CN105999073A - Medicine composition for treating chronic sinusitis and preparation method thereof - Google Patents
Medicine composition for treating chronic sinusitis and preparation method thereof Download PDFInfo
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- CN105999073A CN105999073A CN201610487768.5A CN201610487768A CN105999073A CN 105999073 A CN105999073 A CN 105999073A CN 201610487768 A CN201610487768 A CN 201610487768A CN 105999073 A CN105999073 A CN 105999073A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a medicine composition for treating chronic sinusitis and a preparation method thereof. The medicine composition is prepared from the following traditional Chinese medicinal materials: radix pseudostellariae, poria cocos, coix seeds, fructus forsythiae, herba patriniae, rhizoma wenyujin concisum, cassia twigs, asarum, radices ligustici sinensis, gleditsia sinensis, platycodon grandiflorum, cynanchum glaucescens, sinapis semina and radix paeoniae rubra. The medicine composition has remarkable effects of clearing heat, drying dampness, tonifying qi, strengthening the spleen, promoting blood circulation to remove stasis, restoring consciousness, resolving depression, resolving turbidity and draining pus, and can be used for effectively treating chronic sinusitis caused by various reasons and improving the living quality of patients. Clinical experiment observation shows that the medicine composition has a total effective rate for treating chronic sinusitis of 98 percent, and is worthy of popularization and application.
Description
Technical field
Present invention pharmaceutical composition treating chronic sinusitis and preparation method thereof belongs to technical field of Chinese medicines, is specifically related to
A kind of Chinese medicine preparation treating chronic sinusitis and production method thereof.
Background technology
Sinusitis is the nonspecific inflammation of sinus mucosa, the common frdquently encountered disease of Shi Zhong nose section.In various sinusitis,
Maxillary sinusitis is the most common, secondly for sieve hole, sinus frontalis and the inflammation of sphenoid sinus, can be with single-shot, and can also be multiple, modal pathogenic former
Because secondary nasal sinuses suppurative inflammation after nasal cavity infection.
Sinusitis can be divided into acute and chronic two big classes, and acute purulent nasosinusitis is secondary to acute rhinitis more, with nasal obstruction,
Many pus tears, have a headache for principal character;Chronic purulent sinusitis is often secondary to acute purulent nasosinusitis, is main with many pus tears
Performance, the nasal obstruction that can differ with weight, headache and olfactory disorder.It mostly is chronic sinusitis clinically.The traditional Chinese medical science thinks that nose is clear
Key, for the door of lung, it is unimpeded that it is breathed, and the sensitive complete of olfactory sensation relies clear sun to supplement nutrition.Sinusitis is not how solid by the deficiency of vital energy, and exopathogen is invaded
Attacking, heresy enters heat-transformation, and burn saprophytic pus, and the empty key of delay, disperse empty, clear QI being mixed up with turbid QI, and key gap is inaccessible, causes nasal obstruction watery nasal discharge, headache head
Swollen, the tired limb of intelligence unconsciousness, body is tired, normal easily diseases caused by exogenous pathogenic factor.Diseases caused by exogenous pathogenic factor posterior nasal sinuses inflammation increases the weight of again, such reciprocal causation, recurrent exerbation.
At present, along with the continuous decline of air quality, pathogenic organisms of respiratory tract infects and immunologic function disorder inflammation is extensive
Popular, cause chronic sinusitis sickness rate also cumulative year after year, patient's course of disease typically lasts for even several years several months, has had a strong impact on trouble
The quality of life of person.Treatment chronic sinusitis is many with vasoconstrictor or be equipped with the nasal drop such as antibiotic, hormone clinically, though
So can play certain therapeutical effect, but after these medicine life-time service, both be unfavorable for the recovery of nasal mucosa physiological function, with
Time it is also possible to cause medicamentous rhinitis, therapeutic effect is undesirable.
Summary of the invention
Not enough for prior art, the invention provides a kind of pharmaceutical composition treating chronic sinusitis, medicine of the present invention
Compositions treatment chronic sinusitis not only special effect, controls difficulty in relapse after healing, and has no side effect, preparation technology letter
Single.
