CN105998372A - Traditional Chinese medicine composition for treating cervical spondylosis and preparation method of traditional Chinese medicine composition for treating cervical spondylosis - Google Patents
Traditional Chinese medicine composition for treating cervical spondylosis and preparation method of traditional Chinese medicine composition for treating cervical spondylosis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating cervical spondylosis and a preparation method of the traditional Chinese medicine composition for treating cervical spondylosis. The traditional Chinese medicine composition is prepared from Radix Angelicae Sinensis, Rhizoma Ligustici Wallichii, Radix Rehmanniae Preparata, Fructus Corni, Flos Carthami, Semen Persicae, Pheretima, Scolopendra, Fructus Lycii, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, zaocys dhumnade, Radix Astragali, Radix Codonopsis, Radix Puerariae, Rhizoma et Radix Notopterygii, Radix Saposhnikoviae, Caulis Piperis Kadsurae, Radix Paeoniae Alba, Radix Glycyrrhizae and the like. The traditional Chinese medicine composition is mainly used for treating cervical spondylosis.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating cervical spondylosis and preparation method thereof.
Background technology
Cervical spondylosis, also known as cervical spine syndrome, is osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, cervical vertebra
The general name of Spondylosis disease, is a kind of illness changing into basis with degeneration pathology.Strain for a long time mainly due to cervical vertebra, sclerotin
Hypertrophy, or prolapse of intervertebral disc, ligament thicken, and causes cervical vertebra spinal cord, nerve root or vertebral artery pressurized, a series of dysfunction occurs
Clinical syndrome.
Although there is no the name of disease of " cervical spondylosis " on tcm theory, but due to the symptom of cervical spondylosis and " arthromyodynia " of the traditional Chinese medical science
" myopathy " " headache " " dizziness " " stiffness of the nape " etc. are close seemingly, also have what is called " dislocation of bone, muscle goes out groove " etc. to describe in medical book.
Arthromyodynia is had by Plain Questions of Huangdi's Internal Classic described below: " wet three gas of wind and cold are miscellaneous extremely, combined into numbness also.Its pathogenic wind
Victor is migratory arthralgia, BI-syndrome caused mainly by pathogenic cold being called painful BI, the BI syndrome caused mainly by pathogenic dampness being called fixed BI." traditional Chinese medical science according to symptom and position, also arthromyodynia is divided into muscle
Numbness, BI-syndrome involved the blood vessels, rheumatism involving the bone, BI-syndrome related to skin and BI-syndrome involved the muscle.The description to cervical spondylosis is also included in these describe.
In Chinese medicine, the disease such as neck, shoulder, brachialgia is considered " arthromyodynia " substantially, it is generally recognized that its cause of disease is due to wound, gas
Blood discord, wind-cold damp pathogen invasion and attack, blockage of main and collateral channels etc. are caused, dizzy, dizzy, tinnitus then, liver-wind turbid with expectorant, deficient relevant.The traditional Chinese medical science
Thinking, the main pathogenesis of cervical spondylosis is caused by liver and kidney deficiency, and marrow is not enough, and QI and blood declines few, and dish bone loses in moistening foster, and wind-cold damp pathogen is prone to rapid
Attacking, numbness meridians, qi depression to blood stasis.
The traditional Chinese medical science it is also believed that to the treatment neck to be conceived to of cervical spondylosis, take on, carry on the back, the body part such as arm, also will be organically
Contact meridians, internal organs, QI and blood etc., carry out the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of entirety, and by the function of the internal organs such as spleen, liver, kidney and muscle, muscles and bones,
Function of joint organically combines, and focuses on the effect interacting, mutually promoting therebetween, so cervical spondylosis is divided into not by the traditional Chinese medical science
Same type.
1, disorder of meridian-QI of TAI YANG: the heresy visitor of wind-cold damp pathogen or heat-damp in summer is in sun passages through which vital energy circulates, or lose blood consumption in Tianjin, qi depression to blood stasis, cause
Making disorder of meridian-QI, sun channel course position QI and blood is obstructed, stagnation of QI and blood may bring about pain, head term, nape, limbs pain, movable unfavorable, arrests tight
Numbness, bends and stretches the symptoms such as inconvenience.
The rule for the treatment of: inducing diaphoresis to dispel wind, removing damp and stopping pain.
2, obstruction of meridians and collaterals: wind-cold damp pathogen visitor hinders meridians, long-term strain hematogenous blockage etc. can cause the imbalance of human body QI-blood circulation, warp
Gas is got along well, and venation numbness hinders, and QI and blood is retarded by silt not general rule overall pain.Mainly injure Taiyang channel gas because of it so with upper limb for write.Gas
Blood runs smooth, and body loses supports so there is numbness, atrophy, stiff waits disease.Void, cold heresy numbness resistance meridians, yang-energy is impaired, clearly sun
Do not rise the most nose heave.
