CN1059828C - Pear hypotensor capsules and preparation thereof - Google Patents
Pear hypotensor capsules and preparation thereof Download PDFInfo
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- CN1059828C CN1059828C CN98110103A CN98110103A CN1059828C CN 1059828 C CN1059828 C CN 1059828C CN 98110103 A CN98110103 A CN 98110103A CN 98110103 A CN98110103 A CN 98110103A CN 1059828 C CN1059828 C CN 1059828C
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Abstract
The present invention relates to a pearl capsule for reducing blood pressure and a preparing method thereof, which belongs to the preparation of medicine. The present invention is mainly used for treating hypertension. The present invention is characterized in that the prescription of the capsule is composed of pearl layer powder, uncaria, sophora bud, scutellaria root, glossy privet fruit, rehmannia root, gastrodia tuber, mistletoe, achyranthes root, chrysanthemum flower and spica prunellae in a certain proportion. The preparing method comprises the following technologies: fine powder preparation, decoction, filter concentration, fine powder addition, absorption, baking, pulverization, fine powder capsulation, etc. The pearl capsule for reducing blood pressure has the advantages of obvious, gentle and stable blood pressure reduction, small side effect, small taking dosage, convenient administration, etc., and has the functions of improving hemorheology and electrocardiogram of patients, relieving angina pectoris and improving heart functions.
Description
The invention discloses a kind of pear hypotensor capsules and preparation method thereof, belong to medical preparing technical field, be mainly used in the treatment hypertension.
Hypertension is one of person in middle and old age's common disease, and its sickness rate is the trend of increase year by year.The development of hypertension can cause matter device and functional disorders such as brain, the heart, kidney, and serious harm people's health, particularly its complication-apoplexy have become China's one of cause of disease that mainly causes death, disables.Therefore paid attention to by people for the research of the treatment of this disease always.In the prior art, the medicine of many treatment hypertension such as compound Herba Apocyni veneti (Folium Apocyni Veneti), reserpine, Aiselazine etc. are arranged.But existing various antihypertensive all exists poison to some extent and pays effect, has some to remain serious, and when taking for a long time even up to more than 70%, makes many patients be reluctant to take medicine for a long time as reserpine, Aiselazine etc.; Modern medicine is treated hypertensive principle just at this clinical picture of hypertension on the other hand, and adopt blood pressure lowering to treat merely, do not consider other factors, in case so patient's drug withdrawal, blood pressure promptly gos up again, exhausted few the consolidation, therefore in a single day many patients got hypertension, then need take medicine all the life.This has not only caused mental burden to patient, and has increased their financial burden.The provincial science and technology in 28 Nikkei Shandong Province November in 1997 is looked into new consulting unit and is retrieved according to the Shandong Province State Scientific and Technological Commission " Shandong Province's science and technology is looked into new work of consultation provisional administrative method ", does not consequently find in looking into scope at present and the identical report of content of the present invention.Other looks into the patent gazette that Patent Office of the People's Republic of China publishes, and also finds no identical with the present invention or akin in first to file.
The object of the present invention is to provide a kind of taking dose little, absorb fast, taking convenience, safety, easy to carry, be easy to preserve, hypotensive effect and remarkable to the clinical symptoms therapeutic effect of hypertension, and have the blood samples of patients of improvement rheology, electrocardiogram, and allevating angina pectoris, blood glue capsule and preparation method thereof falls in the Margarita of improving the cardiac function effect.
According to Traditional Chinese medical theory, particularly the main pathogenesis of in recent years hypertension being discovered of this disease is the judgement of " hyperactivity of YANG due to deficiency of YIN; deficiency in origin and excess in superficiality ", in conjunction with the modern medicine scientific achievement, at existing questions in the prior art, basic design of the present invention is with having removing heat from the liver to lower the high blood pressure, nourishing the liver and kidney, conducting blood to flow downwards, the Margarita layer powder that suppresses functions such as vasomotor center and sympathetic nerve, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Spica Prunellae, Radix Scutellariae, the Radix Rehmanniae, Fructus Ligustri Lucidi, Flos Chrysanthemi, parasitic, Radix Achyranthis Bidentatae, the Flos Sophorae Immaturus etc. are compositing formula by a certain percentage, and through the system fine powder, extract, absorb and oven dry, technologies such as dress capsule are made capsule.