For achieving the above object, the present invention adopts the technical scheme that: according to the pathogeny of acute and chronic nasal sinusitis, expectorant is turbid
Pus is pathological product, is again the new cause of disease.Therefore remove the turbid pus of expectorant, stopping the turbid source of expectorant is the key curing primary disease, rises
Clear the turbid descending is then the most basic most effective therapeutic rules.Pharmaceutical composition of the present invention is mainly made up of following crude drug: Radix Pseudostellariae,
Poria, Semen Coicis, Fructus Forsythiae, Herba Patriniae, Rhizoma Wenyujin Concisum, Ramulus Cinnamomi, Herba Asari, Rhizoma Ligustici, Fructus Gleditsia, Radix Platycodonis, Rhizoma Cynanchi Stauntonii, Semen Sinapis, Radix Paeoniae Rubra.Fang Zhongtai
Son ginseng, Poria, Semen Coicis, invigorating the spleen and benefiting QI, promoting diuresis to eliminate damp pathogen;Fructus Forsythiae, Herba Patriniae, heat-clearing and toxic substances removing, detumescence and apocenosis;Rhizoma Wenyujin Concisum, Semen Sinapis,
Radix Paeoniae Rubra, promoting blood circulation to remove obstruction in the collateral, eliminating stasis to stop pain;Ramulus Cinnamomi, Herba Asari, Rhizoma Ligustici, supporing yang sending down the abnormal ascending QI, expelling wind and cold, sensible pain relieving;Fructus Gleditsia, Radix Platycodonis, in vain
Before, lung qi dispersing eliminates the phlegm, logical closing of having one's ideas straightened out.Full side plays clearing heat and expelling damp, replenishing QI to invigorate the spleen, blood circulation promoting and blood stasis dispelling, understanding thing and resolving problem altogether, change turbid evacuation of pus it
Merit, treating both the principal and secondary aspects of a disease, it is possible to the chronic sinusitis that effectively treatment a variety of causes causes.
Preferably, pharmaceutical composition of the present invention is made up of the crude drug of following weight portion: Radix Pseudostellariae 10-16 part, Poria
10-20 part, Semen Coicis 20-30 part, Fructus Forsythiae 5-15 part, Herba Patriniae 15-25 part, Rhizoma Wenyujin Concisum 5-10 part, Ramulus Cinnamomi 10-16 part, Herba Asari
5-10 part, Rhizoma Ligustici 10-20 part, Fructus Gleditsia 10-20 part, Radix Platycodonis 15-25 part, Rhizoma Cynanchi Stauntonii 10-18 part, Semen Sinapis 5-15 part, Radix Paeoniae Rubra 10-18
Part.
Preferably, pharmaceutical composition of the present invention is made up of the crude drug of following weight portion: Radix Pseudostellariae 12-14 part, Poria
14-16 part, Semen Coicis 24-26 part, Fructus Forsythiae 8-12 part, Herba Patriniae 18-22 part, Rhizoma Wenyujin Concisum 7-9 part, Ramulus Cinnamomi 12-14 part, Herba Asari 7-
9 parts, Rhizoma Ligustici 14-16 part, Fructus Gleditsia 14-16 part, Radix Platycodonis 18-22 part, Rhizoma Cynanchi Stauntonii 12-16 part, Semen Sinapis 8-12 part, Radix Paeoniae Rubra 12-16 part.
Preferably, pharmaceutical composition of the present invention is made up of the crude drug of following weight portion: Radix Pseudostellariae 13 parts, Poria 15
Part, Semen Coicis 25 parts, Fructus Forsythiae 10 parts, Herba Patriniae 20 parts, Rhizoma Wenyujin Concisum 8 parts, Ramulus Cinnamomi 13 parts, Herba Asari 8 parts, Rhizoma Ligustici 15 parts, Fructus Gleditsia 15
Part, Radix Platycodonis 20 parts, Rhizoma Cynanchi Stauntonii 14 parts, 10 parts of Semen Sinapis, Radix Paeoniae Rubra 14 parts.
The function of each component of compositions of the present invention cures mainly as follows:
Radix Pseudostellariae, hardship sweet, micro-, flat.Return spleen, lung meridian.Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence,
Weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Poria, sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention is dizzy
Throbbing with fear, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.