The rule for the treatment of: expelling wind and cold, stimulate the menstrual flow eliminating impediment.
3, qi depression to blood stasis: exopathogen is attacked, stagnates meridians, or deficiency of the liver and kindey, and QI-blood circulation is unable, or strain wound, QI and blood
Stasis, or the most evil sick visitor's meridians etc. all can to cause body QI-blood circulation smooth, and qi depression to blood stasis.Blood stasis is the most obstructed in meridians, obstructed
Then pain and fixing disobeying, tenderness.With the passing of time qi depression to blood stasis, involves Liver and kidney, liver blood deficiency of kidney-essence, it is impossible to flourish foster clear key is the most dizzy, eye
Flower, blurred vision.Lack of preservation of spirit is then had a sleepless night, forgetful, frightened cautious.Purplish tongue or have ecchymosis, stringy and thready pulse is puckery is the disease of qi depression to blood stasis.
The rule for the treatment of: activating blood circulation to dissipate blood stasis, dredging the meridian.
4, the expectorant stasis of blood hands over resistance: wind-cold damp pathogen stagnates meridians, condenses for expectorant, or obstruction of meridians and collaterals, qi depression to blood stasis, causes blood Tianjin not cloth
And be that the expectorant stasis of blood hands over resistance, blood stasis then pain, stagnation of phlegm is the most nose heave, dizziness, feels sick, discomfort in the throat.It is similar with wet that expectorant belongs to YIN pathogen, blocks warp
Network mechanism of qi, therefore limbs are heavy, faint cold, numb, swelling.Resistance handed over by spittoon, is stranded weak for fear of mechanism of qi then general lassitude, and it is visible that expectorant covers clear key
Coma, sudden arrives.
The rule for the treatment of: damp eliminating is reduced phlegm, dissipating blood stasis dredging collateral.
5, deficiency of the liver and kindey: because of meridians, the resistance of QI and blood long-term numbness is obstructed, with the passing of time injures Liver and kidney, or overworks for a long time, caused by liver and kidney deficiency.
Deficiency of the liver and kindey, blood and essence asthenia, YANG-orifices failing to be nourished then dizziness and blurred vision, Hiccough and deaf.Deficiency of YIN-blood, hyperactivity of YANG QI, the upper the most then head of empty sun
Feeling of fullness in the head pain, Facial flush, xerostomia dry pharynx.Kidney essense loss then soreness of the waist and knees, praises unable, movable forced.Deficiency of liver-blood, muscle is become homeless
Foster then refuse contraction, tremble, take action difficult.Stringy and thready pulse be deficiency of the liver and kindey as.
The rule for the treatment of: grow wood and contain water, QI and blood regulating.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating cervical spondylosis;
It is a further object of the present invention to provide the preparation method of a kind of Chinese medicine composition treating cervical spondylosis.
It is an object of the invention to by following technical scheme realization:
The Chinese medicine composition for the treatment of cervical spondylosis of the present invention, is to be prepared from by the raw material of Chinese medicine of following weight portion:
Radix Angelicae Sinensis 10-30 part, Rhizoma Chuanxiong 8-25 part, Radix Rehmanniae Preparata 20-40 part, Fructus Corni 8-25 part, Flos Carthami 3-10 part, Semen Persicae 8-25 part,
Pheretima 5-15 part, Scolopendra 2-5 part, Fructus Lycii 8-25 part, Flos Chrysanthemi 8-25 part, Radix Salviae Miltiorrhizae 8-25 part, Zaocys 8-25 part, Radix Astragali 10-
30 parts, Radix Codonopsis 8-25 part, Radix Puerariae 8-25 part, Rhizoma Et Radix Notopterygii 8-25 part, Radix Saposhnikoviae 8-18 part, Caulis Piperis Kadsurae 8-25 part, Radix Paeoniae Alba 8-25 part, Radix Glycyrrhizae
2-8 part.
Preferably, it is to be prepared from by the raw material of Chinese medicine of following weight portion:
Radix Angelicae Sinensis 15-25 part, Rhizoma Chuanxiong 10-20 part, Radix Rehmanniae Preparata 25-35 part, Fructus Corni 10-20 part, Flos Carthami 5-8 part, Semen Persicae 10-20
Part, Pheretima 8-12 part, Scolopendra 3-4 part, Fructus Lycii 10-20 part, Flos Chrysanthemi 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Zaocys 10-20 part,
Radix Astragali 15-25 part, Radix Codonopsis 10-20 part, Radix Puerariae 10-20 part, Rhizoma Et Radix Notopterygii 10-20 part, Radix Saposhnikoviae 10-15 part, Caulis Piperis Kadsurae 10-20 part, white
Chinese herbaceous peony 10-20 part, Radix Glycyrrhizae 4-6 part.
