CN105854106B - A kind of integration module applied on continous way sampled plasma device - Google Patents
A kind of integration module applied on continous way sampled plasma device Download PDFInfo
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- CN105854106B CN105854106B CN201610257644.8A CN201610257644A CN105854106B CN 105854106 B CN105854106 B CN 105854106B CN 201610257644 A CN201610257644 A CN 201610257644A CN 105854106 B CN105854106 B CN 105854106B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/3646—Expelling the residual body fluid after use, e.g. back to the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0028—Special media to be introduced, removed or treated fluid entering a filter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a kind of integration module applied on continous way sampled plasma device, the acquisition module of interface and harvester is provided with integration module, anti-coagulants module, separation module, collection module, transit module, loading module, anticoagulated whole blood pump line and component blood pump line are connected, filter chamber and transfer chamber are set in integration module, filter chamber and transfer chamber are connected with above-mentioned module/pump line by interface channel, air monitering module and pressure monitoring module are provided with integration module.
Description
Technical field
The present invention relates to the structure member on a kind of medical equipment, particularly one kind to be applied to continous way sampled plasma device
On integration module.
Background technology
In sampled plasma process, component blood is not fed back directly, but carries out component blood transfer, and transfer process
Middle anticoagulated whole blood carries out backup collection, and when component blood is fed back, the anticoagulated whole blood of backup collection enters under separator unlatching
One separation circulation, referred to as continous way collecting flowchart.In continous way collecting flowchart, seperator reaches predetermined amount in sampled plasma amount
It can continue to rotate before.
In the prior art there is problems with the collection process of continous way collecting flowchart and used device：
1. the process of collection is time-consuming longer, disposable isolated blood amount is larger, easily causes adverse reaction.
2. in gatherer process, such as running into the decoction of fat slurry or processing adverse reaction needs just be fed back to by Centrifuge Cup
Human body, this flow reduce collecting efficiency, while are unfavorable for alleviating as early as possible the adverse reaction of acquisition target.
3. the monitoring modular of acquisition system is more and scattered, equipment volume is larger, and installation of the consumptive material on each monitoring modular is equal
Need to be manual, limit the efficiency of operating personnel.
In collecting flowchart, separation module working condition lacks pressure monitor means, is unfavorable for operating personnel and grasps collection
Feelings.
The content of the invention
It is an object of the invention to：A kind of integration module applied on continous way sampled plasma device is provided, under
Technical scheme is stated to realize：
A kind of integration module applied on continous way sampled plasma device, it is characterised in that be provided with integration module
The acquisition module of interface and harvester, anti-coagulants module, separation module, collection module, transit module, loading module, anti-freezing
Whole blood pump line and component blood pump line are connected, and filter chamber and transfer chamber are set in integration module, will be filtered by interface channel
Chamber and transfer chamber are connected with above-mentioned module/pump line, and air monitering module and pressure monitoring module are provided with integration module.
Alternatively, interface channel is provided with integration module acquisition module is connected with anti-coagulants module, connection is logical
Air monitering module is provided with road.
Alternatively, interface channel is provided with integration module acquisition module is connected with anticoagulated whole blood pump line, connect
Air monitering module and pressure monitoring module are provided with passage.
Alternatively, interface channel is provided with integration module filter chamber is connected with anticoagulated whole blood pump line and transfer chamber
Connect.
Alternatively, be provided with integration module interface channel by transfer chamber respectively with transit module, separation module and
Loading module is connected, and pressure monitoring module is provided with the interface channel of transfer chamber and separation module.
Alternatively, be provided with integration module interface channel by separation module respectively with component blood pump line and collect mould
Block is connected.
Alternatively, threeway node is provided with integration module respectively by component blood pump line, transit module and feedback branch
Road is connected, and feeds back branch road and is connected via outside integration module with filter chamber, is provided with the passage being connected with feeding back branch road
Connecting node, the through hole being connected with electronic valve is provided with connecting node.