Semen Coicis, sweet, light, cool.Return spleen, stomach, lung meridian.Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, foot
Gas, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis;Verruca plana.
Fructus Forsythiae, bitter, it is slightly cold.Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, pellet
Poison, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, pyretic stranguria urine retention.
Herba Patriniae, pungent, bitter, cool.Enter stomach, large intestine, Liver Channel.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung
Carbuncle and sore and toxic, the stagnant caused chest and abdomen pain of the excess-heat stasis of blood, puerperal the disease such as the stagnant stomachache of the stasis of blood.
Rhizoma Wenyujin Concisum, pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.For amenorrhea due to stagnation of blood, menalgia, breast
The side of body twinges, rheumatic arthralgia, takes on arm pain, injury from falling down.
Ramulus Cinnamomi, acrid, sweet, warm.GUIXIN, lung, bladder warp.Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For
Anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Herba Asari, pungent, temperature.GUIXIN, lung, kidney channel.Expelling wind and cold, sensible pain relieving, warming the lung to resolve fluid-retention.For anemofrigid cold, have a headache,
Toothache, nasal sinusitis of having a stuffy nose, rheumatic arthralgia, phlegm retention is breathed with cough.
Rhizoma Ligustici, pungent, temperature.Return bladder warp.Dispel the wind, cold expelling, dehumidifying, pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatism limb
Joint arthralgia pain.
Fructus Gleditsia, pungent;Salty;Temperature;Poisonous.Lung;Large intestine channel.Expelling phlegm for arresting cough;Have one's ideas straightened out to lead to and close;Parasite killing eliminating stagnation.Main productive cough dyspnea with fullness of the chest;In
Keep silent in air port;Accumulation and obstruction of sputum;Coma is in silence;Epilepsy;Sore throat;Constipation and anuresis;Carbuncle scabies.
Radix Platycodonis, bitter, pungent, flat.Return lung meridian.Lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia,
Hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Rhizoma Cynanchi Stauntonii, pungent, bitter, tepor.Return lung meridian.Sending down the abnormal ascending QI, expectorant, cough-relieving.Stop up real for lung qi, cough with copious phlegm, fullness in the chest dyspnea with rapid respiration.
Semen Sinapis, pungent, temperature.Return lung meridian.Warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.Breath with cough for cold-phlegm, distending pain in the chest and hypochondrium, expectorant
Stagnant meridians, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.
Radix Paeoniae Rubra, bitter, it is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain,
Hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, abdominal mass stomachache, injury from falling down, carbuncle skin infection.
The pharmaceutical composition of the treatment chronic sinusitis that the present invention provides, can make various dosage form, preferably as required
, pharmaceutical composition of the present invention makes oral formulations, and the most described oral formulations can be oral liquid, granule or capsule
Agent, it is preferred that pharmaceutical composition of the present invention makes capsule.Present invention also offers one and prepare above-mentioned prophylactic treatment lower limb
The method of the pharmaceutical composition of deep venous thrombosis, the method comprises the following steps: after each component being pulverized respectively, crosses 100 mesh sieves,
Mixing mixing, is packed in hard rubber softgel shell and makes capsule.
Detailed description of the invention
Hereinafter the detailed description of the invention of the present invention is described in detail.It should be appreciated that described herein specifically
Embodiment is merely to illustrate and explains the present invention, is not limited to the present invention.
Hereinafter will be described the present invention by embodiment.
Embodiment 1 capsule
The present invention treats the pharmaceutical composition of chronic sinusitis and is made up of following medical material: Radix Pseudostellariae 10 parts, 10 parts of Poria, the heart of a lotus seed
Semen Coicis 20 parts, Fructus Forsythiae 5 parts, Herba Patriniae 15 parts, Rhizoma Wenyujin Concisum 5 parts, Ramulus Cinnamomi 10 parts, Herba Asari 5 parts, Rhizoma Ligustici 10 parts, 10 parts of Fructus Gleditsia, Radix Platycodonis
15 parts, Rhizoma Cynanchi Stauntonii 10 parts, 5 parts of Semen Sinapis, Radix Paeoniae Rubra 10 parts.
Preparation technology: weighing after above Chinese medicine component pulverizes respectively according to aforesaid weight portion, cross 100 mesh sieves, mixing is mixed
Even, it is packed in hard rubber softgel shell and makes capsule.
