CN105998559A - 治疗帕金森病的中药组合物 - Google Patents
治疗帕金森病的中药组合物 Download PDFInfo
- Publication number
- CN105998559A CN105998559A CN201610621767.5A CN201610621767A CN105998559A CN 105998559 A CN105998559 A CN 105998559A CN 201610621767 A CN201610621767 A CN 201610621767A CN 105998559 A CN105998559 A CN 105998559A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- chinese medicine
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 9
- 208000018737 Parkinson disease Diseases 0.000 title abstract description 11
- 241001290564 Fimbristylis Species 0.000 claims abstract description 6
- 241000244013 Paraboea dictyoneura Species 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000706 filtrate Substances 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 241000218236 Cannabis Species 0.000 claims description 5
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 239000002893 slag Substances 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 12
- 230000017531 blood circulation Effects 0.000 abstract description 6
- 210000004185 liver Anatomy 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 230000001914 calming effect Effects 0.000 abstract description 3
- 241000227129 Aconitum Species 0.000 abstract 1
- 241001061264 Astragalus Species 0.000 abstract 1
- 241000202726 Bupleurum Species 0.000 abstract 1
- 244000025254 Cannabis sativa Species 0.000 abstract 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 abstract 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 240000006766 Cornus mas Species 0.000 abstract 1
- 241000501743 Gentiana macrophylla Species 0.000 abstract 1
- 241000830535 Ligustrum lucidum Species 0.000 abstract 1
- 241000157491 Morinda Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241001522129 Pinellia Species 0.000 abstract 1
- 240000009022 Smilax rotundifolia Species 0.000 abstract 1
- 235000003205 Smilax rotundifolia Nutrition 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 240000007267 Stephania hernandifolia Species 0.000 abstract 1
- 241000205578 Thalictrum Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 235000009120 camo Nutrition 0.000 abstract 1
- 235000005607 chanvre indien Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000011487 hemp Substances 0.000 abstract 1
- 235000017524 noni Nutrition 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 208000002173 dizziness Diseases 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 6
- 206010044565 Tremor Diseases 0.000 description 6
- 230000036461 convulsion Effects 0.000 description 6
- 206010010904 Convulsion Diseases 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
