CN104189427A - Traditional Chinese medicinal composition for treating wind-cold cough and asthma diseases and application thereof - Google Patents
Traditional Chinese medicinal composition for treating wind-cold cough and asthma diseases and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating wind-cold cough and asthma diseases. The traditional Chinese medicinal composition comprises the following medicinal raw materials: baked ephedra, cassia twig, semen armeniacae amarae, thunberg fritillary bulb, fructus aurantii, cordate houttuynia, ginkgo, bombyx batryticatus, earthworm, salviae miltiorrhizae, platycodon grandiflorum and liquorice. In the formula, ephedra and cassia twig serve as monarch drugs and have functions of dispelling cold, relieving exterior syndrome, and relieving cough and asthma; semen armeniacae amarae, thunberg fritillary bulb, fructus aurantii and cordate houttuynia, which are capable of eliminating phlegm and stopping cough and ginkgo which is capable of reducing qi and eliminating phlegm serve as minister drugs; bombyx batryticatus, earthworm and salviae miltiorrhizae serve as adjuvant drugs and are capable of promoting blood circulation to remove meridian obstruction, enhancing effects of eliminating phlegm, stopping cough, promoting spasmolysis and relieving asthma; liquorice which has the functions of benefiting qi, regulating middle warmer, and coordinating various drugs and platycodon grandiflorum which has functions of diffusing lung, eliminating phlegm, and guiding the drugs to move upwards serve as conductant drugs. Furthermore, the invention discloses application of the traditional Chinese medicinal composition. Clinical tests show that the traditional Chinese medicinal composition disclosed by the invention has an obvious curative effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically, is a kind of Chinese medicine composition for the treatment of wind-cold type disease of cough and asthma and uses thereof.
Background technology
Also cough and to claim cough, breathe heavily also claim to pant, stridulate, dyspnea, dyspnea with wheezing, upper gas etc., be that lung is the cardinal symptom performance of disease.Diseases caused by exogenous pathogenic factor six evil, internal organs internal injury causes functional disorder, involves in lung, causes impairment of dispersing and descending function of the lung, and abnormal rising of lung-QI can occur or cough or breathe heavily or the Symptoms of cough with asthma.Breathe heavily manyly with cough, cough not necessarily with breathing heavily, so cough and breathe heavily all not from lung, also do not terminate in lung, its common pathogenesis all exists " abnormal rising of lung-QI ".
Cough with asthma is common in the alleged upper respiratory tract infection of modern medicine, bronchitis, bronchiectasis, pneumonia, pulmonary tuberculosis, pharyngitis, laryngitis, pertussis, bronchial asthma, asthmatic bronchitis, cardiac asthma, lung abscess, pleuritis, emphysema, the diseases such as pneumosilicosis.
The opinion of cough with asthma starts from < < through > >.< < Plain Questions is coughed opinion > > cloud: " the making us of lung coughed, what also qi uncle to saying: the vital organs of the human body all make us coughing, and non-only lung is also." the < < typhoid fever > > that falls discusses cough card and control, and can be summarized as cold cough with asthma, hot cough with asthma and phlegm retention cough with asthma three major types, faces card when distinguishing cold and heat and asthenia and sthenia, treatment according to the specific symptoms.
35 of < < Treatise on Febrile Diseases > > clauses: " TAI YANG syndrome, has a headache and fever, body pain; lumbago, arthralgia, aversion to wind; no perspiration but asthma person, Ephedrae Decoction master it ", i.e. Ephedrae Decoction side's card, clause 51 " floating pulse person, the disease being located in the exterior, can diaphoresis; should Ephedrae Decoction ", clause 52 " floating and rapid pulse person, can diaphoresis, a surname's Ephedrae Decoction " supplements.The table of the main the whole body of the sun, the exterior tightened by pathogenic windcold, yang-energy is not stretched, therefore general aching on the body; Foot TAI YANG pulse supports in waist, therefore lumbago; From wind and cold, obtain therefore aversion to wind; Wind and cold visitor in outside, fur closes, therefore lossless; The sun is the main gas of all sun, and yang-energy is strongly fragrant in interior, therefore breathe heavily; TAI YANG playing the role of vital function as a door, vertical Ephedrae Decoction is opened it, and all cards are known and are removed.
Chinese patent literature CN101979045A discloses a kind of medicine for the treatment of cough illness, and take Bulbus Lilii, Fructus Perillae, Herba Houttuyniae, Semen Armeniacae Amarum, Radish seed, Flos Lonicerae, Rhizoma Menispermi, Radix Platycodonis, Herba Taraxaci, Radix Glycyrrhizae, Semen Sterculiae Lychnophorae, Fructus Aristolochiae is raw material; Above-mentioned all medicines are put into marmite, by the 1:2 of crude drug gross mass, add water slow fire boiling, boil latter 20 minutes, medicinal liquid is leached, then add water slow fire boiling by the 1:1 of crude drug gross mass, boil latter 20 minutes, medicinal liquid is leached, merge twice filtrate bottling.Chinese patent literature CN101342333B discloses a kind of Chinese medicine for the treatment of cough with asthma, by following bulk drugs, is made: Rhizoma Phragmitis, Semen Trichosanthis, Semen Benincasae, Semen Coicis, Flos Lonicerae, Herba Houttuyniae, sand ginseng, Fructus Schisandrae Chinensis, close moxibustion Semen Armeniacae Amarum, Semen Ginkgo, close Radix Glycyrrhizae Preparata, close moxibustion Flos Farfarae, close moxibustion Radix Asteris, pericarpium citri grandis, Radix Platycodonis, Semen Persicae, Semen Arecae (parched), Fructus Aurantii, Cortex Magnoliae Officinalis, Massa Medicata Fermentata, Endothelium Corneum Gigeriae Galli (parched), Herba Epimedii, Herba Cistanches, Folium Pyrrosiae.The invention provides Chinese medicine composition of a kind for the treatment of wind-cold type disease of cough and asthma that yet there are no report and uses thereof.
Summary of the invention
The object of the invention is for deficiency of the prior art, a kind of Chinese medicine composition for the treatment of wind-cold type disease of cough and asthma is provided.
One object more of the present invention is that a kind of purposes for the treatment of the Chinese medicine composition of wind-cold type disease of cough and asthma is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of Chinese medicine composition for the treatment of wind-cold type disease of cough and asthma, described Chinese medicine composition is made by the crude drug of following weight portion: Herba Ephedrae (processed) 4-8 part, Ramulus Cinnamomi 4-8 part, Semen Armeniacae Amarum 7-13 part, Bulbus Fritillariae Thunbergii 7-13 part, Fructus Aurantii 7-13 part, Herba Houttuyniae 25-35 part, Semen Ginkgo 4-8 part, Bombyx Batryticatus 4-8 part, Pheretima 7-13 part, Radix Salviae Miltiorrhizae 7-13 part, Radix Platycodonis 4-8 part, Radix Glycyrrhizae 4-8 part.
Described Chinese medicine composition is made by the crude drug of following weight portion: Herba Ephedrae (processed) 5-7 part, Ramulus Cinnamomi 5-7 part, Semen Armeniacae Amarum 9-11 part, Bulbus Fritillariae Thunbergii 9-11 part, Fructus Aurantii 9-11 part, Herba Houttuyniae 28-32 part, Semen Ginkgo 5-7 part, Bombyx Batryticatus 5-7 part, Pheretima 9-11 part, Radix Salviae Miltiorrhizae 9-11 part, Radix Platycodonis 5-7 part, Radix Glycyrrhizae 5-7 part.
Described Chinese medicine composition is made by the crude drug of following weight portion: 6 parts of Herba Ephedrae (processed), 6 parts of Ramulus Cinnamomi, 10 parts of Semen Armeniacae Amarums, 10 parts of Bulbus Fritillariae Thunbergiis, 10 parts of Fructus Aurantiis, 30 parts of Herba Houttuyniae, 6 parts of Semen Ginkgoes, 6 parts of Bombyx Batryticatus, 10 parts of Pheretimas, 10 parts of Radix Salviae Miltiorrhizaes, 6 parts of Radix Platycodoniss, 6 parts, Radix Glycyrrhizae.
For realizing above-mentioned second object, the technical scheme that the present invention takes is: the application of described Chinese medicine composition in the medicine of preparation treatment wind-cold type disease of cough and asthma.
Described wind-cold type cough with asthma refers to the acute and chronic bronchitis of wind-cold type, bronchial asthma.
The invention has the advantages that:
Chinese medicine composition of the present invention cures mainly wind-cold type cough with asthma, and clinical trial shows to have significant curative effect.Can reduce antibiotic use, improve the cure rate of acute cough with asthma, reduce the attack times of chronic cough and asthma, improve patient's quality of life.The principle that meets Chinese medicine monarch, has the advantage such as have no side effect, and is applicable to extensively promoting.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment provided by the invention is elaborated.
Wind-cold type cough with asthma (acute and chronic bronchitis, bronchial asthma etc.), with fever with aversion to cold, lossless, cough and expectoration, the color white matter of coughing up phlegm is rare, sound of the sputum in the throat, body of the tongue is light red, white and thin fur, floating pulse is counted accurately as cardinal symptom.
Treat a Chinese medicine composition for wind-cold type disease of cough and asthma, by the crude drug of following weight portion, made:
Herba Ephedrae (processed) 4-8 part, Ramulus Cinnamomi 4-8 part, Semen Armeniacae Amarum 7-13 part, Bulbus Fritillariae Thunbergii 7-13 part, Fructus Aurantii 7-13 part, Herba Houttuyniae 25-35 part, Semen Ginkgo 4-8 part, Bombyx Batryticatus 4-8 part, Pheretima 7-13 part, Radix Salviae Miltiorrhizae 7-13 part, Radix Platycodonis 4-8 part, Radix Glycyrrhizae 4-8 part.
In side, Herba Ephedrae, Ramulus Cinnamomi expelling cold and relieving exterior syndrome, relieving cough and asthma, be monarch drug; Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Herba Houttuyniae, Fructus Aurantii preventing phlegm from forming and stopping coughing, Semen Ginkgo lowering the adverse-rising QI to resolve phlegm, is ministerial drug; Bombyx Batryticatus, Pheretima, Radix Salviae Miltiorrhizae promoting blood circulation to remove obstruction in the collateral, strengthen preventing phlegm from forming and stopping coughing, spasmolytic antiasthmatic effect, is adjuvant drug; Radix Glycyrrhizae QI invigorating and in, coordinating the actions of various ingredients in a prescription, the expectoration of Radix Platycodonis lung qi dispersing, priming are up, for making medicine.
embodiment 1 Chinese medicine composition
6 parts of Herba Ephedrae (processed), 6 parts of Ramulus Cinnamomi, 10 parts of Semen Armeniacae Amarums, 10 parts of Bulbus Fritillariae Thunbergiis, 10 parts of Fructus Aurantiis, 30 parts of Herba Houttuyniae, 6 parts of Semen Ginkgoes, 6 parts of Bombyx Batryticatus, 10 parts of Pheretimas, 10 parts of Radix Salviae Miltiorrhizaes, 6 parts of Radix Platycodoniss, 6 parts, Radix Glycyrrhizae.
embodiment 2 Chinese medicine compositions
5 parts of Herba Ephedrae (processed), 7 parts of Ramulus Cinnamomi, 9 parts of Semen Armeniacae Amarums, 11 parts of Bulbus Fritillariae Thunbergiis, 9 parts of Fructus Aurantiis, 32 parts of Herba Houttuyniae, 5 parts of Semen Ginkgoes, 7 parts of Bombyx Batryticatus, 9 parts of Pheretimas, 11 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Platycodoniss, 7 parts, Radix Glycyrrhizae.
embodiment 3 Chinese medicine compositions
7 parts of Herba Ephedrae (processed), 5 parts of Ramulus Cinnamomi, 11 parts of Semen Armeniacae Amarums, 9 parts of Bulbus Fritillariae Thunbergiis, 11 parts of Fructus Aurantiis, 28 parts of Herba Houttuyniae, 7 parts of Semen Ginkgoes, 5 parts of Bombyx Batryticatus, 11 parts of Pheretimas, 9 parts of Radix Salviae Miltiorrhizaes, 7 parts of Radix Platycodoniss, 5 parts, Radix Glycyrrhizae.
embodiment 4 Chinese medicine compositions
4 parts of Herba Ephedrae (processed), 8 parts of Ramulus Cinnamomi, 7 parts of Semen Armeniacae Amarums, 13 parts of Bulbus Fritillariae Thunbergiis, 7 parts of Fructus Aurantiis, 35 parts of Herba Houttuyniae, 4 parts of Semen Ginkgoes, 8 parts of Bombyx Batryticatus, 7 parts of Pheretimas, 13 parts of Radix Salviae Miltiorrhizaes, 4 parts of Radix Platycodoniss, 8 parts, Radix Glycyrrhizae.
embodiment 5 Chinese medicine compositions
8 parts of Herba Ephedrae (processed), 4 parts of Ramulus Cinnamomi, 13 parts of Semen Armeniacae Amarums, 7 parts of Bulbus Fritillariae Thunbergiis, 13 parts of Fructus Aurantiis, 25 parts of Herba Houttuyniae, 8 parts of Semen Ginkgoes, 4 parts of Bombyx Batryticatus, 13 parts of Pheretimas, 7 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Platycodoniss, 4 parts, Radix Glycyrrhizae.
the preparation of embodiment 6 Chinese medicine compositions
The arbitrary described Chinese medicine composition of embodiment 1-5, decocts with water 1000ml, boil and get 400ml, minute sooner or later 2 times oral, decoction being taken warmly after meal.
the preparation of embodiment 7 Chinese medicine compositions
Any dosage form that the arbitrary described Chinese medicine composition of embodiment 1-5 pharmaceutically allows by the preparation of conventional formulation means, such as granule, capsule, tablet, pill, oral liquid etc.
embodiment 8 clinical trials
1. physical data
The 100 routine wind-cold type cough with asthma patients that during 2012 in December, 1 to 2013, accept for medical treatment the court are divided at random two groups and treat, each 50 examples of every group of patient, treatment group man 45 examples wherein, female's 5 examples, 12～70 years old age, 41.5 years old mean age, the course of disease 2～36 years; Matched group man 44 examples, female's 6 examples, 16～72 years old age, 43.6 years old mean age, the course of disease 2～38 years; The ordinary circumstance difference not statistically significants (P > 0. 05) such as two groups of patients' sex, age, have comparability.
2. diagnostic criteria
Chinese medical discrimination diagnosis wind-cold type cough with asthma, with fever with aversion to cold, lossless, cough and expectoration, the color white matter of coughing up phlegm is rare, sound of the sputum in the throat, body of the tongue is light red, white and thin fur, floating pulse is counted accurately as cardinal symptom.
3. Therapeutic Method
The Chinese medicine composition for the treatment of group: embodiment 1, decocts with water 1000ml, boil and get 400ml, minute sooner or later 2 times oral, decoction being taken warmly after meal.Within 7 days, be 1 course for the treatment of, take continuously 5 courses for the treatment of.
Matched group: the method that adopts Western medicine symptomatic treatment: antibiotic is with amoxicillin or Yan Di etc. and give to the ill the medicines such as relieving cough and asthma.Instructions of taking: amoxicillin 0.5g, 4 times/d, Yan Di 150mg/ time, 2 times/d; As breathe heavily very person and can give aminophylline 0.1g/ time, 3 times/d; Abundant expectoration person gives compound Radix Glycyrrhizae mixture and CHUANBEI ZHIKE TANGJIANG.Within 7 days, be 1 course for the treatment of, take continuously 5 courses for the treatment of.
4. statistical method
Adopt SPSS13.0 statistics software to carry out date processing, measurement data adopts mean ± standard deviation to represent, relatively applies χ between group
2check, the P < 0.05 of take has statistical significance as difference.