When using Chinese medicine preparation of the present invention treatment chronic sinusitis, take prepared capsule, every amount Han crude drug
0.2g, three times a day, each 2-4 grain, take half an hour after meal.
Embodiment 2 capsule
The present invention treats the pharmaceutical composition of chronic sinusitis and is made up of following medical material: Radix Pseudostellariae 16 parts, 20 parts of Poria, the heart of a lotus seed
Semen Coicis 30 parts, Fructus Forsythiae 15 parts, Herba Patriniae 25 parts, Rhizoma Wenyujin Concisum 10 parts, Ramulus Cinnamomi 16 parts, Herba Asari 10 parts, Rhizoma Ligustici 20 parts, 20 parts of Fructus Gleditsia,
Radix Platycodonis 25 parts, Rhizoma Cynanchi Stauntonii 18 parts, 15 parts of Semen Sinapis, Radix Paeoniae Rubra 18 parts.
Preparation technology: weighing after above Chinese medicine component pulverizes respectively according to aforesaid weight portion, cross 100 mesh sieves, mixing is mixed
Even, it is packed in hard rubber softgel shell and makes capsule.
When using Chinese medicine preparation of the present invention treatment chronic sinusitis, take prepared capsule, every amount Han crude drug
0.2g, three times a day, each 2-4 grain, take half an hour after meal.
Embodiment 3 capsule
The present invention treats the pharmaceutical composition of chronic sinusitis and is made up of following medical material: Radix Pseudostellariae 12 parts, 14 parts of Poria, the heart of a lotus seed
Semen Coicis 24 parts, Fructus Forsythiae 8 parts, Herba Patriniae 18 parts, Rhizoma Wenyujin Concisum 7 parts, Ramulus Cinnamomi 12 parts, Herba Asari 7 parts, Rhizoma Ligustici 14 parts, 14 parts of Fructus Gleditsia, Radix Platycodonis
18 parts, Rhizoma Cynanchi Stauntonii 12 parts, 8 parts of Semen Sinapis, Radix Paeoniae Rubra 12 parts.
Preparation technology: weighing after above Chinese medicine component pulverizes respectively according to aforesaid weight portion, cross 100 mesh sieves, mixing is mixed
Even, it is packed in hard rubber softgel shell and makes capsule.
When using Chinese medicine preparation of the present invention treatment chronic sinusitis, take prepared capsule, every amount Han crude drug
0.2g, three times a day, each 2-4 grain, take half an hour after meal.
Embodiment 4 capsule
The present invention treats the pharmaceutical composition of chronic sinusitis and is made up of following medical material: Radix Pseudostellariae 14 parts, 16 parts of Poria, the heart of a lotus seed
Semen Coicis 26 parts, Fructus Forsythiae 12 parts, Herba Patriniae 22 parts, Rhizoma Wenyujin Concisum 9 parts, Ramulus Cinnamomi 14 parts, Herba Asari 9 parts, Rhizoma Ligustici 16 parts, 16 parts of Fructus Gleditsia, Fructus Citri tangerinae
Obstruct 22 parts, Rhizoma Cynanchi Stauntonii 16 parts, 12 parts of Semen Sinapis, Radix Paeoniae Rubra 16 parts.
Preparation technology: weighing after above Chinese medicine component pulverizes respectively according to aforesaid weight portion, cross 100 mesh sieves, mixing is mixed
Even, it is packed in hard rubber softgel shell and makes capsule.
When using Chinese medicine preparation of the present invention treatment chronic sinusitis, take prepared capsule, every amount Han crude drug
0.2g, three times a day, each 2-4 grain, take half an hour after meal.
Embodiment 5 capsule
The present invention treats the pharmaceutical composition of chronic sinusitis and is made up of following medical material: Radix Pseudostellariae 13 parts, 15 parts of Poria, the heart of a lotus seed
Semen Coicis 25 parts, Fructus Forsythiae 10 parts, Herba Patriniae 20 parts, Rhizoma Wenyujin Concisum 8 parts, Ramulus Cinnamomi 13 parts, Herba Asari 8 parts, Rhizoma Ligustici 15 parts, 15 parts of Fructus Gleditsia, Fructus Citri tangerinae
Obstruct 20 parts, Rhizoma Cynanchi Stauntonii 14 parts, 10 parts of Semen Sinapis, Radix Paeoniae Rubra 14 parts.
Preparation technology: weighing after above Chinese medicine component pulverizes respectively according to aforesaid weight portion, cross 100 mesh sieves, mixing is mixed
Even, it is packed in hard rubber softgel shell and makes capsule.
When using Chinese medicine preparation of the present invention treatment chronic sinusitis, take prepared capsule, every amount Han crude drug
0.2g, three times a day, each 2-4 grain, take half an hour after meal.
Comparative example 1 capsule
The present invention treats the pharmaceutical composition of chronic sinusitis and is made up of following medical material: Radix Pseudostellariae 5 parts, 25 parts of Poria, the heart of a lotus seed
Semen Coicis 25 parts, Fructus Forsythiae 10 parts, Herba Patriniae 20 parts, Rhizoma Wenyujin Concisum 8 parts, Ramulus Cinnamomi 13 parts, Herba Asari 8 parts, Rhizoma Ligustici 15 parts, 15 parts of Fructus Gleditsia, Fructus Citri tangerinae
Obstruct 20 parts, Rhizoma Cynanchi Stauntonii 14 parts, 10 parts of Semen Sinapis, Radix Paeoniae Rubra 6 parts.
Preparation technology: weighing after above Chinese medicine component pulverizes respectively according to aforesaid weight portion, cross 100 mesh sieves, mixing is mixed
Even, it is packed in hard rubber softgel shell and makes capsule.
When using Chinese medicine preparation of the present invention treatment chronic sinusitis, take prepared capsule, every amount Han crude drug
0.2g, three times a day, each 2-4 grain, take half an hour after meal.
Comparative example 2 capsule
Radix Pseudostellariae 13 parts, 15 parts of Poria, Semen Coicis 25 parts, Herba Patriniae 20 parts, Rhizoma Wenyujin Concisum 8 parts, Ramulus Cinnamomi 13 parts, Rhizoma Ligustici 15
Part, 15 parts of Fructus Gleditsia, Radix Platycodonis 20 parts, Rhizoma Cynanchi Stauntonii 14 parts, 10 parts of Semen Sinapis, Radix Paeoniae Rubra 14 parts.
Preparation technology: weighing after above Chinese medicine component pulverizes respectively according to aforesaid weight portion, cross 100 mesh sieves, mixing is mixed
Even, it is packed in hard rubber softgel shell and makes capsule.
When using Chinese medicine preparation of the present invention treatment chronic sinusitis, take prepared capsule, every amount Han crude drug
0.2g, three times a day, each 2-4 grain, take half an hour after meal.
The drug composition oral liquor of the present invention is tested for clinical observation
1, physical data:
Select in January, 2014 in January, 2015 in me Out-patient Department or 200 example patients with chronic sinusitis conducts of ward treatment
They are randomly divided into four groups by object of study, often organize 50 examples, wherein treatment group male 22 example, women 18 example, age minimum 18
Year, maximum 66 years old, average (38.26 ± 5.65) year;-10 years half a year of the course of disease, average course of disease (4.54 ± 1.12) year;Compare 1 group
Male 21 example, women 19 example, minimum 17 years old of age, maximum 70 years old, average (39.78 ± 6.24) year;The course of disease 8 months-11 years, flat
The all course of disease (4.56 ± 1.25) years;Compare 2 groups of male 23 examples, women 17 example, minimum 16 years old of age, maximum 68 years old, averagely
(38.46 ± 5.89) year;The course of disease 6 months-11 years, average course of disease (4.48 ± 1.14) year;Compareing 3 groups of male 21 examples, women 19
Example, minimum 17 years old of age, maximum 67 years old, average (38.22 ± 5.35) year;The course of disease 7 months-12 years, average course of disease (4.50 ±
1.10) year.The aspects such as four groups of ages, sex, courses of disease, through statistical procedures, without significant (P > 0.05), have comparable
Property.
