CN105998992A - 一种治疗急性牙周炎的中药复方 - Google Patents
一种治疗急性牙周炎的中药复方 Download PDFInfo
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Abstract
本发明公开了一种治疗急性牙周炎的中药复方,由以下原料制成:雷公笋、树仔菜、乌点规、眼子菜、雾水葛、画眉草、爵床、狗肝菜、田基黄、鸡骨草、狗牙草、紫薇花、槐花、异麦芽酮糖、蜂胶、伏龙肝、青盐、寒水石、纤维素酶、果胶酶、蜂胎素、维生素C。本发明提供的治疗急性牙周炎的中药复方,疗效快速,有效率高达100%,治愈率为77%;维生素C经纯天然提取,安全健康,无毒副作用,提取率高达12.1%,提高利用率;所有中药经多次提取和纯化,得率提高16.3%,节约大量生产成本;口感清香淡甜,无中药异味,使用简单,能够清热除湿,快速抗菌,消炎止痛,促进损伤组织的再生与修复,达到治愈急性牙周炎的目的。
Description
技术领域
本发明主要涉及医药技术领域,尤其涉及一种治疗急性牙周炎的中药复方。
背景技术
牙周炎是累及四种牙周支持组织(牙龈、牙周膜、牙槽骨和牙骨质)的慢性感染性疾病,往往引发牙周支持组织的炎性破坏,牙周炎主要分为慢性牙周炎、急性牙周炎、反映全身疾病的牙周炎、坏死性牙周病。急性牙周炎初起时牙龈肿胀,影响进餐,中医认为,急性牙周炎是湿热熏蒸所致,应该清化湿热,抗菌消炎。牙周炎治疗的目标为:(1)去除病因,消除炎症;(2)恢复软组织及骨的生理外形;(3)恢复功能,保持长久疗效;(4)促进牙周组织的再生;(5)满足美学需要。目前市场上治疗牙周炎的药物多为西药,但是治愈效果极不理想,存在治愈率低、药效缓慢、容易复发、有副作用的缺点,给患者带来严重的身体和精神困扰。
本发明经过多年研究,牙周炎治疗的目标为依据,克服现有治疗牙周炎药物的不足,开发出治愈率高、见效快、不复发、无毒副作用、价格低廉的治疗牙周炎的中药复方。
发明内容
为了弥补已有技术的缺陷,本发明的目的是提供一种治疗急性牙周炎的中药复方。
一种治疗急性牙周炎的中药复方,由以下重量份的原料制成:雷公笋16~18、树仔菜16~18、乌点规15~17、眼子菜13~15、雾水葛13~15、画眉草12~14、爵床11~13、狗肝菜11~13、田基黄10~12、鸡骨草10~12、狗牙草9~11、紫薇花9~11、槐花9~11、异麦芽酮糖7~9、蜂胶7~9、伏龙肝6~8、青盐4~6、寒水石4~6、纤维素酶0.24~0.26、果胶酶0.13~0.15、蜂胎素0.07~0.09、维生素C 0.05~0.07。
优选地,所述的治疗急性牙周炎的中药复方,由以下重量份的原料制成:雷公笋18、树仔菜17、乌点规17、眼子菜15、雾水葛14、画眉草14、爵床13、狗肝菜12、田基黄12、鸡骨草11、狗牙草11、紫薇花10、槐花9、异麦芽酮糖9、蜂胶9、伏龙肝8、青盐6、寒水石5、纤维素酶0.25、果胶酶0.14、蜂胎素0.08、维生素C 0.06。
所述的维生素C,取地石榴、杈把果、仙人果、香蜜果、猕猴桃及飞碟瓜中的一种或几种,洗净,沥水,得维生素C原料,加入维生素C原料重量0.6~0.8倍量的体积分数为2.1~2.3%的醋酸溶液,打浆,过100~120目筛,加入维生素C原料重量1.2~1.4倍量的体积分数为1.4~1.6%的醋酸溶液,密闭,于4℃、54~56转/分钟震荡浸提5~6小时,过滤,得滤液和滤渣,重复浸提3次,合并所有滤液,8000转/分钟离心15分钟,取上清,过0.22μm的滤膜,冷冻干燥至无水分,无有毒试剂,安全健康,提取率高,得维生素C。
一种治疗急性牙周炎的中药复方的制备方法,其具体步骤包括:
(1)将雷公笋、树仔菜、乌点规、眼子菜、雾水葛、画眉草、爵床、狗肝菜、田基黄、鸡骨草、狗牙草、紫薇和槐花粉碎,过80~100目筛,得植物料粉,加入植物料粉重量3~4倍量的蒸馏水,42~44℃水浴,加入纤维素酶和果胶酶,36~38转/分钟搅拌酶解220~240分钟,破坏植物组织结构,提高提取率,得植物酶解料;
(2)将植物酶解料置于90~95℃水浴,36~38kHz超声浸提35~40分钟,5000转/分钟离心10分钟,得提取液A和植物药渣A,向植物药渣A中加入植物药渣A重量2~3倍量的蒸馏水,33~35kHz超声浸提25~30分钟,6000转/分钟离心10分钟,得提取液B和植物药渣B,向植物药渣B中加入植物药渣B重量2~3倍量的体积分数为76~78%的酒精溶液,密闭,64~66℃水浴,31~33kHz超声浸提30~35分钟,8000转/分钟离心10分钟,得提取液C和植物药渣C,合并所有提取液,过120~140目筛,置于80~85℃烘箱,浓缩至原体积的1/3,得植物提取液;
(3)将伏龙肝、青盐和寒水石粉碎,过80~100目筛,得石粉,加入石粉重量5~7倍量的水,大火煮沸,小火熬煮35~40分钟,取出上清液,重新加水,重复熬煮提取3次,合并所有熬煮液,过0.45μm的滤膜,浓缩至石粉重量的2倍,得石粉提取液;
(4)将植物提取液、石粉提取液和蜂胶混合均匀,得中药提取液,向中药提取液中加入中药提取液体积1/5量的乙醚,48~50转/分钟震荡40~50分钟,静置20~30分钟,分离乙醚层和水层,保留水层,得水层提取液,将水层提取液加入分子量为32kD的透析袋中,流水透析22~24小时,取出,于45~47℃真空浓缩至所有原料重量的1/2,加入异麦芽酮糖、蜂胎素和维生素C,得治疗急性牙周炎的中药复方;
(5)分为100份,制备成制剂,包装,34~36℃,119~121MPa超高压杀菌20~25分钟,得成品。
所述步骤(5)的制剂,为片剂或喷雾液体。
所述的治疗急性牙周炎的中药复方,服用方法为每日3次,每餐饭后咀嚼一片或向口中喷雾两下。
本发明的优点是:本发明提供的一种治疗急性牙周炎的中药复方,原料丰富,疗效快速,有效率高达100%,治愈率为77%;原料易得,价格低廉,减轻患者的经济负担;维生素C经纯天然提取,安全健康,无毒副作用,提取率高达12.1%,提高利用率;所有中药经多次提取和纯化,得率提高16.3%,节约大量生产成本;口感清香淡甜,无中药异味,患者不会有抵触感,使用简单,患者只需饭后咀嚼一片或喷雾两下,能够清热除湿,快速抗菌,消炎止痛,促进损伤组织的再生与修复,达到治愈急性牙周炎的目的。
具体实施方式
下面用具体实施例说明本发明。
实施例1
一种治疗急性牙周炎的中药复方,由以下重量份的原料制成:雷公笋18、树仔菜17、乌点规17、眼子菜15、雾水葛14、画眉草14、爵床13、狗肝菜12、田基黄12、鸡骨草11、狗牙草11、紫薇花10、槐花9、异麦芽酮糖9、蜂胶9、伏龙肝8、青盐6、寒水石5、纤维素酶0.25、果胶酶0.14、蜂胎素0.08、维生素C 0.06。
所述的维生素C,取地石榴、杈把果、仙人果、香蜜果、猕猴桃及飞碟瓜中的一种或几种,洗净,沥水,得维生素C原料,加入维生素C原料重量0.7倍量的体积分数为2.2%的醋酸溶液,打浆,过120目筛,加入维生素C原料重量1.4倍量的体积分数为1.6%的醋酸溶液,密闭,于4℃、54转/分钟震荡浸提6小时,过滤,得滤液和滤渣,重复浸提3次,合并所有滤液,8000转/分钟离心15分钟,取上清,过0.22μm的滤膜,冷冻干燥至无水分,无有毒试剂,安全健康,提取率高,得维生素C。
一种治疗急性牙周炎的中药复方的制备方法,其具体步骤包括:
(1)将雷公笋、树仔菜、乌点规、眼子菜、雾水葛、画眉草、爵床、狗肝菜、田基黄、鸡骨草、狗牙草、紫薇和槐花粉碎,过100目筛,得植物料粉,加入植物料粉重量4倍量的蒸馏水,44℃水浴,加入纤维素酶和果胶酶,38转/分钟搅拌酶解240分钟,破坏植物组织结构,提高提取率,得植物酶解料;
