CN106468717A - Biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection - Google Patents
Biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection Download PDFInfo
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- CN106468717A CN106468717A CN201610908987.6A CN201610908987A CN106468717A CN 106468717 A CN106468717 A CN 106468717A CN 201610908987 A CN201610908987 A CN 201610908987A CN 106468717 A CN106468717 A CN 106468717A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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Abstract
The present invention relates to a kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection, including：Glass substrate, housing and the detection plate being located on described glass substrate, below described detection plate, bottom surface and the upper surface of glass substrate fit, described detection plate is provided with detection liquid and adds mouth and one group of detection mouth, detection liquid adds mouth to be connected with each detection mouth by passage, and in described detection plate, the outside in each detection mouth is equipped with and places mouth for the liquid-absorbing block placing liquid-absorbing block；It is opening above described housing, opening is provided with the clamp of protrusion to inner side, and detection plate and glass substrate are located between the base plate of housing and clamp, and described housing is transparent housing, and detection plate is rubber slab.
Description
Technical field
The present invention relates to biochip field, more particularly, to a kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection.
Background technology
HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 is related to various diseases, and HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 species is relatively more.Current HUMAN HEAT SHOCK PROTEINS Hhsp HSP70
Detection chip a certain HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 can only be detected, need during detection to prepare multiple detection chip to carry out individually
Detection, biochip single function, high cost, detection efficiency is low.Meanwhile, with scientific and technological development, the drawbacks of passive type detects
Manifest more and more it is therefore desirable to go patient is diagnosed, this requires more to have mobility more initiatively.
Content of the invention
In order to solve the above problems, the invention provides a kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection, including：
Glass substrate, housing and the detection plate being located on described glass substrate, the upper table of bottom surface and glass substrate below described detection plate
Face fits, and described detection plate is provided with detection liquid and adds mouth and one group of detection mouth, detection liquid add mouth pass through passage and each
Detection mouth is connected, and in described detection plate, the outside in each detection mouth is equipped with and places for the liquid-absorbing block placing liquid-absorbing block
Mouthful；It is opening above described housing, opening is provided with the clamp of protrusion to inner side, detection plate and glass substrate are located at the base plate of housing
And clamp between, described housing is transparent housing, and detection plate is rubber slab.
Biochip structure of the present invention is simple, convenient and practical.
Specific embodiment
Below embodiment of the present invention is described in detail.
In one aspect of the invention, the present invention provides a kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection, including：Glass
Glass substrate, housing and the detection plate being located on described glass substrate, the upper surface of bottom surface and glass substrate below described detection plate
Fit, described detection plate is provided with detection liquid and adds mouth and one group of detection mouth, and detection liquid adds mouth to examine with each by passage
Survey mouth to be connected, in described detection plate, the outside in each detection mouth is equipped with and places mouth for the liquid-absorbing block placing liquid-absorbing block；
Be opening above described housing, opening is provided with the clamp of protrusion to inner side, detection plate and glass substrate be located at the base plate of housing with
Between clamp, described housing is transparent housing, and detection plate is rubber slab.
In order to strengthen the convenience of biochip of the present invention, it is considered as desirable by the inventor to by biochip of the present invention
It is arranged on vehicle.However, due to carrying out a large amount of chemical experiments, and the introducing of large number quipments easily produces security protection aspect
Problem.In prior art, in the case that fire or smog occur, existing vehicle sensory equipment and emergency reaction equipment
Quantity and type can not meet demand, and current emergency reaction equipment remains a need for excessive artificial participation process it is impossible to according to car
Concrete condition is voluntarily reacted, and this substantially prolongs the response time, easily causes the generation of major casualties.Currently simultaneously
There is no the solution of the problems referred to above, in order to overcome above-mentioned deficiency, it is considered as desirable by the inventor in the vehicle arranging described biochip
On build a kind of vehicle fire extinguisher bomb automatic spring system, existing vehicle structure is transformed, existing emergency reaction is set
Standby carry out automatic updating, also the number of sensors and species of vehicle abnormality state-detection is increased simultaneously such that it is able to
In time detection is made a response to abnormalities such as fire and rapidly.