2, diagnostic criteria
Western medicine diagnose standard: meet Chinese Journal of Otorhinolaryngology Head And Neck Surgery editorial board, Chinese Medical Association's ear,nose & throat head
Diagnostic criteria in " diagnosis of chronic nose one sinusitis and treatment guidelines " that neck surgery branch rhinology group is formulated.And per nasal
Hole, nasal endoscopy are diagnosed as chronic sinusitis.
Standards of Chinese Medical Syndrome Differentiation: primary symptom is had a stuffy nose, pus tears, dizzy headache, hyposmia;Looking into and see that nasal secretion is many, concha nasalis swells
Swollen companion sees that anemophobia is afraid of cold, lustreless complexion, fatigue and weakness, light red tongue or light fat, and tongue is white, and moderate pulse is weak.
3. inclusive criteria:
Meet above-mentioned diagnostic criteria;
Do not accepted the symptomatic treatments such as surgical resection therapy, anti-inflammatory analgesic and immunosuppressant;
Complete clinical data, time medical, vital sign is steady;
The course of disease is more than 3 months persons;Signature Informed Consent Form person.
4, exclusion standard:
Merge severe cardiac pulmonary dysfunction;
Merge Serious respiratory tract disease;
Merge nasal cavity, tumor of sinus of nose sexually transmitted disease (STD) becomes;
Gestation or women breast-feeding their children;
Carry out therapist the most on request.
5, Therapeutic Method:
Treatment group: the capsule of oral embodiment 5 preparation, every amount 0.2g Han crude drug, three times a day, and each 2-4 grain, meal
Half an hour after is taken.
Compare 1 group: using fluticasone propionate nasal spray spray nose, every day twice, the most every nostril, side 1 is sprayed;Oral gram
Draw mycin sheet 250mg, every day 1 time.
Compare 2 groups: the capsule of oral contrast embodiment 1 preparation, every amount 0.2g Han crude drug, three times a day, each 2-4
Grain, takes after meal half an hour.
Compare 3 groups: the capsule of oral contrast embodiment 2 preparation, every amount 0.2g Han crude drug, three times a day, each 2-4
Grain, takes after meal half an hour.
Four groups of equal continued treatments of patient observe therapeutic effect after 4 weeks, and follow up a case by regular visits to three months determine curative effect.
6, the standard of curative effect evaluation:
Effective: clinical symptoms, sign disappear, nasal sinuses x-ray checks that abnormal sign disappears, and follows up a case by regular visits to 3 months without recurrence.
Effective: nasal obstruction alleviates, pus tears reduce, and headache disappears or alleviates, in, hypertrophic inferior turbinate or middle nasal concha Polypoid changes subtract
Gently, middle nasal meatus has a small amount of pus tears, and nasal sinuses x-ray inspection exception sign alleviates.
Invalid: clinical symptoms, sign are without changing, and nasal sinuses x-ray checks that abnormal sign is without changing.
Carry out symptom integral statistics, to nasal obstruction, flow turbid tears, head dusk pain, hyposmia, indolent and listless weak, breast gastral cavity painful abdominal mass is vexed, receive
The symptoms such as slow-witted lack of appetite by without, light, in, the most respectively based on 0,1,2,3 points.
7, statistical method
With statistics software SPSS20.0, data being carried out statistical analysis, enumeration data uses x2Inspection;Measurement data
By mean ± standard deviationRepresent, carry out t inspection;P < 0.05 represents that between two groups, diversity is notable.
8. therapeutic outcome
8.1 through treatment in 4 weeks, and followed up a case by regular visits to three months, and four groups specifically to treat clinical effectiveness as shown in table 1.
1. 4 groups of table treatment clinical effectiveness
Group | n | Effective | Effectively | Invalid | Total effective rate |
Treatment group | 50 | 45 | 4 | 1 | 98%*◎△ |
Compare 1 group | 50 | 26 | 14 | 10 | 80% |
Compare 2 groups | 50 | 28 | 14 | 8 | 84% |
Compare 3 groups | 50 | 26 | 13 | 11 | 78% |
Note: compare with compareing 1 group, * P < 0.05, compare with compareing 2 groups,◎P < 0.05, compares with compareing 3 groups,△P <
0.05。
Compared by data above it is found that clinical effective 45 people, total effective rate 98% in treatment group, be superior to comparison
1-3 group, and significant difference, have statistical significance (P < 0.05).Therapeutic component does not compare with the clinical effectiveness compareing 2 and 3 groups
Show, change prescription and/or proportioning, it is impossible to reach the therapeutic effect that pharmaceutical composition of the present invention is excellent equally.