Alternatively, be provided with blood filter screen and pressure monitoring module in filter chamber, in integration module each interface channel with
The position that the position and each interface channel that transfer chamber is connected connect each other is provided with connecting node, is set in connecting node
There is electronic valve.
Each structure of this integration module is with the effect of part and feature：
1. by integrated setting, producers are when carrying out assembling product, without additionally being incited somebody to action again by pipeline or passage
Each part of harvester is attached each other, only need to module-external is corresponding connects by the insertion of each part pipeline of harvester
Head, the passage pre-set by inside modules connect between can realizing part, have saved the set-up time of operating personnel, have carried
Collecting efficiency is risen.
2. set by integration module internal structure, particularly in integration module transfer chamber and the through hole of each connecting node with
The setting that electronic valve is connected, regulation is opened and closed to electronic valve according to running status, different fluid paths is formed, makes
Component blood when feeding back, can carry out the centrifugation of blood simultaneously, decoction and fat slurry can with direct feedback to human body, without via
Ring-separators, the time of collection process and the feedback time of decoction and fat slurry are greatlyd save, improves collecting efficiency, simultaneously
Decoction is inputted as early as possible to acquisition target body, reacted with improper release.
3. being provided with air monitering module in integration module, the amount of liquid in anti-coagulants branch road is monitored, works as monitoring
There is gas to enter to anti-coagulants branch road fashionable, prompt operating personnel to change anti-freezing agent storage device or carry out loop monitoring；Same space-time
Gas monitoring modular is monitored to the fluid passage in integration module, and/feedback progress is inputted with the liquid confirmed in passage.
4. being additionally provided with pressure monitoring module in integration module, the blood supply in fluid passage and feedback pressure are supervised
Survey, ensure that whole process is carried out in normally-pressured neighbor, such as exceed setting value, then prompt operating personnel to be handled；Meanwhile
Pressure monitoring module is monitored to pressure in ring-separators, avoids pressure anomaly in ring-separators from causing to centrifuge leakage.
A kind of continous way sampled plasma device for employing integration module described above, in addition to acquisition module, anti-coagulants
Module, separation module, collection module, transit module, loading module, anticoagulated whole blood pump line and component blood pump line, foregoing each module
And pump line is connected by the interface being arranged on integration module with integration module；Acquisition module connects including blood taking needle with threeway
Device, the tie point of three-way connector are connected with blood taking needle, and second, third branch road is connected by interface with integration module respectively
Connect；Anti-coagulants module includes anti-coagulants pump line and anti-coagulants branch road, anti-coagulants branch road connection anti-coagulants storage device, anticoagulant pump
Peristaltic pump is provided with pipe, anticoagulated whole blood pump line and component blood pump line；Separation module connects including ring-separators with separator
Pipe, the head end of separator connecting tube are connected with the centre gangway of annular connector, and the first to the 3rd branch road of tail end leads to respectively
Interface is crossed with integration module to be connected；Collection module includes blood plasma collecting bag and collects branch road；Loading module includes loading branch road,
Loading branch road connects decoction storage device by puncture needle；Transit module is included in first, second transfer bag and first, second
Turn branch road.
Each structure of this harvester is with the effect of part and feature：With general cup type separator in the prior art
Difference, this programme employ foregoing annular sedimentator design, threeway are realized by separator connecting tube and integration module module
Road connects, and is realized under system control and continues high-speed rotation, blood constituent is separated, and in separation process, blood plasma enters
Collecting bag, component blood enter the second transfer bag by passage, then feed back human body through input channel again through feeding back branch road, and now the
The anticoagulated whole blood to be prestored in one transfer bag continues into ring-separators and separated, and ensures the continuity of whole separation process,
Centrifuge is shut down or is dallied without braking, substantially increase the efficiency of whole sampled plasma process, also improve centrifuge
Service life
A kind of continous way sampled plasma method realized based on foregoing continous way sampled plasma device, it is characterised in that
Comprise the following steps：
1) gather：Blood taking needle is acquired the venipuncture of object, enters venous blood by the effect of anticoagulated whole blood pump line
Three-way connector, while anti-coagulants is led to by anti-coagulants branch road and anti-coagulants pump line into three by the effect of anti-coagulants pump line
Device is connect, venous blood and anti-coagulants are mixed to form anticoagulated whole blood herein, enter filter chamber by the tenth Five-channel；
2) filter：Into filter chamber anticoagulated whole blood after blood strainer filtering, put aside in filter chamber, pass through after product is full
Fourth lane enters transfer chamber, and now the second, the 7th node is closed, and anticoagulated whole blood connects through the 3rd with eight nodes-separator
3rd branch road of pipe enters ring-separators access road；
3) separate：Anticoagulated whole blood is separated into red blood cell layer, tunica albuginea layer and blood plasma by ring-separators under seperator effect
Layer, because each layer density is different, the minimum plasma layer of density is located at disengagement chamber innermost layer, red blood cell layer and tunica albuginea layer positioned at separation
Chamber outermost layer；
4) plasma collection：After annular release intracavitary blood plasma reaches finite concentration, connected by first outlet passage-separator
Ten passages of adapter tie point-the-collection branch road-blood plasma collecting bag is collected；
5) component blood is collected：When being detected tunica albuginea layer in the tie point of separator connecting tube, that is, show to separate
Intracavitary blood plasma, which has been collected, to be finished, and now the through hole electronic valve of the fourth node on the tenth passage is closed, and stops collecting blood plasma, separation
The component blood of intracavitary is logical by second outlet passage-the second branch road of separator connecting tube-the nine under component blood wriggling pumping action
The-the second transfer of the passage branch road of the-the eight passages of node of road -11 passage-the of component blood pump line-the six-first node-the seven enters
Second transfer bag；
6) backup collection：When carrying out component blood collection, blood taking needle continues to be acquired venous blood, while by anticoagulated whole
Blood enters transfer chamber after filter chamber filters, and now the seven, the 8th nodes are closed, and anticoagulated whole blood is logical by section point-the five
It is standby that the transfer of road-the first branch road enters the first transfer bag；
7) transfer blood inputs：After component blood fully enters the second transfer bag in ring-separators, the 3rd node is closed,
8th node is opened, and the anticoagulated whole blood in the first transfer bag flows back to transfer chamber, then is inputted by the third channel of separator connecting tube
Ring-separators, continue blood separation；
8) component blood is fed back：When transfer blood inputs ring-separators, filter chamber is vacant, and the 7th is connected in first node
The through hole electronic valve of passage and the 8th passage is closed, and the component blood in the second transfer bag is through six passages of first node-the-feedback branch
Road inputs filter chamber, anticoagulated whole blood pump line acting in opposition, component blood is fed back in human body；
9) when adverse reaction occurs for acquisition target, physiological saline/decoction passes through twelve earthly branches Lu-the through loading branch road
Seven nodes enter transfer chamber, and now the second, the 8th node is closed, and anticoagulated whole blood pump line acting in opposition, physiological saline/decoction passes through
Three nodes-filter chamber-anticoagulated whole blood pump line is fed back to human body, when collecting flowchart enters last collection circulation, plasma collection
Bag reaches default collection target, and part residual is still arranged at disengagement chamber bottom after component blood is fed back, and now physiological saline passes through the 12nd
The node of passage-the seven enters transfer chamber, and second, third node is closed, and liquid passes through the 8th the-the ten triple channels of node-separator
The third channel of connecting tube enters ring-separators, and the component blood remained in separate cup is taken away, through second outlet passage-separation
The-the eight passage of node of second the-the nine passages of branch road -11 passage-the of component blood pump line-the six of device connecting tube enters first segment
Point, the now node of the passage of UNICOM the 7th and the 8th passage closing, mixing liquid filter through six passages-feedback branch road-entrance
Chamber, inputted under the effect of anticoagulated whole blood pump line in human body, whole gatherer process terminates；
10) monitoring-alarm：In gatherer process, when monitoring that it is fashionable that anti-coagulants branch road has gas to enter, operating personnel are prompted more
Change anti-freezing agent storage device or carry out loop monitoring；When monitoring to centrifuge cup pressure anomaly, device stops seperator fortune
Turn, and close each node in integration module, suspend collecting flowchart, and prompt operating personnel to carry out device inspection.
The characteristics of above method, is：
1. decoction and fat slurry are no longer via ring-separators, but direct feedback greatlys save decoction and fat to human body
The feedback time of slurry, improve collecting efficiency；
1. after single-cycle sampled plasma, when component blood is collected into transfer bag, continue to gather anticoagulated whole blood extremely
In transfer bag, when carrying out component blood feedback human body, the anticoagulated whole blood in transfer bag directly inputs centrifugal separator and separated,
The restarting of module is resurveyed and centrifuged without waiting for acquisition module, while protects centrifugal separator, avoids seperator
Frequent start-stop or idle running；
Effective monitoring is carried out to whole collecting flowchart, avoids that collection accident occurs.
Brief description of the drawings
Fig. 1-Fig. 4 is the schematic diagram of the present invention；
Fig. 5-Fig. 8 is a kind of continous way sampled plasma schematic device for employing this integration module；
Fig. 9 is that the one kind realized based on foregoing continous way sampled plasma device is based on foregoing continous way sampled plasma device
The continous way sampled plasma method realized
In figure, 1 is blood taking needle, and 2 be Active Interface, and 3 be three-way connector, and 3-1 to 3-3 is three-way connector first to the
Three branch roads, 4 be integration module, and 5-1 is anti-coagulants branch road, and 5-2 is anti-coagulants pump line, and 5-3 is anti-coagulants puncture needle, and 6-1 is anti-
Solidifying agent flux controller, 6-2 are infusion drip controller, and 7 be anticoagulated blood pump line, and 8 be component blood pump line, and 9 is feed back branch road,
10-1 is the first transfer branch road, and 10-2 is the first transfer bag, and 11-1 is the second transfer branch road, and 11-2 is the second transfer bag, 12-1
To collect branch road, 12-2 is blood plasma collecting bag, and 13-1 is loading branch road, and 13-2 is loading puncture needle, and 14 be separator connecting tube,
14-1 to 14-3 is the first to the 3rd branch road of separator connecting tube, and 14-4 is jointing, and 15 be ring-separators, and 15-1 is
Separator outer wall, 15-2 are separator inwall, and 15-3 is disengagement chamber, and 15-4 is centre gangway, and 15-5 is dividing wall, 15-6 be into
Mouth passage, 15-7 are baffle plate, and 15-8 is first outlet passage, and 15-9 is second outlet passage, and 15-10 is blend stop, and 15-11 is branch
Fagging, 15-12 are arc joint face, and 15-13 is cover plate, and 15-14 is gap structure, and 16-1 to 16-17 is integration module first
To the 17th interface, 17-1 to 17-15 is the Five-channel of integration module first to the tenth, and 18 be filter chamber, and 19 be blood filter screen,
20-1 to 20-2 is the first to the second air detection module, and 21-1 and 21-2 are first, second pressure monitoring module, and 22-1 is extremely
22-10 is that integration module first to protelum point, 23 is transfer chamber.
Embodiment
With reference to specific embodiments and the drawings, the present invention is further illustrated.
With reference to shown in figure 1- Fig. 4, first passage 17-1 is provided with integration module by anti-coagulants pump line and three-way connector
Second branch road is connected；Anti-coagulants pump line is connected by third channel 17-3 with anti-coagulants branch road；Is provided with third channel
One air detection module 20-1；Anticoagulated whole blood pump line is connected by second channel 17-2 with the branch road of three-way connector the 3rd, and second
The second air detection module 20-2 is provided with passage；Tenth Five-channel 17-15 connection anticoagulated whole blood pump lines, the tenth four-way
17-14 connection filter chambers bottom, the tenth Five-channel are connected with the tenth four-way by the 9th node 22-9；Fourth lane 17-4
Filter chamber top is connected, is connected by the 3rd node 22-3 with transfer chamber；Five-channel 17-5 is connected by section point 22-2
Transfer chamber is connect, while passes through interface 16-8 connection the first transfer branch roads；Tenth triple channel 17-13 passes through the 8th node 29-8 connections
Transfer chamber, while by the 3rd branch road 14-3 of the 17th interface 16-17 connection separator connecting tubes, set in the tenth triple channel
There is second pressure monitoring modular 21-2；12nd passage 17-12 passes through the tenth by the 7th node 22-7 connection transfer chambers
Six interface 16-16 are connected with loading branch road；Tenth passage 17-10 is connected separator with interface 16-13 by interface 16-14
The tie point of pipe is connected with branch road is collected, and fourth node 22-4 is provided with the tenth passage；Set on 9th passage 17-9
There is a protelum point 22-10, and by interface 16-12 and interface 16-15 by the second branch road and composition blood pump of separator connecting tube
Pipe is connected, and the 5th node 22-5 is provided with the 9th passage；11st passage 17-11 coordinator blood pump pipes, pass through the 6th
Node 22-6 is connected with the 8th passage 17-8；7th passage 17-7 is by the tenth interface 16-10 connection the second transfer branch roads, and
Six passage 17-6 feed back branch road 9 by interface 16-9 connections, feed back branch road and are arranged on outside integration module, outside integration module
Filter chamber ledge is connected, and the 6th passage, the 7th passage, the 8th passage form mutually threeway by first node.Each section
The through hole of adjacent two passage of UNICOM is provided with point, through hole is connected with electronic valve.
With reference to shown in figure 4- Fig. 8, a kind of continous way sampled plasma device, in addition to acquisition module, anti-coagulants module, separation
Module, collection module, transit module, loading module, anticoagulated whole blood pump line 7 and component blood pump line 8.
Acquisition module includes blood taking needle 1 and three-way connector 3, three-way connector tie point 3-1 by Active Interface 2 with
Blood taking needle 1 is connected, three-way connector the second branch road 3-2 link block first interface 16-1, and the branch road of three-way connector the 3rd connects
Connection module second interface 16-2.
Anti-coagulants module includes anti-coagulants branch road 5-1 and anti-coagulants pump line 5-2, anti-coagulants branch road pass through anti-coagulants puncture needle
5-3 connection anti-coagulants storage devices.
Separation module includes ring-separators 15 and separator connecting tube 14, the jointing 14-4 of separator connecting tube with
The centre gangway 15-4 of ring-separators is connected, the tie point 14-1 of separator connecting tube by interface 16-14, second
Road 14-2 is connected by interface 16-15, the 3rd branch road 14-3 by interface 16-17 with integration module.
Collection module includes collecting branch road 12-1 and blood plasma collecting bag 12-2, collects branch road by interface 16-13 with integrating
Module is connected.
Transit module is included in the first transfer branch road 10-1 and the first transfer bag 10-2, the second transfer branch road 11-1 and second
Turn bag 11-2, the first transfer branch road is connected by interface 16-8, the second transfer branch road by interface 16-10 with integration module.
Loading module includes loading branch road 13-1, loading branch road by loading puncture needle 13-2 connection decoction storage devices,
And it is connected by interface 16-16 with integration module.
Peristaltic pump is provided with anti-coagulants pump line 5-2 and anticoagulated whole blood pump line 7 and component blood pump line 8.
Separator is hollow cylindrical structural, and separator is set for double wall, between inwall 15-2 and outer wall 15-1
Chamber forms the disengagement chamber 15-3 of annular, and separator center is provided with centre gangway 15-4, and centre gangway is provided with support
Plate 15-11, which is connected with inwall in separator, is provided with disengagement chamber, and centre gangway is connected by fluidic connection channels with disengagement chamber
Connect, fluidic connection channels are provided with the dividing wall 15-5 that one end is connected with outer wall, and fluidic connection channels are divided into entrance leads to
Road 15-6 and exit passageway, fluidic connection channels are additionally provided with the baffle plate 15-7 stretched out to outer wall, and exit passageway is divided into the
One exit passageway 15-8 and second outlet passage 15-9, disengagement chamber, centre gangway, interface channel tip height are concordant, and connection is logical
Road bottom is higher than disengagement chamber and centre gangway, and the link position of first outlet passage and disengagement chamber is provided with arc joint face 15-
12.Baffle plate is provided with blend stop 15-10 close to the outer wall side end, and separator also includes cover plate 15-13, and cover plate is arranged at disengagement chamber
Top is combined as a whole with separator, and cover plate is circle, and cover plate, separator, centre gangway three center line hang down positioned at same
Straight position, the outer circumference diameter of cover plate are more than separator circle diameter.The gap structure to match with blend stop is provided with below cover plate
15-14, after cover plate is combined with separator, blend stop combines to form block, block and disengagement chamber bottom and disengagement chamber with gap structure
Outer wall leaves certain distance.Neck is provided with cover plate, is mutually fixed with the buckle on centrifugal separator to be adapted to.
A kind of continous way sampled plasma method realized based on foregoing continous way sampled plasma device, as shown in Figure 9：
1. collection：Blood taking needle is acquired the venipuncture of object, enters venous blood by the effect of anticoagulated whole blood pump line
Three-way connector, while anti-coagulants is led to by anti-coagulants branch road and anti-coagulants pump line into three by the effect of anti-coagulants pump line
Device is connect, venous blood and anti-coagulants are mixed to form anticoagulated whole blood herein, enter filter chamber by the tenth Five-channel；
2. filtering：Into filter chamber anticoagulated whole blood after blood strainer filtering, put aside in filter chamber, pass through after product is full
Fourth lane enters transfer chamber, and now the second, the 7th node is closed, and anticoagulated whole blood connects through the 3rd with eight nodes-separator
3rd branch road of pipe enters ring-separators access road；
3. separation：Anticoagulated whole blood is separated into red blood cell layer, tunica albuginea layer and blood plasma by ring-separators under centrifuge effect
Layer, because each layer density is different, the minimum plasma layer of density is located at disengagement chamber innermost layer, red blood cell layer and tunica albuginea layer positioned at separation
Chamber outermost layer；
4. plasma collection：After annular release intracavitary blood plasma reaches a certain amount of, connected by first outlet passage-separator
Ten passages of pipe tie point-the-collection branch road-blood plasma collecting bag is collected；
5. component blood is collected：When being detected tunica albuginea layer in the tie point of separator connecting tube, that is, show to separate
Intracavitary blood plasma, which has been collected, to be finished, and now the through hole electronic valve of the fourth node on the tenth passage is closed, and stops collecting blood plasma, point
Component blood from intracavitary passes through second outlet passage-the second branch road of separator connecting tube-the nine under component blood wriggling pumping action
Passage the-the second transfer branch road of the-the eight passages of node of passage -11 passage-the of component blood pump line-the six-first node-the seven enters
Enter the second transfer bag；
6. backup collection：When carrying out component blood collection, blood taking needle continues to be acquired venous blood, while by anticoagulated whole
Blood enters transfer chamber after filter chamber filters, and now the seven, the 8th nodes are closed, and anticoagulated whole blood is logical by section point-the five
It is standby that the transfer of road-the first branch road enters the first transfer bag；
7. transfer blood inputs：After component blood fully enters the second transfer bag in ring-separators, the 3rd node is closed,
8th node is opened, and the anticoagulated whole blood in the first transfer bag flows back to transfer chamber, then is inputted by the third channel of separator connecting tube
Ring-separators, continue blood separation；
8. component blood is fed back：When transfer blood inputs ring-separators, filter chamber is vacant, and the 7th is connected in first node
The through hole electronic valve of passage and the 8th passage is closed, and the component blood in the second transfer bag is through six passages of first node-the-feedback pipe
Road inputs filter chamber, anticoagulated whole blood pump line acting in opposition, component blood is fed back in human body；
9. decoction is fed back：When adverse reaction occurs for acquisition target, physiological saline/decoction passes through the tenth through loading branch road
Two the-the seven nodes of branch road enter transfer chamber, and now the second, the 8th node is closed, anticoagulated whole blood pump line acting in opposition, physiology salt
Water/decoction is fed back to human body by three nodes-filter chamber-anticoagulated whole blood pump line, is circulated when collecting flowchart enters last collection
When, blood plasma collecting bag reaches default collection target, and part residual is still arranged at disengagement chamber bottom after component blood is fed back, now physiological saline
Transfer chamber is entered by the 12nd the-the seven node of passage, second, third node is closed, and liquid passes through the 8th the-the ten threeway of node
The third channel of road-separator connecting tube enters ring-separators, the component blood remained in ring-separators is taken away, through second
The node-the eight of second the-the nine passages of branch road -11 passage-the of component blood pump line-the six of exit passageway-separator connecting tube
Passage enters first node, and now the node of the passage of UNICOM the 7th and the 8th passage is closed, and mixing liquid is through six passages-feedback
Pipeline-enter filter chamber, inputted under the effect of anticoagulated whole blood pump line in human body, whole gatherer process terminates.
10. during plant running, the first air detection module being arranged on third channel is used for anti-coagulants branch
Amount of liquid in road is monitored, and when monitoring that it is fashionable that anti-coagulants branch road has gas to enter, prompts operating personnel to change anti-coagulants storage
Cryopreservation device carries out loop monitoring.The second air detection module being arranged on second channel inputted for detecting anticoagulated whole blood
Whether air is mixed into journey, as being mixed into air more than controlling the 9th node on the tenth Five-channel to close if safety value, pause is whole
Individual flow, and send alarm and reminding operating personnel and carry out pipeline investigation.Pressure detecting module is additionally provided with second channel, is used for
The pressure condition in whole device is detected, to ensure that peristaltic pump runs well, alarm and reminding operator is sent if pressure anomaly
Member carries out pipeline investigation.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (8)
1. a kind of integration module applied on continous way sampled plasma device, it is characterised in that be provided with and connect on integration module
The acquisition module of mouth and harvester, anti-coagulants module, separation module, collection module, transit module, loading module, anticoagulated whole
Blood pump pipe and component blood pump line are connected, and filter chamber and transfer chamber are set in integration module, by interface channel by filter chamber
It is connected with transfer chamber with above-mentioned module/pump line, air monitering module and pressure monitoring module is provided with integration module, integrates
Be provided with module threeway node respectively by component blood pump line, transit module and feed back branch road be connected, feed back branch road via
It is connected outside integration module with filter chamber, is provided with connecting node on the passage being connected with feeding back branch road, is set in connecting node
It is equipped with the through hole being connected with electronic valve.
A kind of 2. integration module applied on continous way sampled plasma device as claimed in claim 1, it is characterised in that collection
Interface channel is provided with into module acquisition module is connected with anti-coagulants module, air monitering mould is provided with interface channel
Block.
A kind of 3. integration module applied on continous way sampled plasma device as claimed in claim 1, it is characterised in that collection
Interface channel is provided with into module acquisition module is connected with anticoagulated whole blood pump line, air monitering is provided with interface channel
Module and pressure monitoring module.
A kind of 4. integration module applied on continous way sampled plasma device as claimed in claim 1, it is characterised in that collection
It is provided with interface channel in into module filter chamber is connected with anticoagulated whole blood pump line and transfer chamber.
A kind of 5. integration module applied on continous way sampled plasma device as claimed in claim 1, it is characterised in that collection
It is provided with interface channel in into module transfer chamber is connected with transit module, separation module and loading module respectively, transfer
Pressure monitoring module is provided with the interface channel of chamber and separation module.
A kind of 6. integration module applied on continous way sampled plasma device as claimed in claim 1, it is characterised in that collection
It is provided with interface channel in into module separation module is connected with component blood pump line and collection module respectively.
A kind of 7. integration module applied on continous way sampled plasma device as claimed in claim 1, it is characterised in that mistake
Be provided with blood filter screen and pressure monitoring module in filter chamber, the position that each interface channel is connected with transfer chamber in integration module with
And the position that each interface channel connects each other is provided with connecting node, and electronic valve is provided with connecting node.
8. a kind of continous way sampled plasma device for employing integration module described in claim 1, it is characterised in that also include adopting
Collect module, anti-coagulants module, separation module, collection module, transit module, loading module, anticoagulated whole blood pump line and composition blood pump
Pipe, foregoing each module and pump line are connected by the interface being arranged on integration module with integration module；Acquisition module includes adopting
Blood pin and three-way connector, the tie point of three-way connector are connected with blood taking needle, and second, third branch road passes through interface respectively
It is connected with integration module；Anti-coagulants module includes anti-coagulants pump line and anti-coagulants branch road, and anti-coagulants branch road connection anti-coagulants is deposited
Storage device, peristaltic pump is provided with anti-coagulants pump line, anticoagulated whole blood pump line and component blood pump line；Separation module includes annular release
Device and separator connecting tube, the head end of separator connecting tube are connected with the centre gangway of annular connector, tail end first to
3rd branch road is connected by interface with integration module respectively；Collection module includes blood plasma collecting bag and collects branch road；Loading mould
Block includes loading branch road, and loading branch road connects decoction storage device by puncture needle；Transit module includes first, second transfer bag
And first, second transfer branch road.
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| CN201610257644.8A CN105854106B (en) | 2016-04-22 | 2016-04-22 | A kind of integration module applied on continous way sampled plasma device |
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| CN201610257644.8A CN105854106B (en) | 2016-04-22 | 2016-04-22 | A kind of integration module applied on continous way sampled plasma device |
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| CN111870758A (en) * | 2020-09-07 | 2020-11-03 | 山东中保康医疗器具有限公司 | Single-needle multi-pump integrated liquid flow control device based on centrifugal method |
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| CN2336802Y (en) * | 1998-08-06 | 1999-09-08 | 四川省南格尔医用器具有限公司 | Device for taking and transfusing component blood and autoblood |
| CN1321098A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions |
| CN204049654U (en) * | 2014-06-27 | 2014-12-31 | 四川南格尔生物科技有限公司 | A kind of novel sampled plasma device |
| CN205667657U (en) * | 2016-04-22 | 2016-11-02 | 四川南格尔生物科技有限公司 | A kind of integration module being applied on continuous way sampled plasma device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066172A2 (en) * | 2000-03-09 | 2001-09-13 | Gambro, Inc. | Extracorporeal blood processing method and apparatus |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2336802Y (en) * | 1998-08-06 | 1999-09-08 | 四川省南格尔医用器具有限公司 | Device for taking and transfusing component blood and autoblood |
| CN1321098A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions |
| CN204049654U (en) * | 2014-06-27 | 2014-12-31 | 四川南格尔生物科技有限公司 | A kind of novel sampled plasma device |
| CN205667657U (en) * | 2016-04-22 | 2016-11-02 | 四川南格尔生物科技有限公司 | A kind of integration module being applied on continuous way sampled plasma device |
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