CN1193532A - Pear hypotensor capsules and preparation thereof - Google Patents
Pear hypotensor capsules and preparation thereof Download PDFInfo
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- CN1193532A CN1193532A CN98110103A CN98110103A CN1193532A CN 1193532 A CN1193532 A CN 1193532A CN 98110103 A CN98110103 A CN 98110103A CN 98110103 A CN98110103 A CN 98110103A CN 1193532 A CN1193532 A CN 1193532A
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- capsules
- fine powder
- radix
- hypotensor
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- 239000002775 capsule Substances 0.000 title claims abstract description 15
- 235000014443 Pyrus communis Nutrition 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title claims description 7
- 239000000843 powder Substances 0.000 claims abstract description 21
- 238000010298 pulverizing process Methods 0.000 claims abstract description 4
- 241000628997 Flos Species 0.000 claims description 14
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 8
- 244000293323 Cosmos caudatus Species 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 230000003071 parasitic effect Effects 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 230000024241 parasitism Effects 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000036772 blood pressure Effects 0.000 abstract description 4
- 230000004217 heart function Effects 0.000 abstract description 3
- 238000000518 rheometry Methods 0.000 abstract description 3
- 241000735234 Ligustrum Species 0.000 abstract 1
- 241000207929 Scutellaria Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 241000157352 Uncaria Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 2
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- ZUXNZUWOTSUBMN-UHFFFAOYSA-N hydralazine hydrochloride Chemical compound Cl.C1=CC=C2C(NN)=NN=CC2=C1 ZUXNZUWOTSUBMN-UHFFFAOYSA-N 0.000 description 2
- 230000001077 hypotensive effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 2
- 229960003147 reserpine Drugs 0.000 description 2
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A pearl capsule for reducing blood pressure is prepared from 11 Chinese-medicinal materials such as pearl layer powder, uncaria stem with hooks, sophora bud, scutellaria root, lucid ligustrum fruit, etc.through proportioning, pulverization, dicoction, filter, concentration, adding fine powder, baking, crushing and loading in capsules, and features distinct reducing and then stabilizing effects to blood pressure, low dosage, quick suction and improving blood rheology and cardiac function.
Description
The invention discloses a kind of pear hypotensor capsules and preparation method thereof, belong to medical preparing technical field, be mainly used in the treatment hypertension.
Hypertension is one of person in middle and old age's common disease, and its sickness rate is the trend of increase year by year.The development of hypertension can cause matter device and functional disorders such as brain, the heart, kidney, and serious harm people's health, particularly its complication-apoplexy have become China's one of cause of disease that mainly causes death, disables.Therefore paid attention to by people for the research of the treatment of this disease always.In the prior art, the medicine of many treatment hypertension such as compound Herba Apocyni veneti (Folium Apocyni Veneti), reserpine, Aiselazine etc. are arranged.But existing various antihypertensive all exists poison to some extent and pays effect, has some to remain serious, and when taking for a long time even up to more than 70%, makes many patients be reluctant to take medicine for a long time as reserpine, Aiselazine etc.; Modern medicine is treated hypertensive principle just at this clinical picture of hypertension on the other hand, and adopt blood pressure lowering to treat merely, do not consider other factors, in case so patient's drug withdrawal, blood pressure promptly gos up again, exhausted few the consolidation, therefore in a single day many patients got hypertension, then need take medicine all the life.This has not only caused mental burden to patient, and has increased their financial burden.The provincial science and technology in 28 Nikkei Shandong Province November in 1997 is looked into new consulting unit and is retrieved according to the Shandong Province State Scientific and Technological Commission " Shandong Province's science and technology is looked into new work of consultation provisional administrative method ", does not consequently find in looking into scope at present and the identical report of content of the present invention.Other looks into the patent gazette that Patent Office of the People's Republic of China publishes, and also finds no identical with the present invention or akin in first to file.
The object of the present invention is to provide a kind of taking dose little, absorb fast, taking convenience, safety, easy to carry, be easy to preserve, hypotensive effect and remarkable to the clinical symptoms therapeutic effect of hypertension, and have the blood samples of patients of improvement rheology, electrocardiogram, and allevating angina pectoris, blood glue capsule and preparation method thereof falls in the Margarita of improving the cardiac function effect.