(2)将植物酶解料置于95℃水浴,38kHz超声浸提40分钟,5000转/分钟离心10分钟,得提取液A和植物药渣A,向植物药渣A中加入植物药渣A重量3倍量的蒸馏水,35kHz超声浸提30分钟,6000转/分钟离心10分钟,得提取液B和植物药渣B,向植物药渣B中加入植物药渣B重量3倍量的体积分数为78%的酒精溶液,密闭,64℃水浴,31kHz超声浸提35分钟,8000转/分钟离心10分钟,得提取液C和植物药渣C,合并所有提取液,过140目筛,置于85℃烘箱,浓缩至原体积的1/3,得植物提取液;
(3)将伏龙肝、青盐和寒水石粉碎,过100目筛,得石粉,加入石粉重量7倍量的水,大火煮沸,小火熬煮40分钟,取出上清液,重新加水,重复熬煮提取3次,合并所有熬煮液,过0.45μm的滤膜,浓缩至石粉重量的2倍,得石粉提取液;
(4)将植物提取液、石粉提取液和蜂胶混合均匀,得中药提取液,向中药提取液中加入中药提取液体积1/5量的乙醚,50转/分钟震荡45分钟,静置30分钟,分离乙醚层和水层,保留水层,得水层提取液,将水层提取液加入分子量为32kD的透析袋中,流水透析24小时,取出,于45℃真空浓缩至所有原料重量的1/2,加入异麦芽酮糖、蜂胎素和维生素C,得治疗急性牙周炎的中药复方;
(5)分为100份,制备成片剂,包装,34℃,121MPa超高压杀菌25分钟,得成品。
所述的治疗急性牙周炎的中药复方,服用方法为每日3次,每餐饭后咀嚼一片。
实施例2
一种治疗急性牙周炎的中药复方,由以下重量份的原料制成:雷公笋18、树仔菜18、乌点规17、眼子菜15、雾水葛15、画眉草14、爵床13、狗肝菜13、田基黄12、鸡骨草12、狗牙草11、紫薇花11、槐花11、异麦芽酮糖9、蜂胶9、伏龙肝8、青盐6、寒水石6、纤维素酶0.26、果胶酶0.15、蜂胎素0.09、维生素C 0.07。
制备方法,同实施例1,制成喷雾液体,每日3次,每餐饭后喷雾2下。
对比例
市售普通治疗急性牙周炎的药物。
实施例和对比例药剂的抑菌效果:
分别取实施例和对比例的药剂100㎎,加等量的蒸馏水稀释,混合均匀,加入胨链球菌、葡萄球菌、奈瑟氏菌、酶乳杆菌和唾液链球菌的培养皿中,进行抑菌试验,培养12~14小时,利用游标卡尺测量抑菌圈的直径大小,实施例和对比例药剂的抑菌效果见表1。
表1:实施例和对比例药剂的抑菌效果
从表1可以看出,实施例的治疗急性牙周炎的中药复方,作用于胨链球菌、葡萄球菌、奈瑟氏菌、酶乳杆菌和唾液链球菌,实施例的各细菌抑菌圈直径均明显大于对比例,对细菌的抑制效果明显优于对比例,说明实施例治疗急性牙周炎的中药复方有明显的抑菌效果。
实施例和对比例药剂治疗急性牙周炎的效果:
用法用量:每日3次,每餐饭后咀嚼1片,连续使用15天。
试验病例:
疗效判定标准:
有效:牙周炎面积减小,出血、红肿及疼痛症状减轻,有所好转;
治愈:牙周炎面积消失,出血、红肿及疼痛症状消失。
随机选择患者200例,选择的标准是:符合西医诊断标准和中医辩证标准、年龄在18~55岁之间,其中,女性100例,男性100例。随机将上述病例分成实施例组和对比例组,各100人,男女各半,实施例和对比例药剂治疗急性牙周炎的效果见表2。
表2:实施例和对比例药剂治疗急性牙周炎的效果
项目 | 患者数 | 有效/(%) | 治愈/(%) | 起效时间/(小时) |
实施例组 | 100 | 100 | 77 | 3.5 |
对比例组 | 100 | 89 | 63 | 2 |
从表2可以看出,实施例的治疗急性牙周炎的中药复方,实施例的有效率为100%,治愈率为77%,作用效果快,说明实施例治疗急性牙周炎的中药复方具有明显的治疗急性牙周炎效果。
Claims (6)
1.一种治疗急性牙周炎的中药复方,其特征在于,由以下重量份的原料制成:雷公笋16~18、树仔菜16~18、乌点规15~17、眼子菜13~15、雾水葛13~15、画眉草12~14、爵床11~13、狗肝菜11~13、田基黄10~12、鸡骨草10~12、狗牙草9~11、紫薇花9~11、槐花9~11、异麦芽酮糖7~9、蜂胶7~9、伏龙肝6~8、青盐4~6、寒水石4~6、纤维素酶0.24~0.26、果胶酶0.13~0.15、蜂胎素0.07~0.09、维生素C
0.05~0.07。
2.根据权利要求1所述的治疗急性牙周炎的中药复方,其特征在于,由以下重量份的原料制成:雷公笋18、树仔菜17、乌点规17、眼子菜15、雾水葛14、画眉草14、爵床13、狗肝菜12、田基黄12、鸡骨草11、狗牙草11、紫薇花10、槐花9、异麦芽酮糖9、蜂胶9、伏龙肝8、青盐6、寒水石5、纤维素酶0.25、果胶酶0.14、蜂胎素0.08、维生素C 0.06。
3.根据权利要求1所述的治疗急性牙周炎的中药复方,其特征在于,所述的维生素C,取地石榴、杈把果、仙人果、香蜜果、猕猴桃及飞碟瓜中的一种或几种,洗净,沥水,得维生素C原料,加入维生素C原料重量0.6~0.8倍量的体积分数为2.1~2.3%的醋酸溶液,打浆,过100~120目筛,加入维生素C原料重量1.2~1.4倍量的体积分数为1.4~1.6%的醋酸溶液,密闭,于4℃、54~56转/分钟震荡浸提5~6小时,过滤,得滤液和滤渣,重复浸提3次,合并所有滤液,8000转/分钟离心15分钟,取上清,过0.22μm的滤膜,冷冻干燥至无水分,得维生素C。
4.根据权利要求1所述治疗急性牙周炎的中药复方的制备方法,其特征在于,包括以下步骤:
(1)将雷公笋、树仔菜、乌点规、眼子菜、雾水葛、画眉草、爵床、狗肝菜、田基黄、鸡骨草、狗牙草、紫薇和槐花粉碎,过80~100目筛,得植物料粉,加入植物料粉重量3~4倍量的蒸馏水,42~44℃水浴,加入纤维素酶和果胶酶,36~38转/分钟搅拌酶解220~240分钟,得植物酶解料;
(2)将植物酶解料置于90~95℃水浴,36~38kHz超声浸提35~40分钟,5000转/分钟离心10分钟,得提取液A和植物药渣A,向植物药渣A中加入植物药渣A重量2~3倍量的蒸馏水,33~35kHz超声浸提25~30分钟,6000转/分钟离心10分钟,得提取液B和植物药渣B,向植物药渣B中加入植物药渣B重量2~3倍量的体积分数为76~78%的酒精溶液,密闭,64~66℃水浴,31~33kHz超声浸提30~35分钟,8000转/分钟离心10分钟,得提取液C和植物药渣C,合并所有提取液,过120~140目筛,置于80~85℃烘箱,浓缩至原体积的1/3,得植物提取液;
(3)将伏龙肝、青盐和寒水石粉碎,过80~100目筛,得石粉,加入石粉重量5~7倍量的水,大火煮沸,小火熬煮35~40分钟,取出上清液,重新加水,重复熬煮提取3次,合并所有熬煮液,过0.45μm的滤膜,浓缩至石粉重量的2倍,得石粉提取液;
(4)将植物提取液、石粉提取液和蜂胶混合均匀,得中药提取液,向中药提取液中加入中药提取液体积1/5量的乙醚,48~50转/分钟震荡40~50分钟,静置20~30分钟,分离乙醚层和水层,保留水层,得水层提取液,将水层提取液加入分子量为32kD的透析袋中,流水透析22~24小时,取出,于45~47℃真空浓缩至所有原料重量的1/2,加入异麦芽酮糖、蜂胎素和维生素C,得治疗急性牙周炎的中药复方;
(5)分为100份,制备成制剂,包装,34~36℃,119~121MPa超高压杀菌20~25分钟,得成品。
5.根据权利要求1所述治疗急性牙周炎的中药复方的制备方法,其特征在于,所述步骤(5)的制剂,为片剂或喷雾液体。
6.根据权利要求1~5所治疗急性牙周炎的中药复方的服用方法,其特征在于,每日3次,每餐饭后咀嚼一片或向口中喷雾两下。
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