, 1-3 parts of copperleaf herbs, 3-6 parts of cacumen platycladi, 1-3 parts of flos sophorae, 3-6 parts of pollen typhae, 2-5 parts of crinis trachycarpi, 2-5 parts of nodus nelumbinis rhizomatis, 3-5 parts of plant soot, 1-3 parts of ophicalcitum, 2-5 parts of herbs of undulate speedwell, 1-3 parts of radix rehmanniae preparata and 3-6 parts of manyflower solomonseal rhizomes are extracted, concentrated and crushed, and the pharmaceutical composition for treating lung-derived hemoptysis is obtained. The preparation method is simple, processing cost is low, the prepared dosage form is convenient for patients to take, and the pharmaceutical composition can rapidly eliminate hemoptysis symptoms, meanwhile nourishes vitality and improves immunity of the human body.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of medicine group treating pulmonary spitting of blood
Compound and preparation method thereof.
Background technology
Pulmonary spitting of blood refers to that larynx and larynx bring up with the hemorrhage per os of lower respiratory tract or lung tissue
Plant clinical symptoms.Clinically often according to patient's spitting of blood amount number, be classified as spitting blood on a small quantity,
Middle amount spitting of blood and a large amount of spitting of blood.But there is no unified defining standard between 3 both at home and abroad, generally
Think that spitting of blood amount is a small amount of spitting of blood less than 100ml person in 24h;100ml~500ml person are middle amount
Spitting of blood;Being more than 100ml person more than 500ml or 1 spitting of blood amount is a large amount of spitting of bloods.Cause spitting of blood
The cause of disease more, clinic common are respiratory system disease, such as acute/chronic bronchitis, bronchus
Expansion, endobronchial tuberculosis, broncholithiasis, good or pernicious tracheal neoplasm, bronchus
Adenoma, constitutional or pulmonary metastasis, pneumonia, pulmonary tuberculosis, pulmonary abscess, Fungal infection of the lung sense
Dye, parasitic disease of lung, pulmonary sequestration, lung cyst, pneumoconiosis, contusion of lung, pulmonary hypertension,
Pulmonary infarction, pulmonary arteriovenous fistula;Blood circulation diseases, such as pulmonary venous pleonaemia etc..Lung source thought by Chinese medicine
Property spitting of blood belong to liver-fire invading the lung, how by feelings will pent-up, stagnated QI transforming into fire, burn lung yin or pathogenic heat are accumulate
Knot liver and gall, on violate in lung, impairment of purifying function of the lung or lung lattice injured caused;The true card of liver-fire invading the lung,
For liver lung with sick, hepatopathy formerly, upper criminal and lung, form liverzang-fire attacking lung, or lung network of burning,
Spitting of blood such as note, therefore the anxious critical card of many genus.
Doctor trained in Western medicine uses naturopathy cooperation to give for the initial therapy of pulmonary patients with serious hemoptysis
Antibiotic, phentolamine, pituitrin, reptilase drug combination are treated;For repeatedly
Massive hemoptysis is invalid through positive expectant treatment, 24h spitting of blood amount is more than 1500ml or 1 spitting of blood amount
Reach 500ml, have cause suffocate tendency and bleeding part clearly and without operation taboo person, take
Emergency operation stops blooding;Massive hemoptysis as uncontrollable in conventional therapy or because pulmonary insufficiency is unsuitable
Open chest surgery person, uses bronchial arterial embolization;To the massive hemoptysis being not suitable for operation
Patient, uses limitation radiotherapy.
The prescription of Chinese traditional treatment pulmonary spitting of blood is various, and the specific aim of each prescription is different, and
And the decoction of Chinese medicine decoction and taking all is inconvenient for, decocting time and take improper meeting to controlling
Treat and bring the biggest impact, it is therefore desirable to one can either effectively treat pulmonary spitting of blood symptom,
The medicine can conveniently taken again is to solve patient suffering.
Summary of the invention
In order to overcome above-mentioned prior art defect, it is an object of the invention to provide a kind for the treatment of
Pharmaceutical composition of pulmonary spitting of blood and preparation method thereof, from motherland's medical treasure-house, according to
Traditional Chinese medical science prescription theory, skims the cream off milk, and reconfigures so that it is drug-specific is coughed up for pulmonary
Mass formed by blood stasis shape works, and plays effect for the treatment of pulmonary spitting of blood, and uses modern pharmaceutical means
Prepare finished product.
