CN105963817B - A kind of integration module on intermittent type sampled plasma device - Google Patents
A kind of integration module on intermittent type sampled plasma device Download PDFInfo
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- CN105963817B CN105963817B CN201610255561.5A CN201610255561A CN105963817B CN 105963817 B CN105963817 B CN 105963817B CN 201610255561 A CN201610255561 A CN 201610255561A CN 105963817 B CN105963817 B CN 105963817B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
- A61M1/382—Optimisation of blood component yield
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a kind of integration modules on intermittent type sampled plasma device, it is characterized in that, connector is provided on integration module with the acquisition module of harvester, anti-coagulants module, collection module, separation module, loading module and anticoagulated whole blood pump line to be connected, integration module is internally provided with filter chamber and butterfly chamber, filter chamber and butterfly chamber are connected with above-mentioned module/pump line by interface channel, air monitering module and pressure monitoring module are provided in integration module.The beneficial effects of the invention are as follows：Pass through the integrated setting of module, the set-up time of operating personnel is saved, the feedback flow required time in gatherer process is saved, it improves collecting efficiency and feeds back efficiency for the liquid of adverse reaction, implementing monitoring is carried out to whole device operating status simultaneously, improves the safety and stablization of device operation.
Description
Technical field
The present invention relates to a kind of medical apparatus, especially a kind of integrated moulds applied on intermittent type sampled plasma device
Block.
Background technology
Sampled plasma needs sampled plasma equipment and acquisition consumptive material to match, and it is quiet to carry out human body by the blood taking needle of consumptive material
Arteries and veins drives the liquid such as the blood in consumptive material channel to flow by collecting device after puncturing so that anticoagulated blood is entered by centrifuge
It drives in high-speed rotating Centrifuge Cup, anticoagulated blood is centrifuged, the blood plasma for centrifuging acquisition enters blood plasma collecting bag
In, centrifuge stops operating after the completion of single cycle, carries out the feedback of component blood in Centrifuge Cup, and next list is carried out after the completion of feeding back
Cycle, until the blood plasma of acquisition set amount, the method for such acquisition blood plasma is referred to as intermittent type collecting flowchart.
There are following drawbacks for existing intermittent type collecting device and mating acquisition consumptive material structure design：
1. the monitoring modular of acquisition system is more and disperses, equipment volume is larger, and installation of the consumptive material on each monitoring modular is equal
It needs manually, to limit the efficiency of operating personnel.
2. in gatherer process, the liquid for such as encountering fat slurry or processing adverse reaction needs just be fed back to by Centrifuge Cup
Human body, this flow reduce collecting efficiency, while being unfavorable for alleviating the adverse reaction of acquisition target as early as possible.
3. in collecting flowchart, separation module working condition lacks pressure monitor means, is unfavorable for operating personnel's grasp and adopts
Collect situation.
Invention content
It is an object of the invention to：A kind of integration module applied on intermittent type sampled plasma device is provided, under
Technical solution is stated to realize：
A kind of integration module on intermittent type sampled plasma device is provided with connector and harvester on integration module
Acquisition module, anti-coagulants module, collection module, separation module, loading module be connected with anticoagulated whole blood pump line, integration module
It is internally provided with filter chamber and butterfly chamber, filter chamber and butterfly chamber are connected with above-mentioned module/pump line by interface channel, is collected
At being provided with air monitering module and pressure monitoring module in module.
Alternatively, interface channel is provided in integration module acquisition module is connected with anti-coagulants module, inside connects
It connects on road and is provided with air monitering module.
Alternatively, it is provided with interface channel in integration module acquisition module is connected with anticoagulated whole blood pump line, connects
Air monitering module and pressure monitoring module are provided on channel.
Alternatively, butterfly chamber is made of left chamber and right chamber, and interface channel is provided in integration module by left chamber
It is connected with anticoagulated whole blood pump line and filter chamber, pressure monitoring module is provided in filter chamber.
Alternatively, interface channel is provided in integration module loading module is connected with right chamber.
Alternatively, interface channel is provided in integration module right chamber is connected with separation module and collection module.
Alternatively, it is provided with interface channel in integration module right chamber is connected with filter chamber, is set on interface channel
It is equipped with pressure monitoring module.
Alternatively, butterfly chamber is connected by node with each channel, is provided in connecting node and is connected with electronic valve
The through-hole connect.
The method have the characteristics that：
1. by integrated setting, for producers when carrying out assembling product, no longer needing to additionally will by pipeline or channel
Each component of harvester is attached each other, only need to each component pipeline be inserted into the corresponding connector of module-external, be passed through mould
The channel pre-set inside block connects between component can be realized, and has saved the set-up time of operating personnel, improves acquisition
Efficiency.