Pear hypotensor capsules of the present invention, it is characterized in that medicine is made by following raw materials by weight percent in this capsule: Margarita layer powder 10-14%, Ramulus Uncariae Cum Uncis 10-14%, Flos Sophorae Immaturus 4-7%, Radix Scutellariae 7-10%, Fructus Ligustri Lucidi 10-14%, Radix Rehmanniae 10-14%, Rhizoma Gastrodiae 7-10%, parasitic 7-10%, Radix Achyranthis Bidentatae 3-6%, Flos Chrysanthemi 7-10%, Spica Prunellae 7-10%.
The preparation method of above-mentioned pear hypotensor capsules is: (1) is with the Margarita layer powder in the above-mentioned prescription, Ramulus Uncariae Cum Uncis, the Flos Sophorae Immaturus, Fructus Ligustri Lucidi, Rhizoma Gastrodiae, mix mutually after Flos Chrysanthemi is weighed by percentage ratio separately and be incorporated in drying under the 60-80 ℃ of temperature conditions, pulverize then, cross 70-90 purpose sieve, it is standby to make fine powder, (2) with the oversize of above-mentioned (1) and the Radix Achyranthis Bidentatae Spica Prunellae of weighing separately by the percentage ratio in the above-mentioned prescription, Radix Scutellariae, the Radix Rehmanniae, parasitism decocts with water twice, each 1-2 hour, twice extracting juice merges after-filtration and be concentrated into proportion is 1-1.05, (3) fine powder that above-mentioned (1) is made joins in the concentrated solution that above-mentioned (2) make, absorb the back 60-80 ℃ of oven dry pulverizing then down, mixing, (4) are got the fine powder that above-mentioned (3) make and are incapsulated the back sterilization.
Outstanding advantage of the present invention be pure in Types of Medicine, the treatment hypertension has hypotensive effect, and gentle stable to improve symptom obvious, the effect of paying is few, preparation technology is simple, taking dose is little, absorbs soon, taking convenience is easy to carry and preserves.Observe treatment 150 routine patients with hypertension statistics according to clinical trial, total effective rate reaches 84%, with the apparent in view compound Herba Apocyni veneti (Folium Apocyni Veneti) that is better than of matched group.And the blood samples of patients of improvement rheology, electrocardiogram are arranged, allevating angina pectoris improves the effect of cardiac function.
One of most preferred embodiment of the present invention is: prescription is by Margarita layer powder 12 grams, and Ramulus Uncariae Cum Uncis 12 restrains, the Flos Sophorae Immaturus 6 grams, and Radix Scutellariae 9 grams, Fructus Ligustri Lucidi 12 grams, the Radix Rehmanniae 12 grams, Rhizoma Gastrodiae 9 restrains, Herba Taxilli 9 grams, Radix Achyranthis Bidentatae 4.5 grams, Flos Chrysanthemi Indici 9 grams, Spica Prunellae 9 gram compositions.Its technology be earlier the Margarita layer powder in the above-mentioned prescription, Ramulus Uncariae Cum Uncis, the Flos Sophorae Immaturus, Fructus Ligustri Lucidi, Rhizoma Gastrodiae, Flos Chrysanthemi Indici are weighed dry under 70 ℃ of temperature conditions behind the mixing, pulverizing 80 mesh sieves then, to make fine powder standby, to decoct with water twice behind the Radix Achyranthis Bidentatae in oversize (being their thick slag) and the prescription, Spica Prunellae, Radix Scutellariae, the Radix Rehmanniae, the Herba Taxilli mixing again, each merges all over after boiling 1.5 hours twice extracting juice, and filtering and filtrate is concentrated into proportion is 1.03; Pour the above-mentioned fine powder that makes of sieving into after making it absorb above-mentioned concentrating in this concentrated solution filtrate, and then dry and make fine powder under 70 ℃, mixing incapsulates this fine powder at last and carries out routine and sterilize promptly by every heavy 0.4 gram.
Change as present embodiment:
1, the shared percentage ratio of each component can suitably be adjusted in the scope of permission, and indivedual components also can be replaced in equivalence;
2, the weight of the dosage form fine powder of particularly packing in each capsule can suitably change.
Claims (2)
1, a kind of pear hypotensor capsules, it is characterized in that medicine is made by following raw materials by weight percent in this capsule: Margarita layer powder 10-14%, Ramulus Uncariae Cum Uncis 10-14%, Flos Sophorae Immaturus 4-7%, Radix Scutellariae 7-10%, Fructus Ligustri Lucidi 10-14%, Radix Rehmanniae 10-14%, Rhizoma Gastrodiae 7-10%, parasitic 7-10%, Radix Achyranthis Bidentatae 3-6%, Flos Chrysanthemi 7-10%, Spica Prunellae 7-10%.
2, the preparation method of the described pear hypotensor capsules of claim 1 is: (1) is with the Margarita layer powder in the above-mentioned prescription, Ramulus Uncariae Cum Uncis, the Flos Sophorae Immaturus, Fructus Ligustri Lucidi, Rhizoma Gastrodiae, mix mutually after Flos Chrysanthemi is weighed by percentage ratio separately and be incorporated in drying under the 60-80 ℃ of temperature conditions, pulverize then, cross 70-90 purpose sieve, it is standby to make fine powder, (2) with the oversize of above-mentioned (1) and the Radix Achyranthis Bidentatae of weighing separately by the percentage ratio in the above-mentioned prescription, Spica Prunellae, Radix Scutellariae, the Radix Rehmanniae, parasitism decocts with water twice, each 1-2 hour, twice extracting juice merges after-filtration and be concentrated into proportion is 1-1.05, (3) fine powder that above-mentioned (1) is made joins in the concentrated solution that above-mentioned (2) make, absorb the back 60-80 ℃ of oven dry pulverizing then down, mixing, (4) are got the fine powder that above-mentioned (3) make and are incapsulated the back sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110103A CN1059828C (en) | 1998-03-09 | 1998-03-09 | Pear hypotensor capsules and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110103A CN1059828C (en) | 1998-03-09 | 1998-03-09 | Pear hypotensor capsules and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1193532A CN1193532A (en) | 1998-09-23 |
| CN1059828C true CN1059828C (en) | 2000-12-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98110103A Expired - Fee Related CN1059828C (en) | 1998-03-09 | 1998-03-09 | Pear hypotensor capsules and preparation thereof |
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| Country | Link |
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| CN (1) | CN1059828C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100423756C (en) * | 2006-07-08 | 2008-10-08 | 刘正礼 | Chinese medicine for treating hypertension |
| CN101554434B (en) * | 2008-04-09 | 2011-02-09 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating clinical hypertension |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113156A (en) * | 1995-02-13 | 1995-12-13 | 张家祥 | Liquid hypotensor with cephalocatharic function |
| CN1148499A (en) * | 1996-09-10 | 1997-04-30 | 宋世昌 | Medicine for reducing blood-pressure and preparation method thereof |
-
1998
- 1998-03-09 CN CN98110103A patent/CN1059828C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113156A (en) * | 1995-02-13 | 1995-12-13 | 张家祥 | Liquid hypotensor with cephalocatharic function |
| CN1148499A (en) * | 1996-09-10 | 1997-04-30 | 宋世昌 | Medicine for reducing blood-pressure and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 《中国中西医结合杂志》1994,15(5) 1994.5.1 石桂华等，复方黄精降压丸治疗II期高血压病30例 * |
| 《新中医》1993,25(12) 1993.12.1 孙炳耀等，金蒲丸治疗高血压病的临床研究 * |
| 《福建中医药》1995,26(3) 1995.3.1 陈美秀等，益寿合剂治疗高血压病155例临床观察 * |
| 《福建中医药》1995,26(3) 1995.3.1 陈美秀等，益寿合剂治疗高血压病155例临床观察;《新中医》1993,25(12) 1993.12.1 孙炳耀等，金蒲丸治疗高血压病的临床研究;《中国中西医结合杂志》1994,15(5) 1994.5.1 石桂华等，复方黄精降压丸治疗II期高血压病30例 * |
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| Publication number | Publication date |
|---|---|
| CN1193532A (en) | 1998-09-23 |
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Free format text: CORRECT: APPLICANT; FROM: QINGDAO HYGIENE SCHOOL, SHANDONG PROVINCE TO: JU WENHAN |
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Address after: Unit 1, building 64, building four, building 602, Qingdao, Fuzhou Road Applicant after: Ju Wenhan Address before: No. 67, Qingdao, Fuzhou Road Applicant before: Qingdao Hygiene School, Shandong Prov. |
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