Cardinal symptom integral contrast before and after 8.2 4 groups of treatments
After four groups of patient treatments, cardinal symptom integration is remarkably decreased before the most relatively treating, and treatment group improvement degree is the most notable,
Respectively with compare each group of 1-3 and compare, significant difference, there is statistical significance (P < 0.05).Concrete data are shown in Table 2.
Cardinal symptom integral contrast before and after table 2. treatment
Note: after treatment, treatment group compares with compareing 1 group, * P < 0.05, compares with compareing 2 groups,◎P < 0.05, and compares 3
Group compares,△P < 0.05.To sum up, the invention provides a kind of pharmaceutical composition and preparation method thereof, this pharmaceutical composition has
Clearing heat and expelling damp, replenishing QI to invigorate the spleen, blood circulation promoting and blood stasis dispelling, understanding thing and resolving problem, change the remarkable efficacy of turbid evacuation of pus, it is possible to effectively treatment a variety of causes draws
The chronic sinusitis risen, improves patients ' life quality, observes through clinical experiment, medicine composite for curing chronic sinusitis of the present invention
Total effective rate reaches 98%, and clinical effectiveness is notable, is worthy of popularization.
Claims (7)
1. the pharmaceutical composition treating chronic sinusitis, it is characterised in that described compositions is by following weight proportioning
Medical material is made: Radix Pseudostellariae 10-16 part, Poria 10-20 part, Semen Coicis 20-30 part, Fructus Forsythiae 5-15 part, Herba Patriniae 15-25 part, sheet
Rhizoma Curcumae Longae 5-10 part, Ramulus Cinnamomi 10-16 part, Herba Asari 5-10 part, Rhizoma Ligustici 10-20 part, Fructus Gleditsia 10-20 part, Radix Platycodonis 15-25 part, Rhizoma Cynanchi Stauntonii 10-
18 parts, Semen Sinapis 5-15 part, Radix Paeoniae Rubra 10-18 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that described compositions is by the Chinese medicine of following weight proportioning
Material is made: Radix Pseudostellariae 12-14 part, Poria 14-16 part, Semen Coicis 24-26 part, Fructus Forsythiae 8-12 part, Herba Patriniae 18-22 part, sheet Rhizoma Zingiberis Recens
Yellow 7-9 part, Ramulus Cinnamomi 12-14 part, Herba Asari 7-9 part, Rhizoma Ligustici 14-16 part, Fructus Gleditsia 14-16 part, Radix Platycodonis 18-22 part, Rhizoma Cynanchi Stauntonii 12-16
Part, Semen Sinapis 8-12 part, Radix Paeoniae Rubra 12-16 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that described compositions is by the Chinese medicine of following weight proportioning
Material is made: Radix Pseudostellariae 13 parts, 15 parts of Poria, Semen Coicis 25 parts, Fructus Forsythiae 10 parts, Herba Patriniae 20 parts, Rhizoma Wenyujin Concisum 8 parts, Ramulus Cinnamomi 13 parts,
Herba Asari 8 parts, Rhizoma Ligustici 15 parts, 15 parts of Fructus Gleditsia, Radix Platycodonis 20 parts, Rhizoma Cynanchi Stauntonii 14 parts, 10 parts of Semen Sinapis, Radix Paeoniae Rubra 14 parts.
4. according to the pharmaceutical composition described in claim 1,2, it is characterised in that the dosage form of this pharmaceutical composition be oral liquid,
Granule, capsule.
Pharmaceutical composition the most according to claim 4, it is characterised in that the dosage form of this pharmaceutical composition is preferably capsule
Agent.
6. the method for the medicament composition capsule agent that a kind is prepared described in claim 1, it is characterised in that the method includes following
Step: after each component being pulverized respectively, crosses 100 mesh sieves, mixing mixing, is packed in hard rubber softgel shell and makes capsule.
7. the pharmaceutical composition as claimed in claim 1 purposes in the medicine of preparation treatment chronic sinusitis.
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Application publication date: 20161012 |