The following is the crude drug source of Chinese medicine preparation of the present invention:
Radix Angelicae Sinensis, for the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.[nature and flavor] sweet,
Pungent, temperature.[return through] returns liver, the heart, spleen channel.[function cures mainly] replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy
Dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine)
Promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Chuanxiong, for samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum
Wallichii Franch.) dry rhizome.[nature and flavor] are pungent, temperature.[return through] returns liver, gallbladder, pericardium channel.[function cures mainly] invigorates blood circulation
Circulation of qi promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.
Radix Rehmanniae Preparata, for the Preparation process product of Radix Rehmanniae.Radix Rehmanniae is scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa
Libosch. fresh or dried root.[nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, benefit
Essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat passes out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, the moon
Through uncomfortable, metrostaxis, dizziness, tinnitus, early whitening of beard and hair.
Fructus Corni, for being dried to of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc.
Ripe sarcocarp.[nature and flavor] are sour, puckery, tepor.[return through] returns liver, kidney channel.[function cures mainly] liver and kidney tonifying, essence astringing and desertion stemming.For dizziness
Tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Flos Carthami, for the dry flower of feverfew Flos Carthami Carthamus tinctorius L..[nature and flavor] are pungent, temperature.[return through]
GUIXIN, Liver Channel.[function cures mainly] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, fall and flutter damage
Wound, skin infection swells and ache.
Semen Persicae, for rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana
(Carr.) dry mature seed of Franch..[nature and flavor] bitter, sweet, flat.[return through] GUIXIN, liver, large intestine channel.[function cures mainly] lives
Blood and dissolving stasis, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea, abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Pheretima, for Ju Yin section animal Pheretima aspergillum Pheretima aspergillum (E. Perrier), popular ring hair
Earthworm Pheretima vulgaris Chen, power simulation Pheretima guillelmi (Michaelsen) or the blind ring of comb
The dry body of hair earthworm Pheretima pectinifera Michaelsen.[nature and flavor] are salty, cold.[return through] returns liver, spleen, bladder
Warp.[function cures mainly] heat clearing away is calmed the frightened, and dredging collateral is relievingd asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons,
Hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Scolopendra, for Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH Scolopendra subspinipes mutilans L. Koch's
Dry body.[nature and flavor] are pungent, temperature;Poisonous.[return through] returns Liver Channel.[function cures mainly] endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.With
In infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Fructus Lycii, for the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..[nature and flavor] are sweet,
Flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, dizziness ear
Ringing, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Flos Chrysanthemi, for the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..[nature and flavor]
Sweet, bitter, it is slightly cold.[return through] returns lung, Liver Channel.[function cures mainly] dissipates wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, dizziness of having a headache,
Conjunctival congestion and swelling pain, eyes is dim-sighted.
Radix Salviae Miltiorrhizae, for the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..[nature and flavor]
Hardship, is slightly cold.[return through] GUIXIN, Liver Channel.[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, warp
Closing dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia;Hepatosplenomegaly, angina pectoris.
Zaocys, for the dry body of Colubridae animal Zaocys Zaocys dhumnades (Cantor).[nature and flavor] are sweet,
Flat.[return through] returns Liver Channel.[function cures mainly] dispels the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis,
Hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
The Radix Astragali, for leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var.
Mongholicus (Bge.) Hsiao's or Radix Astragali Astragalus membranaceus (Fisch.) Bge. is dry
Dry.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.With
Weak in the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, for a long time
Bursting and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst;Chronic nephritis proteinuria, diabetes.
Radix Codonopsis, for Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis
(RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen
The dry root of Codonopsis tangshen Oliv..[nature and flavor] are sweet, flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating middle warmer
QI invigorating, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Radix Puerariae, for legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae rattan Pueraria
The dry root of thomsonii Benth..[nature and flavor] are sweet, pungent, cool.[return through] returns spleen, stomach warp.[function cures mainly] expelling pathogenic factors from muscles for reducing heat, raw
Tianjin, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels;High blood
Pressure neck pain.
Rhizoma Et Radix Notopterygii, samphire Rhizoma Et Radix Notopterygii (back of the body wing celery) Notopterygium incisum Ting ex H. T. Chang
Or the dry rhizome of Radix et Rhizoma Notopterygii Notopterygium forbesii Boiss. and root.[nature and flavor] are pungent, bitter, temperature.[return through]
Return bladder, kidney channel.[function cures mainly] cold expelling, dispels the wind, dehumidifying, pain relieving.Have a headache for anemofrigid cold, rheumatic arthralgia, aching pain in shoulder and back.