Therefore, in another aspect of this invention, the present invention provides a kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection,
Described biochip is arranged on vehicle and includes：Glass substrate, housing and the detection plate being located on described glass substrate, institute
State bottom surface and the upper surface of glass substrate below detection plate to fit, described detection plate is provided with detection liquid and adds mouth and one group of inspection
Survey mouth, detection liquid adds mouth to be connected with each detection mouth by passage, and in described detection plate, the outside in each detection mouth is equal
It is provided with and place mouth for the liquid-absorbing block placing liquid-absorbing block；It is opening above described housing, opening is provided with the clamp of protrusion to inner side,
Detection plate and glass substrate are located between the base plate of housing and clamp, and described housing is transparent housing, and detection plate is rubber slab,
Described vehicle includes vehicle fire extinguisher bomb automatic spring system.
Preferably, in the biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection of the present invention, described vehicle fire extinguisher bomb
Automatic spring system includes：
Flame detection equipment, positioned at roof location, for carrying out image acquisition to obtain in-car image, base to environment inside car
In-car image is carried out with fire defector to split at in-car image and to export flame subimage in preset reference flame pattern,
Flame alarm signal is exported, the output no flare up fire when no flame subimage output while output flame subimage；
Smokescope equipment, positioned at roof location, for detecting to in-car smokescope, output Real-time Smoke is dense
Degree；Smokescope warning device, positioned at roof location, is connected with smokescope testing equipment, for receiving Real-time Smoke concentration,
And when Real-time Smoke concentration is more than or equal to default smoke density threshold value, send smokescope alarm signal, dense in Real-time Smoke
When degree is less than default smoke density threshold value, send smokescope normal signal；
Temperature testing equipment, is arranged near engine location, including the conversion of bimetal leaf, curvature measuring device and signal
Device, bimetallic is sticked together and formed by the different metal of the two panels coefficient of expansion, and curvature measuring device is connected with bimetal leaf, is used for
To export as real-time curvature, signal adapter is connected the degree of crook of detection bimetal leaf with curvature measuring device, for being based on
Real-time curvature determines and exports real time temperature；
Temperature alarming equipment, is connected with temperature testing equipment, for receiving real time temperature, and is more than or equal in real time temperature
During preset temperature threshold value, send temperature anomaly signal, when real time temperature is less than preset temperature threshold value, sends temperature and normally believe
Number；
High definition collecting device, is arranged near safety door, including high-definition camera, support, head, protective cover, flash lamp,
Photoflash controller and ambient brightness detector, high-definition camera is arranged on head to carry out packaged type bat on head
Take the photograph, obtain HD video, head and protective cover are fixed on support, ambient brightness detector is used for detecting the bright of surrounding
Degree, ambient brightness detector surrounding is carried out brightness detect to obtain real time environment brightness, photoflash controller respectively with
Ambient brightness detector and flash lamp connect, for the opening and closing based on real time environment brilliance control flash lamp；
Displacement detection device, is arranged on the head of high definition collecting device, for carrying out on head when high-definition camera
The amount of movement of accumulative high-definition camera when packaged type shoots, when the amount of movement of high-definition camera is more than preset displacement threshold value,
Send scanning shoot signal, when the amount of movement of high-definition camera is less than or equal to preset displacement threshold value, send establishing shot signal；
Fixed reference frame extraction equipment, is connected with high definition collecting device and displacement detection device respectively, receives for working as
During establishing shot signal, from energy-saving mode, return to normal mode of operation, and select to fix a two field picture from HD video
As the reference picture of all successive images, when receiving scanning shoot signal, enter into economize on electricity mould from normal mode of operation
Formula；
Sequence reference frame extraction equipment, is connected with high definition collecting device and displacement detection device respectively, receives for working as
During establishing shot signal, enter into energy-saving mode from normal mode of operation, when receiving scanning shoot signal, from energy-saving mode
In return to normal mode of operation, and select the reference as present image for the previous frame image of present image from HD video
Image；
Vector detection equipment, is connected with fixed reference frame extraction equipment and sequence reference frame extraction equipment respectively and is worked as with obtaining