2. being arranged by integration module internal structure, the structure setting of butterfly chamber and each connection especially in integration module
The setting that the through-hole of node is connect with electronic valve is opened and closed adjusting to electronic valve according to operating status, is formed different
Fluid path, so that liquid is starched with fat can be no longer via separate cup direct feedback to human body, when the feedback of fat slurry is greatly saved
Between, collecting efficiency is improved, while liquid being made to be input to as early as possible in acquisition target body, is reacted with improper release.
3. being provided with air monitering module in integration module, the amount of liquid in anti-coagulants branch is monitored, monitoring is worked as
There is gas into fashionable, prompt operating personnel replacement anti-freezing agent storage device or progress circuit monitoring to anti-coagulants branch；Same space-time
Gas monitoring modular is monitored the fluid passage in integration module, and/feedback progress is inputted with the liquid confirmed in channel.
4. be additionally provided with pressure monitoring module in integration module, in fluid passage blood supply and feed back pressure and supervise
It surveys, ensures that whole process carries out in normally-pressured neighbor, such as exceed setting value, then prompt operating personnel to handle；Meanwhile
Pressure monitoring module is monitored pressure in Centrifuge Cup, and pressure anomaly in Centrifuge Cup is avoided to lead to Centrifuge Cup leakage or quick-fried cup.
In conclusion the beneficial effects of the invention are as follows：By the integrated setting of module, the installation of operating personnel has been saved
Time has saved the feedback flow required time in gatherer process, has improved collecting efficiency and the liquid for adverse reaction
Efficiency is fed back, while implementing monitoring is carried out to whole device operating status, improves the safety and stablization of device operation.
Description of the drawings
Fig. 1-Fig. 4 is the internal structure schematic diagram of integration module；
Fig. 5 is the connection relationship diagram of integration module and each component of sampled plasma device；
In figure, 1 is integration module, and 2-1 to 2-11 is the first to the 11st connector being arranged on module outer wall, and 3-1 is extremely
3-10 is the first to the tenth channel of connection each connector and module in module, and 3-11 is to feed back channel, 4-1 to 4-3 be first to
Third air monitering module, 5-1 to 5-2 are first to second pressure monitoring modular, and 6-1 to 6-6 is that each channel and module are mutual
The first to the 6th node being connected, 7 be filter chamber, and 8 be blood strainer, and 9 be butterfly chamber left chamber, and 10 be butterfly chamber right chamber
Room, 11 be blood taking needle, and 12 be three-way connector, and 12-1 to 12-3 is three-way connector first to third branch, and 12-4 is plug
Connector, 13-1 be anti-coagulants branch, 13-2 be anti-coagulants pump line, 13-3 be anti-coagulants puncture needle, 14 be anticoagulated whole blood pump line, 15
To centrifuge cup, 15-1 to 15-2 is separation module first to the second branch, and 16 be blood plasma collecting bag, and 16-1 is to collect branch
Road, 17 be loading branch, and 17-1 is loading branch puncture needle, and 18-1 to 18-2 is the first to the second peristaltic pump, and 19 be the second pressure
Normally opened through-hole on power detection module, 20 through-hole to be connected with electronic valve on node.
Specific implementation mode
With reference to specific embodiments and the drawings, the present invention is further illustrated.
With reference to shown in figure 1- Fig. 5, it is provided with filter chamber 7 in integration module 1, blood strainer 8 is provided in filter chamber；It is integrated
It is additionally provided with butterfly chamber in module, is made of left chamber 9 and right chamber 10；First passage 3-1 connections are provided in integration module
Three-way connector the second branch 12-2 is connected by the tenth connector 2-10 and the first connector 2-1 with anti-coagulants pump line 13-2；Setting
There are second channel 3-2 connections the second connector 2-2 and third connector 2-3, anti-coagulants branch 13-1 be connected with anti-coagulants pump line,
Make anti-coagulants pass through above-mentioned channel to be mixed into via the venous blood in 1 acquisition target body of blood taking needle at three-way connector 2
Anticoagulated whole blood inputs integration module by three-way connector third branch 12-3, the first air prison is provided on second channel 3-2
Module 4-1 is surveyed, whether has whether anti-coagulants liquid measure in gas entrance and access fills in anti-coagulants module access for monitoring
Foot；
The 4th connector 2-4 and the 11st connector 2-11 of third channel 3-3 connections is provided in integration module, by anticoagulated whole blood
Pump line 14 is connected with three-way connector third branch 12-3, and the second peristaltic pump 18-2 is provided on anticoagulated whole blood pump line；Setting
There is the 5th connector 2-5 of fourth lane 3-4 connections to be connected with left chamber by the 6th node 6-6；Is provided on third channel
Two air monitering module 4-2 and first pressure monitoring modular 5-1, third channel are blood collection and feedback channel with fourth lane
Important channel, first pressure monitoring modular is monitored the also defeated pressure of blood supply pressure and liquid for acquisition target, with
Ensure to carry out under normal pressure, such as exceed setting value, system will be prompted to operating personnel and handle；
It is provided with the tenth channel 3-10 in integration module and passes through third node 6-3 connection left chamber and filter chamber；It is provided with
Five-channel 3-5 connection filter chambers, the 6th channel 3-6 jointing 2-6 feed back channel 3-11 and are connected by second node 6-2
Right chamber, Five-channel, the 6th channel, feedback channel are formed mutually by the normally opened through-hole 19 in second pressure monitoring modular 5-2
Logical, second pressure monitoring modular 5-2 is used to monitor the pressure centrifuged in cup 15.
The 7th channel 3-7 connection first node 6-1 and the 7th connector 2-7 is provided in integration module, by separation module
Two branch 15-2 are connected with right chamber, are provided with the 8th channel 3-8 by fourth node 6-4, will collect branch 16-1 and the right side
Chamber is connected, and is provided with the 5th node 6-5 and the 9th connector 2-9 of the 9th channel 3-9 connections, makes loading branch 15 and right chamber
It is connected.
It is provided with third air monitering module 4-3 in filter chamber 7, is fed back for monitoring the blood collection in channel/liquid
Progress is provided with the second air monitering module 4-2 on third channel as its prevention and spare monitoring, when third air monitering mould
By the second air monitering module as spare monitoring when block breaks down.
Three-way connector first branch 12-1 is connected with blood taking needle 11, and three-way connector the second branch 12-2 passes through the tenth
Connector 2-10, three-way connector third branch 12-3 are connected with integration module respectively by connector 2-11；Anti-coagulants branch 13-
1 by puncture needle 13-3 connection anti-coagulants storage devices, the first peristaltic pump 18-1 are provided on anti-coagulants pump line 13-2, by connecing
Head 2-1,2-2 connect integration module, are provided with the second peristaltic pump 18-2 on anticoagulated whole blood pump line 14, pass through the 4th connector 2-4, the
Five connector 2-5 connection integration modules；Separation module includes centrifuging cup 15 and separation module first branch 15-1, separation module
The second branch 15-2, the separation module first branch pass through the 7th connector 2-7 by connector 2-6, separation module the second branch 15-2
It is separately connected integration module；Collection module includes blood plasma collecting bag 16 and collects branch 16-1, collects branch and passes through the 8th connector
2-8 connection integration modules；Loading module includes loading branch 17, and loading branch passes through loading branch puncture needle 17-1 connection liquids
Storage device, while passing through the 9th connector 2-9 connection integration modules.
The workflow of the present invention：
1. acquisition：Blood taking needle is acquired the venipuncture of object, so that blood is passed through threeway by the second wriggling pumping action
For connector under the first wriggling pumping action, the anti-coagulants that three-way connector is entered by anti-coagulants branch-anti-coagulants pump line is mixed
Enter third branch after being combined into anticoagulated whole blood, enters filter chamber through third channel-anticoagulated whole blood pump line-fourth lane-left chamber；
2. filtering：Into filter chamber anticoagulated whole blood after blood strainer filtering, put aside in filter chamber, pass through after product is full
Six channels of Five-channel-the-separation module first branch enters centrifugation cup；
3. separation：Cup is centrifuged under centrifuge effect, anticoagulated whole blood is separated into red blood cell layer, tunica albuginea layer and blood plasma
Layer, the plasma layer of density minimum are located at separate cup innermost layer；
4. collecting：When centrifuging hold-up in cup, blood plasma is overflowed from Centrifuge Cup, through separation module second
Seven channels Lu-the enter right chamber, and second node and the 5th node are closed at this time, and blood plasma is through eight channels of fourth node-the-collection
Branch enters blood plasma collecting bag；
5. blood recovery：When sampled plasma reach single cycle acquire set amount after, centrifuge brake stop operating, at this time from
Component blood (red blood cell and tunica albuginea layer) in heart separate cup sinks to bottom of a cup, and the reversion of the second peristaltic pump makes the component blood in cup pass through
After acquisition path is fed back in acquisition target body, recycled into next acquisition；
6. brine/fat slurry is fed back：When adverse reaction occurs for acquisition target, physiological saline/liquid is through loading branch, and the 9th
Access enters right chamber, at this time first, fourth node close, the second, the 5th node is opened, and liquid is pressed through second node-the second
The-the Five-channel of power monitoring modular-filter chamber-left chamber-fourth lane-anticoagulated whole blood pump line-third channel-three-way connector
Three branches-blood taking needle is fed back to human body, and when the blood plasma of collection is that fat is starched, fat is starched also according to above-mentioned flow direct feedback to human body
It is interior, it no longer needs to, by centrifuging cup, save the feedback time, improved collecting efficiency；When collecting flowchart enters last acquisition
When cycle, blood plasma collecting bag reaches default acquisition target, and centrifuging bottom of a cup portion after blood recovery still remains fractions blood,
First node is opened at this time, and physiological saline enters centrifugation cup through the separation module first branch by first node, will detach
Remaining component blood is taken away in cup, is fed back in human body through anticoagulated whole blood input path.
The advantages of present apparatus, is：It by the integrated setting of module, has saved the set-up time of operating personnel, has saved
The flow required time is fed back in gatherer process, improve collecting efficiency and feeds back efficiency for the liquid of adverse reaction, together
When to whole device operating status carry out implementing monitoring, improve device operation safety and stablization.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (5)
1. a kind of integration module on intermittent type sampled plasma device, which is characterized in that be provided with connector on integration module
It is connected with the acquisition module of harvester, anti-coagulants module, collection module, separation module, loading module and anticoagulated whole blood pump line
It connects, integration module is internally provided with filter chamber and butterfly chamber；Butterfly chamber is made of left chamber and right chamber, setting in integration module
There is interface channel that left chamber is connected with anticoagulated whole blood pump line and filter chamber；Being additionally provided with different interface channels will divide respectively
It is connected with right chamber from module, collection module, loading module, filter chamber；Be provided in integration module air monitering module and
Pressure monitoring module；It is both provided with the through-hole being connected with electronic valve in each connecting node of butterfly chamber.
2. a kind of integration module on intermittent type sampled plasma device as described in claim 1, which is characterized in that integrated
It is provided with interface channel in module acquisition module is connected with anti-coagulants module, and in the acquisition module and anti-coagulants module
Between interface channel on be provided with air monitering module.
3. a kind of integration module on intermittent type sampled plasma device as claimed in claim 2, which is characterized in that integrated
It is provided with interface channel in module acquisition module is connected with anticoagulated whole blood pump line, and in the acquisition module and anticoagulated whole blood
Air monitering module and pressure monitoring module are provided on interface channel between pump line.
4. a kind of integration module on intermittent type sampled plasma device as claimed in claim 3, which is characterized in that described
Pressure monitoring module is provided in filter chamber.
5. a kind of integration module on intermittent type sampled plasma device as described in claim 1, which is characterized in that described
It is provided with pressure monitoring module on the interface channel of right chamber and filter chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610255561.5A CN105963817B (en) | 2016-04-22 | 2016-04-22 | A kind of integration module on intermittent type sampled plasma device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610255561.5A CN105963817B (en) | 2016-04-22 | 2016-04-22 | A kind of integration module on intermittent type sampled plasma device |
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| Publication Number | Publication Date |
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| CN105963817A CN105963817A (en) | 2016-09-28 |
| CN105963817B true CN105963817B (en) | 2018-08-10 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146172A (en) * | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
| EP1674120A1 (en) * | 2004-12-21 | 2006-06-28 | Therakos, Inc. | Method and apparatus for collecting a blood component and performing a photopheresis treatment |
| CN201205379Y (en) * | 2008-05-26 | 2009-03-11 | 四川南格尔生物医学股份有限公司 | Disposable closed single blood-sampling blood cell separator |
| CN204723474U (en) * | 2015-05-08 | 2015-10-28 | 四川南格尔生物科技有限公司 | Blood collection integrating device |
| CN206007686U (en) * | 2016-04-22 | 2017-03-15 | 四川南格尔生物科技有限公司 | A kind of integration module on intermittent type sampled plasma device |
-
2016
- 2016-04-22 CN CN201610255561.5A patent/CN105963817B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146172A (en) * | 1977-10-18 | 1979-03-27 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing system |
| EP1674120A1 (en) * | 2004-12-21 | 2006-06-28 | Therakos, Inc. | Method and apparatus for collecting a blood component and performing a photopheresis treatment |
| CN201205379Y (en) * | 2008-05-26 | 2009-03-11 | 四川南格尔生物医学股份有限公司 | Disposable closed single blood-sampling blood cell separator |
| CN204723474U (en) * | 2015-05-08 | 2015-10-28 | 四川南格尔生物科技有限公司 | Blood collection integrating device |
| CN206007686U (en) * | 2016-04-22 | 2017-03-15 | 四川南格尔生物科技有限公司 | A kind of integration module on intermittent type sampled plasma device |
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| Publication number | Publication date |
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| CN105963817A (en) | 2016-09-28 |
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