Radix Saposhnikoviae, doing for umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk.
Dry.[nature and flavor] acrid, sweet, warm.[return through] returns bladder, liver, spleen channel.[function cures mainly] inducing diaphoresis to dispel wind, wins wet, relieving convulsion.For feeling
Emit headache, rheumatic arthralgia, rubella pruritus, tetanus.
Caulis Piperis Kadsurae, for the dry rattan of Piperaceae plant Radix seu Caulis fici Martinii Piper kadsura (Choisy) Ohwi.[nature and flavor]
Pungent, bitter, tepor.[return through] returns Liver Channel.[function cures mainly] wind-damp dispelling, the meridian dredging, stopping numbness pain.For anemofrigid-damp arthralgia, arthrodynia of extremities,
Muscle arteries and veins contracture, joint stuffiness.
The Radix Paeoniae Alba, for the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..[nature and flavor] are bitter, sour, micro-
Cold.[return through] returns liver, spleen channel.[function cures mainly] suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, abdomen
Bitterly, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Glycyrrhizae, for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza
Inflata Bat. or the dry root of Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor] are sweet, flat.[return through] returns
The heart, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For spleen
Insufficiency of stomach is weak, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong
Property.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is
Use water to carry or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.Concrete preparation method is as follows:
Scheme one: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight,
Extraction time is 1-3 hour every time, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20
Clear paste, obtain active component.
Scheme two: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medical material total amount
4-10 times, extraction time is 1-4 hour, united extraction liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is
1.15-1.20 clear paste, obtain active component.
Scheme three: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-of medical material gross weight
12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is
The clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80
DEG C time relative density be the extractum of 1.10-1.25, obtain active component.
The Chinese medicine composition for the treatment of cervical spondylosis of the present invention, it is also possible to pharmaceutically acceptable carrier combination,
Make various oral formulations, such as pill, tablet, capsule, oral liquid, syrup, mixture etc..
The pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc..
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc..
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc..
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc..
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, vegetable oil etc..
Correctives: sucrose, monosaccharide, aromatic etc..
Preservative: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc..
Method 1: tablet
Taking one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into this routinely
Invention tablet.
Above-mentioned tablet is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Taking one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into routinely
Capsule of the present invention.
Above-mentioned capsule is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Taking one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into routinely
Syrup of the present invention.
Above-mentioned syrup is commonly used adjuvant and is included one of correctives, preservative, cosolvent or whole.
Method 4: mixture
Taking one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into this routinely
Invention mixture.
Above-mentioned mixture is commonly used adjuvant and is included one of correctives, preservative or whole.
Method 5: oral liquid
Take one of scheme one to scheme three gained active component, dissolve after-purification, concentration, add oral liquid and commonly use adjuvant, by often
Rule production method is prepared into oral liquid of the present invention.
Method 6: pill
Take all medical materials, be dried, then be ground into fine powder, cross 100 mesh sieves, mixing, with distilling water pill in right amount, be dried, polishing, i.e.
?.
The applicant is extensively reading document at all times, uses Traditional Chinese medical theory, on the basis of abundant clinical practice, it is believed that
Kidney governing bones, blood stored in the liver, person in middle and old age's cervical spondylosis is many to be caused due to caused by liver and kidney deficiency, therefore grows with Radix Rehmanniae Preparata, Fructus Corni, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba
Cloudy blood invigorating the liver and kidney is that monarch controls substantially;Gas row then blood, therefore with the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Flos Carthami, Semen Persicae, Rhizoma Chuanxiong benefiting QI for activating blood circulation be
Minister;Radix Puerariae, Pheretima, Scolopendra, Zaocys, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Caulis Piperis Kadsurae dispelling wind and removing obstruction in the collateral, can improve dizziness, neck is unfavorable, numbness of hand is wooden
And it is assistant;Flos Chrysanthemi suppressing the hyperactive liver, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription and for making.Take a broad view of full side, there is nourishing the liver and kidney, benefiting QI for activating blood circulation, dispelling wind and removing obstruction in the collateral it
Effect.Full side cooperates, nourishing the liver and kidney, benefiting QI for activating blood circulation, dispelling wind and removing obstruction in the collateral.For middle-aged and elderly people caused by liver and kidney deficiency, sclerotin degeneration
Pathological changes, blood supply insufficiency caused by vascular compression nerve and the disease such as the dizziness, the neck that cause are unfavorable, numbness of hand is wooden.