According to Traditional Chinese medical theory, particularly the main pathogenesis of in recent years hypertension being discovered of this disease is the judgement of " hyperactivity of YANG due to deficiency of YIN; deficiency in origin and excess in superficiality ", in conjunction with the modern medicine scientific achievement, at existing questions in the prior art, basic design of the present invention is with having removing heat from the liver to lower the high blood pressure, nourishing the liver and kidney, conducting blood to flow downwards, the Margarita layer powder that suppresses functions such as vasomotor center and sympathetic nerve, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Spica Prunellae, Radix Scutellariae, the Radix Rehmanniae, Fructus Ligustri Lucidi, Flos Chrysanthemi, parasitic, Radix Achyranthis Bidentatae, the Flos Sophorae Immaturus etc. are compositing formula by a certain percentage, and through the system fine powder, extract, absorb and oven dry, technologies such as dress capsule are made capsule.
Pear hypotensor capsules of the present invention, the prescription that it is characterized in that medicine in this capsule is by following component and press column weight amount percentage ratio and form: Margarita layer powder 10-14%, Ramulus Uncariae Cum Uncis 10-14%, Flos Sophorae Immaturus 4-7%, Radix Scutellariae 7-10%, Fructus Ligustri Lucidi 10-14%, Radix Rehmanniae 10-14%, Rhizoma Gastrodiae 7-10%, parasitic 7-10%, Radix Achyranthis Bidentatae 3-6%, Flos Chrysanthemi 7-10%, Spica Prunellae 7-10%.
The preparation method of above-mentioned pear hypotensor capsules is: (1) is with the Margarita layer powder in the above-mentioned prescription, Ramulus Uncariae Cum Uncis, the Flos Sophorae Immaturus, Fructus Ligustri Lucidi, Rhizoma Gastrodiae, mix mutually after Flos Chrysanthemi is weighed by percentage ratio separately and be incorporated in drying under the 60-80 ℃ of temperature conditions, pulverize then, cross 70-90 purpose sieve, it is standby to make fine powder, (2) with the oversize of above-mentioned (1) and the Radix Achyranthis Bidentatae Spica Prunellae of weighing separately by the percentage ratio in the above-mentioned prescription, Radix Scutellariae, the Radix Rehmanniae, parasitism decocts with water twice, each 1-2 hour, twice extracting juice merges after-filtration and be concentrated into proportion is 1-1.05, (3) fine powder that above-mentioned (1) is made joins in the concentrated solution that above-mentioned (2) make, absorb the back 60-80 ℃ of oven dry pulverizing then down, mixing, (4) are got the fine powder that above-mentioned (3) make and are incapsulated the back sterilization.
Outstanding advantage of the present invention be pure in Types of Medicine, the treatment hypertension has hypotensive effect, and gentle stable to improve symptom obvious, the effect of paying is few, preparation technology is simple, taking dose is little, absorbs soon, taking convenience is easy to carry and preserves.Observe treatment 150 routine patients with hypertension statistics according to clinical trial, total effective rate reaches 84%, with the apparent in view compound Herba Apocyni veneti (Folium Apocyni Veneti) that is better than of matched group.And the blood samples of patients of improvement rheology, electrocardiogram are arranged, allevating angina pectoris improves the effect of cardiac function.
One of most preferred embodiment of the present invention is: prescription is by Margarita layer powder 12 grams, and Ramulus Uncariae Cum Uncis 12 restrains, the Flos Sophorae Immaturus 6 grams, and Radix Scutellariae 9 grams, Fructus Ligustri Lucidi 12 grams, the Radix Rehmanniae 12 grams, Rhizoma Gastrodiae 9 restrains, Herba Taxilli 9 grams, Radix Achyranthis Bidentatae 4.5 grams, Flos Chrysanthemi Indici 9 grams, Spica Prunellae 9 gram compositions.Its technology be earlier the Margarita layer powder in the above-mentioned prescription, Ramulus Uncariae Cum Uncis, the Flos Sophorae Immaturus, Fructus Ligustri Lucidi, Rhizoma Gastrodiae, Flos Chrysanthemi Indici are weighed dry under 70 ℃ of temperature conditions behind the mixing, pulverizing 80 mesh sieves then, to make fine powder standby, to decoct with water twice behind the Radix Achyranthis Bidentatae in oversize (being their thick slag) and the prescription, Spica Prunellae, Radix Scutellariae, the Radix Rehmanniae, the Herba Taxilli mixing again, each merges all over after boiling 1.5 hours twice extracting juice, and filtering and filtrate is concentrated into proportion is 1.03; Pour the above-mentioned fine powder that makes of sieving into after making it absorb above-mentioned concentrating in this concentrated solution filtrate, and then dry and make fine powder under 70 ℃, mixing incapsulates this fine powder at last and carries out routine and sterilize promptly by every heavy 0.4 gram.