The reference picture of front image, reference picture and present image is all divided into 8 × 8 subimage block, by the upper left in reference picture
The subimage block in the subimage block at angle and the upper right corner respectively as left with reference to subimage block and right with reference to subimage block, for left ginseng
Examine subimage block, search from present image with the left subimage block mating with reference to subimage block as left target subimage
Block, calculates motion vector therebetween and as left movement vector based on left with reference to subimage block and left target subimage block,
For right with reference to subimage block, search from present image with the right subimage block mating with reference to subimage block as right target
Subimage block, calculates motion vector therebetween and as right motion based on right with reference to subimage block and right target subimage block
Vector, determines overall motion vector based on the right motion vector of left movement vector；
Device for image stabilization, is connected with vector detection equipment, for being carried out surely to present image based on overall motion vector
As processing to obtain current steady image；Based on overall motion vector, present image is carried out with steady picture to process to obtain current steady
Image includes：Present image is moved backward the pixel of equivalent to obtain current steady image along overall motion vector；
Distortion correction equipment, is connected with high definition collecting device and device for image stabilization, respectively for detecting high-definition camera
The angle of optical axis and horizontal direction is as correcting angle, to carry out trapezoidal distortion correction based on correcting angle to current steady image
To obtain current remedial frames；
Number testing equipment, is connected with distortion correction equipment, for carrying out successively at edge enhancing to current remedial frames
Reason, wavelet filtering are processed and gray processing is processed to obtain gray level image, and pixel value in gray level image is fallen default humanoid
Gray scale upper limit threshold and the pixel preset between humanoid gray scale lower threshold are defined as humanoid pixel, will be all in gray level image
The quantity of the humanoid pattern of humanoid pixel composition is defined as real-time car door number and exports；
MSP430 single-chip microcomputer, respectively with number testing equipment, flame detection equipment, smokescope warning device and temperature report
Alert equipment connects, for receiving real-time car door number, and while real-time car door number is more than or equal to default number threshold value also
When receiving flame alarm signal, smokescope alarm signal or temperature anomaly signal, send vehicle abnormality signal, otherwise, send out
Go out vehicle normal signal；
Emergency speech playback equipment, is arranged on roof, is connected with MSP430 single-chip microcomputer, for receiving vehicle abnormality letter
Number when, play emergency speech file；Door pump control apparatus, near the door pump of safety door, are connected with MSP430 single-chip microcomputer, use
In when receiving vehicle abnormality signal, the door pump controlling safety door is to automatically open up safety door；
Circuit xegregating unit, including cooling system, extension type closure, stand-by power supply and microcontroller, is located at
Near MSP430 single-chip microcomputer, microcontroller opens equipment with MSP430 single-chip microcomputer, cooling system, stand-by power supply respectively and shell drives
Dynamic equipment connects, for when receiving vehicle abnormality signal, controlling shell driving equipment to shrink extension type closure
To protect MSP430 single-chip microcomputer in extension type closure, cooling system is controlled to carry out empty in extension type closure
Between cooling, control stand-by power supply open equipment with open stand-by power supply for MSP430 single-chip microcomputer provide emergency service；Wherein, may be used
Telescopic closure is made up of fire proofing material；
In-car unlatching equipment, is arranged on body inner side and is located near safety door, the upper surface apart from floor is 1.5 meters,
Horizontal range to corresponding safety door is less than 0.5 meter；Open equipment outside car, be arranged on outside car body and be located near safety door,
It is 1.8 meters apart from ground, the horizontal range to corresponding safety door is less than 0.5 meter；
Brake control device, is arranged on above driving moment, is connected with MSP430 single-chip microcomputer, for receiving vehicle abnormality letter
Number or vehicle normal signal, and send abnormal brake control signal when receiving vehicle abnormality signal；
Brake block, is arranged on above driving moment, is connected with brake control device, for receiving abnormal brake control
During signal, emergency brake operation is executed to driving moment；Fire extinguisher bomb storage case, is arranged on underbody, for accommodating fire extinguisher bomb；
Ejecting mechanism, is connected with fire extinguisher bomb storage case, is also connected with MSP430 single-chip microcomputer, for receiving vehicle abnormality
During signal, eject fire extinguisher bomb and triggering fire extinguishing bomb switchs to automatically open up fire extinguisher bomb.
It is highly preferred that in the biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection of the present invention, described vehicle fire extinguishing
Play automatic spring system also to include：GPS location equipment, is arranged on outside car body, for providing current GPS location.Therefore, originally
Inventor can be conveniently positioned.
Above the present invention is exemplarily described it is clear that the present invention implements is not subject to the restrictions described above,
As long as employing the design of the present invention and the improvement of various unsubstantialities that technical scheme is carried out, or not improved by the present invention's
Design and technical scheme directly apply to other occasions, all within protection scope of the present invention..
Claims (1)
1. a kind of biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection is it is characterised in that include：Glass substrate, housing and be located at
Detection plate on described glass substrate, below described detection plate, bottom surface and the upper surface of glass substrate fit, described detection plate
It is provided with detection liquid and adds mouth and one group of detection mouth, detection liquid adds mouth to be connected with each detection mouth by passage, described inspection
On drafting board, the outside in each detection mouth is equipped with and places mouth for the liquid-absorbing block placing liquid-absorbing block；It is to open above described housing
Mouthful, opening is provided with the clamp of protrusion to inner side, and detection plate and glass substrate are located between the base plate of housing and clamp, described housing
For transparent housing, detection plate is rubber slab.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610908987.6A CN106468717A (en) | 2016-10-18 | 2016-10-18 | Biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610908987.6A CN106468717A (en) | 2016-10-18 | 2016-10-18 | Biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106468717A true CN106468717A (en) | 2017-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610908987.6A Pending CN106468717A (en) | 2016-10-18 | 2016-10-18 | Biochip for HUMAN HEAT SHOCK PROTEINS Hhsp HSP70 detection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106546739A (en) * | 2016-10-18 | 2017-03-29 | 石永录 | A kind of screening lung cancer test kit |
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|---|---|---|---|---|
| US20050275550A1 (en) * | 2004-06-11 | 2005-12-15 | Ching-Sung Wang | Human-carrying vehicle and auxiliary device thereof |
| JP2008243181A (en) * | 2006-12-12 | 2008-10-09 | Ind Technol Res Inst | Smoke detecting device and method thereof |
| CN101458865A (en) * | 2008-05-09 | 2009-06-17 | 丁国锋 | Fire disaster probe system and method |
| CN101927727A (en) * | 2009-06-22 | 2010-12-29 | 张鹏 | Intelligent safety device of bus |
| CN104299351A (en) * | 2014-10-22 | 2015-01-21 | 常州大学 | Intelligent early warning and fire extinguishing robot |
| CN105954524A (en) * | 2016-07-15 | 2016-09-21 | 陶少强 | Biochip for human heat shock protein detection |
-
2016
- 2016-10-18 CN CN201610908987.6A patent/CN106468717A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050275550A1 (en) * | 2004-06-11 | 2005-12-15 | Ching-Sung Wang | Human-carrying vehicle and auxiliary device thereof |
| JP2008243181A (en) * | 2006-12-12 | 2008-10-09 | Ind Technol Res Inst | Smoke detecting device and method thereof |
| CN101458865A (en) * | 2008-05-09 | 2009-06-17 | 丁国锋 | Fire disaster probe system and method |
| CN101927727A (en) * | 2009-06-22 | 2010-12-29 | 张鹏 | Intelligent safety device of bus |
| CN104299351A (en) * | 2014-10-22 | 2015-01-21 | 常州大学 | Intelligent early warning and fire extinguishing robot |
| CN105954524A (en) * | 2016-07-15 | 2016-09-21 | 陶少强 | Biochip for human heat shock protein detection |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106546739A (en) * | 2016-10-18 | 2017-03-29 | 石永录 | A kind of screening lung cancer test kit |
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Application publication date: 20170301 |
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