A kind of Chinese medicine composition treating cervical spondylosis that the present invention provides has the advantage that
1, the composite preparation that the present invention provides is safe and effective, has nourishing the liver and kidney, benefiting QI for activating blood circulation, dispelling wind and removing obstruction in the collateral.In for always
Year people's caused by liver and kidney deficiency, sclerotin degeneration, blood supply insufficiency caused by vascular compression nerve and the dizziness, the neck that cause are unfavorable, hands
The diseases such as numbness.
2, clinical tests prove that, after treating Patients with Cervical Spondylopathy by the present invention, effective percentage reaches 92.4%, shows the present invention
Can effectively treat cervical spondylosis.
3, the Chinese medicinal composition preparation that the present invention provides, scientific formulation is reasonable, and technique is simple, in good taste, low cost.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating
The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention
Claimed scope.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
Embodiment 1 granule
Weigh Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 8g, Radix Rehmanniae Preparata 20g, Fructus Corni 8g, Flos Carthami 3g, Semen Persicae 8g, Pheretima 5g, Scolopendra 2g, Fructus Lycii
8g, Flos Chrysanthemi 8g, Radix Salviae Miltiorrhizae 8g, Zaocys 8g, Radix Astragali 10g, Radix Codonopsis 8g, Radix Puerariae 8g, Rhizoma Et Radix Notopterygii 8g, Radix Saposhnikoviae 8g, Caulis Piperis Kadsurae 8g, the Radix Paeoniae Alba
8g, Radix Glycyrrhizae 2g.Extracting in water 3 times, three times amount of water is respectively 12 times of medical material gross weight, 8 times, 6 times, and three extraction times divide
It is not 3 hours, 2 hours, 1 hour, united extraction liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds
Enter starch, dextrin, pelletize, be dried, granulate and get final product.
Embodiment 2 tablet
Weigh Radix Angelicae Sinensis 30g, Rhizoma Chuanxiong 25g, Radix Rehmanniae Preparata 40g, Fructus Corni 25g, Flos Carthami 10g, Semen Persicae 25g, Pheretima 15g, Scolopendra 5g, Chinese holly
Fructus Lycii 25g, Flos Chrysanthemi 25g, Radix Salviae Miltiorrhizae 25g, Zaocys 25g, Radix Astragali 30g, Radix Codonopsis 25g, Radix Puerariae 25g, Rhizoma Et Radix Notopterygii 25g, Radix Saposhnikoviae 18g, sea
Radix seu Caulis fici Martinii 25g, Radix Paeoniae Alba 25g, Radix Glycyrrhizae 8g.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, and each ethanol is used
Amount is respectively 10 times of medical material total amount, 8 times, and extraction time is respectively 4 hours, 3 hours, united extraction liquid, filters, and filtrate concentrates
It is the extractum of 1.10 to relative density when 80 DEG C, adds supplementary product starch, ethanol, Pulvis Talci, prepare tablet.
Embodiment 3 tablet
Weigh Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Radix Rehmanniae Preparata 25g, Fructus Corni 10g, Flos Carthami 5g, Semen Persicae 10g, Pheretima 8g, Scolopendra 3g, Fructus Lycii
Sub-10g, Flos Chrysanthemi 10g, Radix Salviae Miltiorrhizae 10g, Zaocys 10g, Radix Astragali 15g, Radix Codonopsis 10g, Radix Puerariae 10g, Rhizoma Et Radix Notopterygii 10g, Radix Saposhnikoviae 10g, Caulis Piperis Kadsurae
Rattan 10g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 4g.Extracting in water 3 times, three amount of water be respectively equivalent to 12 times of medical material gross weight, 8 times, 6
Times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction liquid, filter, relative density when filtrate is concentrated into 70 DEG C
Being the clear paste of 1.20, add ethanol, making alcohol content is 40%, stands 24 hours, filters, and filtrate is concentrated into filtrate and is concentrated into 70 DEG C
Time relative density be the extractum of 1.10, add supplementary product starch, ethanol, Pulvis Talci, prepare tablet.
Embodiment 4 capsule
Weigh Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 20g, Radix Rehmanniae Preparata 35g, Fructus Corni 20g, Flos Carthami 8g, Semen Persicae 20g, Pheretima 12g, Scolopendra 4g, Chinese holly
Fructus Lycii 20g, Flos Chrysanthemi 20g, Radix Salviae Miltiorrhizae 20g, Zaocys 20g, Radix Astragali 25g, Radix Codonopsis 20g, Radix Puerariae 20g, Rhizoma Et Radix Notopterygii 20g, Radix Saposhnikoviae 15g, sea
Radix seu Caulis fici Martinii 20g, Radix Paeoniae Alba 20g, Radix Glycyrrhizae 6g.With 40% alcohol reflux 3 times, each ethanol consumption be respectively 10 times of medical material total amount,
8 times, 4 times, 3 hours, 2 hours, 1 hour respectively extraction time, united extraction liquid, filters, relative density when filtrate concentrates 60 DEG C
It is the extractum of 1.25, extractum adds supplementary product starch, ethanol, dextrin, magnesium stearate, makes capsule according to a conventional method.