Change as present embodiment:
1, the shared percentage ratio of each component can suitably be adjusted in the scope of permission, and indivedual components also can be replaced in equivalence;
2, the weight of the dosage form fine powder of particularly packing in each capsule can suitably change.
Claims (2)
1, a kind of pear hypotensor capsules, the prescription that it is characterized in that medicine in this capsule is by following component and press column weight amount percentage ratio and form: Margarita layer powder 10-14%, Ramulus Uncariae Cum Uncis 10-14%, Flos Sophorae Immaturus 4-7%, Radix Scutellariae 7-10%, Fructus Ligustri Lucidi 10-14%, Radix Rehmanniae 10-14%, Rhizoma Gastrodiae 7-10%, parasitic 7-10%, Radix Achyranthis Bidentatae 3-6%, Flos Chrysanthemi 7-10%, Spica Prunellae 7-10%.
2, the preparation method of the described pear hypotensor capsules of claim 1 is: (1) is with the Margarita layer powder in the above-mentioned prescription, Ramulus Uncariae Cum Uncis, the Flos Sophorae Immaturus, Fructus Ligustri Lucidi, Rhizoma Gastrodiae, mix mutually after Flos Chrysanthemi is weighed by percentage ratio separately and be incorporated in drying under the 60-80 ℃ of temperature conditions, pulverize then, cross 70-90 purpose sieve, it is standby to make fine powder, (2) with the oversize of above-mentioned (1) and the Radix Achyranthis Bidentatae of weighing separately by the percentage ratio in the above-mentioned prescription, Spica Prunellae, Radix Scutellariae, the Radix Rehmanniae, parasitism decocts with water twice, each 1-2 hour, twice extracting juice merges after-filtration and be concentrated into proportion is 1-1.05, (3) fine powder that above-mentioned (1) is made joins in the concentrated solution that above-mentioned (2) make, absorb the back 60-80 ℃ of oven dry pulverizing then down, mixing, (4) are got the fine powder that above-mentioned (3) make and are incapsulated the back sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110103A CN1059828C (en) | 1998-03-09 | 1998-03-09 | Pear hypotensor capsules and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110103A CN1059828C (en) | 1998-03-09 | 1998-03-09 | Pear hypotensor capsules and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1193532A true CN1193532A (en) | 1998-09-23 |
| CN1059828C CN1059828C (en) | 2000-12-27 |
Family
ID=5220184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98110103A Expired - Fee Related CN1059828C (en) | 1998-03-09 | 1998-03-09 | Pear hypotensor capsules and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1059828C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100423756C (en) * | 2006-07-08 | 2008-10-08 | 刘正礼 | Chinese medicine for treating hypertension |
| CN101554434B (en) * | 2008-04-09 | 2011-02-09 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating clinical hypertension |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047314C (en) * | 1995-02-13 | 1999-12-15 | 张家祥 | Liquid hypotensor with cephalocatharic function |
| CN1054072C (en) * | 1996-09-10 | 2000-07-05 | 宋世昌 | Medicine for reducing blood-pressure and preparation method thereof |
-
1998
- 1998-03-09 CN CN98110103A patent/CN1059828C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100423756C (en) * | 2006-07-08 | 2008-10-08 | 刘正礼 | Chinese medicine for treating hypertension |
| CN101554434B (en) * | 2008-04-09 | 2011-02-09 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating clinical hypertension |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1059828C (en) | 2000-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: QINGDAO HYGIENE SCHOOL, SHANDONG PROVINCE TO: JU WENHAN |
|
| CP03 | Change of name, title or address |
Address after: Unit 1, building 64, building four, building 602, Qingdao, Fuzhou Road Applicant after: Ju Wenhan Address before: No. 67, Qingdao, Fuzhou Road Applicant before: Qingdao Hygiene School, Shandong Prov. |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |