CN1059561C - 生翘儿感冲剂及制备方法 - Google Patents
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Abstract
本发明涉及到一种从天然植物中提取有效成份而制成的医用配制器及其这种医用制品的制备方法。本发明所述的生翘儿感冲剂由连翘、生地、竹叶柴胡、玄参、桑叶、渐贝母、蒲公英、马兰、滇紫草、桔梗、莱服子、甘草等十二味药组成。本发明所属药物经急性毒性试验、长期毒性试验证明，无毒副作用。经Ⅰ、Ⅱ期临床试验，对风热感冒，发热、咳嗽、咽炎等上呼吸道感染有较好疗效。
Description
本发明涉及到一种从天然植物中提取有效成份而制成的医用配制品及其这种医用制品的制备方法。
中国专利申请GK87104199公开了一种“小儿速效感冒灵的制作方法”，系由扑热息痛粉、扑尔敏粉、牛黄等原料制作而成，属于含有机有效成份的医药配制品类。中国专利申请CN1038763A(申请号89103924.4)公开了一种“小儿伤感咳嗽外用制剂的生产方法”，包括基质的制备、对桑枝、枇杷枝药料中有效成份的提取等内容，属外用药物。
本发明的目的是针对小儿的体质及服药特点，提供一种专治小儿常见病的医用配制品及其制备方法。
本发明所述的生翘儿感冲剂由以下成份组成：连翘400-600g、生地300-500g、竹叶柴胡250-450g、玄参200-300g、桑叶150-300g、浙贝母200-350g、蒲公英150-350g、马兰400-600g、滇紫草150-300g、桔梗400-600g、莱服子300-500g、甘草200-350g。
生地为玄参科植物地黄Rehmannia glutinosa Libosch.的干燥块根，主产河南。收载于《中国药典》(1985年版)一部97页。
玄参为玄参科植物玄参Scrophularia ningpoensis Hemsl的干燥根。收载于《中国药典》(1985年版)一部92页。
桑叶为桑科植物桑Morus alba L.的干燥叶，主产于浙江、四川。收载于《中国药典》(1985年版)一部264页。
竹叶柴胡为伞形科植物竹叶柴胡Bupleurum marginatum wall.ex DC.的干燥全草，主产于云南。收载于《云南省药品标准》滇Q/WS189-1974。
连翘为木犀科植物连翘Forsythia suspensa (Thunb.)Vahl的干燥果实，主产于河南。收载于《中国药典》(1985年版)一部141页。
马兰为爵床科植物马蓝Stvobilanthus Cusia(Ness)O.Kuntze的干燥根及根茎.主产于云南.收载于《中国药典》(1974年版)一部184页。
蒲公英为菊科植物蒲公英Tarxaoum mongolicm Hand.-Mazz或同属数种植物的干燥全草。全国各地均产。收载于《中国药典》(1985年版)一部315页。
滇紫草为紫草科植物滇紫草Onosma Paniculatm Bur.et Franch.的干燥根部栓皮。收载于《云南省药品标准》滇Q/WS 452-1974年版。
浙贝母为百合科植物浙贝母Fritillaria thunbegil Miq.的干燥鳞茎。收载于《中国药典》(1985年版)一部253页。
桔梗为桔梗科植物桔梗Platycodon grandiflirum(Jacq)A.DC.的干燥根，主产于黑龙江、吉林、辽宁、河北。 收载于《中国药典》(1985年版)一部230页。
莱菔子为十字花科植物萝卜Rapanus sativusL.的干燥成熟种子。收载于《中国药典》(1985年版)一部240页。
甘草为豆科植物甘草Glycyrhiza uralensis Fisch、胀果甘草Glycyrrhiza inflata Bat.或光果甘草Glycyrrhiza glabraL.的干燥根及根茎。主产于宁夏、内蒙、黑龙江、吉林、辽宁。收载于《中国药典》(1985年版)一部65页。
本配方中柴胡透表泄热，连翘善散上焦之热毒，消咽喉之肿结，二药合用可疏风解表兼以清热。生地养阴清热，与之共为君药。桑叶能助疏风解表之力，玄参助清热养阴又善解毒散结皆为臣药。蒲公英、马兰助清热，兼能解毒消肿，滇紫草凉血活血，浙贝母、桔梗清热化痰；莱菔子消食健胃，共为佐药，甘草调和诸药以为使。
本发明所述的生翘儿感冲剂的制备方法由以下步骤组成：
(一)、取浙贝母、滇紫草粉碎，用70-95％乙醇迥流提取，过滤备用；
(二)、其它十味药粉碎，加水煎煮二次，每次1.5小时，煎煮液过滤，浓缩至相对密度1.1-1.4，冷至室温，加乙醇至含醇量为60-80％，搅拌、静置，取上清液回收乙醇，然后继续缩至相对密度1.2-1.35；
(三)、将步骤(一)、(二)所得物合并，搅拌、加入药用辅料、干燥、制成冲剂。
本发明所述制备方法中，所成型的剂型为冲剂、片剂、胶囊等。
本发明所述的生翘儿感冲剂经急性毒性试验、长期毒性试验证明，无毒副作用。经免疫试验有明显增强吞噬细胞、吞噬鸡血球和消化鸡血球的作用，无增强小鼠淋巴细胞转化作用。抑制流感病毒试验对流感病毒A/京防86-1和B/京防86-37两种病毒有抑制。对A/贵防86-30毒株也显抑制。抗菌谱试验，对金黄色葡萄球菌，变形杆菌有极强的抑制作用。解热降温试验，本冲剂对三联菌苗致热的家兔，灌胃给4g冲剂/kg ；或2g冲剂/kg、6g冲剂/kg与灌胃给氨基比林50ng/kg的解热降温作用相当；给药后一小时与空白对照组比，体温下降显著，2小时后体温趋向正常。经I、II期临床试验，对风热感冒，发热、咳嗽、咽炎等上呼吸道感染有较好疗效。
实施例：
取浙贝母208g、滇紫草220g粉碎，加70％乙醇迥流提取二次，过滤备用。取连翘416g、生地430g、竹叶紫胡450g、玄参210g、桑叶208g、蒲公英190g、马兰400g、桔梗500g、莱服取子416g、甘草218g粉碎、加水煎煮二次，每次1.5小时，煎煮液过滤，合并滤液浓缩至相对密度1.20(60-65℃)，冷至室温，加乙醇至含醇量为70％，充分搅拌，静置24小时，取上清液回收乙醇后继续浓缩至相对密度为1.30(60-65℃)的浸膏，加糊精250g，蔗糖500g及上述浙贝母滇紫草的醇提液，干燥，制成冲剂，分装，每包8g。
含量测定：本品每袋含总生物碱以贝母素甲(C27H45NO3)计算，应为3.15-4.26mg。
Claims (2)
1、一种生翘儿感冲剂，其特征在于是用下列用量的原料制成：连翘400-600g、生地300-500g、竹叶柴胡250-450g、玄参200-300g、桑叶150-300g、浙贝母200-350g、蒲公英150-350g、马兰400-600g、滇紫草150-300g、桔梗400-600g、莱服子300-500g、甘草200-350g。
2、按照权利要求1所述的生翘儿感冲剂的制备方法，其特征在于由以下步骤组成：
(一)、取浙贝母、滇紫草粉碎，用70-95％乙醇迥流提取，过滤备用：
(二)、其它十味药粉碎，加水煎煮二次，每次1.5小时，煎煮液过滤，浓缩至相对密度1.1-1.4，冷至室温，加乙醇至含醇量为60-80％，搅拌、静置，取上清液回收乙醇，然后继续缩至相对密度1.2-1.35；
(三)、将步骤(一)、(二)所得物合并，搅拌、加入药用辅料、干燥、制成冲剂。
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| CN93109013A CN1059561C (zh) | 1993-07-21 | 1993-07-21 | 生翘儿感冲剂及制备方法 |
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| CN93109013A CN1059561C (zh) | 1993-07-21 | 1993-07-21 | 生翘儿感冲剂及制备方法 |
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| CN1097613A CN1097613A (zh) | 1995-01-25 |
| CN1059561C true CN1059561C (zh) | 2000-12-20 |
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| CN104474236B (zh) * | 2014-11-25 | 2015-10-28 | 健民集团叶开泰国药（随州）有限公司 | 一种治疗感冒的中药及其制备方法 |
| CN106243102B (zh) * | 2016-08-15 | 2018-03-23 | 江苏康缘药业股份有限公司 | 生物碱类化合物的应用 |
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1993
- 1993-07-21 CN CN93109013A patent/CN1059561C/zh not_active Expired - Lifetime
Non-Patent Citations (1)
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| 新编中成药应用指南 1993.5.1 杨思澍，学苑出版社 * |
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