Embodiment 5 granule
Weigh Radix Angelicae Sinensis 18g, Rhizoma Chuanxiong 15g, Radix Rehmanniae Preparata 28g, Fructus Corni 15g, Flos Carthami 7g, Semen Persicae 12g, Pheretima 10g, Scolopendra 3g, Chinese holly
Fructus Lycii 15g, Flos Chrysanthemi 12g, Radix Salviae Miltiorrhizae 12g, Zaocys 15g, Radix Astragali 18g, Radix Codonopsis 12g, Radix Puerariae 15g, Rhizoma Et Radix Notopterygii 15g, Radix Saposhnikoviae 12g, sea
Radix seu Caulis fici Martinii 15g, Radix Paeoniae Alba 12g, Radix Glycyrrhizae 5g.Extracting in water 2 times, each amount of water is respectively equivalent to 12 times of medical material gross weight, 10 times,
Extraction time is respectively 3 hours, 2 hours every time, united extraction liquid, filters, and it is 1.05 that filtrate is concentrated into relative density at 80 DEG C
Clear paste, add ethanol, making alcohol content is 70%, stands 12 hours, filtration, when filtrate is concentrated into 70 DEG C, relative density is 1.25
Extractum, add starch, dextrin, pelletize, be dried, granulate and get final product.
Embodiment 6 syrup
Weigh Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 18g, Radix Rehmanniae Preparata 32g, Fructus Corni 18g, Flos Carthami 8g, Semen Persicae 18g, Pheretima 11g, Scolopendra 5g, Chinese holly
Fructus Lycii 18g, Flos Chrysanthemi 18g, Radix Salviae Miltiorrhizae 18g, Zaocys 18g, Radix Astragali 23g, Radix Codonopsis 18g, Radix Puerariae 18g, Rhizoma Et Radix Notopterygii 18g, Radix Saposhnikoviae 12g, sea
Radix seu Caulis fici Martinii 18g, Radix Paeoniae Alba 18g, Radix Glycyrrhizae 6g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, twice
Extraction time is respectively 2 hours, 1 hour, united extraction liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the leaching of 1.10
Cream.In extractum, addition syrup adjuvant sucrose, sorbic acid, water stir, and prepare syrup.
Embodiment 7 oral liquid
Weigh Radix Angelicae Sinensis 23g, Rhizoma Chuanxiong 12g, Radix Rehmanniae Preparata 30g, Fructus Corni 12g, Flos Carthami 6g, Semen Persicae 15g, Pheretima 9g, Scolopendra 2g, Fructus Lycii
Sub-12g, Flos Chrysanthemi 15g, Radix Salviae Miltiorrhizae 15g, Zaocys 12g, Radix Astragali 20g, Radix Codonopsis 15g, Radix Puerariae 12g, Rhizoma Et Radix Notopterygii 12g, Radix Saposhnikoviae 15g, Caulis Piperis Kadsurae
Rattan 12g, Radix Paeoniae Alba 15g, Radix Glycyrrhizae 3g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, carries for twice
The time of taking is respectively 2 hours, 1 hour, united extraction liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10,
In extractum, addition adjuvant mannitol, sorbic acid, water stir, and subpackage prepares oral liquid.
Embodiment 8 mixture
Weigh Radix Angelicae Sinensis 28g, Rhizoma Chuanxiong 23g, Radix Rehmanniae Preparata 38g, Fructus Corni 23g, Flos Carthami 9g, Semen Persicae 23g, Pheretima 13g, Scolopendra 2g, Chinese holly
Fructus Lycii 23g, Flos Chrysanthemi 23g, Radix Salviae Miltiorrhizae 23g, Zaocys 23g, Radix Astragali 28g, Radix Codonopsis 23g, Radix Puerariae 23g, Rhizoma Et Radix Notopterygii 23g, Radix Saposhnikoviae 15g, sea
Radix seu Caulis fici Martinii 23g, Radix Paeoniae Alba 23g, Radix Glycyrrhizae 7g.Extracting in water 3 times, three amount of water be respectively equivalent to 12 times of medical material gross weight, 8 times, 6
Times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction liquid, filter, it is that medical material is total that filtrate is concentrated into gross weight
3 times of weight, fill, addition mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, and prepare mixture.
Embodiment 9 pill
Weigh Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 9g, Radix Rehmanniae Preparata 23g, Fructus Corni 9g, Flos Carthami 4g, Semen Persicae 9g, Pheretima 6g, Scolopendra 3g, Fructus Lycii
9g, Flos Chrysanthemi 9g, Radix Salviae Miltiorrhizae 9g, Zaocys 9g, Radix Astragali 12g, Radix Codonopsis 9g, Radix Puerariae 9g, Rhizoma Et Radix Notopterygii 9g, Radix Saposhnikoviae 10g, Caulis Piperis Kadsurae 9g, the Radix Paeoniae Alba
9g, Radix Glycyrrhizae 3g.Pulverize, cross 100 mesh sieves, mixing, with distilling water pill in right amount, be dried, polishing, to obtain final product.
Clinical trial is summed up
1 physical data
Choose cervical spondylopathy patient 170 example, the maleest 80 examples, female 90 example, age 35-70 year, wherein 40-55 year person 133
Example, the course of disease 6 months-8 years, all with cervical region deadlock pain as cardinal symptom.All patients all meet " disease of tcm diagnosis curative effect mark
Accurate " in the diagnostic criteria of cervical spondylosis.
2 Therapeutic Method
Give and treat with the embodiment of the present invention 9 pill, each 10g, every day 2 times.Take 28 days continuously.
3 clinical efficacy evaluation criterias
Cervical spondylosis curative effect is evaluated according to " Shanghai City Chinese medical disease conventional treatment ".
Curing: original various transference cure, muscular strength is normal, and neck, limb functional recover are normal, can participate in normal work and work
Make;
Taking a turn for the better: original various symptom alleviates, and neck, shoulder and back ache alleviate, neck, limb function improve;
Invalid: symptom is without improving.4 results
Table 1 efficacy result
Cure | Take a turn for the better | Invalid | (%) | |
Curative effect | 69 | 88 | 13 | 92.4 |
Clinical effectiveness shows: after treating Patients with Cervical Spondylopathy by the present invention, effective percentage reaches 92.4%, shows that the present invention can effectively control
Treat cervical spondylosis.
Model case
1, Wei XX, man, 35 years old, IT worker.Patient is because for a long time to computer work, causing occipitalia, whole nape portion, bilateral scapula
Vertebral margin of scapula acid, tired, heavy, head is sent out heavy, hypomnesis, time have nauseating, cardiopalmus, uncomfortable in chest, eyes blurred vision, eyelid to send out
Tightly, right omarthralgia.Pale tongue with white fur, slippery and rapid pulse.Row x ray examination shows: cervical spine interlocks, line slightly right avertence, second and the 3rd
Cervical vertebral space trailing edge is the most broadening, the 5th and sixth cervical vertebra leading edge hypertrophy, the third and fourth, the 4th and the five, the 5th and the 6th neck
Vertebra narrowing of intervertebral space.In conjunction with patient medical history, symptom, sign, having a medical check-up and x ray examination result, tentative diagnosis is cervical spondylosis, shoulder
Scorching.It is obviously improved to patient's state of an illness after treating 2 months with the embodiment of the present invention 3, is mainly manifested in that nape portion is the most aching and tired, head disease
Shape, eye blurred vision, hypomnesis, cardiopalmus, transference cure uncomfortable in chest.Neck functional activity: anteflexion 45 degree, after stretch 40 degree, left side
Bend 40 degree, right side bend 40 degree, left side spin 60 degree, right side rotation 60 degree, all reach the normal number of degrees and without discomfort.
2, X slowly, female, 65 years old.There is dizzy, headache without obvious inducement before 1 year in patient, and companion's Wry Neck is uncomfortable, without half body
Unsuccessful, tic of the limbs symptom, ignores thing rotation, malasia, heating, aversion to cold symptom, without hectic fever, night sweat, dry cough symptom.Do neck
After vertebra x-ray checks, it is diagnosed as cervical spondylosis.Giving after treating 3 months with the embodiment of the present invention 8, dizzy, headache, Wry Neck is uncomfortable
It is wholly absent.