- 210000003414 extremity Anatomy 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 235000014347 soups Nutrition 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 208000033240 Progressive symmetric erythrokeratodermia Diseases 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 210000001364 upper extremity Anatomy 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000021760 high fever Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010051290 Central nervous system lesion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010037714 Quadriplegia Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000008361 herbal raw material Substances 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 229960000715 nimodipine Drugs 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种药物配方领域,具体地说是一种治疗帕金森病的中药组合物,其特征在于由如下重量份的原料药制成:赤芍17~22,鸡血藤13~17,山茱萸17~22,柴胡3~7,岩扫把13~17,羌活17~22,鞘菝葜17~22,巴戟天13~17,秦艽17~22,女贞子22~28,大还魂13~17,千金藤3~7,硬飘拂草13~17,狗脊8~12,黄连8~12,麻仁5~10,黄芪13~17,白附子8~12,合欢皮8~12,半夏17~22,将上述原料用水浸泡,煎熬后去渣得滤液。本发明成本低,治疗帕金森病疗效高,无毒副作用,具有补益、滋阴、平肝、熄风、活血、化瘀的功能。
Description
技术领域
本发明涉及一种中成药制剂,具体地说是一种治疗帕金森病的中药组合物。
背景技术
众所周知,帕金森病是一种严重危害中老年健康的以黑质-纹状体多巴胺神经元进行性变性、多巴胺递质缺乏为主要病理生化基础的中枢神经系统退行性疾病。我国初步估计该病患病率为57/10万人以上,随着社会老龄化进展和寿命的延长,其患病率逐步升高。目前,所有的治疗措施仍停留在对症治疗阶段,且长期应用会产生疗效减退及症状波动、异动症等难以克服的副作用。
发明内容
本发明的目的就是为了克服上述现有的技术不足,提供一种治疗帕金森病的中药组合物,成本低,治疗帕金森病疗效高,无毒副作用,具有补益、滋阴、平肝、熄风、活血、化瘀的功能。
本发明解决上述技术问题采用的技术方案是:一种治疗帕金森病的中药组合物,其特征在于由如下重量份的原料药制成:赤芍17~22,鸡血藤13~17,山茱萸17~22,柴胡3~7,岩扫把13~17,羌活17~22,鞘菝葜17~22,巴戟天13~17,秦艽17~22,女贞子22~28,大还魂13~17,千金藤3~7,硬飘拂草13~17,狗脊8~12,黄连8~12,麻仁5~10,黄芪13~17,白附子8~12,合欢皮8~12,半夏17~22,将上述原料用水浸泡,煎熬后去渣得滤液。
本发明的有益效果是,成本低,治疗帕金森病疗效高,无毒副作用,具有补益、滋阴、平肝、熄风、活血、化瘀的功能。
具体实施方式
下面结合实施例对本发明作进一步的描述:
实施例1:
由如下重量份的原料药制备而成,赤芍20,鸡血藤15,山茱萸20,柴胡5,岩扫把15,羌活20,鞘菝葜20,巴戟天15,秦艽20,女贞子25,大还魂15,千金藤5,硬飘拂草15,狗脊10,黄连10,麻仁8,黄芪15,白附子10,合欢皮10,半夏20。取上述20味中草药原料,总重量为200克加净化水1000毫升,浸泡6小时,然后用武火煮沸文火煎熬120分钟,去渣得滤液约150毫升,药渣再加水200毫升,煎熬30分钟,去渣得滤液约30毫升,共得约180毫升药汁,每日分早中晚3次口服,每次约60毫升温药汤空腹服用,30天为一个病程。
本发明赤芍有清热凉血,活血祛瘀的功效;鸡血藤具有活血舒筋,养血调经的功效。治风湿痹痛,手足麻木,肢体瘫痪;山茱萸具有滋补,健胃,利尿,补肝肾,益气血等功效;柴胡有和解表里,疏肝升阳之功效;岩扫把祛风清热解毒,治小儿惊风抽搐;羌活用于外感风寒,头痛无汗,寒湿痹,上肢风湿疼痛;鞘菝葜祛风除湿,活血顺气,止痛;巴戟天主治阳痿遗精,宫冷不孕,月经不调,少腹冷痛,风湿痹痛,筋骨痿软;秦艽祛风湿,清湿热,止痹痛。用于筋脉拘挛,骨节酸痛;女贞子补益肝肾,明目,清虚热。主治:头晕目眩,须发早白,视物昏花;大还魂活血散瘀,消肿止痛;千金藤清热解毒,利尿消肿,祛风活络;硬飘拂草滋阴润燥,补虚益损。治虚弱头晕,痨伤盗汗;狗脊用于风湿痹痛,腰膝酸软,下肢无力;黄连有清热燥湿,泻火解毒之功效;麻仁治水肿,利小便,破积血,疏通血脉;黄芪具有补气固表,利水退肿,托毒排脓,生肌等功效;白附子具有祛风痰,定惊搐,解毒散结,止痛的功效;合欢皮有解郁,和血,宁心,消痈肿之功。有治心神不安,忧郁,失眠功效;半夏燥湿化痰,降逆止呕,消痞散结。用于痰多咳喘,痰饮眩悸,风痰眩晕,痰厥头痛。全方配伍严谨,诸药配合,气血并顾,益气健脾以固本虚,标本兼治,相得益彰。
本发明各原料还可按下表所列重量比例混合的实施例来实现。其加工工艺与实施例1相同。(单位:重量份)
实施例 | 赤芍 | 鸡血藤 | 山茱萸 | 柴胡 | 岩扫把 | 羌活 | 鞘菝葜 | 巴戟天 | 秦艽 | 女贞子 | 大还魂 | 千金藤 | 硬飘拂草 | 狗脊 | 黄连 | 麻仁 | 黄芪 | 白附子 | 合欢皮 | 半夏 |
二 | 17 | 17 | 17 | 7 | 13 | 22 | 17 | 17 | 17 | 28 | 13 | 7 | 13 | 12 | 8 | 10 | 13 | 12 | 8 | 22 |
三 | 22 | 13 | 22 | 3 | 17 | 17 | 22 | 13 | 22 | 22 | 17 | 3 | 17 | 8 | 12 | 5 | 17 | 8 | 12 | 17 |
下面结合我院进行的临床试验对本发明作进一步、详细地描述:
临床资料:临床观察帕金森病患者80例。
一、诊断依据:
依据1992年中华全国中医学会老年医学会《中医老年帕金森病诊断和疗效评定标准》。
1)主症:头或肢体颤振,少动,肢体拘痉,颈背僵直。
2)兼症;表情呆板,头胸前倾,言语壅涩,上肢协调不能,皮脂外溢,口角流挺,智力减退或精神碍障,生活自理能力降低。
3)发病年龄在55岁以上。
4)发病诱因:可有明显诱因,如感受外邪,中毒或脑部病变,也可无诱因。
5)慢性起病或进行性加重。
具有主症两个以上,慢性起病或进行性加重,结合年龄、诱因等特点可确诊为老年帕金森病。
二、治疗方法:
对照组:常规使用美多芭0.25g(生产厂家:上海罗氏制药厂,批号:200207),口服,每日3次。30天为1个疗程。
治疗组:服用实施例一药液,每日分早中晚3次口服,每次约60毫升温药汤空腹服用,共治疗3个月。
三、疗效评价标准:
根据改良Webster症状评分方法及中医老年帕金森病诊断和疗效评定标准中的评分方法。应用尼莫地平法进行评分,疗效指数=(治疗后得分-治疗前得分)/治疗前得分×100%。
