JPH03284263A - Device for collecting plasma and concentrated erythrocyte - Google Patents
Device for collecting plasma and concentrated erythrocyteInfo
- Publication number
- JPH03284263A JPH03284263A JP2083382A JP8338290A JPH03284263A JP H03284263 A JPH03284263 A JP H03284263A JP 2083382 A JP2083382 A JP 2083382A JP 8338290 A JP8338290 A JP 8338290A JP H03284263 A JPH03284263 A JP H03284263A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- plasma
- concentrated red
- collecting
- storage container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003743 erythrocyte Anatomy 0.000 title claims abstract description 68
- 210000004369 blood Anatomy 0.000 claims abstract description 79
- 239000008280 blood Substances 0.000 claims abstract description 79
- 239000000835 fiber Substances 0.000 claims description 21
- 230000036770 blood supply Effects 0.000 claims description 20
- 210000004204 blood vessel Anatomy 0.000 claims description 20
- 239000012530 fluid Substances 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 11
- 239000002699 waste material Substances 0.000 claims description 11
- 239000003146 anticoagulant agent Substances 0.000 claims description 6
- 229940127219 anticoagulant drug Drugs 0.000 claims description 6
- 230000037452 priming Effects 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 description 85
- 210000001772 blood platelet Anatomy 0.000 description 22
- 210000000265 leukocyte Anatomy 0.000 description 21
- 238000000926 separation method Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 239000012503 blood component Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は血漿および濃厚赤血球採取用器具に関するもの
である。詳しく述べると本発明は、採血された血液から
、白血球および面小板を含まない濃厚赤血球と血漿を完
全閉鎖系で分別採取する血漿および濃厚赤血球採取用器
具に関するものである。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a device for collecting plasma and concentrated red blood cells. Specifically, the present invention relates to a device for collecting plasma and concentrated red blood cells, which separates and collects concentrated red blood cells and plasma, which do not contain white blood cells and face platelets, from collected blood in a completely closed system.
（従来の技術）
近年、患者に必要とする血液成分のみを輸血する血液成
分療法が活発に行なわれるようになっている。例えば、
赤血球を必要とする患者へは、従来、血漿分離フィルタ
ー、ないしは遠心分離を用いた操作によって得られる濃
厚赤血球液が赤血球の成分製剤として輸注されている。(Prior Art) In recent years, blood component therapy, in which only blood components required by a patient are transfused, has been actively carried out. for example,
Conventionally, concentrated red blood cell fluid obtained by operations using a plasma separation filter or centrifugation is infused as a component preparation of red blood cells to patients who require red blood cells.
しかしながら、上記のような操作によって得られる濃厚
赤血球液は、多くの白血球および血小板を含んでおり、
赤血球のみを必要としている患者に赤血球濃厚液の輸注
により合せて多量の白血球および血小板が輸注されるこ
とが問題視されている。However, the concentrated red blood cell fluid obtained by the above procedure contains many white blood cells and platelets,
It has become a problem that patients who require only red blood cells are injected with a large amount of white blood cells and platelets due to the infusion of concentrated red blood cells.
このため、上記のような濃厚赤血球を患者に輸注する場
合、使用に際して、白血球および血小板除去用フィルタ
ーを接続し、濃厚赤血球液から白血球および血小板を除
去するがなされている。Therefore, when the above-mentioned concentrated red blood cells are infused into a patient, a filter for removing white blood cells and platelets is connected to remove the white blood cells and platelets from the concentrated red blood cell fluid.
しかしながら、このような方法によると、輸血の際に白
血球および血小板除去用フィルターを新たに接続しなけ
ればならず、完全な閉鎖系が保てなくなり、滅菌処理操
作の煩雑化、あるいは感染症併発の危険性の増大などが
生じることとなる。However, with this method, a filter for removing white blood cells and platelets must be newly connected during blood transfusion, making it impossible to maintain a completely closed system, complicating sterilization operations, and increasing the risk of infection. This will result in an increase in risk.
さらに、このように輸血の際に白血球および血小板除去
用フィルターを設けた場合、この白血球および血小板除
去用フィルターの血液通過速度が律速となるために、急
速な輸血を必要とする場合に問題となった。Furthermore, when a filter for removing white blood cells and platelets is provided during blood transfusion, the rate at which blood passes through the filter for removing white blood cells and platelets becomes rate-limiting, which poses a problem when rapid blood transfusion is required. Ta.
（発明が解決しようとする課題）
従って本発明は、改良された血漿および濃厚赤血球採取
用器具を提供することを目的とするものである。本発明
はまた、白血球および血小板を含まない濃厚赤血球と血
漿とが完全閉鎖系で採取可能な血漿および濃厚赤血球採
取用器具を提供することを目的とするものである。(Problems to be Solved by the Invention) Accordingly, it is an object of the present invention to provide an improved device for collecting plasma and concentrated red blood cells. Another object of the present invention is to provide a device for collecting plasma and concentrated red blood cells that can collect concentrated red blood cells and plasma that do not contain white blood cells and platelets in a completely closed system.
（課題を解決するための手段）
上記諸口的は、採血針に繊維を内部に収納してなる貯血
容器を第一送血管により連通し、この貯血容器に血漿分
離器を第二送血管により連通し、さらにこの血漿分離器
に濃厚赤血球採取用器具
び血漿輸送管により連通してなり、前記採血針、貯血容
器、血漿分離器、濃厚赤血球採取用器具
を任意に変えることができることを特徴とする血漿およ
び濃厚赤血球採取用器具によって達成される。(Means for Solving the Problems) In the above aspects, a blood storage container formed by storing fibers inside a blood collection needle is connected through a first blood supply tube, and a plasma separator is connected to this blood storage container through a second blood supply tube. The plasma separator is further connected to a concentrated red blood cell collection device and a plasma transport tube, and the blood collection needle, blood storage container, plasma separator, and concentrated red blood cell collection device can be changed as desired. Accomplished by plasma and packed red blood cell collection devices.
本発明はまた、前記貯血容器内には、生理的等張な抗凝
固剤がさらに収納されている血漿および濃厚赤血球採取
用器具を示すものである。本発明はさらに、前記第一送
血管、第二送血管および血漿輸送管ヒに回路開閉手段を
設けてなる血漿および濃厚赤血球採取用器具を示すもの
である。本発明はさらに、前記第二送血管に連通ずるプ
ライミングラインと、前記第三送血管に連通ずる廃液ラ
インとをさらに有する血漿および濃厚赤血球採取用器具
を示すものである。本発明はさらにまた、前記貯血容器
内に収納された繊維、の繊維径が１０μｍ以下である血
漿および濃厚赤血球採取用器具を示すものである。The present invention also provides a device for collecting plasma and concentrated red blood cells, wherein the blood storage container further contains a physiologically isotonic anticoagulant. The present invention further provides a device for collecting plasma and concentrated red blood cells, in which the first blood vessel, the second blood vessel, and the plasma transport tube are provided with circuit opening/closing means. The present invention further provides a device for collecting plasma and concentrated red blood cells, further comprising a priming line communicating with the second blood vessel and a waste liquid line communicating with the third blood vessel. The present invention further provides a device for collecting plasma and concentrated red blood cells, wherein the fibers housed in the blood storage container have a fiber diameter of 10 μm or less.
（作用）
このように本発明の血漿および濃厚赤血球採取用器具に
おいては、採血針より血漿分離器に至る間に内部に繊維
を収納してなる貯血容器を設けているために、健常人よ
り採血された血液は、血漿分離器へと導入される前に、
この貯血容器中において内部に収納された繊維に接触さ
せられ、白血球および血小板を粘着除去されることとな
る。このため後続する血漿分離器には、貯血容器より導
出される白血球および血小板を含まない血液が直接導入
されることとなり、白血球および血小板を含まない濃厚
赤血球液と血漿とが完全閉鎖系で採取できるものである
。さらに本発明の血漿および濃厚赤血球採取用器具にお
いては、」二記したように白血球および血小板が除去さ
れた血液が血漿分離器へと供給されるため、血漿分離器
における血漿分離膜への白血球および血小板の吸着が軽
減され、安定した血漿分離性能を得ることができるもの
となる。(Function) As described above, in the device for collecting plasma and concentrated red blood cells of the present invention, since a blood storage container containing fibers is provided between the blood collection needle and the plasma separator, blood can be collected from a healthy person. The collected blood is then passed through the plasma separator before being introduced into the plasma separator.
In this blood storage container, it is brought into contact with the fibers housed inside, and white blood cells and platelets are removed by adhesion. For this reason, blood that does not contain white blood cells and platelets derived from the blood storage container is directly introduced into the subsequent plasma separator, and concentrated red blood cell fluid and plasma that do not contain white blood cells and platelets can be collected in a completely closed system. It is something. Furthermore, in the device for collecting plasma and concentrated red blood cells of the present invention, as described in Section 2, since blood from which white blood cells and platelets have been removed is supplied to the plasma separator, white blood cells and concentrated red blood cells are transferred to the plasma separation membrane in the plasma separator. Platelet adsorption is reduced and stable plasma separation performance can be obtained.
（実施例） 以下、本考案を実施態様に基づきより詳細に説明する。(Example) Hereinafter, the present invention will be explained in more detail based on embodiments.
第１図は本発明の血漿および濃厚赤血球採取用器具の一
実施態様の構成を示す模式図である。FIG. 1 is a schematic diagram showing the configuration of one embodiment of the device for collecting plasma and concentrated red blood cells of the present invention.
第１図に示す実施態様の血漿および濃厚赤血球採取用器
具において、採血針２は、第一送血管３により、繊維１
４を内部に収納してなる貯血容器４の血液導入口へと接
続されている。なお、採血針２には、必要に応じてキャ
ップが被嵌される。In the apparatus for collecting plasma and concentrated red blood cells according to the embodiment shown in FIG.
4 is connected to a blood inlet of a blood storage container 4 which houses a blood vessel 4 therein. Note that the blood collection needle 2 is fitted with a cap as necessary.
この貯血容器４内に収納される繊維：１４としては、血
液との接触において効率よく白血球および血小板を粘着
により捕捉除去できるものが望ましく、具体的にはその
繊維径が１０μｍ以下、より好ましくは１〜５μｍのも
のとされる。また、貯血容器４内における該繊維１４の
嵩密度としては０．５ｇ／ｃｍ３以下、より好ましくは
０．０１〜０．１ｇ／ｃｍ３程度であることが望まれる
。The fibers 14 stored in this blood storage container 4 are desirably ones that can efficiently capture and remove white blood cells and platelets through adhesion when in contact with blood. Specifically, the fiber diameter is 10 μm or less, more preferably 1 μm or less. ~5 μm. Further, it is desirable that the bulk density of the fibers 14 in the blood storage container 4 be 0.5 g/cm 3 or less, more preferably about 0.01 to 0.1 g/cm 3 .
なお、貯血容器４内への該繊維１４の充填形態としては
、この繊維を絡み合せて綿状にしたものでも、あるいは
常法に従い２次加工して不織布、織布あるいは編布状し
たものであってもよい。Note that the fibers 14 may be filled into the blood storage container 4 by intertwining the fibers into a cotton-like form, or by secondary processing using a conventional method to form a non-woven fabric, a woven fabric, or a knitted fabric. There may be.
さらにこの貯血容器４内へは、例えば、ＣＰＤ、ＡＣＤ
などのような生理的等張な抗凝固剤が収納されているこ
とが望ましい。Furthermore, into this blood storage container 4, for example, CPD, ACD, etc.
It is desirable that a physiologically isotonic anticoagulant such as
この実施態様において、前記貯血容器４の血液導出口は
、第二送血管５により、内部に血漿分離膜を備えた血漿
分離器６の血液導入口に接続されている。さらにこの血
漿分離器６の処理血液導出口には、第三送血管７により
、濃厚赤血球採取用器具
の血漿（濾液）導出口には、血漿輸送管９により、血漿
採取用容器１０が接続されている。In this embodiment, the blood outlet of the blood storage container 4 is connected by a second blood supply tube 5 to a blood inlet of a plasma separator 6 equipped with a plasma separation membrane therein. Further, a plasma collection container 10 is connected to the processed blood outlet of the plasma separator 6 through a third blood supply tube 7, and to a plasma (filtrate) outlet of the concentrated red blood cell collection device through a plasma transport tube 9. ing.
さらに、この実施態様の血漿および濃厚赤血球採取用器
具においては、前記第一送血管３、第二送血管５および
血漿輸送管９上に、回路開閉手段１１．１２および１３
がそれぞれ設けられており、操作時にこれらの管路を適
宜開放ないし閉鎖できるようにしである。しかしながら
、これらの回路開閉手段は、別途クレンメ等の管路閉鎖
部制を用意すれば、必ずしもこの血漿および濃厚赤血球
採取用器具自体に設ける必要はない。Furthermore, in the apparatus for collecting plasma and concentrated red blood cells of this embodiment, circuit opening/closing means 11, 12 and 13 are provided on the first blood vessel 3, the second blood vessel 5, and the plasma transport tube 9.
are respectively provided, so that these pipes can be opened or closed as appropriate during operation. However, these circuit opening/closing means do not necessarily need to be provided in the apparatus for collecting plasma and concentrated red blood cells themselves, if a pipe closing system such as a drain pipe is separately prepared.
なお、この実施態様の血漿および濃厚赤血球採取用器具
において、前記採血針２、貯血容器４、血漿分離器６、
濃厚赤血球液採取用容器８および血漿採取用容器１０は
、上記したように管路、すなわち、第一送血管３、第二
送血管５、第三送血管７あるいは血漿輸送管９により、
それぞれが他の１ないしそれ以上の部材と互いに接続さ
れているのみであるために、これらの部材の相対的な高
低の位置関係は、任意に変えることができる。In addition, in the device for collecting plasma and concentrated red blood cells of this embodiment, the blood collecting needle 2, the blood storage container 4, the plasma separator 6,
The container 8 for collecting concentrated red blood cells and the container 10 for collecting plasma are connected to each other by the conduits, that is, the first blood vessel 3, the second blood vessel 5, the third blood vessel 7, or the plasma transport tube 9, as described above.
Since each member is only interconnected with one or more other members, the relative height positional relationship of these members can be changed arbitrarily.
このような構成を有する血漿および濃厚赤血球採取用器
具を用いて、白血球および血小板を含まない濃厚赤血球
液、ならびに血漿を完全閉鎖系で得る操作は、例えば次
の通りである。An operation for obtaining concentrated red blood cell fluid and plasma that do not contain white blood cells and platelets in a completely closed system using a device for collecting plasma and concentrated red blood cells having such a configuration is, for example, as follows.
すなわち、まず採血に先立ち、回路開閉手段のうち、第
一送血管３上に位置する回路開閉手段１１のみを開とし
、それ以外の回路開閉手段１２．１３を閉とする。そし
て、供血者１の静脈に採血針２を穿刺し、貯血容器４を
採血針２よりも低い位置において、静脈より流出した血
液を落差により、第一送血管３を介して貯血容器４に採
取する。That is, first, prior to blood collection, among the circuit opening/closing means, only the circuit opening/closing means 11 located on the first blood supply tube 3 is opened, and the other circuit opening/closing means 12, 13 are closed. Then, the blood collection needle 2 is punctured into the vein of the blood donor 1, and the blood storage container 4 is placed at a lower position than the blood collection needle 2, and the blood flowing out from the vein is collected into the blood storage container 4 via the first blood supply tube 3 by a drop. do.
一定量の血液を採取した時点で採血針２を静脈より抜去
し、回路開閉手段１１を閉とする。When a certain amount of blood has been collected, the blood collection needle 2 is removed from the vein, and the circuit opening/closing means 11 is closed.
採取された血液は、該貯血容器４内において、収納され
ている繊維１４と接触し、血液中の白面球および血小板
が該繊維１４へと粘着する。また合せて、貯血容器４内
においては、血液があらかじめ収納されていた抗凝固剤
と混合される。The collected blood comes into contact with the fibers 14 stored in the blood storage container 4, and the white blood and platelets in the blood adhere to the fibers 14. At the same time, in the blood storage container 4, the blood is mixed with the anticoagulant stored in advance.
白血球および血小板の該繊維″１４への粘霜か十分に生
起するのに要する所定時間が経過したら、各部材の高低
の位置関係を上方から貯血容器４、血漿分離器６、濃厚
赤血球液採取用容器８の順に設置する。血漿採取用容器
も血漿分離器６よりも下方に設置する。この状態で、第
二送血管５１−に位置する回路開閉手段１２および血漿
輸送管９１−に位置する回路開閉手段１３を開とする。After the predetermined time required for sufficient frost to form on the fibers 14 of white blood cells and platelets has elapsed, the height positional relationship of each member is adjusted from above to the blood storage container 4, plasma separator 6, and concentrated red blood cell fluid collection. Containers 8 are installed in this order. Plasma collection containers are also installed below the plasma separator 6. In this state, the circuit opening/closing means 12 located in the second blood supply pipe 51- and the circuit located in the plasma transport pipe 91- The opening/closing means 13 is opened.
貯血容器４内において抗凝固剤と混和されかつ繊維１４
に白血球および血小板を粘着除去された血液は、落差に
より、第二送血管を介して、血漿分離器６へと導入され
る。血漿分離器６において血液は、濃厚赤血球液と血漿
とに分離され、濃厚赤血球液は第三送血管７を介して濃
厚赤血球液採取用容器８へと、また血漿は血漿輸送管９
を介して血漿採取用容器１０へと、落差によりそれぞれ
回収されるものである。The fibers 14 are mixed with an anticoagulant in the blood storage container 4.
The blood from which white blood cells and platelets have been adhered is introduced into the plasma separator 6 via a second blood vessel due to a drop. In the plasma separator 6, the blood is separated into concentrated red blood cell fluid and plasma.The concentrated red blood cell fluid is transferred to a container 8 for collecting concentrated red blood cell fluid via a third feeding tube 7, and the plasma is transferred to a plasma transport tube 9.
The plasma is collected via a drop into the plasma collection container 10, respectively.
０
第２図は、本発明の血漿および濃厚赤血球採取用器具の
別の実施態様の構成を示す模式図である。0 FIG. 2 is a schematic diagram showing the configuration of another embodiment of the device for collecting plasma and concentrated red blood cells of the present invention.
第２図に示す実施態様の血漿および濃厚赤血球採取用器
具は、第二送血管５に連通するプライミングライン１５
と、前記第三送血管７に連通ずる廃液ライン１６とをさ
らに有し、また、このプライミングライン１５上に回路
開閉手段１７、廃液ライン１６上に回路開閉手段１８、
第三送血管７」二に回路開閉手段１９をそれぞれ設けた
以外は、前記第１図に示す実施態様と同様の構成を有す
るものである。なお、廃液ライン１６の末端には廃液用
容器２０が設けである。この実施態様の血漿および濃厚
赤血球採取用器具においては、採血に先立ち、第二送血
管５上に位置する回路開閉手段１２、第三送血管７−に
に位置する回路開閉手段１９および血漿輸送管９上に位
置する回路開閉手段１３を閉としておき、プライミング
ライン１５より生理食塩水等を第二送血管５を介して連
通する血漿分離器６に導入し、さらに血漿分離器６より
導出された生理食塩水等を第三送血管７を介して１
連通ずる廃液ライン１６から廃液用容器２０へと導き、
その後回路開閉手段１７および１８を閉じることにより
、血漿分離器６のプライミングが可能とされている。こ
の第２図に示す実施態様の血漿および濃厚赤血球採取用
器具により血漿および濃厚赤血球液を得る際における後
続する操作は、前記第１図に示す実施態様の場合と同様
である。The apparatus for collecting plasma and concentrated red blood cells according to the embodiment shown in FIG.
and a waste liquid line 16 communicating with the third feeding tube 7, and a circuit opening/closing means 17 on the priming line 15, a circuit opening/closing means 18 on the waste liquid line 16,
This embodiment has the same structure as the embodiment shown in FIG. 1, except that circuit opening/closing means 19 are provided in each of the third blood vessels 7'. Note that a waste liquid container 20 is provided at the end of the waste liquid line 16. In the apparatus for collecting plasma and concentrated red blood cells of this embodiment, prior to blood collection, the circuit opening/closing means 12 located on the second blood supply tube 5, the circuit opening/closing means 19 located on the third blood supply tube 7-, and the plasma transport tube The circuit opening/closing means 13 located above the plasma separator 9 is kept closed, and physiological saline or the like is introduced from the priming line 15 into the plasma separator 6 that communicates with it via the second blood supply tube 5, and further extracted from the plasma separator 6. Physiological saline or the like is led from the waste liquid line 16 through the third blood supply tube 7 to the waste liquid container 20,
Thereafter, by closing the circuit opening/closing means 17 and 18, the plasma separator 6 can be primed. The subsequent operations when obtaining plasma and concentrated red blood cell fluid using the device for collecting plasma and concentrated red blood cells of the embodiment shown in FIG. 2 are the same as in the embodiment shown in FIG. 1 above.
（発明の効果）
以１−述べたように、本発明は、採血針に繊組°を内部
に収納してなる貯血容器を第二送血管により連通し、こ
の貯血容器に血漿分離器を第二送血管により連通し、さ
らにこの血漿分離器に濃厚赤血球液採取用容器および血
漿採取用容器をそれぞれ第三送血管および血漿輸送管に
より連通してなり、前記採血針、貯血容器、血漿分離器
、濃厚赤血球液採取用容器および血漿採取用容器の相対
的な高低の位置関係を任意に変えることができることを
特徴とする血漿および濃厚赤血球採取用器具であるから
、白血球および血小板を含まない濃厚赤血球液と血漿と
を完全閉鎖系で採取できることとな２
す、該器具を用いて採取した濃厚赤血球液を用いれば、
似者に輸注する際に、白血球および血小板除去フィルタ
ーを接続する必要がなく、該フィルターを接続すること
に起因する滅菌の煩雑化ないしは感染症の危険性の増大
、あるいは急速輸血を必要とする場合における該フィル
ターを通過する血液の速度が律速となるといった問題が
なくなり、濃厚赤血球の釘尾よい輸注が可能となるもの
である。さらに、本発明の血漿および濃厚赤血球採取用
器具においては、白血球および血小板が除去された血液
が血漿分離器へと供給されるため、血漿分離器における
血漿分離膜への白血球および血小板の吸着が軽減され、
安定した血漿分離性能を得ることができるものとなり、
より高品質な濃厚赤血球液および血漿を提供できるもの
となる。さらにまた、本発明の血漿および濃厚赤血球採
取用器具において、前記貯血容器内に生理的等張な抗凝
固剤が収納されており、前記第一送血管、第二送血管お
よび血漿輸送管−Ｉ−に回路開閉手段が設けられており
、また、前記第二送血管に連通するブラ３
イミングラインと、前記第三送血管に連通ずる廃液ライ
ンとが設けられていると、血漿および濃厚赤血球液を得
る操作がより容易にかつ安定して行なえるものとなり、
さらに前記貯血容器内に収納された繊維の繊維径が１０
ｌｔ ｍ以下であると、得られる濃厚赤血球液はより
品質の高いものとなる。(Effects of the Invention) As described in 1-1 above, the present invention provides a blood storage container in which a blood collection needle is housed with a fiber assembly, which is connected to the blood storage container through a second blood supply tube, and a plasma separator is connected to the blood storage container. The blood collection needle, the blood storage container, and the plasma separator are connected to each other by two blood supply tubes, and a concentrated red blood cell collection container and a plasma collection container are connected to the plasma separator by a third blood supply tube and a plasma transport tube, respectively. , is a device for collecting plasma and concentrated red blood cells, which is characterized in that the relative height positional relationship of the container for collecting concentrated red blood cells and the container for collecting plasma can be arbitrarily changed. If the concentrated red blood cell fluid collected using this device is used, fluid and plasma can be collected in a completely closed system.
When infusing into a similar person, there is no need to connect a white blood cell and platelet removal filter, and connecting the filter would complicate sterilization or increase the risk of infection, or if rapid blood transfusion is required. This eliminates the problem of the rate of blood passing through the filter being rate-limiting, and enables efficient transfusion of concentrated red blood cells. Furthermore, in the device for collecting plasma and concentrated red blood cells of the present invention, since blood from which white blood cells and platelets have been removed is supplied to the plasma separator, adsorption of white blood cells and platelets to the plasma separation membrane in the plasma separator is reduced. is,
It is possible to obtain stable plasma separation performance,
This makes it possible to provide higher quality concentrated red blood cell fluid and plasma. Furthermore, in the device for collecting plasma and concentrated red blood cells of the present invention, a physiologically isotonic anticoagulant is stored in the blood storage container, and the first blood vessel, the second blood vessel and the plasma transport tube -I - is provided with a circuit opening/closing means, and is also provided with a bra 3 imming line communicating with the second blood supply tube and a waste liquid line communicating with the third blood supply tube. The operation to obtain the information becomes easier and more stable.
Furthermore, the fiber diameter of the fibers accommodated in the blood storage container is 10
If it is below lt m, the obtained concentrated red blood cell fluid will be of higher quality.
第１図は本発明の血漿および濃厚赤血球採取用器具の一
実施態様の構成を示す模式図であり、また第２図は本発
明の血漿および濃厚赤血球採取用器具の別の実施態様の
構成を示す模式図である。
１・・・供面者、２・・・採血針、３・・・第一送血管
、４・・・貯血容器、５・・・第二送血管、６・・・血
漿分離器、７・・・第三送血管、８・・・濃厚赤血球採
取用器具１１、’ １２．１３゜
１７．１８．１９・・・回路開閉手段、１４・・・繊維
、１５・・・プライミングライン、１６・・・廃液ライ
ン、２θ・・・廃液用容器。
４
図面の浄書（内容に変更なし）
特開平
２８４２６３ （５）
手続補正書
平成２年
５月
９日FIG. 1 is a schematic diagram showing the configuration of one embodiment of the device for collecting plasma and concentrated red blood cells of the present invention, and FIG. 2 is a schematic diagram showing the configuration of another embodiment of the device for collecting plasma and concentrated red blood cells of the present invention. FIG. DESCRIPTION OF SYMBOLS 1... Donor, 2... Blood collection needle, 3... First blood vessel, 4... Blood storage container, 5... Second blood vessel, 6... Plasma separator, 7... ...Third blood supply tube, 8... Instrument for collecting concentrated red blood cells 11, ' 12.13゜17.18.19... Circuit opening/closing means, 14... Fiber, 15... Priming line, 16. ...Waste liquid line, 2θ... Container for waste liquid. 4. Engraving of drawings (no change in content) JP-A-284263 (5) Procedural amendment dated May 9, 1990
Claims (5)
一送血管により連通し、この貯血容器に血漿分離器を第
二送血管により連通し、さらにこの血漿分離器に濃厚赤
血球液採取用容器および血漿採取用容器をそれぞれ第三
送血管および血漿輸送管により連通してなり、前記採血
針、貯血容器、血漿分離器、濃厚赤血球液採取用容器お
よび血漿採取用容器の相対的な高低の位置関係を任意に
変えることができることを特徴とする血漿および濃厚赤
血球採取用器具。(1) A blood storage container with fibers stored inside the blood collection needle is connected through a first blood supply tube, a plasma separator is connected to this blood storage container through a second blood supply tube, and concentrated red blood cell fluid is connected to the plasma separator. The collection container and the plasma collection container are connected through a third blood supply tube and a plasma transport tube, respectively, and the blood collection needle, blood storage container, plasma separator, concentrated red blood cell fluid collection container, and plasma collection container are connected to each other. A device for collecting plasma and concentrated red blood cells, characterized in that the height positional relationship can be changed arbitrarily.
らに収納されているものである請求項１に記載の血漿お
よび濃厚赤血球採取用器具。(2) The device for collecting plasma and concentrated red blood cells according to claim 1, wherein the blood storage container further contains a physiologically isotonic anticoagulant.
に回路開閉手段をさらに設けてなるものである請求項１
または２に記載の血漿および濃厚赤血球採取用器具。(3) A circuit opening/closing means is further provided on the first blood vessel, the second blood vessel, and the plasma transport tube.
or the instrument for collecting plasma and concentrated red blood cells according to 2.
、前記第三送血管に連通する廃液ラインとをさらに有す
るものである請求項１〜３のいずれかに記載の血漿およ
び濃厚赤血球採取用器具。(4) The apparatus for collecting plasma and concentrated red blood cells according to any one of claims 1 to 3, further comprising a priming line communicating with the second blood vessel and a waste liquid line communicating with the third blood vessel. .
μｍ以下である請求項１〜４のいずれかに記載の血漿お
よび濃厚赤血球採取用器具。(5) The fiber diameter of the fibers stored in the blood storage container is 10
The device for collecting plasma and concentrated red blood cells according to any one of claims 1 to 4, which has a particle size of µm or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2083382A JP2888590B2 (en) | 1990-03-30 | 1990-03-30 | Equipment for plasma and packed red blood cell collection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2083382A JP2888590B2 (en) | 1990-03-30 | 1990-03-30 | Equipment for plasma and packed red blood cell collection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03284263A true JPH03284263A (en) | 1991-12-13 |
| JP2888590B2 JP2888590B2 (en) | 1999-05-10 |
Family
ID=13800874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2083382A Expired - Fee Related JP2888590B2 (en) | 1990-03-30 | 1990-03-30 | Equipment for plasma and packed red blood cell collection |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2888590B2 (en) |
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| JP2017094207A (en) * | 2011-08-10 | 2017-06-01 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | Integrated type white blood cell, oxygen and/or carbon dioxide depletion/plasma separation filter device |
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|---|---|---|---|---|
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| JP2017094207A (en) * | 2011-08-10 | 2017-06-01 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | Integrated type white blood cell, oxygen and/or carbon dioxide depletion/plasma separation filter device |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2888590B2 (en) | 1999-05-10 |
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