3, Wu XX, man, 45 years old.Neck portion companion's shoulder pain 10 days, pain involves to scapula, and upper limb can not be outward
Exhibition, can not put down sleeping during rest.Check: Bilateral Cervical tension C 2-5 articular process, spinous process tenderness are obvious, in bilateral omoplate
There are friction sound and tenderness, head flexing and spinning obstacle in upper angle.Cervical region X line prompting curvature straightens, and C 5-6 intervertebral space is obvious
Narrowing, at C 4-6 spinous process level, ligamentum nuchae is shown in calcification, all hook facet joint hypertrophy.Cervical region CT points out: C 4-5, C 5-
6 intervertebral disk hernia.It is diagnosed as: cervical spondylosis.Give after treating 3 weeks with the embodiment of the present invention 6, neck pain, upper limb numbness symptom
Basic disappearance.Continue to strengthen symptom after treating 1 week all to eliminate, pay a return visit patients symptomatic after 2 months without repeatedly.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching
Stating, but on the basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (7)
1. the Chinese medicine composition treating cervical spondylosis, it is characterised in that it is to be prepared from by the raw material of Chinese medicine of following weight portion
:
Radix Angelicae Sinensis 10-30 part, Rhizoma Chuanxiong 8-25 part, Radix Rehmanniae Preparata 20-40 part, Fructus Corni 8-25 part, Flos Carthami 3-10 part, Semen Persicae 8-25 part,
Pheretima 5-15 part, Scolopendra 2-5 part, Fructus Lycii 8-25 part, Flos Chrysanthemi 8-25 part, Radix Salviae Miltiorrhizae 8-25 part, Zaocys 8-25 part, Radix Astragali 10-
30 parts, Radix Codonopsis 8-25 part, Radix Puerariae 8-25 part, Rhizoma Et Radix Notopterygii 8-25 part, Radix Saposhnikoviae 8-18 part, Caulis Piperis Kadsurae 8-25 part, Radix Paeoniae Alba 8-25 part, Radix Glycyrrhizae
2-8 part.
2. the Chinese medicine composition treating cervical spondylosis as claimed in claim 1, it is characterised in that it is by including following weight portion
Raw material of Chinese medicine be prepared from: Radix Angelicae Sinensis 15-25 part, Rhizoma Chuanxiong 10-20 part, Radix Rehmanniae Preparata 25-35 part, Fructus Corni 10-20 part, Flos Carthami
5-8 part, Semen Persicae 10-20 part, Pheretima 8-12 part, Scolopendra 3-4 part, Fructus Lycii 10-20 part, Flos Chrysanthemi 10-20 part, Radix Salviae Miltiorrhizae 10-20 part,
Zaocys 10-20 part, Radix Astragali 15-25 part, Radix Codonopsis 10-20 part, Radix Puerariae 10-20 part, Rhizoma Et Radix Notopterygii 10-20 part, Radix Saposhnikoviae 10-15 part, sea
Radix seu Caulis fici Martinii 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Glycyrrhizae 4-6 part.
3. the Chinese medicine composition treating cervical spondylosis as claimed in claim 1 or 2, it is characterised in that its active component is to use
Water carries or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.
4. the as claimed in claim 3 Chinese medicine composition treating cervical spondylosis, it is characterised in that its active component be by with
Lower section method is prepared from: taking whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to medical material gross weight
6-12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is
1.15-1.20 clear paste, obtain active component.
5. the as claimed in claim 3 Chinese medicine composition treating cervical spondylosis, it is characterised in that its active component be by with
Lower section method is prepared from: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medicine
4-10 times of material total amount, extraction time is 1-4 hour, united extraction liquid, filters, relative density when filtrate is concentrated into 70-80 DEG C
For the clear paste of 1.15-1.20, obtain active component.
6. the as claimed in claim 3 Chinese medicine composition treating cervical spondylosis, it is characterised in that its active component be by with
Lower section method is prepared from: taking whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to medical material gross weight
6-12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is
The clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80
DEG C time relative density be the extractum of 1.10-1.25, obtain active component.
7. treat a preparation for cervical spondylosis, by Chinese medicine composition and the medicine and pharmacology of the treatment cervical spondylosis described in claim 1-6
Upper acceptable carrier prepares and forms.
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Citations (4)
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CN1148973A (en) * | 1996-09-20 | 1997-05-07 | 秦文华 | Oral liquid for enriching blood and clearing numbness |
CN1418696A (en) * | 2002-12-13 | 2003-05-21 | 马新华 | Traditional Chinese medicine prepn. for treating cervical vertebra disease |
CN101095783A (en) * | 2006-06-30 | 2008-01-02 | 唐志杰 | Medicinal composition for treating spondyle disease and method for preparing the same |
CN102743531A (en) * | 2012-07-27 | 2012-10-24 | 龙剑 | Drug for treating cervical or lumbar diseases and preparation method thereof |
-
2016
- 2016-07-22 CN CN201610578671.5A patent/CN105998372A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1148973A (en) * | 1996-09-20 | 1997-05-07 | 秦文华 | Oral liquid for enriching blood and clearing numbness |
CN1418696A (en) * | 2002-12-13 | 2003-05-21 | 马新华 | Traditional Chinese medicine prepn. for treating cervical vertebra disease |
CN101095783A (en) * | 2006-06-30 | 2008-01-02 | 唐志杰 | Medicinal composition for treating spondyle disease and method for preparing the same |
CN102743531A (en) * | 2012-07-27 | 2012-10-24 | 龙剑 | Drug for treating cervical or lumbar diseases and preparation method thereof |
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Application publication date: 20161012 |