四、治疗结果:
对照组:显效7例,有效20例,无效13例,有效率为67.5%。
治疗组:显效10例,有效28例,无效2例,有效率为95%。
典型病例:
邓某某,男,71岁。右上肢震颤,休息及情绪激动时震颤明显,走路不稳,伴头晕纳差,口苦口干,肢体僵硬,腰膝酸软,中医诊断为帕金森病。每日分早中晚3次口服,每次约60毫升温药汤空腹服用。共服药50剂诸症消失,病痊愈,随访至今未复发。
胡某某,男,65岁。患者出现右肢不自主震颤,行走不平稳,面部表情僵硬,伴头晕耳鸣,失眠多梦,口干,中医诊断为帕金森病。每日分早中晚3次口服,每次约60毫升温药汤空腹服用。服药30剂震颤明显减轻,夜间睡眠好转,食欲转佳,生活能够自理,精神较前明显好转。
Claims (1)
1.一种治疗帕金森病的中药组合物,其特征在于由如下重量份的原料药制成:赤芍17~22,鸡血藤13~17,山茱萸17~22,柴胡3~7,岩扫把13~17,羌活17~22,鞘菝葜17~22,巴戟天13~17,秦艽17~22,女贞子22~28,大还魂13~17,千金藤3~7,硬飘拂草13~17,狗脊8~12,黄连8~12,麻仁5~10,黄芪13~17,白附子8~12,合欢皮8~12,半夏17~22,将上述原料药用水浸泡,煎熬后去渣得滤液。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610621767.5A CN105998559A (zh) | 2016-08-02 | 2016-08-02 | 治疗帕金森病的中药组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610621767.5A CN105998559A (zh) | 2016-08-02 | 2016-08-02 | 治疗帕金森病的中药组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105998559A true CN105998559A (zh) | 2016-10-12 |
Family
ID=57134424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610621767.5A Pending CN105998559A (zh) | 2016-08-02 | 2016-08-02 | 治疗帕金森病的中药组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105998559A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107233371A (zh) * | 2017-07-27 | 2017-10-10 | 广州中医药大学 | 大驳骨在制备预防和/或治疗神经退行性疾病的药物中的应用及药物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103239598A (zh) * | 2012-02-13 | 2013-08-14 | 杨明会 | 一种治疗帕金森病的中药组合物及其应用 |
CN103239597A (zh) * | 2012-02-13 | 2013-08-14 | 杨明会 | 一种治疗帕金森病的中药组合物的制备方法 |
-
2016
- 2016-08-02 CN CN201610621767.5A patent/CN105998559A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103239598A (zh) * | 2012-02-13 | 2013-08-14 | 杨明会 | 一种治疗帕金森病的中药组合物及其应用 |
CN103239597A (zh) * | 2012-02-13 | 2013-08-14 | 杨明会 | 一种治疗帕金森病的中药组合物的制备方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107233371A (zh) * | 2017-07-27 | 2017-10-10 | 广州中医药大学 | 大驳骨在制备预防和/或治疗神经退行性疾病的药物中的应用及药物 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101912572B (zh) | 一种多效外用膏药 | |
CN1253201C (zh) | 一种治疗偏头痛的药物 | |
CN104491435B (zh) | 一种治疗神经衰弱的中药制剂及制备方法 | |
CN103463586B (zh) | 一种治疗不安腿综合征的中药组合物 | |
CN104491675B (zh) | 活血化瘀汤 | |
CN1390585A (zh) | 神阙排毒中药组合物及其制备方法 | |
CN103239588B (zh) | 一种治疗颈椎病的中药组合物 | |
CN104258366A (zh) | 一种用于腰痛的中药制剂及其制备方法 | |
CN103721082B (zh) | 一种治疗肩周炎的中药组合物 | |
CN105412899A (zh) | 一种用于缓解红斑性肢痛病的中药制剂及其制备方法 | |
CN104784346A (zh) | 一种治疗瘙痒症的中药洗剂制备方法 | |
CN104771652A (zh) | 一种治疗眩晕的中药组合物 | |
CN105998559A (zh) | 治疗帕金森病的中药组合物 | |
CN103356932A (zh) | 一种治疗外阴鳞状上皮细胞增生的药物组合物 | |
CN103202985A (zh) | 治疗腰椎、颈椎、坐骨神经、风湿病的中药及其制备方法 | |
CN102988833B (zh) | 一种治疗风湿病的中药组合物 | |
CN102716244B (zh) | 治疗头痛山豆根中药制剂及制备方法 | |
CN101422577B (zh) | 一种治疗烫伤和烧伤的外用中药及其制备方法 | |
CN103127258A (zh) | 一种治疗风湿性关节炎的中药 | |
CN104922595A (zh) | 一种用于带状疱疹的中药制剂及其制备方法 | |
CN106109630A (zh) | 用于治疗颈椎病的中药组合物 | |
CN104758539A (zh) | 一种治疗乏力的中药组合物 | |
CN105213989A (zh) | 一种治疗痰湿内阻证型脑鸣的中药汤剂 | |
CN105079522A (zh) | 一种治疗慢性前列腺炎的药物 | |
CN105106786A (zh) | 一种通络舒筋的中药组合物及其制剂和制法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161012 |