In order to solve above-mentioned technical problem, the present invention takes following technical scheme:
A kind of pharmaceutical composition treating pulmonary spitting of blood, including: Semen Coicis 3~6 parts, Roripa
Li 2~5 parts, Radix Stephaniae Tetrandrae 2~5 parts, Rhizoma Cyperi 6~10 parts, Flos Farfarae 1~3 parts, Bulbus Lilii 1~3
Part, Rhizoma Zingiberis 3~5 parts, Herba Agrimoniae 3~5 parts, Folium Callicarpae Formosanae 3~5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2~5 parts, Semen Viciae fabae
Spend 2~5 parts, Flos Capsellae 1~3 parts, Herba Acalyphae 1~3 parts, Cacumen Platycladi 3~6 parts, Flos Sophorae 1~3
Part, Pollen Typhae 3~6 parts, charred Petiolus Trachycarpi 2~5 parts, Nodus Nelumbinis Rhizomatis 2~5 parts, Pulvis Fumi Carbonisatus 3~5 parts, pistil
Stone 1~3 parts, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 2~5 parts.
Further, described pharmaceutical composition also includes: Radix Rehmanniae 1~3 parts, Rhizoma Polygonati 3~6 parts.
Further, optimum weight part of described pharmaceutical composition consists of: Semen Coicis 3 parts,
Semen Lepidii (Semen Descurainiae) 4 parts, Radix Stephaniae Tetrandrae 5 parts, Rhizoma Cyperi 6 parts, Flos Farfarae 2 parts, Bulbus Lilii 3 parts, Rhizoma Zingiberis 3
Part, Herba Agrimoniae 5 parts, Folium Callicarpae Formosanae 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Flos Viciae fabae 4 parts, Flos Capsellae 2 parts,
Herba Acalyphae 1 part, Cacumen Platycladi 4 parts, 2 parts of Flos Sophorae, Pollen Typhae 4 parts, charred Petiolus Trachycarpi 5 parts, Nodus Nelumbinis Rhizomatis 3
Part, Pulvis Fumi Carbonisatus 3 parts, Ophicalcitum 1 part, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 2 parts, 1 part of Radix Rehmanniae Preparata, Rhizoma Polygonati 4 parts.
Wherein, the primarily serving the purpose of of said herbal medicine composition:
Semen Coicis, slightly sweet flavor, feeble QI is cool, and property edges down and oozes, therefore the diuretic that can dry, with it
Will is wet, thus energy profit joint, except tinea pedis, control flaccidity weak contracture arthralgia chiefly caused by damp pathogen, consumer edema pain, profit is little
Just pyretic stranguria, also kills ascarid.Edging down with it, therefore also control cough saliva pus, profit diaphragm appetizing, with it
Cool in nature, therefore can heat clearing away, only excessive thirst, upper gas.
Semen Lepidii (Semen Descurainiae) hardship fall is pungent to be dissipated, and cold, therefore can break stagnant relieving accumulation of pathogens, determines check and breathes heavily, diuretic
Detumescence;" herbal classic " cures mainly, and all lets out as justice with broken;The only product of diarrhea due to cold pathogen, having of energy tonneau pathogen
Remaining, it is impossible to the deficiency of tonification healthy energy, Gou Feishi heat stagnation stops up, and is scrupled from knowing;" not Lu "
Clothes make us empty for a long time, are originally famous dictums;So lung man phlegm-fire is jammed, and cold fluid-retention fills the air, dyspnea with rapid respiration tachypnea,
Or demonstrate,prove for swelling etc., this also must be relied to wear armor and carry weapons, to become to smash the achievement in plough front yard, cave.
Radix Stephaniae Tetrandrae, acrid in the mouth, hardship, flat, warm, nontoxic.Treat edema, swelling due to wind, go bladder heat,
Typhoid fever, cold and heat pathogen, apoplexy hands muscle spasm of the leg and foot, stopping leak, dissipate carbuncle, dislike and tie, all snail scabies,
Worm skin ulcer, logical space between skin and muscles, profit nine orifices.
Rhizoma Cyperi is regulated the flow of vital energy resolving depression, and scattered seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, solves six kinds of stagnation-syndromes, and the diet that disappears gathers,
Phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, tinea pedis, only trusted subordinate, limbs, head, mesh, tooth, ear are all
Bitterly, ulcer sores, spit blood, hematochezia, the disease such as hematuria.
Bulbus Lilii sweet in the mouth, cold nature.GUIXIN, lung meridian;Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization;For
Deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded;There is yin nourishing
Nourishing the lung to arrest cough effect, for the cough caused by dryness-heat of deficiency of lung-YIN, sputum mixed with blood, chronic cough of deficiency lung, labor
Cough spitting of blood;Having clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency is palpitated with fear, insomnia
Dreaminess etc..
Flos Farfarae, main pneumonopathy, energy using pungent drugs for dispersion and bitter drugs for purgation pent-up, determine check and breathe heavily, special main cough, cough with controlling
Against upper gas, being apt to breathe heavily, sore throat, because kidney is bitter dry and cold physique drink is cold, being attacked by pathogenic dampness in autumn person begin preferably;Or
Burning hot punishment gold, or withering lung lobes with stuffy lung-QI, probably benefit disappears bright injuring;Pathogenic fluid-retention in cold bundle lung gold is breathed heavily and is coughed
The most suitable, though right abnormal smells from the patient is warm, embellish but not dry, then the heresy of warm, strongly fragrant must not catharsis in lung meridian
Person, also can control it.
