CN105954524B - For the biochip of human heat shock protein detection - Google Patents
For the biochip of human heat shock protein detection Download PDFInfo
- Publication number
- CN105954524B CN105954524B CN201610561635.8A CN201610561635A CN105954524B CN 105954524 B CN105954524 B CN 105954524B CN 201610561635 A CN201610561635 A CN 201610561635A CN 105954524 B CN105954524 B CN 105954524B
- Authority
- CN
- China
- Prior art keywords
- detection
- mouth
- biochip
- housing
- heat shock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Abstract
The invention discloses a kind of biochips for human heat shock protein detection, including glass substrate, it further includes housing and sets detection plate on a glass substrate, bottom surface and the upper surface of glass substrate fit below detection plate, the detection plate is equipped with detection liquid and adds in mouth and one group of detection mouth, detection liquid adds in mouth and is connected by channel with each detection mouth, is equipped on the outside of each detection mouth in the detection plate and places mouth for placing the liquid-absorbing block of liquid-absorbing block；It is opening above the housing, opening is equipped with the snap-gauge of protrusion inwardly, and detection plate and glass substrate are located between the bottom plate of housing and snap-gauge, and the housing is transparent housing, and detection plate is rubber slab.The biochip is reasonable in design, and a variety of human heat shock proteins can be detected simultaneously with a biochip, save biochip, reduces testing cost, and detection efficiency is high.
Description
Technical field
The present invention relates to biochip technology field, more particularly, to a kind of biological core for human heat shock protein detection
Piece.
Background technology
Human heat shock protein is related to various diseases, and human heat shock protein type is relatively more.Current human heat shock protein
Detection chip a certain human heat shock protein can only be detected, when detection need to prepare a variety of detection chips carry out it is independent
Detection, biochip function is single, of high cost, and detection efficiency is low.
Invention content
It is examined in view of the shortcomings of the prior art, the technical problems to be solved by the invention are to provide a kind of human heat shock protein that is used for
The biochip of survey can while be detected a variety of human heat shock proteins, the high purpose of detection efficiency with reaching.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
This is used for the biochip of human heat shock protein detection, including glass substrate, further includes housing and is located at glass base
The upper surface of the detection plate of on piece, detection plate lower section bottom surface and glass substrate fits, and the detection plate is equipped with detection liquid and adds
Entrance and one group of detection mouth, detection liquid adds in mouth and is connected by channel with each detection mouth, in each inspection in the detection plate
It surveys to be equipped on the outside of mouth and places mouth for the liquid-absorbing block for placing liquid-absorbing block；It is opening above the housing, opening is set inwardly
There is the snap-gauge of protrusion, detection plate and glass substrate are located between the bottom plate of housing and snap-gauge, and the housing is transparent housing, is examined
Drafting board is rubber slab.
Channel in the detection plate includes main channel and subchannel, and main channel directly adds in mouth with detection liquid and is connected, respectively
A detection mouth is connected by subchannel with main channel.
The upper surface edge of the glass substrate is equipped with raised item, and the bottom surface edge of detection plate is equipped with corresponding with raised item
Positioning groove.
The both sides of the main channel are equipped with subchannel, and the subchannel of main channel both sides shifts to install.
The positioning groove is dovetail groove.
Cover board is further included, the snap-gauge is equipped with card slot, and deck side edge can be inserted into card slot.
The bottom plate of the housing is equipped with through-hole.
The upper surface edge of the detection plate is equipped with positioning convex strip, and the snap-gauge is equipped with and the corresponding limit of positioning convex strip
Position slot.
The cover board is L-square, and L-square includes transverse slat and riser, and transverse slat is corresponding with the opening of upper part of the housing, riser
It is corresponding with the opening of housing side.
Compared with prior art, the present invention it has the following advantages：The biochip is reasonable in design, with a biological core
Piece can simultaneously be detected a variety of human heat shock proteins, save biochip, reduce testing cost, and detection efficiency is high.
Description of the drawings
The content to this specification expressed by each width attached drawing and the label in figure are briefly described below：
Fig. 1 is present invention detection plate structure schematic diagram.
Fig. 2 is glass substrate structure diagram of the present invention.
Fig. 3 is inventive shell structure diagram.
Fig. 4 is covering plate structure schematic diagram of the present invention.
In figure：1. detection plate, 101. detection liquid add in mouth, 102. main channels, 103. subchannels, 104. detection mouths, 105.
Liquid-absorbing block, 106. positioning convex strips, 2. glass substrates, 201. raised items, 202. convex blocks, 3. housings, 301. snap-gauges, 302. limitings
Slot, 303. card slots, 4. cover boards.
Specific embodiment
Below against attached drawing, by the description of the embodiment, making to the specific embodiment of the present invention further details of
Explanation.
As shown in Figures 1 to 4, biochip for being used for human heat shock protein detection, including housing 3, cover board 4, glass
Substrate 2 and detection plate 1, wherein, detection plate 1 is located in glass substrate 2, and glass substrate 2 is the support carrier of detection plate, is detected
Plate is located at the surface of glass substrate, and detection plate is rectangle tabular structure as glass substrate size dimension.
Bottom surface and the upper surface of glass substrate fit below detection plate, and the upper surface edge of glass substrate 2 is equipped with protrusion
Item 201, the bottom surface edge of detection plate be equipped with the corresponding positioning groove of raised item, positioning groove is dovetail groove；Glass substrate
Raised item one end on the inside of be equipped with convex block 202, positioning groove one end be equipped with slot corresponding with convex block, to detection plate and glass substrate
It is positioned.Detection plate is rubber slab, rubber slab and glass substrate flexible contact, and fitting effect is good.
Detection plate 1 adds in mouth 101 and one group of detection mouth 104 equipped with liquid is detected, and detection liquid addition mouth is by channel and respectively
A detection mouth is connected；Specifically, channel includes main channel 102 and subchannel 103, main channel 102 is directly added in detection liquid
Mouth 101 is connected, and each detection mouth 104 is connected by subchannel with main channel, is all provided on the outside of each detection mouth in detection plate
The liquid-absorbing block for being useful for placing liquid-absorbing block 105 places mouth, and liquid-absorbing block is the paper block or sponge block that can be absorbed water.It can by liquid-absorbing block
The detection liquid for adding in detection liquid addition mouth is drawn onto automatically in each detection mouth, various human heat shock proteins can be added in detection mouth
Antigen or antibody；The both sides of main channel are equipped with subchannel, and the subchannel of main channel both sides shifts to install, it is ensured that detection
Reliability.
Housing 3 is fixed the two for accommodating detection plate and glass substrate.Housing 3 be rectangular box-like structure, shell
3 top of body and one side are opening, and housing upper opening is equipped with the snap-gauge 301 of protrusion inwardly, and detection plate and glass substrate are set
Between the bottom plate and snap-gauge of housing.It can be inserted into housing by the opening of housing side after detection plate and glass substrate cooperation.
The upper surface edge of detection plate 1 is equipped with positioning convex strip 106, and snap-gauge 301 is equipped with and the corresponding limit of positioning convex strip
Position slot 302, detection plate and glass substrate are inserted into housing, ensure the position of the two in the housing by positioning convex strip, fixed
It is reliable and stable.
Snap-gauge 301 is equipped with card slot 303, and 4 side of cover board can be inserted into card slot.Cover board is L-square, and L-square includes horizontal stroke
Plate and riser, transverse slat is corresponding with the opening of upper part of the housing, and riser is corresponding with the opening of housing side.Cover board is hollow modeling
Flitch, cover board are squeezed elastically deformable, cover board be inserted into card slot position it is reliable.
The bottom plate of housing 3 is equipped with through-hole or housing is transparent housing, it is ensured that detection result；Such as the bottom plate of housing
Through-hole is equipped with, through-hole can be rectangular through-hole, pass through support of the edge of through-hole to glass substrate.
A variety of human heat shock proteins can be detected simultaneously with a biochip, save biochip, reduce detection
Cost, detection efficiency are high.
The present invention is exemplarily described above in conjunction with attached drawing, it is clear that present invention specific implementation is not by aforesaid way
Limitation, as long as employ the present invention design and technical solution carry out various unsubstantialities improvement or it is not improved will
The design and technical solution of the present invention directly applies to other occasions, within protection scope of the present invention.
Claims (9)
1. a kind of biochip for human heat shock protein detection, including glass substrate, it is characterised in that：Further include housing and
If detection plate on a glass substrate, bottom surface and the upper surface of glass substrate fit below detection plate, are set in the detection plate
There is detection liquid to add in mouth and one group of detection mouth, detection liquid adds in mouth and is connected by channel with each detection mouth, the detection plate
On be equipped on the outside of each detection mouth for place liquid-absorbing block liquid-absorbing block place mouth；It is opening above the housing, opens
Mouth is equipped with the snap-gauge of protrusion inwardly, and detection plate and glass substrate are located between the bottom plate of housing and snap-gauge, and the housing is
Bright housing, detection plate are rubber slab；Detection plate is as glass substrate size dimension.
2. as described in claim 1 for the biochip of human heat shock protein detection, it is characterised in that：In the detection plate
Channel includes main channel and subchannel, and main channel directly adds in mouth with detection liquid and is connected, and each detection mouth passes through subchannel and master
Channel is connected.
3. as described in claim 1 for the biochip of human heat shock protein detection, it is characterised in that：The glass substrate
Upper surface edge is equipped with raised item, and the bottom surface edge of detection plate is equipped with and the corresponding positioning groove of raised item.
4. as claimed in claim 2 for the biochip of human heat shock protein detection, it is characterised in that：The two of the main channel
Side is equipped with subchannel, and the subchannel of main channel both sides shifts to install.