5. curative effect determinate standard
1. clinic control: patient, after treatment, pants, the clinical symptom disappearance such as cough, auscultation of lung wheezing sound or substantially disappear.2. effective: after treatment, the clinical symptoms such as cough with asthma and sign are obviously improved.3. effective: cough with asthma symptom obviously alleviates, there is improvement to a certain degree.4. invalid: the indexs such as clinical symptoms and sign are all not improved.
6. index determining
Before and after two groups of patient treatments, all adopt immune turbidimetry to detect serum immune globulin IgA, IgG, IgM content, and be analyzed.
7. result
The comparison of 7.1 liang of group patient curative effects
In therapeutic process there is not significant discomfort case in treatment group.Two groups of wind-cold type cough with asthma patients are after the treatment of 5 courses for the treatment of, and treatment group total effective rate is 94%, and matched group total effective rate is that 66%, two group of patient's total effective rate difference has statistical significance (P < 0.05).Illustrate that the curative effect for the treatment of group is apparently higher than matched group, concrete outcome is in Table 1.
The Comparison of therapeutic of table 1 treatment group and matched group
The IgA of immunoglobulin after 7.2 liang of group patient treatments, IgG, IgM content balance is analyzed
After the treatment of 5 courses for the treatment of, treatment group patient's Immunoglobulin IgA, IgG, the level of IgM is apparently higher than matched group, and difference has statistical significance (P < 0.05), the results are shown in Table 2.
Immunoglobulin contrast after table 2 liang group patient treatment
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (5)
1. a Chinese medicine composition for the treatment of wind-cold type disease of cough and asthma, it is characterized in that, described Chinese medicine composition is made by the crude drug of following weight portion: Herba Ephedrae (processed) 4-8 part, Ramulus Cinnamomi 4-8 part, Semen Armeniacae Amarum 7-13 part, Bulbus Fritillariae Thunbergii 7-13 part, Fructus Aurantii 7-13 part, Herba Houttuyniae 25-35 part, Semen Ginkgo 4-8 part, Bombyx Batryticatus 4-8 part, Pheretima 7-13 part, Radix Salviae Miltiorrhizae 7-13 part, Radix Platycodonis 4-8 part, Radix Glycyrrhizae 4-8 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is made by the crude drug of following weight portion: Herba Ephedrae (processed) 5-7 part, Ramulus Cinnamomi 5-7 part, Semen Armeniacae Amarum 9-11 part, Bulbus Fritillariae Thunbergii 9-11 part, Fructus Aurantii 9-11 part, Herba Houttuyniae 28-32 part, Semen Ginkgo 5-7 part, Bombyx Batryticatus 5-7 part, Pheretima 9-11 part, Radix Salviae Miltiorrhizae 9-11 part, Radix Platycodonis 5-7 part, Radix Glycyrrhizae 5-7 part.
3. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is made by the crude drug of following weight portion: 6 parts of Herba Ephedrae (processed), 6 parts of Ramulus Cinnamomi, 10 parts of Semen Armeniacae Amarums, 10 parts of Bulbus Fritillariae Thunbergiis, 10 parts of Fructus Aurantiis, 30 parts of Herba Houttuyniae, 6 parts of Semen Ginkgoes, 6 parts of Bombyx Batryticatus, 10 parts of Pheretimas, 10 parts of Radix Salviae Miltiorrhizaes, 6 parts of Radix Platycodoniss, 6 parts, Radix Glycyrrhizae.
4. the application in the medicine of preparation treatment wind-cold type disease of cough and asthma according to the arbitrary described Chinese medicine composition of claim 1-3.
5. application according to claim 4, is characterized in that, described wind-cold type cough with asthma refers to the acute and chronic bronchitis of wind-cold type, bronchial asthma.
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Cited By (1)
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| CN110575505A (en) * | 2019-09-09 | 2019-12-17 | 首都医科大学附属北京朝阳医院 | Medicine for treating acute bronchitis and acute attack of chronic bronchitis and preparation method and application thereof |
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| CN110575505A (en) * | 2019-09-09 | 2019-12-17 | 首都医科大学附属北京朝阳医院 | Medicine for treating acute bronchitis and acute attack of chronic bronchitis and preparation method and application thereof |
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