Rhizoma Zingiberis nature and flavor are pungent, hot, return spleen, stomach, kidney, the heart, lung meridian, have warming spleen and stomach for dispelling cold, temperature
Through the function of hemostasis, controlling Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, is told nosebleed metrorrhagia, and yang deficiency is lost blood.
Herba Agrimoniae taste is sweet, and property is put down;Enter lung, liver, spleen channel;Can stop blooding, stomach invigorating.Control spitting of blood,
Spit blood, hematuria, have blood in stool, dysentery, bleeding not during menses, impairment caused by overstrain takes off power, carbuncle, traumatic injury,
Wound hemorrhage.
Folium Callicarpae Formosanae acrid in the mouth, hardship, property is put down;Return liver, lung, stomach warp;Dissipating blood stasis stops blooding, and detumescence is only
Bitterly.For spitting blood, spitting of blood, epistaxis, have blood in stool;External curing traumatic hemorrhage.
Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet, puckery, cold nature;Attach to the lung and stomach meridians;Matter is viscous holds back puckery, and can dissipate can
Receive, there is astringing to arrest bleeding, effect of detumescence and promoting granulation;Cure mainly pulmonary tuberculosis spitting of blood, spit blood, epistaxis,
Have blood in stool, traumatic hemorrhage, ulcerative carbuncle toxic swelling, scrofula, anal fistula, burn and scald, rhagadia manus et pedis, anus
Split.
Flos Viciae fabae sweet in the mouth, puckery, property is put down, and returns liver, spleen channel;Can cooling blood for hemostasis, leukorrhagia stopping, fall
Flat.Main over-strained hemoptysis, cough spitting of blood, bleeding not during menses, hypertension.
Flos Capsellae sweet in the mouth, cool in nature;Return large intestine channel, can cooling blood for hemostasis;Clearing away heat-damp and promoting diuresis.Main dysentery
Disease, metrorrhagia, hematuria, spitting of blood, epistaxis, children's's infantile dyspepsia, leucorrhea with red and white discharge.
Herba Acalyphae bitter in the mouth, puckery, cool in nature;GUIXIN, lung meridian;Energy heat-clearing and toxic substances removing, dampness removing, receive
Hold back hemostasis.For enteritis, dysentery, haematemesis, epistaxis, have blood in stool, hematuria, metrorrhagia;External treatment
Carbuncle furuncle infections, dermatitis and eczema.
Cacumen Platycladi bitter in the mouth, puckery, cold in nature;Return lung, liver, spleen channel;Can cooling blood for hemostasis, hair growth promoting
Black hair.For hematemesis and epistaxis, spitting of blood, having blood in stool, metrostaxis, heat in blood alopecia, beard and hair is early
In vain.
Flos Sophorae bitter in the mouth, cold nature;Return liver, large intestine channel;Energy cooling blood for hemostasis, purging liver-fire,
For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, dizziness of having a headache.
Pollen Typhae sweet in the mouth, property is put down;Return liver, pericardium channel;Can stop blooding, blood stasis dispelling, treating stranguria.For
Spit blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, fall and flutter
Swell and ache, blood strangury and dry pain.
Charred Petiolus Trachycarpi bitter in the mouth, puckery, property is put down;Return lung meridian, Liver Channel, large intestine channel;Can astringing to arrest bleeding.
For spitting blood, spitting of blood, metrorrhagia of having blood in stool.
Nodus Nelumbinis Rhizomatis sweet in the mouth, puckery, property is put down;Return liver, lung, stomach warp;Can stop blooding, repercussive.For
Spit blood, spitting of blood, hematuria, metrorrhagia.
Pulvis Fumi Carbonisatus acrid in the mouth, gas is put down, is entered liver, lung, stomach three warp;Can stop blooding, removing food stagnancy.Control and tell
Blood, epistaxis, have blood in stool, metrorrhagia, leukorrhagia, dysentery, food stagnation, all skin ulcers of throat dispute.
Ophicalcitum sour in the mouth, puckery, property is put down;Return Liver Channel, can removing stasis to stop bleeding.For spitting blood, tell
Blood, traumatic hemorrhage, falls and flutters the pain of injury.
Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) is cold in nature, bitter in the mouth, nontoxic.Can promoting blood circulation and hemostasis, removing toxic substances and promoting subsidence of swelling.For throat
Swell and ache, hemoptysis of pulmonary tuberculosis, rheumatalgia, menoxenia, thrombocytopenic purpura, fall
Play damage.Fracture, carbuncle furuncle and phyma poison are controlled in external.
Primarily serving the purpose of of the medicinal herb components of above-mentioned interpolation:
Radix Rehmanniae Preparata sweet in the mouth, warm in nature;Returning Liver Channel, kidney channel, essence moist, beneficial of enriching blood fills out marrow.
Rhizoma Polygonati sweet in the mouth, property is put down.Energy nourishing kidney lung moistening, invigorating the spleen and replenishing QI.There is boosting qi and nourishing yin, strong
Spleen, lung moistening, kidney benefiting functions.For treating weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite,
Deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as is quenched one's thirst the disease.
In the present invention, Radix Rehmanniae Preparata, Rhizoma Polygonati regulate the drug effect of other medical materials, are improved patient and exempt from
Epidemic disease power, the effect of enhancing patient's body constitution, it is to avoid the body deficient syndrome shape caused because of pulmonary spitting of blood is sent out
Raw.
Further object is that the preparation method that described Chinese medicine composition is provided, bag
Include following steps:
The first step, weigh on request Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae,
Bulbus Lilii, Rhizoma Zingiberis, Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae,
Cacumen Platycladi, Flos Sophorae, Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, water hardship sell,
With ethanol extraction after Radix Rehmanniae Preparata, Rhizoma Polygonati co-grinding, extracting solution is standby;
Second step, the medicinal residues extracting in water that the first step is obtained, filter, extracting solution is standby;
3rd step, through dry, powder after mixing the extracting solution that the first step obtains with second step
Broken, add adjuvant, pelletize, make required dosage form.
Further, in the first step, described Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi,
Flos Farfarae, Bulbus Lilii, Rhizoma Zingiberis, Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae,
Herba Acalyphae, Cacumen Platycladi, Flos Sophorae, Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum,
The condition that water hardship is sold, Radix Rehmanniae Preparata, Rhizoma Polygonati are pulverized after mixing is: the medicinal mixture mistake after pulverizing
20 mesh sieves, pulverized and are slightly unfavorable for extracting, and it is meticulous to pulverize, and extracting solution thickness is unfavorable for filtering.
Further, in the first step, described Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi,
Flos Farfarae, Bulbus Lilii, Rhizoma Zingiberis, Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae,
Herba Acalyphae, Cacumen Platycladi, Flos Sophorae, Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum,
Water hardship is sold, extracting mode after Radix Rehmanniae Preparata, Rhizoma Polygonati co-grinding is: medicinal material mixture adds 16~20
80~the ethanol of 90% again extract 7~10 hours under conditions of 80~90 DEG C.
Further, in second step, the method for described medicinal residues extracting in water is: add 8~10
Pure water again extracts 2~4 hours under conditions of 95~100 DEG C.
Further, in the third step, the mode that described extracting solution is dried is: vacuum drying,
Or vacuum lyophilization, or constant-pressure and high-temperature is dried.
Further, in the third step, the condition of described pulverizing is: extract solid passes through
Chinese medicine grinder is pulverized, and crosses 120 mesh sieves.
Further, in the third step, the dosage form of described pharmaceutical composition is granule, ball
Agent, soft capsule, capsule, tablet.
The invention have the advantage that
A kind of pharmaceutical composition treating pulmonary spitting of blood disclosed by the invention and preparation side thereof
Method, for pure Chinese medicinal preparation, in conjunction with modern pharmaceutical technique, revises on the basis of ancient prescription, makes
Curative effect is more rapid, and preparation method is simple, processing cost is low, evident in efficacy, without any poison
Side effect, the medicine efficacy of a drug of preparation is strong, instant effect, and dosage form facilitates patient to take, can be rapidly
Eliminate spitting of blood symptom, nourish vigour simultaneously, improve body immunity.
Detailed description of the invention
The specific embodiment of the present invention given below, is used for making the present invention the most specifically
Bright.
Experimental technique in following embodiment, if no special instructions, is conventional method.Under
State in embodiment medicinal raw material used, reagent material etc., if no special instructions, be city
Sell purchase product.
Embodiment 1
A kind of pharmaceutical composition treating pulmonary spitting of blood
Crude drug forms: (unit: g)
Semen Coicis 300, Semen Lepidii (Semen Descurainiae) 200, Radix Stephaniae Tetrandrae 200, Rhizoma Cyperi 600, Flos Farfarae 100, Bulbus Lilii
100, Rhizoma Zingiberis 300, Herba Agrimoniae 300, Folium Callicarpae Formosanae 300, the Pseudobulbus Bletillae (Rhizoma Bletillae) 200, Flos Viciae fabae 200, shepherd's purse
Cauliflower 100, Herba Acalyphae 100, Cacumen Platycladi 300, Flos Sophorae 100, Pollen Typhae 300, charred Petiolus Trachycarpi 200,
Nodus Nelumbinis Rhizomatis 200, Pulvis Fumi Carbonisatus 300, Ophicalcitum 100, water hardship sell 200, Radix Rehmanniae Preparata 100, Rhizoma Polygonati 300.
It is prepared via a method which:
(1) weigh on request Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, Bulbus Lilii,
Rhizoma Zingiberis, Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae, Cacumen Platycladi,
Flos Sophorae, Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Radix Rehmanniae Preparata, Huang
Essence co-grinding extracts 7 with the ethanol 81.6kg of 80% after crossing 20 mesh sieves under conditions of 80 DEG C
Hour, to filter, filtrate is standby.
(2) 40.8kg that added water by the medicinal residues that (1) obtains extracts 4 hours at 95 DEG C, filters,
Extracting solution is standby;
(3) extracting solution obtained in (1), (2) merges, and is 95 DEG C in normal pressure temperature
Under the conditions of, it is condensed into dry cream, through pulverizing, crosses 120 mesh sieves and obtain powder 765g;According to
Drug powder: starch: the ratio of sucrose=3:1:1 adds starch 255g, sucrose 255g, mixed
Close uniformly, pelletize, make granule, subpackage, every bag of 5g, there are granule 255 bags.
Embodiment 2
A kind of pharmaceutical composition treating pulmonary spitting of blood
Crude drug forms: (unit: g)
Semen Coicis 600, Semen Lepidii (Semen Descurainiae) 500, Radix Stephaniae Tetrandrae 500, Rhizoma Cyperi 1000, Flos Farfarae 300, hundred
Close 300, Rhizoma Zingiberis 500, Herba Agrimoniae 500, Folium Callicarpae Formosanae 500, the Pseudobulbus Bletillae (Rhizoma Bletillae) 500, Flos Viciae fabae 500,
Flos Capsellae 300, Herba Acalyphae 300, Cacumen Platycladi 600, Flos Sophorae 300, Pollen Typhae 600, charred Petiolus Trachycarpi
500, Nodus Nelumbinis Rhizomatis 500, Pulvis Fumi Carbonisatus 500, Ophicalcitum 300, water hardship sell 500, Radix Rehmanniae Preparata 300, yellow
Essence 600.
It is prepared via a method which:
(1) by Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, Bulbus Lilii, Rhizoma Zingiberis,
Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae, Cacumen Platycladi, Flos Sophorae,
Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Radix Rehmanniae Preparata, Rhizoma Polygonati mixing
Extracted 10 hours under conditions of 80 DEG C with the ethanol 220kg of 90% after pulverizing 20 mesh sieves,
Filtering, filtrate is standby.
(2) 110kg that added water by the medicinal residues that (1) obtains extracts 2 hours at 100 DEG C, filters,
Extracting solution is standby;
(3) extracting solution obtained in (1), (2) merges, and drying chamber pressure 100Pa adds
Hot plate temperature 40 DEG C, at pre-freezing temperature-44 DEG C, freeze-off time 7h;Sublimation drying mode is straight
Connecing and shelf temperature is set as 45 DEG C, in the middle part of cold-trap, circulation pipe temperature is set as-46 DEG C, is dried
Time is to process filtrate lyophilization under conditions of 6h;After through pulverizing, cross 120 mesh sieves
Obtain pharmaceutical composition powder 1.65kg, add 70% appropriate amount of ethanol, with 60 DEG C after mixing thoroughly
Temperature is dried 1 hour, pelletizes, and dries 1.5 hours with the temperature of 70 DEG C, is mixed by medicated powder after drying
Thing powder, through the encapsulated process of granulator, every encapsulated 400mg, obtains capsule 4125
Grain.
Embodiment 3
A kind of pharmaceutical composition treating pulmonary spitting of blood
Crude drug forms: (unit: kg)
Semen Coicis 4.5, Semen Lepidii (Semen Descurainiae) 3.5, Radix Stephaniae Tetrandrae 3.5, Rhizoma Cyperi 8, Flos Farfarae 2, Bulbus Lilii 2, dry
Rhizoma Zingiberis Recens 4, Herba Agrimoniae 4, Folium Callicarpae Formosanae 4, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3.5, Flos Viciae fabae 3.5, Flos Capsellae 2, Herba Acalyphae 2,
Cacumen Platycladi 4.5, Flos Sophorae 2, Pollen Typhae 4.5, charred Petiolus Trachycarpi 3.5, Nodus Nelumbinis Rhizomatis 3.5, Pulvis Fumi Carbonisatus 4, pistil
Stone 2, water hardship sell 3.5, Radix Rehmanniae Preparata 2, Rhizoma Polygonati 4.5.
It is prepared via a method which:
(1) by Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, Bulbus Lilii, Rhizoma Zingiberis,
Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae, Cacumen Platycladi, Flos Sophorae,
Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Radix Rehmanniae Preparata, Rhizoma Polygonati mixing
Extracted 8 hours under conditions of 85 DEG C with the ethanol 1450kg of 85% after pulverizing 20 mesh sieves,
Filtering, filtrate is standby.
(2) 685kg that added water by the medicinal residues that (1) obtains extracts 3 hours at 96 DEG C, filters,
Extracting solution is standby;
(3) extracting solution obtained in (1), (2) merges, and is 46kPa at dry pressure,
Filtrate is dried to the drug extract solid of 12.075kg by temperature under the conditions of being 70 DEG C;Pass through
Pulverize, cross 120 mesh sieves and obtain compositions powder 12kg, add 75% appropriate amount of ethanol, system
Grain, dries 1.5 hours with the temperature of 80 DEG C, after drying by medicinal mixture powder through tablet machine
Tabletting processes, and every 400mg obtains medicine 30000.
Embodiment 4
A kind of pharmaceutical composition treating pulmonary spitting of blood
Crude drug forms: (unit: kg)
Semen Coicis 3, Semen Lepidii (Semen Descurainiae) 4, Radix Stephaniae Tetrandrae 5, Rhizoma Cyperi 6, Flos Farfarae 2, Bulbus Lilii 7, Rhizoma Zingiberis 3,
Herba Agrimoniae 5, Folium Callicarpae Formosanae 5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4, Flos Viciae fabae 4, Flos Capsellae 2, Herba Acalyphae 1, Cacumen Platycladi 4,
Flos Sophorae 2, Pollen Typhae 4, charred Petiolus Trachycarpi 5, Nodus Nelumbinis Rhizomatis 3, Pulvis Fumi Carbonisatus 3, Ophicalcitum 1, water hardship sell 2,
Huang 1, Rhizoma Polygonati 4.
It is prepared via a method which:
(1) by Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, Bulbus Lilii, Rhizoma Zingiberis,
Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae, Cacumen Platycladi, Flos Sophorae,
Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Radix Rehmanniae Preparata, Rhizoma Polygonati mixing
Extracted 9 hours under conditions of 88 DEG C with the ethanol 1360kg of 88% after pulverizing 20 mesh sieves,
Filtering, filtrate is standby.
(2) 720kg that added water by the medicinal residues that (1) obtains extracts 2.5 hours at 97 DEG C, filters,
Extracting solution is standby;
(3) extracting solution obtained in (1), (2) merges, and is 90 DEG C in normal pressure temperature
Under the conditions of, it is condensed into dry cream, through pulverizing, crosses 120 mesh sieves and obtain drug powder 12kg;
Addition Cera Flava, hydrogenated palm oil, soybean phospholipid are sufficiently stirred for, and mix homogeneously stands, takes out
Vacuum, treats that in medicinal liquid, bubble is removed substantially, with the glue pelleting changed, every dress 400mg
Compacting, obtains soft capsule 50000.
Embodiment 5
A kind of pharmaceutical composition treating pulmonary spitting of blood
Crude drug forms: (unit: kg)
Semen Coicis 5, Semen Lepidii (Semen Descurainiae) 4, Radix Stephaniae Tetrandrae 4, Rhizoma Cyperi 9, Flos Farfarae 2, Bulbus Lilii 2, Rhizoma Zingiberis 4,
Herba Agrimoniae 4, Folium Callicarpae Formosanae 4, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3, Flos Viciae fabae 3, Flos Capsellae 2, Herba Acalyphae 2, Cacumen Platycladi 4,
Flos Sophorae 2, Pollen Typhae 4, charred Petiolus Trachycarpi 4, Nodus Nelumbinis Rhizomatis 4, Pulvis Fumi Carbonisatus 4, Ophicalcitum 2, water hardship sell 4.
It is prepared via a method which:
(1) by Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, Bulbus Lilii, Rhizoma Zingiberis,
Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae, Cacumen Platycladi, Flos Sophorae,
Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), Radix Rehmanniae Preparata, Rhizoma Polygonati mixing
Extracted 8.5 hours under conditions of 89 DEG C with the ethanol 1444kg of 89% after pulverizing 20 mesh sieves,
Filtering, filtrate is standby.
(2) 646kg that added water by the medicinal residues that (1) obtains extracts 2.5 hours at 99 DEG C, filters,
Extracting solution is standby;
(3) extracting solution obtained in (1), (2) merges, and is 50kPa at dry pressure,
Filtrate is dried to the drug extract solid of 11.4kg by temperature under the conditions of being 60 DEG C;Through powder
Broken, cross 120 mesh sieves and obtain compositions powder 11.4kg;Add Mel 4.3kg, Jing Guoqi
Mould, molding, capping prepare the pill 3140 of every 5g.
Experimental example 1
The animal acute toxicity test of the Chinese medicine composition of the present invention
The present embodiment 2 mensuration by Mouse oral administration medicine median lethal dose(LD 50), investigates
The Chinese medicine composition of embodiment 2 preparation is to the acute toxic reaction of mice and death condition.
Take mice 30, often group 10, divide 3 groups, the most high, medium and low 3 dosage groups (0.8,
0.4,0.2ml/15g) gastric infusion 3 times/day, it was predicted that the scope of Calculating Median Lethal Dose of Drugs.Knot
Fruit display, high dose group does not measures median lethal dose(LD 50), therefore by medicine gastric infusion median lethal
The mensuration of amount changes the mensuration doing maximum volume purgation maximum lane point maximum tolerated dose.
Take mice 30, on an empty stomach after 12 hours, with the selected 0.8ml/15g metering of prediction by
Gastric infusion is to animal subject 3 times/day, Continuous Observation 7 days.
Giving by test product 24 hours in gavage, mice voluntary activity declines, and ingests, takes the photograph water and subtract
Few;Within second day, voluntary activity gradually tends to normal, stool, urine no abnormality seen, and mice lives
Dynamic, food ration, body weight growths, feces etc. are all normal, observe the rear test mice that expires whole
Survival.
Observe and put to death whole test mice gross necropsy after expiring, find each important organ, as
The heart, liver, spleen, lung, kidney, ovary, intestinal, stomach etc. change without obvious pathomorphism.
The maximum dosage-feeding result of the test of medicine gastric infusion shows: 30 mices are equal after being administered
Without obvious toxic reaction, also without dead in one week.Record to after mouse stomach administration medicine
Maximum tolerated dose is 39.9g/kg d, as become human oral dosage form 8.0g/60kg to calculate by clinic,
Then the mice of this medicine gavage maximum tolerated dose on the one is clinical adult oral dose on the one
[(39.9g/kg) ÷ (8.0g/60kg) ≈ 299] times.Chinese medicine composition of the present invention is described
The safety of thing is good.
Experimental example 2
The clinical observation on the therapeutic effect of medicine of the present invention
1, physical data
Accept out-patient's totally 200 example, less than 25 years old age, 22 examples, 26~55 years old 134 for medical treatment
Example, more than 56 years old 44 examples.
2, diagnostic criteria
Pulmonary massive hemoptysis classical symptom is that chronic cough companion spits blood repeatedly.
Chronic cough companion's spitting of blood can happen over and over again varying degree, from a small amount of expectorant blood to a large amount of spitting of bloods,
Spitting of blood amount is the most inconsistent with coincident with severity degree of condition, during after pulmonary massive hemoptysis, general nothing is obvious
Toxication shape.
If secondary infection bronchial drainage is smooth repeatedly, blood is difficult to expectoration, can feel uncomfortable in chest not
Suitable inflammation expands to the lung tissue of perilesional, occur high heat, poor appetite night sweat, become thin, lean
The symptoms such as blood.
3, Therapeutic Method
Select above-mentioned experimental example 1 medicament, take to patient, every day 2 times, each 1 dose,
Decoction being taken warmly at twice.Within 30 days, it is a course for the treatment of, takes two courses for the treatment of continuously.
4, efficacy assessment standard
Effective: pulmonary massive hemoptysis symptom is fully recovered, recover normal;
Take a turn for the better: pulmonary massive hemoptysis symptom alleviates, and the state of an illness progressively takes a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (see table):
In above-mentioned treatment, with Drug therapy pulmonary patients with hemoptysis 200 example of the present invention, knot
The most effective 182 examples, obvious effective rate is 91%, and take a turn for the better 10 examples, and improvement rate is 5%, invalid 8 examples,
Total effective rate is 96%.
These are only the preferred embodiments of the present invention and experimental example, be not limited to this
Invention, for a person skilled in the art, the present invention can have various modifications and variations.
All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement made
Deng, should be included within the scope of the present invention.
Claims (8)
1. the pharmaceutical composition treating pulmonary spitting of blood, it is characterised in that including: Semen Coicis
Core, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, Bulbus Lilii, Rhizoma Zingiberis, Herba Agrimoniae, purple
Pearl grass, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae, Cacumen Platycladi, Flos Sophorae, Pollen Typhae,
Charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae), described pharmaceutical composition by
Following weight parts forms: Semen Coicis 3 parts~6 parts, Semen Lepidii (Semen Descurainiae) 2 parts~5 parts, Radix Stephaniae Tetrandrae 2
Part~5 parts, Rhizoma Cyperi 6 parts~10 parts, Flos Farfarae 1 part~3 parts, Bulbus Lilii 1 part~3 parts,
Rhizoma Zingiberis 3 parts~5 parts, Herba Agrimoniae 3 parts~5 parts, Folium Callicarpae Formosanae 3 parts~5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2 parts
~5 parts, Flos Viciae fabae 2 parts~5 parts, Flos Capsellae 1 part~3 parts, Herba Acalyphae 1 part~3 parts,
Cacumen Platycladi 3 parts~6 parts, 1 part~3 parts of Flos Sophorae, Pollen Typhae 3 parts~6 parts, charred Petiolus Trachycarpi 2 parts
~5 parts, Nodus Nelumbinis Rhizomatis 2 parts~5 parts, Pulvis Fumi Carbonisatus 3 parts~5 parts, Ophicalcitum 1 part~3 parts,
Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 2 parts~5 parts.
Pharmaceutical composition the most according to claim 2, it is characterised in that its drug regimen
Thing also includes: 1 part~3 parts of Radix Rehmanniae Preparata, Rhizoma Polygonati 3 parts~6 parts.
Pharmaceutical composition the most according to claim 3, it is characterised in that its drug regimen
Thing weight portion consists of: Semen Coicis 3 parts, Semen Lepidii (Semen Descurainiae) 4 parts, Radix Stephaniae Tetrandrae 5 parts, Rhizoma Cyperi 6
Part, Flos Farfarae 2 parts, Bulbus Lilii 3 parts, Rhizoma Zingiberis 3 parts, Herba Agrimoniae 5 parts, Folium Callicarpae Formosanae 5
Part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Flos Viciae fabae 4 parts, Flos Capsellae 2 parts, Herba Acalyphae 1 part, Cacumen Platycladi
4 parts, 2 parts of Flos Sophorae, Pollen Typhae 4 parts, charred Petiolus Trachycarpi 5 parts, Nodus Nelumbinis Rhizomatis 3 parts, Pulvis Fumi Carbonisatus 3
Part, Ophicalcitum 1 part, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae) 2 parts, 1 part of Radix Rehmanniae Preparata, Rhizoma Polygonati 4 parts.
4. the preparation method of a pharmaceutical composition as claimed in claim 3, it is characterised in that
Preparation method is as follows:
The first step, by Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, Bulbus Lilii,
Rhizoma Zingiberis, Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae, side
Cacumen Platycladi (Cacumen Biotae), Flos Sophorae, Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, Herba Veronicae Undullatae (Herba Veronicae anagallis-aquaticae),
16 times~the ethanol of the 80% of 20 times~90% is added after Radix Rehmanniae Preparata, Rhizoma Polygonati co-grinding,
Extracting 7 hours~10 hours under conditions of 80 DEG C~90 DEG C, extracting solution is standby;
Second step, the medicinal residues extracting in water first step obtained, filter, and extracting solution is standby
With;
Through vacuum after the mixing of 3rd step, the extracting solution that the first step, second step are obtained
It is dried, or vacuum lyophilization, or constant-pressure and high-temperature is dried, after obtaining extract solid
Pulverize, add adjuvant, pelletize, obtain the pharmaceutical composition of required dosage form.
The preparation method of pharmaceutical composition the most according to claim 3, it is characterised in that
In the first step, described Semen Coicis, Semen Lepidii (Semen Descurainiae), Radix Stephaniae Tetrandrae, Rhizoma Cyperi, Flos Farfarae, hundred
Conjunction, Rhizoma Zingiberis, Herba Agrimoniae, Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Viciae fabae, Flos Capsellae, Herba Acalyphae,
Cacumen Platycladi, Flos Sophorae, Pollen Typhae, charred Petiolus Trachycarpi, Nodus Nelumbinis Rhizomatis, Pulvis Fumi Carbonisatus, Ophicalcitum, water hardship
The condition pulverized after the mixing of Mai, Radix Rehmanniae Preparata, Rhizoma Polygonati is: the medicinal mixture mistake after pulverizing
20 mesh sieves.
The system of a kind of pharmaceutical composition treating pulmonary spitting of blood the most according to claim 3
Preparation Method, it is characterised in that in second step, the method for medicinal residues extracting in water is:
Add the pure water of 8 times~10 times to extract under conditions of 95 DEG C~100 DEG C 2 hours~4 little
Time.
The system of a kind of pharmaceutical composition treating pulmonary spitting of blood the most according to claim 3
Preparation Method, it is characterised in that in the third step, the condition of described pulverizing is: by institute
State extract solid to pulverize through Chinese medicine grinder, cross 120 mesh sieves.
The system of a kind of pharmaceutical composition treating pulmonary spitting of blood the most according to claim 3
Preparation Method, it is characterised in that in the third step, described dosage form is granule or pill
Or soft capsule or capsule or tablet.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101785839A (en) * | 2010-04-23 | 2010-07-28 | 泰一和浦(北京)中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method thereof for hemoptysis treatment |
CN105435034A (en) * | 2015-12-12 | 2016-03-30 | 徐士魁 | Medicine for treating hemoptysis and preparation method thereof |
CN107224536A (en) * | 2016-03-23 | 2017-10-03 | 蔡寿阳 | A kind of hemostatic |
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2016
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101785839A (en) * | 2010-04-23 | 2010-07-28 | 泰一和浦(北京)中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method thereof for hemoptysis treatment |
CN105435034A (en) * | 2015-12-12 | 2016-03-30 | 徐士魁 | Medicine for treating hemoptysis and preparation method thereof |
CN107224536A (en) * | 2016-03-23 | 2017-10-03 | 蔡寿阳 | A kind of hemostatic |
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Application publication date: 20161012 |