5. as claimed in claim 3 for the biochip of human heat shock protein detection, it is characterised in that：The positioning groove is
Dovetail groove.
6. as described in claim 1 for the biochip of human heat shock protein detection, it is characterised in that：Cover board is further included, institute
Snap-gauge is stated equipped with card slot, deck side edge can be inserted into card slot.
7. as described in claim 1 for the biochip of human heat shock protein detection, it is characterised in that：The bottom plate of the housing
It is equipped with through-hole.
8. as described in claim 1 for the biochip of human heat shock protein detection, it is characterised in that：The detection plate it is upper
Surface edge is equipped with positioning convex strip, and the snap-gauge is equipped with and the corresponding limiting slot of positioning convex strip.
9. as claimed in claim 6 for the biochip of human heat shock protein detection, it is characterised in that：The cover board is right angle
Plate, L-square include transverse slat and riser, and transverse slat is corresponding with the opening of upper part of the housing, and riser is opposite with the opening of housing side
It should.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610561635.8A CN105954524B (en) | 2016-07-15 | 2016-07-15 | For the biochip of human heat shock protein detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610561635.8A CN105954524B (en) | 2016-07-15 | 2016-07-15 | For the biochip of human heat shock protein detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105954524A CN105954524A (en) | 2016-09-21 |
| CN105954524B true CN105954524B (en) | 2018-06-29 |
Family
ID=56900816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610561635.8A Active CN105954524B (en) | 2016-07-15 | 2016-07-15 | For the biochip of human heat shock protein detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105954524B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106468717A (en) * | 2016-10-18 | 2017-03-01 | 秦艳霞 | Biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2565022Y (en) * | 2002-08-23 | 2003-08-06 | 上海博昇微晶科技有限公司 | Microfluid chip with three-layer structure |
| CN101382538B (en) * | 2007-09-04 | 2013-06-05 | 财团法人工业技术研究院 | Auto-shunting microfluid apparatus |
| JP6090330B2 (en) * | 2012-10-31 | 2017-03-08 | 日立化成株式会社 | Sensor chip and measurement system |
| CN104226385A (en) * | 2013-06-09 | 2014-12-24 | 北京百康芯生物科技有限公司 | A novel micro-fluidic chip and a using method thereof |
| CN103389303A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Multi-index analysis paper chip and preparation method thereof |
| CN205844338U (en) * | 2016-07-15 | 2016-12-28 | 陶少强 | A kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection |
-
2016
- 2016-07-15 CN CN201610561635.8A patent/CN105954524B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105954524A (en) | 2016-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0606176A2 (en) | conductor for double-sided smart card connection | |
| CN105954524B (en) | For the biochip of human heat shock protein detection | |
| CN106248957B (en) | A kind of biochip for being used to detect human heat shock protein | |
| CN205844338U (en) | A kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection | |
| CN209594116U (en) | A kind of inset type double-sided wiring board | |
| CN209373935U (en) | A kind of device signboard | |
| CN208780604U (en) | A kind of ultraviolet (UV) aging test chamber | |
| CN209764730U (en) | Kit for rapidly detecting feed additive | |
| CN106018786B (en) | For detecting the intelligent detection equipment of Procalcitonin | |
| CN105929152B (en) | A kind of intelligent detecting instrument for Procalcitonin detection | |
| CN209257100U (en) | A kind of LED display board localization tool | |
| CN219328913U (en) | Diffusion piece with quick connection structure | |
| CN206413906U (en) | A kind of novel stationery case | |
| CN106153875B (en) | A kind of portable reagent detection box | |
| CN207842434U (en) | A kind of enterprise's meeting management work dedicated folder | |
| CN200988376Y (en) | Picture plate type compasses | |
| CN204513100U (en) | A kind of backlight module, display unit and terminal | |
| CN203607039U (en) | Electronic tag for goods shelf | |
| CN211124117U (en) | Waterproof type RFID electronic tags | |
| CN210721542U (en) | Intelligent card supporting three-frequency non-contact communication | |
| CN210640940U (en) | Image sensor with a plurality of pixels | |
| CN214671708U (en) | Elevator advertisement display board convenient to change content | |
| CN208171715U (en) | A kind of quick detection glass slide of improvement | |
| CN205942937U (en) | Cell -phone POS machine | |
| CN210200012U (en) | Magnetic geometric figure assembling teaching aid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20171127 Address after: 241000 Anhui Province, Wuhu city Jinghu District long Fang Culture Park (big long Fang No. 77) B03 Building Room 303 Applicant after: Anhui National Science Biotechnology Co., Ltd. Address before: West Road in Shushan District of Hefei City, Anhui Province, No. 32 230000 Applicant before: Tao Shaoqiang Applicant before: Li Yufeng Applicant before: Zhang Shiwei Applicant before: Zhang Bin Applicant before: Wang Xiaoyang Applicant before: Yang Yanqi |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |