CN105963351A - Traditional Chinese medicine composition for treating lung squamous carcinoma and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating lung squamous carcinoma and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating lung squamous carcinoma. The traditional Chinese medicine composition is prepared from the following raw material components in parts by weight: 0.5 to 2 parts of taxus chinensis, 0.5 to 2 parts of folium et ramulus cephalotaxi, 0.5 to 2 parts of herba catharanthi rosei, 5 to 15 parts of centipedes, 3 to 9 parts of radix sophorae subprostrata, 5 to 15 parts of dried toad skins, 5 to 15 parts of radix ginsengs, 5 to 15 parts of cortex cinnamomi, 5 to 15 parts of radix platycodon, 10 to 50 parts of herba rabdosiae rubescentis, 10 to 40 parts of rhizoma sparganii, 20 to 120 parts of rhizoma curcumae, 20 to 150 parts of ganodorma lucidum and 50 to 150 parts of agaricus blazei. According to the traditional Chinese medicine composition, all the raw material components are sufficiently extracted and reasonably matched; the traditional Chinese medicine composition has no toxic side effect, is convenient to take and is high in healing rate of the lung squamous carcinoma.
Description
Technical field
The invention belongs to a kind of Chinese medicine composition, particularly to a kind of Chinese medicine composition treating lung squamous cancer.
Background technology
Scale cancer is also known as lung squamous cell cancer, including carcinoma sarcomatodes, is modal type, accounts for primary lung cancer
40%~51%.Lung squamous cancer is more common in elderly men, has substantial connection with smoking.At present, treatment lung squamous cancer with surgical operation therapy,
Chemotherapy and radiation is main.Many tissues of surgical injury human body, life has to preferentially employ a large amount of " goods and materials " and " energy
Power " repair；Chemotherapy is plunderred the normal cell of the body that kills a person the most comprehensively and is included can resisting in a large number the leukocyte of cancerous cell；Radiotherapy removes
The leukocyte can be made equally outside tissue injury to reduce, cell carcinogenesis can be facilitated simultaneously.So, these methods for cancer, be not
Help the restorative method of human body.
Chinese medicine is one piece of rarity in Chinese traditional culture, and the sanitary health career for the Chinese nation is made for thousands of years
Tremendous contribution, the most still plays an important role.Aspect is prevented and treated, the especially treatment to late malignant tumour in tumor
In, differentiation of tcm has embodied powerful vitality.It is therefore necessary to develop the Chinese medicine composition effectively resisting lung squamous cancer.
Summary of the invention
For solving above-mentioned technical problem, the invention provides a kind of Chinese medicine composition treating lung squamous cancer, each raw material components
Extracting fully, compatibility is reasonable, has no side effect, taking convenience, and treatment lung squamous cancer cure rate is high.
The technical scheme is that
A kind of Chinese medicine composition treating lung squamous cancer of the present invention, it is characterised in that it includes the raw material components of following parts by weight:
Ramulus et folium taxi cuspidatae 0.5 ~ 2 part, Folium et Ramulus Cephalotaxi 0.5 ~ 2 part, Herba Catharanthi Rosei 0.5 ~ 2 part, Gekko Swinhonis 5 ~ 15 parts, root of subprostrate sophora 3 ~ 9 parts, dry maxima skin 5 ~ 15
Part, Radix Ginseng 5 ~ 15 parts, Cortex Cinnamomi 5 ~ 15 parts, Radix Platycodonis 5 ~ 15 parts.
It is preferred that the parts by weight of each crude drug are: Ramulus et folium taxi cuspidatae 0.8 ~ 1.5 part, Folium et Ramulus Cephalotaxi 0.8 ~ 1.5 part, Herba Catharanthi Rosei 0.8
~ 1.5 parts, Gekko Swinhonis 8 ~ 12 parts, root of subprostrate sophora 4 ~ 7 parts, dry maxima skin 6 ~ 12 parts, Radix Ginseng 8 ~ 12 parts, Cortex Cinnamomi 6 ~ 10 parts, Radix Platycodonis 8 ~ 14 parts,
Rabdosia rubescens 20 ~ 40 parts, Rhizoma Sparganii 10-30 part, Rhizoma Curcumae 50-100 part, Ganoderma 80-120 part, Agaricus blazei Murrill 80-120 part..
More preferably, Ramulus et folium taxi cuspidatae 1.2 parts, Folium et Ramulus Cephalotaxi 1 part, Herba Catharanthi Rosei 1.1 parts, Gekko Swinhonis 10 parts, root of subprostrate sophora 6 parts, dry maxima skin 9
Part, Radix Ginseng 10 parts, Cortex Cinnamomi 8 parts, Radix Platycodonis 12 parts, Rabdosia rubescens 35 parts, Rhizoma Sparganii 20 parts, Rhizoma Curcumae 80 parts, Ganoderma 100 parts, Agaricus blazei Murrill
100 parts.
A kind of Chinese medicine composition treating lung squamous cancer of the present invention is prepared as powder, and its preparation method comprises the steps:
(1) Ramulus et folium taxi cuspidatae, Folium et Ramulus Cephalotaxi, Herba Catharanthi Rosei, Gekko Swinhonis, root of subprostrate sophora, dry maxima skin, Radix Ginseng, Cortex Cinnamomi, Fructus Citri tangerinae are weighed respectively by preset blending ratio
Stalk, Rabdosia rubescens, Rhizoma Sparganii, Rhizoma Curcumae, Ganoderma and Agaricus blazei Murrill；
(2) putting in container by the Ramulus et folium taxi cuspidatae weighed in step (1), adding mass fraction in this container is the ethanol of 60%, adds
Enter 15 ~ 30 times that quality is the whole constituent masses weighed in step (1) of ethanol, with ethanol by Ramulus et folium taxi cuspidatae diafiltration 2 times, pour out
Extracting liq, at 80 DEG C, by extracting liqConcentrate the clear paste for relative density is 1.30～1.35；Add in container and steam
Distilled water, adds 8 ~ 10 times that quality is the whole constituent masses weighed in step (1) of distilled water, and water extraction is by Ramulus et folium taxi cuspidatae decocting in water
Continue 20 ~ 40 minutes after boiling, pour out extracting liq, at 80 DEG C, by extracting liqConcentrate for relative density be 1.30～
1.35 clear paste；
(3) putting in container by the Folium et Ramulus Cephalotaxi weighed in step (1), adding mass fraction in this container is the ethanol of 85%, adds
Enter 8-10 times that quality is the whole constituent masses weighed in step (1) of ethanol, be heated to reflux boiling and continue 120 ~ 140 points
Clock, pours out extracting solution, then addition mass fraction is the ethanol of 85% in this container, and the quality adding ethanol is to claim in step (1)
6-8 times of the whole constituent masses taken, is heated to reflux boiling and continues 120 ~ 140 minutes, pour out extracting solution, then add in this container
Enter the ethanol that mass fraction is 85%, add 6-8 times that quality is the whole constituent masses weighed in step (1) of ethanol, heating
Boiled under reflux continues 120 ~ 140 minutes, pours out extracting solution, and merging three extracting solution is extracting solution, at 80 DEG C, will extract
LiquidConcentrate the clear paste for relative density is 1.30～1.35；
(4) putting in container by the Herba Catharanthi Rosei weighed in step (1), adding mass fraction is the ethanol of 80%, adds the matter of ethanol
Amount is weigh in step (1) 8-10 times of whole constituent masses, after addition ultrasonic 40 ~ 60 minutes, then pours out extracting solution, instead
Multiple 3 operations, add 8-10 times that quality is the whole constituent masses weighed in step (1) of ethanol every time, merge and carry for three times
Take liquid and form extracting solution, at 80 DEG C, by extracting liqConcentrate the clear paste for relative density is 1.30～1.35；
(5) putting in container by the Gekko Swinhonis weighed in step (1), add distilled water, the quality adding distilled water is in step (1)
8-12 times of the whole constituent masses weighed, continues 180 minutes after ebuillition of heated, pours out extracting solution, then adds steaming in container
Distilled water, adds 8-10 times that quality is the whole constituent masses weighed in step (1) of distilled water, continues 120 after ebuillition of heated
Minute, pour out extracting solution, merging twice extracting solution is extracting solution, it is concentrated into medicinal liquid 1:1, then stirring clear paste limit in limit adds quality
Mark is 95% ethanol, makes clear paste alcohol content reach 80%, stands 72 hours, take precipitation, is dried, and baking temperature is 60 ~ 75 DEG C, makes clear
Cream moisture Control is within 4%；
(6) putting in container by the root of subprostrate sophora weighed in step (1) and add distilled water, the quality adding distilled water is step
(1) 8 ~ 12 times of the whole constituent masses weighed in, continue 120 minutes after ebuillition of heated, pour out extracting solution, repeatable operation two
Secondary, merging twice extracting solution is extracting solution, at 80 DEG C, by extracting liqConcentrating as relative density is 1.30～1.35
Clear paste, then stirring clear paste limit in limit adds ethanol, makes clear paste alcohol content reach 60%, filters, and it is phase that taking precipitate concentrates at 80 DEG C
To the clear paste that density is 1.30～1.35；
(7) putting in container by the dry maxima skin weighed in step (1), add distilled water, the quality adding distilled water is step (1)
In weigh 8-12 times of whole constituent masses, continue 120 minutes after ebuillition of heated, pour out extracting solution, then add in container
Distilled water, adds 8-10 times that quality is the whole constituent masses weighed in step (1) of distilled water, continues after ebuillition of heated
120 minutes, pouring out extracting solution, merging twice extracting solution is extracting solution, it is concentrated into medicinal liquid 1:1, then limit stirring clear paste limit
Adding mass fraction is 95% ethanol, makes clear paste alcohol content reach 60%, stands 72 hours, take precipitation, is dried, and baking temperature is 60 ~ 75
DEG C, make clear paste moisture Control within 4%；
(8) putting in container by the Radix Ginseng weighed in step (1), adding mass fraction is the ethanol of 75%, adds the quality of ethanol
For step (1) weighs 8 ~ 10 times of whole constituent mass, after ebuillition of heated, continue 90 ~ 150 minutes, pour out extracting solution, then to
Adding mass fraction 75% ethanol in container, addition quality is 6 ~ 8 times that weigh whole constituent mass in step (1), heating boiling
Continue 90 ~ 150 minutes after rising, pour out extracting liq, then in container, add mass fraction 75% ethanol, add the quality of ethanol
For 6 ~ 8 times that weigh whole constituent mass in step (1), continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting liq, close
And three extracting solution are extracting solution, at 80 DEG C, concentrate the clear paste for relative density is 1.30～1.35；
(9) putting in container by the Cortex Cinnamomi weighed in step (1), adding mass fraction is 50% ethanol, and the quality adding ethanol is
In step (1) 8 ~ 10 times that weigh whole constituent mass, ultrasonic lasting 20 ~ 40 minutes, pour out extracting solution, then add in container
Entering mass fraction is 50% ethanol, and the quality adding ethanol is 6 ~ 8 times that weigh whole constituent mass in step (1), ultrasonic holds
Continuous 20 ~ 40 minutes, pouring out extracting liq, merging twice extracting solution is extracting solution, at 80 DEG C, by extracting liqConcentrate
For the clear paste that relative density is 1.30～1.35；
(10) putting in container by the Radix Platycodonis weighed in step (1), adding mass fraction is the ethanol of 70%, adds the matter of ethanol
Amount is 8 ~ 10 times that weigh whole constituent mass in step (1), ultrasonic lasting 50 ~ 70 minutes, pours out extracting solution, then to container
Middle addition mass fraction is 70% ethanol, and the quality adding ethanol is 6 ~ 8 times that weigh whole constituent mass in step (1), super
Sound continues 50 ~ 70 minutes, pours out extracting liq, then addition mass fraction is 70% ethanol in container, and the quality adding ethanol is
In step (1) 6 ~ 8 times that weigh constituent mass, ultrasonic lasting 50 ~ 70 minutes, pour out extracting liq, merge three extracting solution
For extracting solution；
(11) putting in container by the Rabdosia rubescens weighed in step (1), adding mass fraction in this container is the ethanol of 95%,
Add 15 ~ 30 times that quality is the whole constituent masses weighed in step (1) of ethanol, with ethanol by Rabdosia rubescens diafiltration 2 times, fall
Go out extracting liq XI, at 80 DEG C, extracting liq XI is concentrated the clear paste for relative density is 1.30～1.35；
(12) Rhizoma Curcumae weighed in step (1), Rhizoma Sparganii being put in container and add distilled water, the quality adding distilled water is
8 ~ 12 times of the whole constituent masses weighed in step (1), continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, repeat
Operating twice, merging twice extracting solution is extracting solution, at 80 DEG C, extracting liqConcentrating as relative density is 1.30
～the clear paste of 1.35；
(13) putting in container by the Agaricus blazei Murrill weighed in step (1) and add distilled water, the quality adding distilled water is step
(1) 8 ~ 12 times of the whole constituent masses weighed in, continue 170 ~ 200 minutes after ebuillition of heated, pour out extracting solution, in a reservoir
Add distilled water, add 8 ~ 12 times that quality is the whole constituent masses weighed in step (1) of distilled water, after ebuillition of heated
Continuing 170 ~ 200 minutes, pour out extracting solution, add distilled water in a reservoir, the quality adding distilled water is to claim in step (1)
8 ~ 12 times of the whole constituent masses taken, continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, and merging three extracting solution is
Extracting solutionII, at 80 DEG C, by extracting liqII concentration is the clear paste that relative density is 1.30～1.35, and then limit is stirred
Mixing clear paste limit and add ethanol, make clear paste alcohol content reach 80%, filter, taking precipitate is dried at 60 ~ 75 DEG C；(14) by step (1)
In the Ganoderma that weighs put in container and add distilled water, the quality adding distilled water is the whole components weighed in step (1)
8 ~ 12 times of quality, continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, repetitive operation twice, merge twice extracting solution
For extracting solution XIV, at 80 DEG C, extracting liq XIV concentrates the clear paste for relative density is 1.30～1.35；
(15) clear paste that step (2) ~ (14) finally give is separately dried, and mix homogeneously, baking temperature is 60 ~ 75 DEG C, makes
Clear paste moisture Control is within 4%；
(16) the clear paste mixture of dried mix homogeneously is pulverized.
Use granule prepared by a kind of Chinese medicine composition treating lung squamous cancer of the present invention, it is characterised in that its preparation method
Comprise the steps:
Step (1)-(15) are identical with the preparation method of the preparation of a kind of Chinese medicine composition treating adenocarcinoma of lung, and step (16) is will
The clear paste mixture of dried mix homogeneously is pelletized after pulverizing.
Use capsule prepared by a kind of Chinese medicine composition treating lung squamous cancer of the present invention, it is characterised in that its preparation method bag
Include following step:
Step (1)-(15) are identical with the preparation method of the preparation of a kind of Chinese medicine composition treating adenocarcinoma of lung, and step (16) is will
The clear paste mixture of dried mix homogeneously fills No. 0 capsule after pulverizing, and each capsule contents receives the Chinese medicinal components of 0.5-0.7g.
In pharmaceutical composition of the present invention:
Ramulus et folium taxi cuspidatae: the paclitaxel contained in Ramulus et folium taxi cuspidatae, has the anticancer machine-processed and higher active anticancer of uniqueness, cancer can be stoped thin
The breeding of born of the same parents, the migration of suppression tumor cell, being recognized is most important anti-cancer active matter in current natural medicine field.Profit
Urine detumescence, treatment nephropathy, diabetes, nephritis edema, dysuria, gonorrhea etc..The kidney warming stimulates the menstrual flow, treats menoxenia, puerperal
Blood stasis, dysmenorrhea wait until effective effect.
Folium et Ramulus Cephalotaxi: function with cure mainly anticancer, for lymphosarcoma, pulmonary carcinoma etc..Seed anthelmintic, removing food stagnancy, for ascariasis, hook
Parasitosis, food stagnation.Branch, leaf are anticancer, for malignant tumor.Cephalotaxus fortunei total alkaloids has preferable curative effect to lymphosarcoma, pulmonary carcinoma etc..
Herba Catharanthi Rosei: removing heat from blood blood pressure lowering, tranquillizing and allaying excitement, for hypertension, burning hot wound, malignant lymphoma, chorionic epithelioma, list
Monocytic leukemia.
Gekko Swinhonis: abnormal smells from the patient is pungent, warm, poisonous, dispels the wind, active, eliminating stagnation, for paralysis due to windstroke, rheumatic arthritis, osteomyelitis, drenches
Fawn on tuberculosis, tumor.
Root of subprostrate sophora: cold in nature, bitter in the mouth.Qinghuo Jiedu, reducing swelling and alleviating pain.For throat gingival swelling and pain, cough due to lung-heat's excessive thirst, Huang
Subcutaneous ulcer, constipation with heat retention.
Dry maxima skin: sweet in the mouth, pungent, cool in nature, slightly poisonous.Subduing swelling and detoxicating, pain relieving diuresis.It is applicable to kinds of tumors, such as hepatocarcinoma, lung
Cancer, gastric cancer, malignant lymphoma, intestinal cancer, the esophageal carcinoma, leukemia etc.；External treatment skin carcinoma, cervical cancer, breast carcinoma etc..With the fat extracted
Bufotalin (having another name called lysol essence, Resibufogein, C24H32O3) treatment hemorrhagic shock, septic shock.
Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian, heart channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung is raw
Quench the thirst in Tianjin, Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly that impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma rushs, spontaneous perspiration sudden collapse, are shied
Throb with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, all qi-blood-body fluids are not enough
Disease.
Cortex Cinnamomi: return kidney, spleen, the heart, Liver Channel.Lead to for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian
Arteries and veins.
Radix Platycodonis: return lung meridian.Lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, profit the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Cure mainly cough expectorant
Many, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Rabdosia rubescens: bitter, sweet, is slightly cold.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.
Rhizoma Sparganii: pungent, bitter is flat.Return liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, for lump in the abdomen mass in the abdomen, dysmenorrhea, blood stasis
Amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Promoting the circulation of QI to relieve pain, long-pending eliminating stagnation, removing blood stasis effect can be controlled.
Ganoderma: warm in nature, lightly seasoned.Gas is special, and mildly bitter flavor is puckery.Nervous system is had inhibitory action, blood circulation to have fall by Ganoderma
Pressure and the effect of reinforcement cardiac contractile force, have phlegm-dispelling functions to respiratory system, additionally, also hepatoprotective, raising immunologic function, antibacterial
Deng effect.Cure mainly asthenia, cough, pant, have a sleepless night, dyspepsia, malignant tumor etc..
Agaricus blazei Murrill: property is put down, sweet in the mouth；GUIXIN, lung, liver, kidney channel.There is brain-strengthening, antiinflammatory, kidney tonifying, blood sugar lowering, improve glycosuria
Disease, cholesterol reducing, enhancing energy, improve the effect such as arteriosclerosis, anti-angiocardiopathy.
The usage and dosage of the present invention:
Capsule: 3-5 grain every time, three times a day.Powder or granule: 2.1g-4.5g every time, three times a day.
The technique effect of the present invention is as follows:
The raw material of the present invention is mainly derived from natural anti-cancer drugs, containing the abundant alkaloid with active anticancer, Jing Guoke
The compatibility learned, jointly acts between each active component, can not only effectively kill lung pancreas cancer cancerous cell and suppress lung pancreatic cancer again
Raw, additionally it is possible to effective suppression lung squamous cancer tumor angiogenesis；The present invention is by regulation strengthening the body resistance, enhancing human body immunity
Power, treating both the principal and secondary aspects of a disease, have no side effect；The raw material components of the present invention, through effectively extracting, improves drug effect, and prepared medicament is prone to
Take, patient's good absorbing effect.
A kind of Chinese medicine composition treating lung squamous cancer of the present invention is described in detail below in conjunction with specific embodiment:
Table 1 embodiment 1-4
Preparation method is as follows:
(1) Ramulus et folium taxi cuspidatae, Folium et Ramulus Cephalotaxi, Herba Catharanthi Rosei, Gekko Swinhonis, root of subprostrate sophora, dry maxima skin, Radix Ginseng, Cortex Cinnamomi, Fructus Citri tangerinae are weighed respectively by preset blending ratio
Stalk, Rabdosia rubescens, Rhizoma Sparganii, Rhizoma Curcumae, Ganoderma and Agaricus blazei Murrill；
(2) putting in container by the Ramulus et folium taxi cuspidatae weighed in step (1), adding mass fraction in this container is the ethanol of 60%, adds
Enter 15 ~ 30 times that quality is the whole constituent masses weighed in step (1) of ethanol, with ethanol by Ramulus et folium taxi cuspidatae diafiltration 2 times, pour out
Extracting liq, at 80 DEG C, by extracting liqConcentrate the clear paste for relative density is 1.30～1.35；Add in container and steam
Distilled water, adds 8 ~ 10 times that quality is the whole constituent masses weighed in step (1) of distilled water, and water extraction is by Ramulus et folium taxi cuspidatae decocting in water
Continue 20 ~ 40 minutes after boiling, pour out extracting liq, at 80 DEG C, by extracting liqConcentrate for relative density be 1.30～
1.35 clear paste；
(3) putting in container by the Folium et Ramulus Cephalotaxi weighed in step (1), adding mass fraction in this container is the ethanol of 85%, adds
Enter 8-10 times that quality is the whole constituent masses weighed in step (1) of ethanol, be heated to reflux boiling and continue 120 ~ 140 points
Clock, pours out extracting solution, then addition mass fraction is the ethanol of 85% in this container, and the quality adding ethanol is to claim in step (1)
6-8 times of the whole constituent masses taken, is heated to reflux boiling and continues 120 ~ 140 minutes, pour out extracting solution, then add in this container
Enter the ethanol that mass fraction is 85%, add 6-8 times that quality is the whole constituent masses weighed in step (1) of ethanol, heating
Boiled under reflux continues 120 ~ 140 minutes, pours out extracting solution, and merging three extracting solution is extracting solution, at 80 DEG C, will extract
LiquidConcentrate the clear paste for relative density is 1.30～1.35；
(4) putting in container by the Herba Catharanthi Rosei weighed in step (1), adding mass fraction is the ethanol of 80%, adds the matter of ethanol
Amount is weigh in step (1) 8-10 times of whole constituent masses, after addition ultrasonic 40 ~ 60 minutes, then pours out extracting solution, instead
Multiple 3 operations, add 8-10 times that quality is the whole constituent masses weighed in step (1) of ethanol every time, merge and carry for three times
Take liquid and form extracting solution, at 80 DEG C, by extracting liqConcentrate the clear paste for relative density is 1.30～1.35；
(5) putting in container by the Gekko Swinhonis weighed in step (1), add distilled water, the quality adding distilled water is in step (1)
8-12 times of the whole constituent masses weighed, continues 180 minutes after ebuillition of heated, pours out extracting solution, then adds steaming in container
Distilled water, adds 8-10 times that quality is the whole constituent masses weighed in step (1) of distilled water, continues 120 after ebuillition of heated
Minute, pour out extracting solution, merging twice extracting solution is extracting solution, it is concentrated into medicinal liquid 1:1, then stirring clear paste limit in limit adds quality
Mark is 95% ethanol, makes clear paste alcohol content reach 80%, stands 72 hours, take precipitation, is dried, and baking temperature is 60 ~ 75 DEG C, makes clear
Cream moisture Control is within 4%.
(6) putting in container by the root of subprostrate sophora weighed in step (1) and add distilled water, the quality adding distilled water is step
Suddenly 8 ~ 12 times of the whole constituent masses weighed in (1), continue 120 minutes after ebuillition of heated, pour out extracting solution, repeatable operation two
Secondary, merging twice extracting solution is extracting solution, at 80 DEG C, by extracting liqConcentrating as relative density is 1.30～1.35
Clear paste, then stirring clear paste limit in limit adds ethanol, makes clear paste alcohol content reach 60%, filters, and it is phase that taking precipitate concentrates at 80 DEG C
To the clear paste that density is 1.30～1.35；
(7) putting in container by the dry maxima skin weighed in step (1), add distilled water, the quality adding distilled water is step (1)
In weigh 8-12 times of whole constituent masses, continue 120 minutes after ebuillition of heated, pour out extracting solution, then add in container
Distilled water, adds 8-10 times that quality is the whole constituent masses weighed in step (1) of distilled water, continues after ebuillition of heated
120 minutes, pouring out extracting solution, merging twice extracting solution is extracting solution, it is concentrated into medicinal liquid 1:1, then stirring clear paste limit in limit adds
Mass fraction is 95% ethanol, makes clear paste alcohol content reach 60%, stands 72 hours, take precipitation, is dried, and baking temperature is 60 ~ 75 DEG C,
Make clear paste moisture Control within 4%.
(8) putting in container by the Radix Ginseng weighed in step (1), adding mass fraction is the ethanol of 75%, adds ethanol
Quality is weigh whole constituent mass in step (1) 8 ~ 10 times, continues 90 ~ 150 minutes, pour out extracting solution after ebuillition of heated,
Adding mass fraction 75% ethanol again in container, addition quality is 6 ~ 8 times that weigh whole constituent mass in step (1), adds
Continue 90 ~ 150 minutes after heat boiling, pour out extracting liq, then in container, add mass fraction 75% ethanol, add ethanol
Quality is 6 ~ 8 times that weigh whole constituent mass in step (1), continues 90 ~ 150 minutes, pour out extracting solution after ebuillition of heated
Body, merging three extracting solution is extracting solution, at 80 DEG C, concentrate the clear paste for relative density is 1.30～1.35；
(9) putting in container by the Cortex Cinnamomi weighed in step (1), adding mass fraction is 50% ethanol, and the quality adding ethanol is
In step (1) 8 ~ 10 times that weigh whole constituent mass, ultrasonic lasting 20 ~ 40 minutes, pour out extracting solution, then add in container
Entering mass fraction is 50% ethanol, and the quality adding ethanol is 6 ~ 8 times that weigh whole constituent mass in step (1), ultrasonic holds
Continuous 20 ~ 40 minutes, pouring out extracting liq, merging twice extracting solution is extracting solution, at 80 DEG C, by extracting liqConcentrate
For the clear paste that relative density is 1.30～1.35；
(10) putting in container by the Radix Platycodonis weighed in step (1), adding mass fraction is the ethanol of 70%, adds the matter of ethanol
Amount is 8 ~ 10 times that weigh whole constituent mass in step (1), ultrasonic lasting 50 ~ 70 minutes, pours out extracting solution, then to container
Middle addition mass fraction is 70% ethanol, and the quality adding ethanol is 6 ~ 8 times that weigh whole constituent mass in step (1), super
Sound continues 50 ~ 70 minutes, pours out extracting liq, then addition mass fraction is 70% ethanol in container, and the quality adding ethanol is
In step (1) 6 ~ 8 times that weigh constituent mass, ultrasonic lasting 50 ~ 70 minutes, pour out extracting liq, merge three extracting solution
For extracting solution；
(11) putting in container by the Rabdosia rubescens weighed in step (1), adding mass fraction in this container is the ethanol of 95%,
Add 15 ~ 30 times that quality is the whole constituent masses weighed in step (1) of ethanol, with ethanol by Rabdosia rubescens diafiltration 2 times, fall
Go out extracting liq XI, at 80 DEG C, extracting liq XI is concentrated the clear paste for relative density is 1.30～1.35；
(12) Rhizoma Curcumae weighed in step (1), Rhizoma Sparganii being put in container and add distilled water, the quality adding distilled water is
8 ~ 12 times of the whole constituent masses weighed in step (1), continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, repeat
Operating twice, merging twice extracting solution is extracting solution, at 80 DEG C, extracting liqConcentrating as relative density is 1.30
～the clear paste of 1.35；
(13) putting in container by the Agaricus blazei Murrill weighed in step (1) and add distilled water, the quality adding distilled water is step
(1) 8 ~ 12 times of the whole constituent masses weighed in, continue 170 ~ 200 minutes after ebuillition of heated, pour out extracting solution, in a reservoir
Add distilled water, add 8 ~ 12 times that quality is the whole constituent masses weighed in step (1) of distilled water, after ebuillition of heated
Continuing 170 ~ 200 minutes, pour out extracting solution, add distilled water in a reservoir, the quality adding distilled water is to claim in step (1)
8 ~ 12 times of the whole constituent masses taken, continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, and merging three extracting solution is
Extracting solutionII, at 80 DEG C, by extracting liqII concentration is the clear paste that relative density is 1.30～1.35, and then limit is stirred
Mixing clear paste limit and add ethanol, make clear paste alcohol content reach 80%, filter, taking precipitate is dried at 60 ~ 75 DEG C；(14) by step (1)
In the Ganoderma that weighs put in container and add distilled water, the quality adding distilled water is the whole components weighed in step (1)
8 ~ 12 times of quality, continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, repetitive operation twice, merge twice extracting solution
For extracting solution XIV, at 80 DEG C, extracting liq XIV concentrates the clear paste for relative density is 1.30～1.35；
(15) clear paste that step (2) ~ (14) finally give is separately dried, and mix homogeneously, baking temperature is 60 ~ 75 DEG C, makes
Clear paste moisture Control is within 4%；
(16) the clear paste mixture of dried mix homogeneously is pulverized, obtain the powder of embodiment 1, when taking, three times a day, every time
2.4g。
Embodiment 2 is granule, it is characterised in that its preparation method comprises the steps:
Step (1)-(15) of embodiment 2 are identical with the preparation method of embodiment 1 powder, and step (16) will be for mixing after drying all
Even clear paste mixture is pelletized after pulverizing.When taking, three times a day, each 2.4g.
Embodiment 3 and embodiment 4 are capsule, and preparation method comprises the steps: step (1)-(15) and embodiment 1
The preparation method of powder is identical, and step (16) is to fill No. 0 capsule, often by after the clear paste mixture pulverizing of dried mix homogeneously
Individual capsule contents receives the Chinese medicinal components of 0.6g.When taking, within one day, take three times, each 4.
Clinical experiment report is as follows:
Taking 260 example inpatients, the age is 39-75 year, 53 years old mean age.All patients all learn through fiber bronchial tissue
Or sputum cytology turns out to be Lung Squamous Carcinoma Patients, the most non-underwent operative of all patients or radiotherapy.It is randomly divided into matched group and treatment group two
Group, often organizes 130 examples.Matched group gives conventional chemotherapy；Treatment group takes the medicine of embodiment 1, taken three times a day, every time
2.4g.Take half a year.
Control the change of rear focus: according to national antitumor drug curative effect universal standard evaluation in 1978.It is hospitalized for treatment with patient
Front and back lung CT imaging examination compares.Result shows, in treatment group 130 example, complete incidence graph 25 example, part is alleviated
72 examples, stablize 19 examples, are in progress 14 examples, total effective rate 74.6%, and in matched group in 130 examples, complete incidence graph 12 example, part alleviates 39
Example, stablizes 51 examples, is in progress 28 examples, total effective rate 39.2%.From data, treatment group curative effect is substantially better than matched group.
Experimental example 1 mouse lung scale cancer model
(1) weight SPF level nude mice at 20-24g, Mus 6-8 in age week, 100 male Mus and 100 female Mus are chosen respectively.Random point
For treatment group 1, treatment group 2, treatment group 3, treatment group 4 and matched group, often group 40, conventional raising.
(2) strain of L78 people's Lung Squamous Carcinoma Cells is set up by Beijing tuberculosis prevention and treatment institute, is stored in Sino-Japan close friend's clinical medicine
Institute biochemistry room.The L78 tumor strain of recovery liquid nitrogen cryopreservation, washes 1 time with RPMI1640 culture fluid, collects cell suspension in containing 10%
In hyclone RPMI1640 culture fluid, 37 DEG C, the constant-temperature incubation case of 5%CO2 saturated humidity is cultivated.With No. 6 syringe needle registrations of band
It is subcutaneous that device extraction cancer cell suspension is inoculated in the right armpit of nude mice, inoculates oncocyte number 2 × 106。
(3) gavage is started the next day injected, treatment group 1, treatment group 2, treatment group 3 and treatment group 4, respectively every to each group
White mouse gavage embodiment 1, embodiment 2, embodiment 3 and the Chinese medicine composition of embodiment 4, press own wt gavage every day for every
25.75g/kg；Every white mouse of matched group is normally raised, every every day gavage 0.2mL normal saline, after feeding 20 days, tumor is long
Arrive a certain size, peel off tumor, weigh weight, calculate the meansigma methods of each group of 40 white mouse tumor weights, the results are shown in Table 1.
Table 1 mouse tumor weight
| Packet | Tumor weight g |
| Treatment group 1 | 0.24 |
| Treatment group 2 | 0.28 |
| Treatment group 3 | 0.30 |
| Treatment group 4 | 0.26 |
| Matched group | 1.12 |
From table 1 it follows that Chinese medicine composition of the present invention can effectively suppress Lung Squamous Carcinoma Cells to grow, retardance lung squamous cancer is thin
Born of the same parents' cycle.
Mean vascular density is tested: put in 10% formalin fixing after being taken out by the tumor tissues of above-mentioned stripping, conventional
Paraffin section, thickness 0.8 μm, paraffin section de-waxing aquation；3%H2O2 closes endogenous peroxydase 10min；Washing；
0.01mol/L TBS immersion bubble 5min；Electric furnace boiling method repairs antigen 60min；Normal Goat Serum hatches 30min；Drip little
Mus antihuman CD 34 monoclonal antibody (1:100), 4 DEG C of refrigerator overnight, negative control replaces mouse anti human with Normal Goat Serum
CD34 monoclonal antibody；TBS washes, and drips biotinylated sheep anti-mouse antibody, hatches 30min, TBS for 37 DEG C and wash；Dropping Radix Cochleariae officinalis enzyme
The strepto-avidin complex of labelling, hatches 30min, TBS for 37 DEG C and fully washs；Develop the color under DAB nitrite ion room temperature 5-10min；
Fully washing；Routine operation, optical microphotograph Microscopic observation.The counting of tumor microvessel density is entered by the method for Weidner report
OK.First observing whole section with low power lens, find out focus height vessel density district, it is usually located at the marginal zone of tumor capsule.With
200 times of light microscopics calculate the average of 3 visual field medium vessels numbers, as the vessel density of every tumor.Through test, each group is swollen
The mean vascular density of tumor tissue is shown in Table 2.
The mean vascular density of tumor tissues respectively organized by table 2
| Packet | Mean vascular density |
| Treatment group 1 | 36 |
| Treatment group 2 | 42 |
| Treatment group 3 | 38 |
| Treatment group 4 | 40 |
| Matched group | 148 |
Tumor cell passes through intercellular signal system, regulation surrounding normal cell (such as intravascular cells), vascular endothelial cell
Propagation, induced tumor new vessels is formed, and promotes tumor growth.From Table 2, it can be seen that Chinese medicine composition of the present invention can have
The suppression lung squamous cancer tumor angiogenesis of effect.
Described above to the disclosed embodiments, makes professional and technical personnel in the field be capable of or uses the present invention.
Multiple amendment to these embodiments will be apparent from for those skilled in the art, as defined herein
General Principle can realize without departing from the spirit or scope of the present invention in other embodiments.Therefore, the present invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and principles disclosed herein and features of novelty phase one
The widest scope caused.
Claims (6)
1. the Chinese medicine composition treating lung squamous cancer, it is characterised in that it includes the raw material components of following parts by weight: Semen Phaseoli
China fir 0.5 ~ 2 part, Folium et Ramulus Cephalotaxi 0.5 ~ 2 part, Herba Catharanthi Rosei 0.5 ~ 2 part, Gekko Swinhonis 5 ~ 15 parts, root of subprostrate sophora 3 ~ 9 parts, dry maxima skin 5 ~ 15 parts, people
Join 5 ~ 15 parts, Cortex Cinnamomi 5 ~ 15 parts, Radix Platycodonis 5 ~ 15 parts, Rabdosia rubescens 10 ~ 50 parts, Rhizoma Sparganii 10-40 part, Rhizoma Curcumae 20-120 part, Ganoderma
20-150 part, Agaricus blazei Murrill 50-150 part.
A kind of Chinese medicine composition treating lung squamous cancer the most according to claim 1, it is characterised in that the weight of each crude drug
Number is: Ramulus et folium taxi cuspidatae 0.8 ~ 1.5 part, Folium et Ramulus Cephalotaxi 0.8 ~ 1.5 part, Herba Catharanthi Rosei 0.8 ~ 1.5 part, Gekko Swinhonis 8 ~ 12 parts, root of subprostrate sophora 4 ~ 7
Part, dry maxima skin 6 ~ 12 parts, Radix Ginseng 8 ~ 12 parts, Cortex Cinnamomi 6 ~ 10 parts, Radix Platycodonis 8 ~ 14 parts, Rabdosia rubescens 20 ~ 40 parts, Rhizoma Sparganii 10-30 part,
Rhizoma Curcumae 50-100 part, Ganoderma 80-120 part, Agaricus blazei Murrill 80-120 part.
3. according to the arbitrary described a kind of Chinese medicine composition treating lung squamous cancer of claim 1 or 2, it is characterised in that each crude drug
Parts by weight be: Ramulus et folium taxi cuspidatae 1.2 parts, Folium et Ramulus Cephalotaxi 1 part, Herba Catharanthi Rosei 1.1 parts, Gekko Swinhonis 10 parts, root of subprostrate sophora 6 parts, dry maxima skin 9 parts,
Radix Ginseng 10 parts, Cortex Cinnamomi 8 parts, Radix Platycodonis 12 parts, Rabdosia rubescens 35 parts, Rhizoma Sparganii 20 parts, Rhizoma Curcumae 80 parts, Ganoderma 100 parts, Agaricus blazei Murrill 100
Part.
4. use the powder that the Chinese medicine composition described in claim 1 prepares, it is characterised in that: its preparation method includes following step
Suddenly,
(1) Ramulus et folium taxi cuspidatae, Folium et Ramulus Cephalotaxi, Herba Catharanthi Rosei, Gekko Swinhonis, root of subprostrate sophora, dry maxima skin, Radix Ginseng, Cortex Cinnamomi, Fructus Citri tangerinae are weighed respectively by preset blending ratio
Stalk, Rabdosia rubescens, Rhizoma Sparganii, Rhizoma Curcumae, Ganoderma and Agaricus blazei Murrill；
(2) putting in container by the Ramulus et folium taxi cuspidatae weighed in step (1), adding mass fraction in this container is the ethanol of 60%, adds
Enter 15 ~ 30 times that quality is the whole constituent masses weighed in step (1) of ethanol, with ethanol by Ramulus et folium taxi cuspidatae diafiltration 2 times, pour out
Extracting liq, at 80 DEG C, by extracting liqConcentrate the clear paste for relative density is 1.30～1.35；Add in container and steam
Distilled water, adds 8 ~ 10 times that quality is the whole constituent masses weighed in step (1) of distilled water, and water extraction is by Ramulus et folium taxi cuspidatae decocting in water
Continue 20 ~ 40 minutes after boiling, pour out extracting liq, at 80 DEG C, by extracting liqConcentrate for relative density be 1.30～
1.35 clear paste；
(3) putting in container by the Folium et Ramulus Cephalotaxi weighed in step (1), adding mass fraction in this container is the ethanol of 85%, adds
Enter 8-10 times that quality is the whole constituent masses weighed in step (1) of ethanol, be heated to reflux boiling and continue 120 ~ 140 points
Clock, pours out extracting solution, then addition mass fraction is the ethanol of 85% in this container, and the quality adding ethanol is to claim in step (1)
6-8 times of the whole constituent masses taken, is heated to reflux boiling and continues 120 ~ 140 minutes, pour out extracting solution, then add in this container
Enter the ethanol that mass fraction is 85%, add 6-8 times that quality is the whole constituent masses weighed in step (1) of ethanol, heating
Boiled under reflux continues 120 ~ 140 minutes, pours out extracting solution, and merging three extracting solution is extracting solution, at 80 DEG C, by extracting solution
BodyConcentrate the clear paste for relative density is 1.30～1.35；
(4) putting in container by the Herba Catharanthi Rosei weighed in step (1), adding mass fraction is the ethanol of 80%, adds the matter of ethanol
Amount is weigh in step (1) 8-10 times of whole constituent masses, after addition ultrasonic 40 ~ 60 minutes, then pours out extracting solution, instead
Multiple 3 operations, add 8-10 times that quality is the whole constituent masses weighed in step (1) of ethanol every time, merge and carry for three times
Take liquid and form extracting solution, at 80 DEG C, by extracting liqConcentrate the clear paste for relative density is 1.30～1.35；
(5) putting in container by the Gekko Swinhonis weighed in step (1), add distilled water, the quality adding distilled water is in step (1)
8-12 times of the whole constituent masses weighed, continues 180 minutes after ebuillition of heated, pours out extracting solution, then adds steaming in container
Distilled water, adds 8-10 times that quality is the whole constituent masses weighed in step (1) of distilled water, continues 120 after ebuillition of heated
Minute, pour out extracting solution, merging twice extracting solution is extracting solution, it is concentrated into medicinal liquid 1:1, then stirring clear paste limit in limit adds quality
Mark is 95% ethanol, makes clear paste alcohol content reach 80%, stands 72 hours, take precipitation, is dried, and baking temperature is 60 ~ 75 DEG C, makes clear
Cream moisture Control is within 4%；
(6) putting in container by the root of subprostrate sophora weighed in step (1) and add distilled water, the quality adding distilled water is step
(1) 8 ~ 12 times of the whole constituent masses weighed in, continue 120 minutes after ebuillition of heated, pour out extracting solution, repeatable operation two
Secondary, merging twice extracting solution is extracting solution, at 80 DEG C, by extracting liqConcentrating as relative density is 1.30～1.35
Clear paste, then stirring clear paste limit in limit adds ethanol, makes clear paste alcohol content reach 60%, filters, and it is relative that taking precipitate concentrates at 80 DEG C
Density is the clear paste of 1.30～1.35；
(7) putting in container by the dry maxima skin weighed in step (1), add distilled water, the quality adding distilled water is step (1)
In weigh 8-12 times of whole constituent masses, continue 120 minutes after ebuillition of heated, pour out extracting solution, then add in container
Distilled water, adds 8-10 times that quality is the whole constituent masses weighed in step (1) of distilled water, continues after ebuillition of heated
120 minutes, pouring out extracting solution, merging twice extracting solution is extracting solution, it is concentrated into medicinal liquid 1:1, then stirring clear paste limit in limit adds
Mass fraction is 95% ethanol, makes clear paste alcohol content reach 60%, stands 72 hours, take precipitation, is dried, and baking temperature is 60 ~ 75 DEG C,
Make clear paste moisture Control within 4%；
(8) putting in container by the Radix Ginseng weighed in step (1), adding mass fraction is the ethanol of 75%, adds the quality of ethanol
For step (1) weighs 8 ~ 10 times of whole constituent mass, after ebuillition of heated, continue 90 ~ 150 minutes, pour out extracting solution, then to
Adding mass fraction 75% ethanol in container, addition quality is 6 ~ 8 times that weigh whole constituent mass in step (1), heating boiling
Continue 90 ~ 150 minutes after rising, pour out extracting liq, then in container, add mass fraction 75% ethanol, add the quality of ethanol
For 6 ~ 8 times that weigh whole constituent mass in step (1), continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting liq, close
And three extracting solution are extracting solution, at 80 DEG C, concentrate the clear paste for relative density is 1.30～1.35；
(9) putting in container by the Cortex Cinnamomi weighed in step (1), adding mass fraction is 50% ethanol, and the quality adding ethanol is
In step (1) 8 ~ 10 times that weigh whole constituent mass, ultrasonic lasting 20 ~ 40 minutes, pour out extracting solution, then add in container
Entering mass fraction is 50% ethanol, and the quality adding ethanol is 6 ~ 8 times that weigh whole constituent mass in step (1), ultrasonic holds
Continuous 20 ~ 40 minutes, pouring out extracting liq, merging twice extracting solution is extracting solution, at 80 DEG C, by extracting liqConcentration is
Relative density is the clear paste of 1.30～1.35；
(10) putting in container by the Radix Platycodonis weighed in step (1), adding mass fraction is the ethanol of 70%, adds the matter of ethanol
Amount is 8 ~ 10 times that weigh whole constituent mass in step (1), ultrasonic lasting 50 ~ 70 minutes, pours out extracting solution, then to container
Middle addition mass fraction is 70% ethanol, and the quality adding ethanol is 6 ~ 8 times that weigh whole constituent mass in step (1), super
Sound continues 50 ~ 70 minutes, pours out extracting liq, then addition mass fraction is 70% ethanol in container, and the quality adding ethanol is
In step (1) 6 ~ 8 times that weigh constituent mass, ultrasonic lasting 50 ~ 70 minutes, pour out extracting liq, merge three extracting solution
For extracting solution；
(11) putting in container by the Rabdosia rubescens weighed in step (1), adding mass fraction in this container is the ethanol of 95%,
Add 15 ~ 30 times that quality is the whole constituent masses weighed in step (1) of ethanol, with ethanol by Rabdosia rubescens diafiltration 2 times, fall
Go out extracting liq XI, at 80 DEG C, extracting liq XI is concentrated the clear paste for relative density is 1.30～1.35；
(12) Rhizoma Curcumae weighed in step (1), Rhizoma Sparganii being put in container and add distilled water, the quality adding distilled water is
8 ~ 12 times of the whole constituent masses weighed in step (1), continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, repeat
Operating twice, merging twice extracting solution is extracting solution, at 80 DEG C, extracting liqConcentrate for relative density be 1.30～
1.35 clear paste；
(13) putting in container by the Agaricus blazei Murrill weighed in step (1) and add distilled water, the quality adding distilled water is step
(1) 8 ~ 12 times of the whole constituent masses weighed in, continue 170 ~ 200 minutes after ebuillition of heated, pour out extracting solution, in a reservoir
Add distilled water, add 8 ~ 12 times that quality is the whole constituent masses weighed in step (1) of distilled water, after ebuillition of heated
Continuing 170 ~ 200 minutes, pour out extracting solution, add distilled water in a reservoir, the quality adding distilled water is to claim in step (1)
8 ~ 12 times of the whole constituent masses taken, continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, and merging three extracting solution is
Extracting solutionII, at 80 DEG C, by extracting liqII concentrates as the clear paste that relative density is 1.30～1.35, then limit stirring
Clear paste limit adds ethanol, makes clear paste alcohol content reach 80%, filters, and taking precipitate is dried at 60 ~ 75 DEG C；(14) by step (1)
The Ganoderma weighed is put in container and adds distilled water, and the quality adding distilled water is the whole component matter weighed in step (1)
8 ~ 12 times of amount, continue 90 ~ 150 minutes after ebuillition of heated, pour out extracting solution, repetitive operation twice, and merging twice extracting solution is
Extracting solution XIV, at 80 DEG C, extracting liq XIV concentrates the clear paste for relative density is 1.30～1.35；
(15) clear paste that step (2) ~ (14) finally give is separately dried, and mix homogeneously, baking temperature is 60 ~ 75 DEG C, makes
Clear paste moisture Control is within 4%；
(16) the clear paste mixture of dried mix homogeneously is pulverized.
5. use granule prepared by the preparation method of claim 4, it is characterised in that its preparation method is:
The product described step (16) finally given is pelletized after pulverizing.
6. use capsule prepared by the preparation method of claim 4, it is characterised in that its preparation method comprises the steps:
The product described step (16) finally given fills No. 0 capsule after pulverizing, and each capsule contents is received in 0.5-0.7g
Medicine component.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1678335A (en) * | 2002-07-02 | 2005-10-05 | 协和工程株式会社 | Agaricus blazei murill extract capable of preventing cancer induction or metastasis |
| CN102949385A (en) * | 2012-11-05 | 2013-03-06 | 江苏红豆杉生物科技股份有限公司 | Yew branch and leaf extract, extraction method and applications thereof |
| CN104740499A (en) * | 2013-12-25 | 2015-07-01 | 孔祥涛 | Traditional Chinese medicine oral decoction for treating lung cancer |
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2016
- 2016-05-11 CN CN201610309677.2A patent/CN105963351A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1678335A (en) * | 2002-07-02 | 2005-10-05 | 协和工程株式会社 | Agaricus blazei murill extract capable of preventing cancer induction or metastasis |
| CN102949385A (en) * | 2012-11-05 | 2013-03-06 | 江苏红豆杉生物科技股份有限公司 | Yew branch and leaf extract, extraction method and applications thereof |
| CN104740499A (en) * | 2013-12-25 | 2015-07-01 | 孔祥涛 | Traditional Chinese medicine oral decoction for treating lung cancer |
Non-Patent Citations (1)
| Title |
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| 袁素整理: "《中国中医药报》", 30 September 2015 * |
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Application publication date: 20160928 |